CATMAT Statement: Measures to Prevent Arthropod Bites
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Published by: The Public Health Agency of Canada
Issue: Volume 38 ACS-3
Date published: November 2012
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Volume 38 ACS-3, November 2012
An Advisory Committee Statement (ACS)
Committee to Advise on Tropical Medicine and Travel (CATMAT)†
Statement on Personal Protective Measures to Prevent Arthropod Bites
Members: Dr. A. McCarthy (Chair); Dr. A.K. Boggild; Dr. J. Brophy; Dr. Y. Bui; Dr. C. Greenaway; Dr. M. Crockett; Dr. W. Ghesquiere; Ms. A. Henteleff; Dr. M. Libman; Dr. K.L. McClean; Dr. P.J. Plourde; Dr. P. Teitelbaum.
Ex-Officio Representatives: Dr. P. Charlebois; Dr. P. McDonald; Dr. S. Schofield; Dr. M. Tepper.
Liaison Representatives: Dr. G. Brunette; Dr. C. Hui.
Member Emeritus: Dr. C.W.L. Jeanes.
† This statement was prepared by S. Schofield and P. Plourde and approved by CATMAT.
CATMAT gratefully acknowledges the Pest Management Regulatory Agency, the World Health Organization Pesticide Evaluation Scheme (WHOPES) and the Armed Forces Pest Management Board for contributing to the development of the statement.
The Committee to Advise on Tropical Medicine and Travel (CATMAT) provides the Public Health Agency of Canada (PHAC) with ongoing and timely medical, scientific, and public health advice relating to tropical infectious disease and health risks associated with international travel. The Agency acknowledges that the advice and recommendations set out in this statement are based upon the best current available scientific knowledge and medical practices, and is disseminating this document for information purposes to both travellers and the medical community caring for travellers.
Persons administering or using drugs, vaccines, or other products should also be aware of the contents of the product monograph(s) or other similarly approved standards or instructions for use. Recommendations for use and other information set out herein may differ from that in the product monograph(s) or other similarly approved standards or instructions for use by the licensed manufacturer(s). Manufacturers have sought approval and provided evidence as to the safety and efficacy of their products only when used in accordance with the product monographs or other similarly approved standards or instructions for use.
A variety of pathogens are transmitted to humans by arthropod vectors, including some that cause important travel-related diseases (e.g., malaria and dengue). Typically, though not always (e.g., Chagas disease and louse-borne typhus), transmission is through the bite of a vector, with the offending pathogens generally completing a portion of their lifecycle within the arthropod.
While mosquitoes are the most notorious and important vector of arthropod-associated diseases (AAD), there are many other arthropods capable of transmitting pathogens (e.g., ticks, sandflies, tabanids, lice, mites, fleas, tsetse flies and reduviid bugs) (see Appendix 1). This diversity can make prevention and treatment of AAD challenging because not only are there many diseases of concern, the range of vectors is vast, as are the associated behaviours and epidemiologies. This complexity is well-illustrated by contrasting two groups of mosquitoes, Aedes and Anopheles, respectively the genera responsible for transmission of dengue and malaria. While these groups of mosquitoes might look somewhat similar, they diverged from each other more than 100 million years agoFootnote 1, and hence have had substantial time to develop different life-history strategies. Thus, on one hand, there is Aedes aegypti, the principal vector of dengueFootnote 2 which typically lives in and around developed areas and generally bites during daylight hours, albeit more often in the morning or towards evening. On the other hand, there is Anopheles gambiae s.s., found in Africa and the world's most efficient vector of malaria. This species is primarily found in rural areas and tends to bite inside and during the hours of darkness. While both species feed on human hosts and transmit important pathogens, it is their differences that are relevant with respect to the when and the where of disease threat. Such diversity is not limited to disparate genera of mosquitoes or classes of insect. Indeed, even among the forty or so important species of malaria vectorsFootnote 3, there are significant and intervention-relevant differences in behaviour and biology. For example, the aforementioned A. gambiae s.s. tends to be endophagic, that is, it bites inside buildings. This predilection, combined with its nighttime habits, means that bed nets are a critical interventionFootnote 4. In contrast, A. albimanus, an important vector in the Americas, often bites outside and earlier in the evening, before people sleep. Hence, bed nets, while still important, are likely relatively less so for protection against this species, at least compared against topical repellents and appropriate clothing. Complicating matters for this latter species are data that suggest that it has enhanced "tolerance" to the insect repellent DEET (N,N-diethyl-3-methyl- benzamide, also known as N,N-diethyl-m-toluamide) such that duration of protection is shortenedFootnote 5.
The important take-home message for the clinician and traveller is that significant variability exists among vectors and, wherever possible, preventive approaches should be sufficiently flexible to take account of this. This could be as simple as re-applying repellent when bites are noted instead of strictly adhering to label-indicated protection times, or using a bed net whenever resting, regardless of the time of day.
