Contents of immunizing agents available for use in Canada: Canadian Immunization Guide

For health professionals

Notice

  • This CIG chapter has not been updated to contain information regarding COVID-19 vaccines. For this information, refer to the COVID-19 vaccine chapter.
Last partial content update (see Table of Updates): January2020

This chapter was updated to align with changes made to:

December 2020: This chapter was updated to align with changes made to:

Last complete chapter revision (see Table of Updates): April 2017

On this page

Introduction

The following tables provide a comprehensive list of contents of immunizing agents available in Canada. Table 1 lists contents of active vaccines and Table 2 lists contents of passive immunizing agents. Vaccine providers should consult the product label, product leaflet, or product monograph for current product information. Manufacturers provide evidence of vaccine safety and efficacy and receive authorization for the immunizing agent only when it is used in accordance with the product monograph available through Health Canada's Drug Product Database. Information about the vaccine manufacturer/distributor is available in vaccine-specific chapters in Part 4. For more information about immunoglobulins, refer to Basic Immunology and Vaccinology in Part 1.

Contents of immunizing agents

In addition to the active component (antigen or instructions for the antigen in case of vaccines or antibody in case of immunoglobulins), immunizing agents may contain additional ingredients such as adjuvants, preservatives, additives, and traces of other substances.

Adjuvants

An adjuvant is a substance that is added to a vaccine to enhance the resulting immune response and to extend the duration of B and T cell activation. An adjuvant allows a reduction in the amount of antigen per dose or the total number of doses needed to achieve immunity, and helps to improve the immune response in individuals with some degree of immune suppression (for example, the elderly). The adjuvants used in vaccines currently marketed in Canada are:

  • aluminum salts (aluminum hydroxide, aluminum phosphate, or aluminum hydroxyphosphate sulfate)
  • AS01B (3-O-desacyl-4'-monophosphoryl lipid A [MPL], Quillaja saponaria Molina, fraction 21 [QS-21], cholesterol, dioleoyl phosphatidylcholine [DOPC], disodium phosphate anhydrous, potassium dihydrogen phosphate, sodium chloride, water for injection)
  • AS04 (3-O-desacyl-4'-monophosphoryl lipid A adsorbed onto aluminum [as hydroxide salt])
  • MF59 (oil-in-water emulsion composed of squalene as the oil phase, stabilized with the surfactants polysorbate 80 and sorbitan trioleate, in citrate buffer).

Preservatives

Chemicals (for example, thimerosal, phenol, 2-phenoxyethanol) may be added to vaccines to prevent serious infections which may result from bacterial or fungal contamination of the vaccine. Most vaccines available for use in Canada do not contain thimerosal.

Other contents of immunizing agents

Other substances that may be found in immunizing agents include:

