Pathogen Safety Data Sheets: Infectious Substances – Mayaro virus

Section I - Infectious Agent

Name

Mayaro virus

Synonym or Cross Reference

Epidemic polyarthritis and rash, Mayaro fever, MAY

Characteristics

Togaviridae (formerly group A arboviruses), genus Alphavirus; spherical, enveloped virions 60 nm in diameter, single-stranded, positive-sense RNA genome

Section II - Hazard Identification

Pathogenicity / Toxicity

Self limiting febrile viral disease; characterized by arthralgia or arthritis typically in the knee, ankle and small joints of the extremities, followed by a maculopapular rash; buccal and palatal enanthea can occur; inapparent infections are common, immunity is long lasting.

Epidemiology

Found in South and Central America.

Host Range

Humans, primates, other mammals, birds.

Infectious Dose

Not known.

Mode of Transmission

By bite of an infective mosquito.

Incubation Period

Usually 3-11 days.

Communicability

No evidence of person-to-person transmission.

Section III - Dissemination

Reservoir

Most likely primates.

Zoonosis

Probable - most likely from primates which generate high viremia but manifest no disease.

Vectors

Mosquitoes - Haemogogus spp.

Section IV - Stability and Viability

Drug Susceptibility

No antiviral available to date.

Susceptibility to Disinfectants

Sensitive to 70% ethanol, 1% sodium hypochlorite, 2% glutaraldehyde, sensitive to lipid solvents.

Physical Inactivation

Inactivated by moist, dry heat> 58 °C; sensitive to drying.

Survival Outside Host

Unknown, less than one day in culture medium at 37° C.

Section V - First Aid / Medical

Surveillance

Monitor for symptoms; confirm by serological analysis and viral isolation in tissue culture (vero cells).

First Aid / Treatment

Mainly supportive therapy.

Immunization

None available to date.

Prophylaxis

None available.

Section VI - Laboratory Hazards

Laboratory - Acquired Infections

At least 6 reported cases.

Sources / Specimens

Blood.

Primary Hazards

Accidental parenteral inoculation, aerosols.

Special Hazards

None.

Section VII - Exposure Controls / Personal Protection

Risk Group Classification

Risk group 2.

Containment Requirements

Containment Level 2 facilities, equipment, and operational practices for work involving infectious or potentially infectious materials, animals, or cultures.

Protective Clothing

 Lab coat. Gloves when direct skin contact with infected materials or animals is unavoidable. Eye protection must be used where there is a known or potential risk of exposure to splashes.

Other Precautions

 All procedures that may produce aerosols, or involve high concentrations or large volumes should be conducted in a biological safety cabinet (BSC). The use of needles, syringes, and other sharp objects should be strictly limited. Additional precautions should be considered with work involving animals or large scale activities.

Section VIII - Handling and Storage

Spills

Allow aerosols to settle and, wearing protective clothing, gently cover the spill with paper towels and apply suitable disinfectant starting at the perimeter and working towards the center. Allow sufficient contact time (30 min) before clean up.

Disposal

Decontaminate all wastes before disposal by steam sterilization, chemical disinfection, and/or incineration.

Storage

The infectious agent should be stored in leak-proof containers that are appropriately labelled.

Section IX - Regulatory and Other Information

Regulatory Information

The import, transport, and use of pathogens in Canada is regulated under many regulatory bodies, including the Public Health Agency of Canada, Health Canada, Canadian Food Inspection Agency, Environment Canada, and Transport Canada. Users are responsible for ensuring they are compliant with all relevant acts, regulations, guidelines, and standards.

Date prepared

 February, 2018

Prepared by

Centre for Biosecurity, Public Health Agency of Canada

Although the information, opinions and recommendations contained in this Material Safety Data Sheet are compiled from sources believed to be reliable, we accept no responsibility for the accuracy, sufficiency, or reliability or for any loss or injury resulting from the use of the information. Newly discovered hazards are frequent and this information may not be completely up to date.

Copyright©
Public Health Agency of Canada, 2018

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