Personal protective measures
Considering the substantial diversity among vectors, it is striking that a single approach (i.e., bite prevention) works for all of the different genera, and further that a small suite of interventions (i.e. personal protective measures [PPM]) show broad utility in this regard. This is in marked contrast to other preventive medical interventions such as vaccines and chemoprophylactic drugs where effectiveness is often limited to a particular pathogen to prevent a specific disease.
This statement provides guidance and recommendations on the use of PPM to prevent arthropod bites. These interventions have a long history of use in traditional societiesFootnote 6-Footnote 7, with modern approaches to research, development and discovery evolving over the last century, often as a result of military-sponsored innovationFootnote 8. While many different types of PPM likely have some protective benefitFootnote 9, this statement will concentrate on physical (e.g., clothing, bed nets) and chemical (e.g., topical repellents and bed net treatments) barriers. This emphasis reflects, firstly, a strategy to manage the level of guideline development effort required, and secondly the committee's belief that the focus was best directed at PPM for which:
- use is primarily under the control of the individual traveller;
- access is possible in/from Canada; and
- relevant, robust and contemporary data are available by which benefits and harms can be judged (e.g., repellents and insecticides).
Evaluation of evidence and recommendations
Evidence was evaluated as per the 1994 CATMAT statement on evidence-based medicine (EBM) (Appendix 2)Footnote 10. CATMAT makes the following points related to this review process:
- a systematic collection and review of evidence was not performed. Rather, the evidence collected and evaluated to develop the 2005 statementFootnote 11 was updated by conducting literature searches using PubMed. The search terms were "repellent" or "bed net" or "personal protection" alone, or in combination with "traveller". Searches were limited to articles published since 2005. The authors also screened the entomological literature, first by entering the same search terms into the literature retrieval system of the Armed Forces Pest Management BoardFootnote 12, and second by identifying other published and non-published information, in particular through conversation with national pesticide regulatory authorities. Specific inclusion criteria were not used, rather relevancy was subjectively assigned on the bases of novelty (e.g., a new approach that has become available since 2005), and robustness (e.g., randomized trials and/or traveller-relevant endpoints).
- while CATMAT recognizes that well-executed randomized studies with travellers would provide the highest quality of evidence for PPM, these are lacking. There have been, however, a number of randomized studies carried out with PPM (especially bed nets) in endemic areas with resident populations. Although it can be argued that indirectness reduces the quality of these data when applied to travellersFootnote 13, CATMAT feels they can still yield strong recommendations, especially if relevant endpoints (e.g., prevention of clinical disease) and populations (e.g., all ages) are used, and/or where the magnitude of effect is large and consistentFootnote 14.
- CATMAT has high confidence that the risk-based pesticide regulatory systems of Canada and the United States are robust and conservativeFootnote 15-Footnote 16. This reflects the emphasis, on the part of regulators, on product safety wherein multiple and multiplicative safety factors are employed. Hence, PPM products approved by these systems are considered to have excellent safety profiles and are unlikely to present risks that are relevant to health-based decision-making.
- CATMAT notes that much of the evidence concerning repellents comes from relatively small-scale entomological studies in which protection against bites rather than against disease was the outcome of interest. Individually, such studies are not considered to provide a high quality of evidence regarding disease prevention. However, CATMAT does consider protection against bites to be a reasonable, albeit indirect, proxy for protection against clinical disease. Hence, where there is consistency in outcome(s) across studies and if the estimated effect is large, CATMAT considers that the aggregate result is sufficient to make a strong recommendation for use.
- CATMAT appreciates that there are a myriad of possible vector-disease combinations, and that the majority of these have not been subjected to significant inquiry regarding the protective utility of PPM. Rather, analytic emphasis and consequently evidence has been principally on/for mosquitoes and PPM. For other vectors (e.g., ticks, tsetse flies, sandflies) there is less evidence, but what is available generally supports that the PPM that work against mosquitoes also work against these groups. Hence, recommendations made herein are principally based on mosquito-derived evidence, but are considered to be generally applicable to arthropod vectors. A systematic vector-by-vector evaluation of PPM utility was not done.
- CATMAT's perspective for analysis is that of the traveller. In general, this simplifies matters as indirect and longer term effects of PPM on human and vector populations at the community level need not be considered. On the other hand, it can amplify concerns associated with vector-based variability. For example, resistance among malaria vectors to the pyrethroid insecticides that are used to treat bed nets has been documented in parts of Africa, although it remains unclear what the impact of such resistance will be at the community levelFootnote 17 Footnote 18. However, because insecticide resistance seems to be associated with an increased probability that mosquitoes will bite "through" a treated net, it likely attenuates bed net utility at the individual (including traveller) level.
- Appendix 3 provides a summary of all recommendations made in this statement.