  • Minute amounts of chemicals that are used during the production process, such as for the growth or purification of specific antigens or the inactivation of toxins. For example, antibiotics that prevent contamination during viral cell culture; egg or yeast proteins glycerol, serum, amino acids and enzymes that are needed for the growth of bacteria and viruses; and formaldehyde that is used to inactivate viruses and protein toxins.
  • Small amounts of chemicals that support product stability. For example, additives such as potassium or sodium salts, lactose, and polysorbate help control product acidity (pH) and maintain the quality of vaccine antigens.
Table 1: Types and contents of vaccines available for use in Canada
Brand name Route Vaccine type
(live; inactivated)
Immunogen Adjuvant Preservative Potential allergensTable 1 - Footnote 1 Other materials Abbreviation
Act-HIB® IM non-live Hib - - Tetanus toxoid carrier protein
  • Sodium chloride
  • Sucrose
  • Trometamol
Hib
ADACEL® IM non-live
  • T
  • d
  • ap
Alum PE -
  • Formaldehyde
  • Glutaraldehyde
Tdap
ADACEL®-POLIO IM non-live
  • T
  • d
  • ap
  • IPV
Alum PE
  • Neomycin
  • Polymyxin B
  • Streptomycin
  • Bovine serum albumin
  • Formaldehyde
  • Glutaraldehyde
  • Polysorbate 80
  • Water for injection
Tdap-IPV
AFLURIA® TETRA IM non-live Inf - TmTable 1 - Footnote 2
  • Beta-propiolactone
  • Calcium chloride
  • Dibasic sodium phosphate
  • Monobasic potassium phosphate
  • Monobasic sodium phosphate
  • Potassium chloride
  • Sodium chloride
  • Sodium taurodeoxycholate
  • Sucrose
  • Water for injection
IIV4-SD
AGRIFLU® IM non-live Inf - TmTable 1 - Footnote 2
  • Barium
  • Calcium chloride dihydrate
  • Cetyltrimethylammonium bromide
  • Citrates
  • Disodium phosphate dihydrate
  • Formaldehyde
  • Hydrocortisone
  • Magnesium chloride hexahydrate
  • Polysorbate 80
  • Potassium chloride
  • Potassium dihydrogen phosphate
  • Sodium chloride
  • Water for injection
IIV3-SD
AVAXIM® IM Inactivated HA Alum
  • PE
  • CH2O
Neomycin
  • Medium 199 Hanks
  • Polysorbate 80
  • Water for injection
HA
AVAXIM® Pediatric
BEXSERO® IM non-live Men B Alum -
  • Latex in tip cap of syringe
  • Kanamycin (Residue)
  • Histidine
  • Sodium chloride
  • Sucrose
  • Water for injections
4CMenB
BOOSTRIX® IM non-live
  • T
  • d
  • ap
Alum - -
  • Formaldehyde
  • Glycine
  • Polysorbate 80
  • Sodium chloride
  • Water for injection
Tdap
BOOSTRIX®-POLIO IM non-live
  • T
  • d
  • ap
  • IPV
Alum -
  • Neomycin
  • Polymyxin B
  • Formaldehyde
  • Medium 199
  • Sodium chloride
  • Water for injection
Tdap-IPV
CERVARIX® IM non-live HPV AS04 - Latex in plunger stopper of pre-filled syringe
  • Hydrated sodium chloride
  • Sodium dihydrogen phosphate dihydrate
  • Water for injection
HPV2
DUKORAL® Oral non-live
  • Chol
  • Ecol
- - -
  • Citric acid
  • Disodium hydrogen phosphate
  • Raspberry flavor
  • Saccharin sodium
  • Sodium carbonate
  • Sodium citrate
  • Sodium chloride
  • Sodium dihydrogen phosphate
  • Sodium hydrogen carbonate
  • Water for injection
Chol-Ecol-O
ENGERIX®-B IM Inactivated HB Alum
  • Disodium phosphate dihydrate
  • Polysorbate 20
  • Sodium chloride
  • Sodium dihydrogen phosphate dihydrate
HB
ENGERIX®-B Pediatric dose
FLUAD® IM Inactivated Inf MF59  
  • Egg protein
  • Kanamycin
  • Neomycin
  • Barium
  • Calcium chloride dihydrate
  • Cetyltrimethylammonium bromide
  • Disodium phosphate dihydrate
  • Formaldehyde
  • Hydrocortisone
  • Magnesium chloride hexahydrate
  • Potassium chloride
  • Potassium dihydrogen phosphate
  • Sodium chloride
  • Water for injection
IIV3-Adj
FLUAD Pediatric®
FLUCELVAX®QUAD IM Non-Live INF   TmTable 1 - Footnote 2 -
  • Beta-propiolactone
  • Cetyltrimethylammonium bromide
  • Disodium phosphate dihydrate
  • Magnesium chloride hexahydrate
  • Polysorbate 80
  • Potassium chloride
  • Potassium dihydrogen phosphate
