Tricyclic Sesquiterpenes and Triterpenoids Group
These substances were identified for action under the Chemicals Management Plan (CMP). The assessment focuses on 14 substances, referred to collectively under the CMP as the Tricyclic Sesquiterpenes and Triterpenoids Group, which are a part of the larger Terpenes and Terpenoids Group.
| Substance group | Subgroup | CAS RN | Common name | DSL name | Draft assessment | Risk management scope | Proposed conclusion on section 64 criteria | Follow-up activities |
|---|---|---|---|---|---|---|---|---|
| Tricyclic Sesquiterpenes and Triterpenoids Group | Tricyclic Sesquiterpene subgroup 1 | 469-61-4 | Alpha-cedrene | 1H-3a,7-Methanoazulene, 2,3,4,7,8,8a-hexahydro-3,6,8,8-tetramethyl-, [3R-(3α,3aβ,7β,8aα)]- | HTML | None | Does not meet | None planned at this time |
| Tricyclic Sesquiterpene subgroup 1 | 470-40-6 | Thujopsene | Cyclopropa[d]naphthalene, 1,1a,4,4a,5,6,7,8-octahydro-2,4a,8,8-tetramethyl-, [1aS-(1aα,4aβ,8aR)]- | None | Does not meet | None planned at this time | ||
| Tricyclic Sesquiterpene subgroup 1 | 489-40-7 | Alpha-gurjunene | 1H-Cycloprop[e]azulene, 1a,2,3,4,4a,5,6,7b-octahydro-1,1,4,7-tetramethyl-, [1aR-(1aα,4α,4aβ,7bα)]- | None | Does not meet | None planned at this time | ||
| Tricyclic Sesquiterpene subgroup 1 | 514-51-2 | Beta-patchoulene | 4,7-Methanoazulene, 1,2,3,4,5,6,7,8-octahydro-1,4,9,9-tetramethyl-, [1S-(1α,4α,7α)]- | None | Does not meet | None planned at this time | ||
| Tricyclic Sesquiterpene subgroup 1 | 546-28-1 | Beta-cedrene | 1H-3a,7-Methanoazulene, octahydro-3,8,8-trimethyl-6-methylene-, [3R-(3α,3aβ,7β,8aα)]- | None | Does not meet | None planned at this time | ||
| Tricyclic Sesquiterpene subgroup 1 | 8000-27-9Footnote a | Cedarwood oil | Oils, cedarwood | HTML | Meets one or more of the criteria | Refer to the risk management scope | ||
| Tricyclic Sesquiterpene subgroup 1 | 68608-32-2Footnote a | T&T cedarwood oil | Terpenes and Terpenoids, cedarwood-oil | None | Does not meet | None planned at this time | ||
| Tricyclic Sesquiterpene subgroup 1 | 68990-83-0Footnote a | Texan cedarwood oil | Oils, cedarwood, Texan | HTML | Meets one or more of the criteria | Refer to the risk management scope | ||
| Individual (Tricyclic Sesquiterpene) | 59056-62-1 | Amboryl acetate | 2,3b-Methano-3bH-cyclopenta[1,3]cyclopropa[1,2]benzene-4-methanol, octahydro-7,7,8,8-tetramethyl-, acetate | None | Does not meet | None planned at this time | ||
| Triterpenoid subgroup 2 | 471-53-4 | Enoxolone | Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3β,20β)- | HTML | Meets one or more of the criteria | Refer to the risk management scope | ||
| Triterpenoid subgroup 2 | 4572-09-2Footnote a | Allantoin glycyrrhetinic acid | Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3β,20β)-, compd. with (2,5-dioxo-4-imidazolidinyl)urea (1:1) | None | Does not meet | None planned at this time | ||
| Individual (Triterpenoid) | 8031-03-6Footnote a | Mimosa oil | Oils, mimosa | HTML | Meets one or more of the criteria | Refer to the risk management scope | ||
| Individual (Triterpenoid) | 84082-54-2Footnote a | Ivy extract | Ivy, Hedera helix, ext. | HTML | Meets one or more of the criteria | Refer to the risk management scope | ||
| Individual (Triterpenoid) | 90045-38-8Footnote a | American ginseng extract | Ginseng, Panax quinquefolium, ext. | None | None planned at this time | None planned at this time | ||