Recommendations for personal protection
If insects cannot bite, they cannot transmit pathogens. It follows that reducing exposure to arthropods, whether by avoidance or by reducing access to skin through use of barriers, can prevent AAD. These tactics are complimentary and should be used in concert. Importantly, PPM are intended to augment, not replace the use of appropriate medications and vaccines (e.g., malaria chemoprophylaxis for prevention of malaria)Footnote 19. Of course, this point presupposes the availability of medications and/or vaccines which, for many AAD (e.g., dengue, leishmaniasis), do not exist, i.e. PPM often are the only tactic available for risk reduction.
There are several ways by which arthropods can be avoided, and it seems self-evident that these should reduce the risk of acquisition of AAD. However, there is little direct scientific evidence to support this supposition. Despite these evidentiary shortcomings, CATMAT believes that the following avoidance measures are likely to have some utility and further, because their use is unlikely to present a risk, that they should be undertaken when/where possible.
- Avoid travelling to risk areas during the season(s) when transmission of AAD is most likely.
- Reduce exposure by avoiding times or places when/where vectors are known to be active (e.g., by staying indoors during peak activity periods, minimizing exposure in rural areas or other habitats associated with specific vectors).
There are a variety of physical barriers that can be used to reduce contact between vectors and their human hosts. Some are easily implemented at the time of exposure (e.g., wearing of appropriate clothing, using of mosquito netting), whereas others, such as window and door screening, air conditioning and closed eaves might require advance planning to ensure that they are available. CATMAT makes the following recommendations related to the use of physical barriers:
- Protect work and accommodation areas against vectors. This can be achieved by use of screening on doors and windows, closing eaves, eliminating holes in roofs and walls and closing other gaps around a building. These interventions have been linked to historical reductions of malaria risk in North America and EuropeFootnote 20 Footnote 21 and were associated with reduced entry of malarious mosquitoes into huts and lower levels of anemia in hut occupants, in a recent randomized trial in Africa using intention-to-treat analysisFootnote 22. Several other smaller-scale trials in Africa also have demonstrated that house "screening", including the closing of eaves, can significantly reduce the number of malaria mosquitoes entering buildingsFootnote 23.
- Use bed nets. CATMAT recommends use of insecticide-treated bed nets (ITN), though there is evidence that untreated nets can provide substantial protection against the bites of mosquitoes and other arthropods. Bed nets, treated or untreated, also are thought to act as a barrier against other animals (e.g., bed bugs, rodents and scorpions), and there are data suggesting that they can reduce the risk of bites from venomous snakesFootnote 24.
- Wear appropriate clothing. There is entomological literature demonstrating that covering skin with cloth can reduce mosquito bitingFootnote 25, though efficacy is affected by: the type of fabric; the number of fabric layers present; and weave. There also are data to suggest that clothing can be protective against malariaFootnote 26 Footnote 27, though their quality is rather poor. Despite such limited evidence, CATMAT recommends that appropriate clothing (full length, loose fitting, light coloured) be worn appropriately (sleeves rolled down, pants tucked in) to protect against arthropod bites. This position reflects the integration of three factors: first, there is some entomologic and observational evidence to support this intervention, and it is plausible from a mechanistic perspective; second, it seems unlikely that wearing appropriate clothing presents any risk relevant to health-based decision-making; and third, wearing such clothing might offer added benefits such as sun protection.
Of note, light-coloured clothing is thought to help wearers spot and remove ticks before they are able to biteFootnote 28 Footnote 29.
Though somewhat arbitrary, we differentiate between two types of chemical barrier: repellents, usually topical, which have as a primary effect the prevention of insects and other arthropods from biting; and insecticides which generally kill insects and other arthropods upon contact or soon thereafter. In reality, there can be overlap in activity, with insecticides sometimes also acting as repellents (e.g., permethrin) and with some topical repellents showing toxicant properties (e.g., DEET).
Application of topical repellents to exposed areas of skin prevents arthropods from biting, but does not necessarily prevent their approach towards the host. Though used for thousands of yearsFootnote 6 Footnote 7, science-based repellent evaluation and development has primarily been during the last century. Further, it only has been very recently that the mode of action of DEET and its analogues has started to be elucidatedFootnote 30-Footnote 32, with these compounds apparently having a direct effect on insect sensilla. Concurrent with these efforts has been a veritable explosion of investigations into novel repellent products, in particular "natural" compoundsFootnote 7. That naturally-derived repellents exist is hardly surprising given the multitude of plant-derived chemicals that target insects. Indeed, it has been postulated that the sensitivity of haematophagous arthropods to some of these compounds represents an evolutionary relic of their plant feeding pastFootnote 7. However, despite some success at commercialization, there are few registered natural repellent products available on the North American market. Further, several authors have cautioned against the dangerous generalization that natural equals safeFootnote 6 Footnote 7, i.e. there is no a priori reason to expect that unregistered natural repellents are safe or effective. Hence, CATMAT recommends against use of unregistered "natural" (or other) topical repellents to protect against the bites of mosquitoes and other arthropods.