  • Sodium chloride
  • Water for injections
IIV4-cc
Flulaval™ Tetra IM non-live Inf - TmTable 1 - Footnote 2 IIV4-SD
Flulaval™ Tetra IM non-live Inf - TmTable 1 - Footnote 2
  • α-tocopheryl hydrogen succinate
  • Disodium hydrogen phosphate heptahydrate
  • Ethanol
  • Formaldehyde
  • Polysorbate 80
  • Potasium chloride
  • Potassium dihydrogen phosphate
  • Sodium deoxycholate
  • Sodium chloride
  • Sucrose
  • Water for injection
IIV4-SD
FLUMIST® QUADRIVALENT IN Live Inf - -
  • Arginine hydrochloride
  • Egg protein
  • Gelatin
  • Gentamicin
  • Dibasic potassium phosphate
  • Monosodium glutamate
  • Monobasic potassium phosphate
  • Sucrose
LAIV4
FLUVIRAL® IM non-live Inf - Tm
  • α-tocopheryl hydrogen succinate
  • Disodium hydrogen phosphate heptahydrate
  • Ethanol
  • Formaldehyde
  • Polysorbate 80
  • Potassium chloride
  • Potassium dihydrogen phosphate
  • Sodium chloride
  • Sodium deoxycholate
  • Sucrose
  • Water for injection
IIV3-SD
FLUZONE® HD IM non-live Inf - -
  • Egg protein
  • Formaldehyde
  • Sodium phosphate
  • Sodium chloride
  • Triton® X-100
IIV3-HD
FLUZONE® Quadrivalent IM non-live Inf - TmTable 1 - Footnote 2
  • Formaldehyde
  • Sodium chloride solution
  • Sodium phosphate
  • Triton® X-100
IIV4-SD
GARDASIL® IM non-live HPV Alum - Yeast protein
  • L-histidine
  • Polysorbate 80
  • Sodium borate
  • Sodium chloride
  • Water for injection
HPV4
GARDASIL® 9 IM non-live HPV Alum - Yeast protein
  • L-histidine
  • Polysorbate 80
  • Sodium borate
  • Sodium chloride
HPV9
HAVRIX® IM Inactivated HA Alum   Neomycin
  • Amino acids
  • Disodium phosphate
  • Formaldehyde
  • Monopotassium phosphate
  • Polysorbate 20
  • Potassium chloride
  • Sodium chloride
  • Water for injection
HA
HAVRIX® 720 JUNIOR
HIBERIX® IM non-live Hib - - Tetanus toxoid carrier protein
  • Lactose
  • Sodium chloride
Hib
IMOVAX® Polio SC non-live IPV - PE
  • Neomycin
  • Polymyxin B
  • Streptomycin
  • Bovine serum
  • Formaldehyde
  • Medium 199 Hanks
  • Polysorbate 80
IPV
IMOVAX® Rabies IM non-live Rab - -
  • Neomycin
  • Phenol red
  • Human albumin
  • Water for injection
HDCV
IMVAMUNE® SC Live Vaccinia - -
  • Chicken Protein
  • Gentamicin
  • Bromobutyl rubber stopper
  • Benzonase
  • Hydrochloric acid
  • Sodium chloride
  • Tris-hydroxymethyl-amino methane
  • Water for injection
-
INFANRIX hexa® IM non-live
  • D
  • T
  • aP
  • HB
  • IPV
  • Hib
Alum -
  • Butyl in stopper
  • Neomycin
  • Polymyxin B
  • Yeast protein
  • Disodium phosphate
  • Formaldehyde
  • Glycine
  • Lactose
  • M199
  • Monopotassium phosphate
  • Polysorbate 20 and 80
  • Potassium chloride
  • Sodium chloride
  • Water for injection
DTaP-HB-IPV-Hib
INFANRIX®-IPV IM non-live
  • D
  • T
  • aP
  • IPV
- -
  • Neomycin
  • Polymixin
  • Sodium chloride
  • Aluminum Salts
  • M 199
  • Water for injections
DTaP-IPV
INFANRIX®-IPV/Hib IM non-live
  • D
  • T
  • aP
  • IPV
  • Hib
Alum -
  • Neomycin sulphate
  • Polymixin sulphate
  • Lactose
  • Sodium chloride
  • M199
  • Water for injection
  • Residual formaldehyde
  • Polysorbate 80
  • Potassium chloride
  • Disodium phosphate
  • Monopotassium phosphate
  • Glycine
DTaP-IPV-Hib
INFLUVAC® IM non-live Inf - -
  • Chicken protein
  • Egg protein
  • Gentamicin
  • Calcium chloride dihydrate
  • Cetyltrimethylammonium bromide
  • Disodium phosphate dihydrate
  • Formaldehyde
  • Magnesium chloride hexahydrate
  • Polysorbate 80
  • Potassium chloride
  • Potassium dihydrogen phosphate
  • Sodium chloride
  • Water for injection
IIV3-SD
INFLUVAC® TETRA SC/IM non-live Inf - -
  • Chicken protein
  • Egg Material
  • Calcium chloride dihydrate
  • Cetyltrimethyl ammonium bromide
  • Disodium phosphate dihydrate
  • Formaldehyde
  • Gentamicin sulphate
  • Hydrocortisone
  • Magnesium chloride hexahydrate
  • Neomycin sulphateTable 1 - Footnote 5
  • Polymyxin B sulphateTable 1 - Footnote 5