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| Date | Activity |
|---|---|
| March 2026 | Anticipated publication of the final assessment and proposed risk management approach. |
| March 1, 2025 | Publication and start of 60-day public comment period on the Draft Assessment for Terpenes and Terpenoids Tricyclic Sesquiterpenes and Triterpenoids and the Risk Management Scope for Terpenes and Terpenoids Tricyclic Sesquiterpenes and Triterpenoids Group: Cedarwood oil, Texan cedarwood oil, Enoxolone, Mimosa oil, and Ivy extract. The related notice was published in the Canada Gazette, Part I: Vol. 159, No. 9. |
Background
The assessment focuses on 14 substances referred to as the Tricyclic Sesquiterpenes and Triterpenoids Group. The human health risk assessment addressed 10 of the 14 substances under 2 subgroups, due to similarities in chemical structure, properties, or toxicity, while the remaining 4 substances were addressed individually. The ecological risks of substances in this group were characterized using the Ecological Risk Classification of Organic Substances (ERC) Approach. These 14 substances are a part of a larger group of 76 substances referred to collectively under the CMP as the Terpenes and Terpenoids Group.
Three of these 76 substances were subsequently determined to be of low concern to both human health and the environment through other approaches. The conclusion for CAS RN 25428-43-7 is provided in the Final Screening Assessment for the Rapid Screening of Substances with Limited General Population Exposure. Conclusions for CAS RNs 29350-73-0 and 68916-97-2 are provided in the Final Screening Assessment of Substances Identified as Being of Low Concern using the Ecological Risk Classification of Organic Substances and the Threshold of Toxicological Concern (TTC)-based Approach for Certain Substances.
Fifteen of these 76 substances (CAS RNs 80-56-8, 1113-21-9, 8000-46-2, 8002-09-3, 8006-64-2, 8007-01-0, 8007-02-1, 8008-31-9, 8008-52-4, 8008-57-9, 8014-19-5, 8015-77-8, 8016-85-1, 8021-28-1 and 9005-90-7) were assessed as a part of the Acyclic, Monocyclic, and Bicyclic Monoterpenes Group.
Sixteen of these 76 substances (CAS RNs 495-62-5, 8001-61-4, 8007-0-7, 17627-44-0, 65113-99-7, 107898-54-4, 87-44-5, 88-84-6, 3691-12-1, 4630-07-3, 68917-29-3, 489-86-1, 639-99-6, 22451-73-6, 489-84-9 and 8006-87-9) were assessed as a part of the Monocyclic and Bicyclic Sesquiterpenes Group.
Twelve of these 76 substances (CAS RNs 8006-78-8, 8016-88-4, 8022-96-6, 8024-43-9, 8024-08-6, 80-54-6, 91-51-0, 37677-14-8, 52474-60-9, 52475-86-2, 65405-84-7 and 66327-54-6) were assessed as a part of the Phenylpropanoids and Aldehydes Group.
Fourteen of these substances of these 76 substances (CAS RNs 8013-10-3, 8023-75-4, 70788-30-6, 84961-67-1, 90045-36-6, 3738-00-9, 8016-37-9, 164288-52-2, 8022-56-8, 8008-93-3, 3407-42-9, 66068-84-6, 68877-29-2 and 70955-71-4) were assessed as a part of the Fourteen Terpene and Terpenoid Substances Group.
Two of these 76 substances (CAS RNs 117-98-6 and 68917-65-7) were originally included in the Tricyclic Sesquiterpenes and Triterpenoids Group but have been removed to be assessed in a separate assessment.
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