Year 2 of pesticide chemistry verification process and updated work plan
Pest Management Regulatory Agency
1 August 2025
The Pest Management Regulatory Agency (PMRA) has initiated Year 2 of its pesticide chemistry verification process as described below. The five-year work plan has been updated to confirm active ingredients subject to verification in FY2025-26 and in other years.
Registrants of active ingredients on the FY2025-26 list have received a request to provide chemistry verification information for their registered technical products in May 2025 with a submission deadline of 90 days. The review process is expected to be completed at the end of March 2026.
Iodosulfuron-methyl-sodium, prohexadione calcium, and German cockroach extract are now subject to chemistry verification in 2026-27 due to recent re-evaluation activity.
Results of Year 1 verification will be published later in 2025.
Updated pesticide chemistry verification process and work plan
The PMRA has modernized its pesticide review process through the implementation of a continuous oversight model. As part of this process modernization effort, the PMRA’s approach for verifying product chemistry information of technical grade active ingredient products is updated.
Verifying product chemistry as part of continuous oversight is an important component for ensuring that health and environmental risk assessments are relying on the best available chemistry information. This initiative will contribute to improved monitoring of pesticide active ingredients to confirm they are being manufactured consistent with approved specifications and methods. It will also ensure that the PMRA’s chemistry review is up-to-date when an active undergoes re-evaluation, resulting in more timely decisions.
To provide registrants with advance notice of when their active ingredients will be subject to chemistry verification and to keep other interested stakeholders informed, the PMRA is maintaining a transparent five-year chemistry verification work plan, which will be updated annually.Footnote 1
Through this updated process, chemistry verification for each active ingredient is expected to occur at least every 10 years, with the flexibility to require chemistry verification sooner when warranted. For example:
- When actives or sources are known to contain impurities or contaminants of health or environmental concern;
- When the PMRA becomes aware of a potential issue that requires further assessment;
- When there is a history of discrepancies in specifications for certain actives or sources.
Registrants will be requested to submit listed chemistry information regarding their active ingredient, including quality control data, description of the current manufacturing process and up-to-date product specification form. When needed, the PMRA will request additional GLP-compliant chemistry batch data and/or impurity of concern data to support continued registration.
If the chemistry verification determines that the product composition is not within approved specifications, or the manufacturing process has changed without proper reporting, Health Canada may consider appropriate compliance and enforcement actions.
Additional details on the process are provided in the “Memorandum to Registrants: Verifying Chemistry of Registered Technical Grade Active Ingredients and Integrated System Products”.
Below is the five-year chemistry verification work plan for 1 April 2025 to 31 March 2030.
Active ingredients subject to chemistry verification in 2025-2026 - confirmed
- 1,2-Benzisothiazolin-3-one, BIT
- 6-Benzylaminopurine (or: 6-benzyladenine)
- Bromoxynil
- Saponins of Chenopodium quinoa
- Chloridazon
- 2,4-D
- 2,4-D (present as amine salts: dimethylamine salt, diethanolamine salt, or other amine salts)
- 2,4-D (present as low volatile esters)
- 2,4-D (present as choline salt)
- Dicamba (present as acid, ester, salt)
- Dodine
- Ethametsulfuron-methyl
- Gibberellins A4 and A7 (omitted from Year 1)
- Imazapyr
- Mandipropamid
- MCPA (present as acid)