  • Polysorbate 80
  • Potassium chloride
  • Potassium dihydrogen phosphate
  • Sodium chloride
  • Sodium citrate
  • Sucrose
  • Tylosine tartrate
  • Water for injection
IIV4-SD
IXIARO® IM non-live JE Alum - -
  • Disodium hydrogen phosphate
  • Potassium dihydrogen phosphate
  • Sodium chloride
  • Water for injection
JE
Menactra® IM non-live Men - - Diphtheria toxoid carrier protein
  • Sodium chloride
  • Sodium phosphate dibasic (anhydrous)
  • Sodium phosphate monobasic
  • Water for injection
Men-C-ACYW-DT
Menjugate® IM non-live Men Alum -
  • Latex in tip cap of syringe
  • Diphtheria CRM197 toxoid carrier protein
  • Disodium phosphate heptahydrate
  • Mannitol
  • Sodium chloride
  • Sodium dihydrogen phosphate monohydrate
  • Water for injection
Men-C-C-CRM
MENJUGATE Liquid IM Non-live Men Alum  
  • Diphtheria CRM197 toxoid carrier protein
  • Bromobutyl rubber stopper
  • Histidine
  • Sodium chloride
  • Water for injection
Men-C-C-CRM
Menveo™ IM non-live Men - - Diphtheria CRM197 toxoid carrier protein
  • Disodium hydrogen phosphate bihydrate
  • Potassium dihydrogen phosphate
  • Sodium chloride
  • Sodium dihydrogen phosphate monohydrate
  • Sucrose
  • Water for injection
Men-C-ACYW-CRM
M-M-R® II SC Live
  • Meas
  • Mumps
  • R
- -
  • Neomycin
  • Phenol red
  • Porcine gelatin
  • Residual components of chick embryo cell cultures
  • Fetal bovine serum
  • Medium 199 with Hank's salts
  • Minimum essential medium (Eagle)
  • Monosodium L-glutamate monohydrate
  • Potassium phosphate dibasic (anhydrous)
  • Potassium phosphate monobasic
  • Recombinant human albumin
  • Sodium bicarbonate
  • Sodium phosphate dibasic (anhydrous)
  • Sodium phosphate monobasic
  • Sorbitol
  • Sucrose
  • Water for injection
MMR
Moderna COVID-19 Vaccine IM Non-live SARS-CoV-2 - -
  • Polyethylene Glycol (PEG)
  • 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC)
  • Acetic acid
  • Cholesterol
  • Lipid SM-102
  • PEG2000 DMG 1,2-dimyristoyl-racglycerol, methoxy-polyethyleneglycol
  • Sodium acetate
  • Sucrose
  • Tromethamine
  • Tromethamine hydrochloride
  • Water for injection
COVID-19
NeisVac-C® Vaccine IM non-live Men Alum - Tetanus toxoid carrier protein Sodium chloride Men-C-C-TT
NIMENRIX® IM non-live Men - - Tetanus toxoid carrier protein
  • Sucrose
  • Trometamol
  • Sodium chloride
  • Water for injection
Men-C-ACYW-TT
PEDIACEL® IM non-live
  • D
  • T
  • aP
  • -IPV
  • Hib
Alum PE
  • Neomycin
  • Polymyxin B
  • Streptomycin
  • Bovine serum albumin
  • Formaldehyde
  • Glutaraldehyde
  • Polysorbate 80
DTaP-IPV-Hib
Pfizer-BioNTech COVID-19 Vaccine IM Non-live SARS-CoV-2 - -
  • Polyethylene Glycol (PEG)
  • ALC-0315 = ((4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate)
  • ALC-0159 = 2-[(polyethylene glycol)-2000]-N,N-ditetradecylacetamide
  • 1,2-Distearoyl-sn-glycero-3-phosphocholine
  • Cholesterol
  • Dibasic sodium phosphate dihydrate
  • Monobasic potassium phosphate
  • Potassium chloride
  • Sodium chloride
  • Sucrose
  • Water for injection
COVID-19
PNEUMOVAX® 23 SC/IM non-live Pneu - P -
  • Sodium chloride
  • Water for injection
Pneu-P-23
Prevnar® 13 IM non-live Pneu Alum - Diphtheria CRM197 toxoid carrier protein
  • Polysorbate 80
  • Sodium chloride
  • Succinic acid
  • Water for injection
Pneu-C-13
PRIORIX® SC/IM Live
  • Meas
  • Mumps
  • R
- -
  • Egg protein
  • Neomycin
  • Amino acids
  • Lactose
  • Mannitol
  • Sorbitol
  • Water for injection
MMR
PRIORIX-TETRA® SC/IM Live
  • Meas
  • Mumps
  • R
  • Var
- -
  • Egg protein
  • Neomycin
  • Amino Acids
  • Lactose
  • Mannitol
  • Sorbitol
  • Water for injection
MMRV
PROQUAD™ SC Live
  • Meas
  • Mumps
  • R
  • Var
- -
  • Gelatin
  • Neomycin
  • Chicken protein
  • Sucrose
  • Urea
  • Sodium chloride
  • Sorbitol
  • Monosodium L-glutamate
  • Sodium phosphate
  • Human albumin
MMRV
QUADRACEL® IM non-live
  • D
  • T
  • aP
  • IPV