Topical and other repellents (and insecticide barriers, see below) must be reviewed for efficacy and safety by Health Canada's Pest Management Regulatory Agency (PMRA) before they can be sold and used in Canada. There is a similar requirement in the United States (US), where the Environmental Protection Agency (EPA) has responsibility for product registration. For both agencies, emphasis is placed on product safety. Efficacy is also considered, though the relevant endpointsFootnote 33 are intended to meet regulatory needs and hence can at best be considered indirect measures in a disease protection context. Nevertheless, the evidence that repellents prevent the bites of insects and other arthropods is overwhelming and generally consistent, and CATMAT considers that there is a very high probability that prevention of bites will reduce exposure to arthropod-associated pathogens. Further, there is direct evidence from a randomized trial that use of a topical repellent can reduce the incidence of malaria amongst residents in an endemic settingFootnote 34.
CATMAT makes the following recommendations related to use of topical repellents:
- Use topical repellent on exposed areas of skin to prevent arthropod bites and to reduce the risk of AAD.
- Five active ingredients are currently registered in Canada: DEET, icaridin (also called picardin or KBR 3023), p-menthane-3,8-diol (PMD), soybean oil and citronella. Of these, DEET has the longest history of use and has consistently demonstrated a high level of efficacy. Icaridin (1-piperidinecarboxylic acid 2-(2-hydroxyethyl)-1-methylpropylester), approved for use in Canada in 2012, demonstrates levels of efficacy similar to DEET, has been available in other jurisdictions for some time and is recommended by the United States Centres for Disease Control and Prevention (US CDC) Footnote 35 Footnote 36 for protection against the bites of mosquito vectors. Further, it has been evaluated by the World Health Organization's Pesticide Evaluation Scheme (WHOPES) Footnote 37 Footnote 38 which recommends it as a "safe and effective insect repellent for human use". Based on these traits, DEET and icaridin are recommended as the first choice topical repellents for protection against arthropod bites and AAD. Use of topical repellents containing PMD have been shown to prevent malaria Footnote 34 and are recommended by the US CDC Footnote 35 Footnote 36 for protection against the bites of mosquito vectors. However, products currently available in Canada contain no more than 10% PMD and are not considered to provide the same duration of protection afforded by higher concentrations of DEET and icaridin. Additionally, use of PMD-containing repellents is restricted to persons three years of age and older. For these reasons, products containing PMD should be considered as a second choice for use by Canadian travellers. Other active ingredients currently registered as topical repellents in Canada (e.g., citronella, soybean oil), are not widely available and/or do not provide sufficiently long protection times against bites Footnote 39 Footnote 40, and are not recommended for use to protect travellers against the bites of vectors.
- In general, as the concentration of DEET (Appendix 4) or icaridin increases so too does the period of bite protection. Currently, the maximum concentrations permitted for adult (civilian) use in Canada are: 30% DEET plus active related toluamides, or 20% icaridin. CATMAT believes that higher concentration products offer an advantage in that they need not be reapplied as frequently, and therefore recommends that adults use products that contain 20% or more DEET or 20% icaridin. For children, the PMRA currently permits use of up to 10% DEET three times daily for those aged two to 12 years and once a day for children aged six months to two years. By contrast, children aged six months or older are permitted to use up to 20% icaridin. Hence, icaridin is the preferred repellent for this age category, with DEET as a second choice. The PMRA does not permit use of DEET or icaridin on infants under the age of six months Footnote 41 ( Icaridin Registration Decision Document [PDF document]). CATMAT acknowledges these regulations, but points out that they were not developed to prevent AAD, but rather reflect regulatory decision-making based on the Canadian context of prevention of nuisance biting. For this reason, CATMAT believes that, for travel outside of Canada where AAD are endemic/epidemic and where exposure is likely, the risk for AAD likely outweighs the risk of an adverse reaction to DEET or icaridin. In such situations and if vectors cannot be otherwise excluded (e.g., through use of insecticide-treated netting), use of up to 10% DEET or icaridin should be considered for infants under six months of age. Product should be applied as per label directions for infants > six months of age.
- Reapply repellent when required. The labels of topical repellents often provide protection time estimates, for example "protects against mosquitoes for six hours". These values, while based on evaluation of efficacy data, are not developed against the backdrop of AAD risk, and further do not sufficiently account for variation based on factors such as sweating Footnote 42, species of mosquito Footnote 43 and numbers of mosquitoes Footnote 44. Thus, for travel outside of Canada to areas where AAD is a threat, repellent might reasonably be applied more frequently than is indicated on the label. As a general rule, if biting is noted before the interval on the label has expired, then reapplication of repellent is recommended. If there is a desire to minimize use of repellent, treatment can be timed so as to optimize protection with a minimum number of applications. For example, applying a long-lasting formulation before or immediately after exiting a treated bed net in the morning and applying it again in the late afternoon to cover the period from dinner until entry into a treated bed net would likely offer protection during the period of higher activity for many malaria vectors.
