Ethers Group - information sheet
On this page
- Overview
- About these substances
- Human and ecological exposures
- Key health and ecological effects (hazard)
- Risk assessment outcomes
- Related information
Overview
- The Government of Canada conducted a science-based screening assessment under the Canadian Environmental Protection Act, 1999 (CEPA 1999) to address the potential for harm to Canadians and to the environment from the 4 substances in the Ethers Group.
- Under CEPA 1999, the risk posed by a substance is determined by considering both its hazardous properties (its potential to cause adverse human health or ecological effects) and the amount of exposure there is to people and the environment.
- The ecological hazard and exposure potentials of these 4 substances were classified using the Ecological Risk Classification of Organic Substances (ERC) Approach.
- As a result of the draft screening assessment, the 4 substances in the Ethers Group are proposed not to be harmful to human health or to the environment at levels of exposure considered in the assessment.
About these substances
- The screening assessment summarized here focuses on 4 substances: ethane, 1,1'-oxybis-; benzene, 1,1'-oxybis-; methane, oxybis-; and propanol, 1(or 2)-(2-methoxymethylethoxy)-, also referred to as diethyl ether (DEE), diphenyl ether (DPE), dimethyl ether (DME) and dipropylene glycol methyl ether (DPGME), respectively. They were assessed under the Chemicals Management Plan (CMP).
- DEE, DPE and DME naturally occur at low levels in some foods, but DPGME does not occur naturally in the environment.
- According to information gathered by the Government, these substances are mainly used in Canada in air care, automotive, aircraft and transportation, cleaning and furnishing care, fuels and related products, oil and natural gas extraction, as well as paints and coatings. They may be used in food packaging materials, food processing aids, food flavouring agents, medicinal or non-medicinal ingredients in disinfectant, human or veterinary drug products and natural health products, cosmetics, various other products available to consumers, and as formulants (inactive ingredients) in pest control products.
Human and ecological exposures
- Canadians may be exposed to substances in the Ethers Group from environmental media and food. The general population may also be exposed to these substances from the use of products available to consumers; for example:
- DEE from the use of body lotions, corn and callus removers, and automotive starting fluids
- DPE from air fresheners and hand creams
- DME from spray sunscreens
- According to the information considered under the ERC Approach, DEE, DPE and DPGME were identified as having low ecological exposure potential. DME, however, was classified as having a high ecological exposure potential based on a long overall persistence and a large annual import quantity.
Key health and ecological effects (hazard)
- To inform the health effects characterization in the draft screening assessment, international reports of data on these substances were considered. This included assessments by the Joint FAO/WHO Expert Committee on Food Additives (JECFA), the United States Environmental Protection Agency (U.S. EPA), the Organisation for Economic Cooperation and Development (OECD), and the European Food Safety Authority, among others.
- A comparative approach using similar chemicals, called read-across, was used to inform the human health assessment to address some limitations in the dataset.
- The critical effects for DEE were body weight changes, liver toxicity and decreased survival rates in rats exposed to high oral doses. Changes in body weight were noted as the main critical effects for oral and long-term inhalation exposure to DPE. The critical effect for DME was decreased survival rates in rats exposed via long-term inhalation. DPGME was not identified as inducing any adverse effects in any of the available studies and is considered to be of low hazard potential.
- According to information considered under the ERC Approach, all 4 substances were identified as having a low ecological hazard potential.
Risk assessment outcomes
- On the basis of the information presented in the draft screening assessment, the risk to human health from the 4 substances in the Ethers Group is low.
- Based upon the outcome of the ERC Approach, these 4 substances are considered unlikely to be causing ecological harm.
- The Government of Canada published the Draft Screening Assessment for the Ethers Group on March 13, 2021. The public is invited to comment on the assessment during the 60-day public comment period ending on May 12, 2021.
Proposed screening assessment conclusions
- The Government is proposing that DEE, DPE, DME and DPGME are not harmful to human health at levels of exposure considered in the assessment.
- The Government is also proposing that DEE, DPE, DME and DPGME are not entering the environment at levels that are harmful to the environment.
Related information
- Ethers may be found in products available to consumers. Canadians should follow any safety warnings and directions related to the product and dispose of products responsibly.
- Visit Do it for a Healthy Home for more information on chemical safety in and around the home.
- The screening assessment focused on potential risks from exposure of the general population of Canada, rather than occupational exposure. Hazards related to chemicals used in the workplace are defined within the Workplace Hazardous Materials Information System. For information concerning workplace health and safety and what steps to take in the workplace, Canadians should consult their employer and/or the Occupational Health and Safety Regulator in their jurisdiction.
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