- MCPA (present as amine salts: diethanolamine, dimethylamine, or mixed amines)
- MCPA (present as esters)
- MCPA (present as potassium salt or as sodium salt)
- Mineral oil
- Nicosulfuron
- Oxirane derivatives (50% minimum)
- Pendimethalin
- 2-Phenylphenol
- 2-Phenylphenol (present as potassium salt)
- 2-Phenylphenol (present as sodium salt)
- Propylene glycol
- Rimsulfuron
- Sodium chlorate
- Sodium chloride
- Sodium chlorite
- Spirotetramat
- Sulfentrazone
- Tetrakis (hydroxymethyl) phosphonium sulfate (THPS)
Active ingredients subject to chemistry verification in 2026-2027
- n-Alkyl(25% c12, 60% c14, 15% c16)dimethylbenzylammonium chloride
- Alkyl(40% c12, 50% c14, 10% c16)dimethylbenzylammonium chloride
- n-Alkyl(68% c12, 32% c14)dimethyl ethylbenzyl ammonium chloride
- n-Alkyl (60% c14, 30% c16, 5% c12, 5% c18)dimethyl benzyl ammonium chloride
- n-Alkyl(40% c12, 50% c14, 10% c16)dimethylbenzylammonium saccharinate
- n-Alkyl(67% c12, 25% c14, 7% c16, 1% c18)dimethylbenzylammonium chloride
- Diisobutylphenoxyethoxyethyldimethylbenzylammonium chloride
- n-Dialkyl(5% c12, 60% c14, 30% c16, 5% c18)methylbenzylammonium chloride
- 1-Alkyl(c6-c18)-1,3-propanediamine
- N-Alkyl-1,3-propanediamine acetate
- N-coco-alkyl trimethylene diamines (present as monobenzoate salt)
- 1,3-bis(hydroxymethyl)-5,5-dimethylhydantoin, hydroxymethyl-5,5-dimethylhydantoin
- Ammonium soap of fatty acid
- Bifenthrin
- Carbathiin
- Chlorthal (present as dimethyl ester)
- Cloransulam-methyl
- Chlormequat chloride
- Codlelure
- Cyprosulfamide
- n-Decanol
- Desmedipham
- Diazinon
- Didecyldimethylammonium chloride
- Dimethenamid-p
- Dioctyldimethylammonium chloride
- Dithiopyr
- Flumioxazin
- Formetanate hydrochloride
- German cockroach extract
- Glutaraldehyde
- Hexazinone
- Imazamethabenz-methyl
- Iodosulfuron-methyl-sodium
- Lime sulphur
- Mono- and dipotassium phosphite
- Metsulfuron-methyl
- Metaldehyde
- Maleic hydrazide
- Naphthylacetic acid
- Oxydiethylene bis(alkyl dimethyl ammonium chloride)
- 1-Octanol
- r-(-)-1-Octen-3-ol
- Octyldecyldimethylammonium chloride
- Oxycarboxin
- Ozone
- Picloram (present as acid)
- Picloram (present as amine salts)
- Picloram (present as potassium salt)
- Prohexadione calcium
- Propyzamide
- Phenmedipham
- Saflufenacil
- Simazine plus related active triazines
- Streptomycin
- Thiencarbazone-methyl
- Thifensulfuron-methyl
- Tribenuron-methyl
- Trifluralin
- Available chlorine, present as sodium hypochloriteFootnote 2
Active ingredients subject to chemistry verification in 2027-2028
- Ancymidol
- Arsenic acid
- Available chlorine present as 1-bromo-3-chloro-5,5-dimethylhydantoin and related hydantoins
- Available bromine present as 1-bromo-3-chloro-5,5-dimethylhydantoin and related hydantoins
- Available chlorine present as 1-bromo-3-chloro-5,5-dimethylhydantoin, 1,3-dichloro-5,5-dimethylhydantoin, 1,3-dichloro-5-ethyl-5-methylhydantoin and related hydantoins
- Available chlorine present as 1,3-dichloro-5,5-dimethylhydantoin and 1,3- dichloro-5-ethyl-5-methylhydantoin
- Clopyralid (present as acid, or as salts)
- Copper (present as copper naphthenate)
- Copper (present as copper 8-quinolinolate)
- Copper, present as basic copper carbonate
- Basic copper sulfate
- Bromethalin
- Chlorpropham
- Chlorsulfuron
- Chromic acid
- Citronella oil
- Clomazoneb
- Copper (present as cuprous oxide, cupric oxide and metallic copper)
- Copper (present as cupric oxide)
- Creosote
- Cyazofamid
- Diflubenzuron
- Diphacinone (present in free form or as sodium salt)
- Diphenylamine
- Dried blood
- Endothal or endothall
- EPTC
- Fluopicolide
- Formaldehyde
- Formic acid
- Icaridin
- Indaziflam
- 3-Methyl-2-cyclohexen-1-one
- Methyl nonyl ketone
- Metofluthrin
- Oriental mustard seed meal
- Paraformaldehyde
- Penflufen
- Penthiopyrad
- Propiconazole
- Verbenone
- Extract of Reynoutria sachalinensis
- Zinc as elemental (present as zinc naphthenate)
- Zinc (present as zinc oxide)
- Available chlorine, present as calcium hypochloriteFootnote 3
Active ingredients subject to chemistry verification in 2028-2029
- Abamectin