- Uptake of PPM can be poor among travellers Footnote 45-Footnote 47. Though there is little data that evaluates interventions targeting increased compliance, it is plausible that individual preferences might positively influence adherence. For this reason, CATMAT encourages practitioners and travellers to tailor repellent recommendations/choices to individual preference(s) (e.g. some persons might prefer a cream repellent product, others a liquid and others a spray).
- The use of repellent and sunscreen combination products is not supported by the PMRA, and also is not recommended by CATMAT. This partly reflects that directions for use of these products are somewhat at odds - sunscreens are to be applied often and liberally, whereas repellents should be applied less liberally and less often. There also is evidence that co-administration can reduce the performance of sunscreen and conversely that it can enhance percutaneous absorption of DEETFootnote 48-Footnote 52, though this might not be the case with icaridinFootnote 50. Because interaction between sunscreen and repellent are likely to decrease with the interval between their respective applications, it is recommended that, if both are required, sunscreen be applied first and allowed to penetrate the skin (e.g., for 15 minutes) before applying repellent. Where this is not possible, CATMAT considers that the protective utility of these interventions outweigh any risks that their co-administration might pose, i.e. application of both is recommended even if sunscreen cannot be applied before repellent.
A variety of insecticide-based barrier strategies can be utilized to reduce exposure to vector bites. Indeed, some of these approaches (i.e. insecticide-treated bed nets [ITN] and indoor-residual spraying [IRS]), represent keystone interventions for malaria control in endemic countries. They have been shown to provide substantial protection against malaria, including a significant reduction in all-cause childhood mortalityFootnote 53-Footnote 55. Of the two, this statement will only address in detail the use of ITN since IRS is applied by professionals in an endemic setting, and hence is outside the sphere of control for most travellers. However, for long-term travellers, expatriates, persons spending significant time in rural areas of risk, etc., a preference for accommodations or areas that are subject to IRS would not be unreasonable. For further information on IRS, readers are referred to the WHOPESFootnote 37, which provides information on IRS testingFootnote 56, and an up-to-date listing of approved IRS productsFootnote 57. Importantly, IRS is not considered an alternative to ITN, but rather a complement, i.e. ITN are recommended whether or not IRS has been done. In addition to ITN, several other insecticide-based PPM strategies are available of which insecticide-treated clothing will be considered in some detail by this statement.
- Though little work has been done that specifically evaluates the utility of ITN for travellers, there are robust data to show that they provide significant protection against malaria amongst residents of endemic areas (e.g., 50% reduction in uncomplicated malaria episodes)Footnote 53. CATMAT considers these data to be sufficient to make a strong recommendation that all travellers to foreign destinations endemic or epidemic for AAD should use ITN. ITN are also recommended to provide protection against peridomestic bugs that transmit pathogens (e.g., triatomids) or that cause nuisance (e.g., bed bugs).
- While ITN and related products (portable insecticide-treated netting) are typically deployed at night, they should be used whenever and wherever appropriate, including when resting indoors during the daytime and to protect children in cribs or strollers.
- In Canada, insecticide treatments of bed nets fall under the regulatory control of the PMRA. Excepting products for military use, there are no current Canadian ITN-related registrations, nor is there a specific policy that permits their sale in Canada for use abroad. Nevertheless, ITN can be obtained from some Canadian travel health clinics and other domestic and international suppliers. While a Canadian-registered ITN would be preferred, CATMAT does not consider it likely that registration will occur in the proximate future. However, the World Health Organization, through WHOPES, offers a process by which their safety and efficacy can be evaluatedFootnote 37-Footnote 58. In this respect, the WHOPES recommends specific insecticide formulations for treatment of conventional ITN (Appendix 5)Footnote 59 Footnote 60 and recommends specific products (Appendix 6)Footnote 61 that have met their criteriaFootnote 62 as long-lasting insecticide-treated nets (LN). The latter represent a specific category of ITN that have met very stringent performance endpoints (e.g., field efficacy that persists for three or more years, maintenance of efficacy through 20 or more launderings). CATMAT considers that the WHOPES program is robust and recommends that bed nets should be selected based on a full or interim recommendation from the WHOPES, whether referenced against insecticide formulationFootnote 59 or specific LN productFootnote 61
- Several ITN or ITN treatments (e.g., Insect Shield®), including LN (i.e. Pramex®/Duration® Nets; US EPA registration number 73049-433; nets are based on Olyset® technology), have been registered by the US EPA. Where these ITN are based on technologies for which there is a WHOPES recommendation (e.g., Olyset®, Appendix 6), they are preferred over: products without an US EPA registration; or with a WHOPES recommendation, but not an EPA registration. Should ITN eventually be registered in Canada, a similar algorithm would apply, with a preference for Canadian registered products over US-registered products.