Alum PE
  • Neomycin
  • Polymyxin B
  • Bovine serum albumin
  • Formaldehyde
  • Glutaraldehyde
  • Polysorbate 80
DTaP-IPV
RabAvert® IM non-live Rab - -
  • Amphotericin B
  • Chicken protein
  • Chlortetracycline
  • Neomycin
  • Polygeline (gelatin)
  • Egg protein
Human serum albumin PCECV
RECOMBIVAX HB® IM non-live HB Alum -
  • Latex in vial stopper
  • Yeast protein
  • Formaldehyde
  • Sodium borate
  • Sodium chloride
  • Water for injection
HB
ROTARIX® Oral Live Rot - - -
  • Disodium adipate
  • DNA fragments from porcine circovirus 1
  • Dulbecco's Modified Eagle Medium
  • Sterile water
  • Sucrose
Rot-1
RotaTeq® Oral Live Rot - - -
  • DNA fragments from porcine circoviruses 1 and 2
  • Fetal bovine serum
  • Polysorbate 80
  • Residual protein from cell culture
  • Sodium citrate dihydrate
  • Sodium hydroxide
  • Sodium phosphate monobasic monohydrate
  • Sucrose
Rot-5
SHINGRIX IM non-live VZVgE AS01B - -
  • Dipotassium phosphate
  • Polysorbate 80
  • Sodium dihydrogen phosphate dihydrate
  • Sucrose
  • Water for injection
RZV
Smallpox (dried)Table 1 - Footnote 3 ID Live Vaccinia - -
  • Latex in stopper of vaccine vial
  • Neomycin
  • Streptomycin
  • Bovine tissue (trace)
  • Glycerol
  • McIlvaine buffer
  • Phenol
Sma
Smallpox (frozen)Table 1 - Footnote 4 - - - - - - - Sma
SYNFLORIX® IM non-live Pneu Alum -
  • Latex in syringe components
  • Diphtheria toxoid carrier protein
  • Tetanus toxoid carrier protein
  • Non-typeable Haemophilus influenzae protein D carrier protein
  • Sodium chloride
  • Water for injection
Pneu-C-10
Td ADSORBED IM non-live
  • T
  • d
Alum PE -
  • Formaldehyde
  • Sodium chloride
  • Water for injection
Td
Td POLIO ADSORBED IM non-live
  • T
  • d
  • IPV
Alum PE
  • Neomycin
  • Polymyxin B
  • Bovine serum albumin
  • Formaldehyde
  • Polysorbate 80
Td-IPV
TRUMENBA® IM Non-live Men B      
  • Aluminum phosphate
  • Histidine
  • Polysorbate 80
  • Sodium chloride
  • Water for injection
MenBf-HBP
TWINRIX® IM Inactivated
  • HA
  • HB
Alum  
  • Neomycin
  • Yeast protein
  • Amino acids
  • Formaldehyde
  • Polysorbate 20
  • Sodium chloride
  • Water for injection
HAHB
TWINRIX® Junior
TYPHIM Vi® IM non-live Typh - P - Isotonic buffer solution Typh-I
VAQTA® IM non-live HA Alum -
  • Latex in vial stopper
  • Neomycin
  • Bovine albumin
  • DNA
  • Formaldehyde
  • Residual protein from cell culture
  • Sodium borate
  • Sodium chloride
  • Water for injection
HA
VARILRIX® SC Live Var - - Neomycin
  • Amino acids
  • Human albumin
  • Lactose
  • Polyalcohols
  • Water for injection
Var
VARIVAX® III SC Live Var - -
  • Neomycin
  • Porcine gelatin
  • Fetal bovine serum
  • Monosodium L-glutamate
  • Potassium chloride
  • Potassium phosphate monobasic
  • Residual protein from cell culture
  • Sodium chloride
  • Sodium phosphate dibasic
  • Sucrose
  • Urea
  • Water for injection
Var
ViVAXIM® IM non-live Typh (HA) Alum
  • PE
  • CH2O
Neomycin
  • Disodium phosphate dihydrate
  • Medium 199 Hanks
  • Polysorbate 80
  • Sodium chloride
  • Sodium dihydrogen phosphate dihydrate
  • Water for injection
HA-Typh-I
Vivotif® Oral Live Typh - - Gelatin
  • Amino acid mixture
  • Ascorbic acid
  • Dibutyl phthalate
  • Diethyl phthalate
  • Erythrosine FD+C red 3
  • Ethylene glycol
  • Hydroxypropylcellulose-phthalate
  • Lactose
  • Magnesium stearate
  • Red iron oxide
  • Sucrose
  • Titanium dioxide
  • Yellow iron oxide
Typh-O
YF-VAX® SC Live YF - -
  • Chicken protein
  • Egg protein
  • Gelatin
  • Latex in stopper of diluent vial
  • Sodium chloride
  • Sorbitol
YF
ZOSTAVAX® SC Live Var - -
  • Neomycin
  • Porcine gelatin
  • Bovine calf serum
  • Monosodium L-glutamate monohydrate
  • Potassium chloride
  • Potassium phosphate monobasic
  • Residual protein from cell culture
  • Sodium chloride
  • Sucrose
  • Sodium phosphate dibasic
  • Sucrose
  • Urea
  • Water for injection
LZV