- Acequinocyl
- Ametoctradin
- Aminopyralid
- Ammonia (present as ammonium sulfate)
- Ammonium bromide
- Atrazine (plus related active triazines)
- Azoxystrobin
- Bifenazate
- Bensulide
- Benzyl benzoate
- Bromacil (present in free form, as dimethylamine salt, or as lithium salt)
- Liquid carbon dioxide
- Cloquintocet-mexyl
- Chlorfenapyr
- Cyantraniliprole
- Denatonium benzoate
- 3-Decen-2-one
- 1,2-Dibromo-2,4-dicyanobutane
- Difethialone
- Dodecylguanidine hydrochloride
- Ethalfluralin
- (E,Z)-2,13-octadecadien-1-yl acetate
- Fenoxaprop-p-ethyl
- Ferric sodium ethylenediaminetetraacetic acid
- Fluazifop-p-butyl and s-isomer
- Fluopyram
- Fluoxastrobin
- Fluxapyroxad
- Fosetyl-al
- Garlic juice
- Glufosinate-ammonium
- Halosulfuron (present as methyl ester)
- Hydramethylnon
- Imiprothrin
- Kasugamycin hydrochloride hydrate
- Malathion
- MCPB
- MCPB (present as sodium salt)
- Mesotrione
- Metalaxyl-m and S-isomer
- 1-Methylcyclopropene
- Metribuzin
- Mono- and dibasic sodium, potassium, and ammonium phosphites
- Myclobutanil
- Naled
- Natamycin
- Niclosamide
- Octenol
- Oil of lemon eucalyptus, hydrated, cyclized
- d-Phenothrin
- Potassium dimethyldithiocarbamate
- Poly[oxyethylene(dimethyliminio)ethylene(dimethyliminio)ethylene dichloride]
- Picoxystrobin
- Pyroxasulfone
- Quinclorac (present as dimethylamine salt)
- Sedaxane
- S-metolachlor and R-enantiomer
- Sulfoxaflor
- Tea tree oil
- Tetraconazole
- Tributyl tetradecyl phosphonium chloride
Active ingredients subject to chemistry verification in 2029-2030
- Acetamiprid
- Acifluorfen-sodium
- Aluminum phosphide
- Aminocyclopyrachlor
- Benzovindiflupyr
- Bicyclopyrone
- 1,4-Bis(bromoacetoxy)-2-butene
- Blad polypeptide
- Borax
- Brassica hirta white mustard seed powder + sodium alpha-olefin sulfonate
- Broflanilide
- Bronopol
- Capsaicin + related capsaicinoids
- Carbaryl
- Carbon dioxide gas
- Cedarwood oil
- Cellulose (from powdered corn cobs)
- 4-Chloro-3-methylphenol (sodium salt)
- Clofentezine
- Copper octanoate
- Cyflumetofen
- D-Cis,trans-allethrin
- 2,2-Dibromo-3-nitrilopropionamide
- Dichlorvos
- Dimethoate
- Dimethomorph
- Di-n-propyl isocinchomeronate
- Disodium octaborate tetrahydrate
- (Z)-9-Dodecenyl acetate
- Ethaboxam
- Ethephon
- Etofenprox
- Etoxazole
- Fatty acids
- Fenamidone
- Fenbuconazole
- Fenbutatin oxide
- Fenpropathrin
- Fenpyroximate
- Ferrous sulfate heptahydrate
- Flufenacet
- Flumetsulam
- Flupyradifurone
- Flutriafol
- Foramsulfuron
- From nanogen: chlorocresol (or: parachlorocresol)
- Halauxifen-methyl
- Inpyrfluxam
- Iodosulfuron-methyl-sodium
- Isofetamid
- Isoxaben
- Kaolin
- 3-Ketopetromyzonol-24-sulfate, ammonium salt
- Lemongrass oil
- Linuron
- Magnesium phosphide
- Methoxyfenozide
- Novaluron
- Noviflumuron
- (e,z)-3,13-Octadecadien-1-yl acetate + (z,z)-3,13-octadecadien-1-yl acetate
- Octadec-9-enoic acid, methyl ester + octadec-9-enoic acid, ethyl ester
- Oil of geranimum ethyl alcohol, camphor oil, euaclyptus oil, lemon oil, pine needle oil
- Oxathiapiprolin
- 10,10'-Oxybis(phenoxarsine)
- Oxyfluorfen
- Paclobutrazol
- Peppermint oil
- Phorate
- Phosmet
- Picolinafen
- Prohydrojasmon
- Propamocarb hydrochloride
- Propoxur
- Propoxycarbazone-sodium
- Prosulfuron
- Pyraflufen-ethyl
- Pyridate
- Quintozene
- Racemic camphor, eucalyptus oil, l-menthol and thymol
- Silicon dioxide (present as 100% diatomaceous earth) - fresh water fossils
- s-Methoprene
- Sodium monofluoroacetate
- Spiroxamine
- Tau-fluvalinate
- Tetrachlorvinphos
- (9Z,12E)-9,12-Tetradecadien-1-yl acetate
- (E,Z)-11-Tetradecenal
- Thiophanate-methyl
- Topramezone
- Triflusulfuron-methyl
Footnotes
- Footnote 1
-
This five-year work plan may change in response to workload and emerging issues that require priority action.
- Footnote 2
-
Only select sources for this active ingredient will be subject to chemistry verification in fiscal year 2026-27.
- Footnote 3
-
Only select sources for this active ingredient will be subject to chemistry verification in fiscal year 2027-28.
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