- There are many different types of ITN available internationally, and manufacturing standards might not all be similarly exacting. For this reason, CATMAT recommends use of nets that are registered in Canada or the US and/or where the supplier/manufacturer can provide documentation to assure that WHOPES specifications have been met. Of note, some bed nets are marketed as LN without having been so designated by WHOPES. CATMAT recommends that such products not be used or marketed as LN.
- To minimize exposure to pesticides that might occur through spills or improper treatment of nets, CATMAT recommends that travellers use pre-treated nets rather than nets that they treat themselves. Where such is not possible, the WHOPES treatment/re-treatment guidelines should be followedFootnote 63.
- For the majority of travellers, conventional ITNs should provide sufficiently long-lasting protection. However, where travel to a risk area is frequent and/or is expected to be for a long period (e.g., six months or greater), LNs might offer some advantage.
- In some areas, the mosquito vectors of malaria have resistance to the insecticides (i.e. pyrethroids) that are currently used to treat ITN. It is not clear what the impact of such resistance is, or will beFootnote 17 Footnote 18. At this time, aside from using additional and complementary techniques as already discussed in this statement, CATMAT does not have any specific recommendations related to use of insecticide-treated materials where resistance has been documented.
- Insecticide-treated clothing (ITC) have been shown to protect against the bites of arthropodsFootnote 64-Footnote 67 and there also is evidence that they can protect against AADFootnote 68. Use of ITC is therefore recommended for protection against AAD. ITC products currently registered in Canada contain permethrin and are limited to military use. However, many permethrin-based ITC products are available for civilian use in the US. They generally are available as a formulation that contains 0.5% permethrin and that the consumer applies to their own clothing, or as clothing that has been pre-treated to a level of 0.52% permethrin weight/weight. These approaches differ in that the latter approach is labelled to provide protection through tens of washes whereas the 0.5% product typically protects through several washes. Both are available from major US online retailers, and should be obtainable for personal use by Canadian consumers*Footnote 69. For all treated garments or garment treatments, users should adhere to instructions provided on the label. As for topical repellents and ITN, until such time as ITC are registered in Canada, US EPA registered products are preferred over those available in other non-Canadian jurisdictions
- To optimize protection against bites, ITC should be used in combination with an appropriate repellent productFootnote 66-Footnote 70, preferably long-lasting, such that skin is near to completely protected, (i.e. apply topical repellent to exposed skin that is not covered by ITC).
- For certain vectors, ITC are considered relatively more important. For example, ITC are thought to provide excellent protection against the bites of the ticks that transmit Borrelia burgdorferi, the causative agent of Lyme diseaseFootnote 67. There also are data to suggest that treated clothing protected military personnel against scrub typhus during WWIIFootnote 71.
Other insecticide products
- There are a variety of other insecticide-based approaches that are purported to control vectors and/or nuisance arthropods like bed bugs. They include insecticide coils that are burned, insecticide vaporisers, aerosols and space sprays, and insecticide treated sheets. Many of these have been critical interventions during historic malaria control campaigns. For example, house fumigation with various products was used as part of an integrated strategy to control/eliminate malaria vectors during the construction of the Panama Canal and to rid Brazil of the African malaria vector A. gambiaeFootnote 72 Footnote 73. However, some of these approaches involve indoors release of relatively large doses of insecticide and hence are less likely to meet current regulatory standards for safety. Others, for example currently approved thermal vaporisers in Canada and the US, are limited by the paucity of data demonstrating their public health efficacy. Finally, while presumably efficacious against bed bugs and perhaps malaria vectorsFootnote 74, products such as treated sheets are likely associated with increased insecticide exposure due to enhanced contact between the skin and the treated item.
CATMAT did not carry out a thorough literature review on these alternative approaches. Hence, it does not have a high degree of confidence in its assessment, but nevertheless recommends that the above-listed approaches not be used for prevention of AAD or nuisance bites. This determination is based on several factors: uncertainty about the safety profile of some of these interventions, uncertainty about their efficacy or the availability of alternatives that have demonstrated efficacy and acceptable safety profiles (e.g., ITN, ITC and topical repellents).
There are many products that are marketed as effective PPM interventions. However, for some of these, there is not sufficient scientific evidence to support claims of efficacy and/or safety. Examples include electronic (ultrasonic) devicesFootnote 75 Footnote 76, wristbands, neckbands, and ankle bands impregnated with repellentsFootnote 40, electrocuting devicesFootnote 75-Footnote 77, odour-baited mosquito trapsFootnote 78-Footnote 80, the Citrosa plantFootnote 78-Footnote 81 Footnote 82, oral vitamin B1Footnote 83, and skin moisturizers that do not contain an approved repellent active ingredientFootnote 40. CATMAT recommends that these interventions not be used for protection against arthropod bites and related AAD.