Empty boxes indicate that there are no materials of relevance in the product.

Table 1 - Footnote 1

Any component in a vaccine may be a potential allergen. This table identifies most common allergens; adjuvants and preservatives may be potential allergens, but this is extremely rare.

Return to Table 1 footnote 1 referrer

Table 1 - Footnote 2

Multi-dose presentation only.

Return to Table 1 footnote 2 referrer

Table 1 - Footnote 3

Smallpox vaccine (dried) is not available for general use.

Return to Table 1 footnote 3 referrer

Table 1 - Footnote 4

Smallpox vaccine (frozen liquid) is not a Health Canada authorized product but will be released under Health Canada's Special Access Program if required.

Return to Table 1 footnote 4 referrer

Table 1 - Footnote 4

Only used if gentamicin cannot be used. If not used, not present.

Return to Table 1 footnote 5 referrer

Abbreviations

Route-

ID
intradermal
IM
intramuscular
IN
intranasal
SC
subcutaneous

Immunogen-

aP
acellular pertussis
ap
acellular pertussis (reduced)
BCG
Bacillus Calmette-Guérin
Chol
cholera
D
diphtheria
d
diphtheria (reduced)
Ecol
enterotoxigenic Escherichia coli
Hib
Haemophilus influenzae type b
HA
hepatitis A
HB
hepatitis B
HPV
human papillomavirus
Inf
influenza
IPV
inactivated poliomyelitis
JE
Japanese encephalitis
Men
meningococcus
Men B
Neisseria meningitidis Serogroup B protein
Meas
measles
Mumps
mumps
Pneu
pneumococcus
Rab
rabies
Rot
rotavirus
R
rubella
T
tetanus
Typh
typhoid
Var
varicella
YF
yellow fever
Zos
herpes zoster

Adjuvant-

Alum
aluminum-containing adjuvant
AS01B
3-O-desacyl-4'-monophosphoryl lipid A [MPL], Quillaja saponaria Molina, fraction 21 [QS-21], cholesterol, dioleoyl phosphatidylcholine [DOPC], disodium phosphate anhydrous, potassium dihydrogen phosphate, sodium chloride, water for injection
AS04
3-O-desacyl-4'-monophosphoryl lipid A adsorbed onto aluminum (as hydroxide salt)
MF59
squalene, polysorbate 80, sorbitan trioleate, sodium citrate, citric acid, water for injection

