Considerations for the use of nirmatrelvir/ritonavir (brand name Paxlovid) to treat COVID-19

Last updated: June 22, 2022

On January 17, 2022, Health Canada authorized the antiviral drug nirmatrelvir to be used in combination with ritonavir (brand name Paxlovid) to treat mild to moderate COVID-19 in adults at high risk of progressing to serious disease. A limited, initial supply was immediately made available to provinces and territories.

In February 2022, to help ensure the initial supply of Paxlovid reached those who would benefit most, the Public Health Agency of Canada (PHAC) published a document entitled Considerations for the use of nirmatrelvir/ritonavir to treat COVID-19 in the context of limited supply.

The supply of nirmatrelvir/ritonavir is no longer limited: shipments have continued to arrive and Canada expects to receive a total of 1.5 million treatment courses in 2022. As such, the document has been archived.

Clinicians should refer to their jurisdiction's guidelines for management of COVID-19, including eligibility criteria. In addition, the following health technology agencies have provided guidance and tools for healthcare providers to assist with prescribing Paxlovid for the treatment of COVID-19 in the outpatient setting:

Please refer to the CADTH Drug Implementation Advice document: Nirmatrelvir and Ritonavir (Paxlovid) for Mild to Moderate COVID-19. Tools published on March 23, 2022, by INESSS include a:

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