|Vector||Disease caused||Peak biting times and areas|
|Usually bite between sunset and sunrise. Peak biting hours may vary. Some species prefer to bite indoors, while others prefer outdoors.|
|Can bite throughout the day, often outside, but some important vectors bite inside.|
West Nile virus
|Usually bite between sunset and sunrise, often outdoors, but sometimes indoors.|
|Mansonia mosquitos||Filariasis||Usually bite at night, mostly outdoors.|
|Can bite throughout day, usually outdoors|
Crimean-Congo hemorrhagic fever
Rocky Mountain spotted fever
Tick-borne relapsing fever
|Widely dispersed in forest vegetation, meadows, and grassy environments; wait on grasses or branches of low bushes for passing hosts. Some species are more aggressive and actively search out their host(s).|
|Found indoors and outdoors, often associated with a specific type of host, but will feed on a variety of mammals (including humans).|
|Body lice||Epidemic typhus
Louse-borne relapsing fever
|Usually found in clothing, except when feeding on human host.|
Sand fly fever
|Usually bite at night; many bite outdoors, but some also feed indoors.|
|Black flies||Human onchocerciasis||Usually bite in the daytime, outdoors, in areas around rivers or streams.|
|Deer and horse flies (Tabanids)||Loiasis
|Active during the daytime outdoors, often during the sunniest hours; rarely feed indoors.|
|Tsetse flies (Glossina)||African Trypanosomiasis||Usually active during the daytime (though some important vector species are active at dusk or dawn) and usually bite outdoors.|
|Triatomine/ reduviid bugs||American Trypanosomiasis||Active at night and usually feed indoors on human blood.|
Note: ReferencesFootnote 87 Footnote 88 in English and French, respectively, provide a series of detailed tables related to vectors, the diseases that they are associated with, and risk areas.
|Categories for the Strength of Each Recommendation|
|A||Good evidence to support a recommendation for use.|
|B||Moderate evidence to support a recommendation for use.|
|C||Poor evidence to support a recommendation for or against use.|
|D||Moderate evidence to support a recommendation against use.|
|E||Good evidence to support a recommendation against use.|
|Categories for the Quality of Evidence on Which Recommendations are Made|
|I||Evidence from at least one properly randomized, controlled trial.|
|II||Evidence from at least one well-designed clinical trial without randomization, from cohort or case-controlled analytic studies, preferably from more than one centre, from multiple time series, or from dramatic results in uncontrolled experiments.|
|III||Evidence from opinions or respected authorities on the basis of clinical experience, descriptive studies, or reports of expert committees.|
|Recommendations||EBM ratingFootnote 10|
|1. Avoid travelling to risk areas during the season(s) when transmission of AAD is most likely.||BIII|
|2. Reduce exposure by avoiding times or places when/where vectors are known to be active (e.g., by staying indoors during peak activity periods, minimizing exposure in rural areas or other habitats associated with specific vectors).||CIII|
|1. Use screening on doors and windows, close eaves, eliminate holes in roofs and walls and close other gaps to protect work and accommodation areas against vectors.||BI|
|2. Wear appropriate clothing (e.g., full length, loose fitting and light-coloured garments).||BIII|
|1. Use topical repellents that are registered in Canada on exposed areas of skin to prevent arthropod bites and to reduce the risk of AAD.||AI|
|i. Repellents that contain DEET (20-30%) or icaridin (20%) should be the first choice for adults.||AII|
|ii. Repellents that contain icaridin (20%) should be the first choice for children aged six months to twelve years. Repellents containing age-appropriate concentrations of DEET should be considered as a second choice for children aged six months to twelve years.||AII|
|iii. Repellents that contain p-menthane-3,8-diol should be considered second-choice topical repellents for adults and children aged three years or older.||AII|
|iv. Other active ingredients currently registered in Canada (e.g., citronella, soybean oil) are not widely available and/or do not provide sufficiently long protection times against bites, and are not recommended for use to protect travellers against the bites of vectors.||EII|
|iv. For travel outside of Canada to endemic/epidemic areas, the risk for arthropod-associated diseases (AAD) likely outweighs the risk of an adverse reaction to DEET or icaridin. In such situations and if vectors cannot be otherwise excluded (e.g., through use of insecticide-treated netting), use of up to 10% DEET or 10% icaridin should be considered for infants under six months of age.||BIII|
|vi. If biting is noted before the re-application interval indicated on the label has expired, reapply repellent.||BII|
|vii. Where there is interest in minimizing the amount of repellent used, apply at times of the day where vectors are most active and exposure is more likely (e.g., when leaving a bed net in the morning and in the late afternoon).||CIII|
|viii. Where possible, choose PPM to suit each traveller's needs (e.g., a cream, spray or liquid topical repellent, to enhance the likelihood of product use).||CIII|
|ix. Do not use repellent and sunscreen combination products.||EII|
|x. It is preferable to apply sunscreen first and allow it to penetrate the skin before applying repellent. Where this is not possible, apply both products even if such is done contemporaneously.||CIII|
|1. For long-term travellers, expatriates, persons spending significant time in rural areas of risk, etc., a preference for accommodations or areas that are subject to indoor residual spraying is reasonable.||CIII|
|1. Use insecticide-treated nets (ITN) for protection against arthropod bites and related diseases.||AI|
|i. While ITN and related products (portable insecticide-treated netting) are typically deployed at night, they should be used whenever and wherever appropriate, including when resting indoors during the daytime or to protect children in cribs and strollers.||AI|
|ii. Where possible, bed nets should be selected based on a PMRA or EPA registration and a full or interim recommendation from the World Health Organization Pesticide Evaluation Scheme (WHOPES).||AII|
|iii. Use products manufactured where there is greater assurance of quality (e.g., in western countries or where the supplier/manufacturer can provide documentation to assure that WHOPES specifications have been met).||CIII|
|iv. Some products are marketed as LN without having been so designated by WHOPES. CATMAT cannot evaluate the veracity of such claims, and hence recommends that these products not be used or marketed as long-lasting ITN (LN).||DIII|
|v. To minimize exposure to pesticides that might occur through spills or improper treatment of nets, use pre-treated nets rather than nets that you treat yourself.||DIII|
|vi. Where travel is frequent and/or is expected to be for a long period (e.g., six months or greater) use LN.||CIII|
|vii. Use ITN to reduce the bites from nuisance arthropods and to protect against snake bites.||BII|
|1. Use insecticide-treated clothing (ITC) to protect against the bites of vectors and nuisance arthropods.||BII|
|i. To optimize protection against bites, ITC should be used in combination with an appropriate repellent product, preferably long-lasting, such that skin is near to completely protected, i.e. apply topical repellent to exposed skin that is not covered by ITC.||AII|
|ii. Until such time as ITC are registered in Canada for civilian use, use ITC that have been registered by the United States Environmental Protection Agency (US EPA).||AII|
|Other insecticide products:|
|1. CATMAT recommends against use of/reliance on other insecticide-based approaches such as insecticide coils that are burned, insecticide vaporizers, aerosols and space sprays, and insecticide-treated sheets.||CIII|
|2. CATMAT recommends against use of insect personal protection measures that are ineffective, or that have not been convincingly shown to be efficacious against arthropod vectors and related diseases. They include:
|% DEET||Complete protection time|
|Mean||Lower residual||Upper residual|
|Minutes||HoursAppendix A Footnote *||Minutes||HoursAppendix A Footnote *||Minutes||HoursAppendix A Footnote *|
Source: Health Canada, Pest Management Regulatory Agency RRD 2002-01Footnote 41
|Insecticide||FormulationAppendix 5.1 Footnote 1||DosageAppendix 5.1 Footnote 2|
|Deltamethrin||SC 1%; WT 25%; and WT 25% + binderAppendix 5.1 Footnote 3||15-25|
|Product name||Product type||Status of WHO recommendation|
|ICON®MAXX||Lambda-cyhalothrin 10% CS + binder Target dose of 50 mg/m2||Interim|
Source: World Health Organization Pesticide Evaluation Scheme (WHOPES)Footnote 59.
|Product name||Product type||Status of WHO recommendation||Status of publication of WHO specification|
|DawaPlus® 2.0||Deltamethrin coated on polyester||Interim||Published|
|Duranet®||Alpha-cypermethrin incorporated into polyethylene||Interim||Published|
|Interceptor®||Alpha-cypermethrin coated on polyester||Full||Published|
|LifeNet®||Deltamethrin incorporated into polypropylene||Interim||Published|
|MAGNet™||Alpha-cypermethrin incorporated into polyethylene||Interim||Published|
|Netprotect®||Deltamethrin incorporated into polyethylene||Interim||Published|
|Olyset®||Permethrin incorporated into polyethylene||Full||Published|
|Olyset® Plus||Permethrin and PBO incorporated into polyethylene||Interim||Pending|
|PermaNet® 2.0||Deltamethrin coated on polyester||Full||Published|
|PermaNet® 2.5||Deltamethrin coated on polyester with strengthened border||Interim||Published|
|PermaNet® 3.0||Combination of deltamethrin coated on polyester with strengthened border (side panels) and deltamethrin and PBO incorporated into polyethylene (roof)||Interim||Published|
|Royal Sentry®||Alpha-cypermethrin incorporated into polyethylene||Interim||Published|
|Yorkool® LN||Deltamethrin coated on polyester||Full||Published|
Notes: 1. Reports of the WHOPES Working Group Meetings should be consulted for detailed guidance on use and recommendations. These reports are available on the WHO homepage ; and 2. WHO recommendations on the use of pesticides in public health are valid ONLY if linked to WHO specifications for their quality control. WHO specifications for public health pesticides are available on the WHO homepage 3. For an updated list, access the access the WHOPES website>
Source: World Health Organization Pesticide Evaluation Scheme (WHOPES)Footnote 61
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