Preservative-

CH 2O
formaldehyde
P
phenol
PE
2-phenoxyethanol
Tm
thimerosal
Table 2: Types and contents of passive immunizing agents available for use in Canada
Brand name Route Passive immunizing agent type Origin of antibodies Protects against or treats Preservative Potential allergens Other materials Abbreviation
A dash [ - ] indicates that there are no materials of relevance in the product.
Antidiphtheria serumFootnote 1 IV Antitoxin Horse serum or Horse plasma D Type varies with supplier Equine protein
  • Contents vary with supplier
DAT
BAT®Footnote 2 IV Antitoxin Horse plasma B N/A Equine protein
  • Maltose
  • Polysorbate 80
BAT
Baby BIG®Footnote 1 Footnote 2 IV Immunoglobulin Human plasma B None -
  • Human albumin
  • Sucrose
BIG-IV
Cytogam®Footnote 3 IV Immunoglobulin Human plasma CMV None -
  • Human albumin
  • Sucrose
CMVIg
CNJ-016™ IV Immunoglobulin Human plasma Vac None -
  • Maltose
  • Polysorbate 80
  • Water for injection
VIG
GamaSTAN®S/D IM Immunoglobulin Human plasma
  • HA
  • Meas
None  
  • Glycine
Ig
HepaGam B® IM/IV Immunoglobulin Human plasma HB None -
  • Maltose
  • Polysorbate 80
  • Tri-n-butyl phosphate
  • Triton®X-100
HBIg
HyperHEP B®S/D IM Immunoglobulin Human plasma HB None -
  • Glycine
HBIg
HYPERRAB®™ S/D IM/ -local Immunoglobulin Human plasma Rab None -
  • Glycine
RabIg
HYPERTET®S/D IM Immunoglobulin Human plasma Tet None -
  • Glycine
TIg
IMOGAM®Rabies Pasteurized IM/ -local Immunoglobulin Human plasma Rab None -
  • Glycine
  • Human albumin
  • Neomycin
  • Phenol red
RabIg
KamRAB™ IM Immunoglobulin Human plasma Rab None -
  • Glycine
  • Sodium hydroxide
  • Water for injection
RabIg
SYNAGIS®(palivizumab) IM Humanized monoclonal antibody Recombinant DNA technology RSV None -
  • Glycine
  • Histidine
  • Mannitol
RSVAb
VariZIG® IV/ IM Immunoglobulin Human plasma Var - -
  • Glycine
  • Human plasma protein
  • Polysorbate 80
  • Sodium chloride
  • Sodium phosphate
  • Tri-n-butyl phosphate
  • Triton®X-100
VarIg

Notes de bas de page

Note de bas de page 1

Only available on an emergency basis by application to Health Canada's Special Access Programme (SAP) (https://www.canada.ca/en/health-canada/services/drugs-health-products/special-access/drugs.html). Public health should be contacted for assistance in obtaining these products. Information can also be obtained from the SAP website or by contacting the SAP office (telephone: 613-941-2108; fax: 613-941-3194; Available 24 hours a day, 7 days a week).

Retour à la référence de la note de bas de page 1

Note de bas de page 2

For further information refer to Health Canada: Botulism - Guide for healthcare professionals at https://www.canada.ca/en/health-canada/services/food-nutrition/legislation-guidelines/guidance-documents/botulism-guide-healthcare-professionals-2012.html

Retour à la référence de la note de bas de page 2

Note de bas de page 3

Should be used in consultation with a specialist in immunodeficiency.

Retour à la référence de la note de bas de page 3

Abbreviations:

Route-

IM
intramuscular
IV
intravenous

Protects against or treats-

B

Botulism
CMV

Cytomegalovirus
D
diphtheria
HA
hepatitis A
HB
hepatitis B
Meas
measles
R
rubella
Rab:
rabies
RSV
respiratory syncytial virus
T
tetanus
Vac
vaccinia
Var
varicella
N/A
Not applicable

Preservative-

P
phenol

Selected references

  • Keith LS, Jones DE, Chou C. Aluminum toxicokinetics regarding infant diet and vaccinations. Vaccine 2002;20:S13-17.
  • Offit PA, Jew RK. Addressing parents' concerns: Do vaccines contain harmful preservatives, adjuvants, additives, or residuals? Pediatrics 2003;112:1394-97.
Report a problem or mistake on this page
Please select all that apply:

Thank you for your help!

You will not receive a reply. For enquiries, contact us.

Date modified: