Register of Innovative Drugs
Contact: Office of Patented Medicines and Liaison
- Products for Human Use - Active Data Protection Period
- Products for Human Use - Expired Data Protection Period
- Products for Veterinary Use - Active Data Protection Period
- Products for Veterinary Use - Expired Data Protection Period
| Medicinal Ingredient(s) Footnote 1 |
Submission Number | Innovative Drug | Manufacturer | Drug(s) Containing the Medicinal Ingredient / Variations | Notice of Compliance Date yyyy-mm-dd | 6 Year "No File" Date |
Pediatric Extension Yes/No | Data Protection Ends |
|---|---|---|---|---|---|---|---|---|
| abemaciclib | 215268 | Verzenio | Eli Lilly Canada Inc. | N/A | 2019-04-08 | 2025-04-08 | N/A | 2027-04-08 |
| acalabrutinib | 214504 | Calquence | AstraZeneca Canada Inc. | N/A | 2019-08-23 | 2025-08-23 | N/A | 2027-08-23 |
| afatinib dimaleate | 158730 | Giotrif | Boehringer Ingelheim (Canada) Ltd. | N/A | 2013-11-01 | 2019-11-01 | N/A | 2021-11-01 |
| aflibercept | 149321 | Eylea | Bayer Inc. | N/A | 2013-11-08 | 2019-11-08 | N/A | 2021-11-08 |
| albiglutide | 165145 | Eperzan | GlaxoSmithKline Inc. | N/A | 2015-07-15 | 2021-07-15 | N/A | 2023-07-15 |
| alectinib hydrochloride | 189442 | Alecensaro | Hoffmann-La Roche Limited | N/A | 2016-09-29 | 2022-09-29 | N/A | 2024-09-29 |
| alirocumab | 183116 | Praluent | Sanofi-aventis Canada Inc. | N/A | 2016-04-11 | 2022-04-11 | N/A | 2024-04-11 |
| alogliptin benzoate | 158335 | Nesina | Takeda Canada Inc. | Kazano Oseni |
2013-11-27 | 2019-11-27 | N/A | 2021-11-27 |
| alpelisib | 226941 | Piqray | Novartis Pharmaceuticals Canada Inc. | N/A | 2020-03-11 | 2026-03-11 | N/A | 2028-03-11 |
| amifampridine (supplied as amifampridine phosphate) | 232685 | Firdapse | Kye Pharmaceuticals Inc. | N/A | 2020-07-31 | 2026-07-31 | N/A | 2028-07-31 |
| anthrax immune globulin (human) | 200446 | Anthrasil | Emergent BioSolutions Canada Inc. | N/A | 2017-11-06 | 2023-11-06 | Yes | 2026-05-06 |
| antihemophilic factor (recombinant BDD), Fc fusion protein | 163447 | Eloctate | Sanofi-Aventis Canada Inc. | N/A | 2014-08-22 | 2020-08-22 | Yes | 2023-02-22 |
| antihemophilic factor (recombinant), pegylated | 189709 | Adynovate | Takeda Canada Inc. | N/A | 2016-11-17 | 2022-11-17 | Yes | 2025-05-17 |
| antihemophilic factor (recombinant, B-domain deleted, pegylated) (also known as damoctocog alfa pegol) | 210935 | Jivi | Bayer Inc. | N/A | 2018-10-18 | 2024-10-18 | Yes | 2027-04-18 |
| antihemophilic factor (recombinant, B-domain deleted) (also known as simoctocog alfa) | 169551 | Nuwiq | Octapharma Pharmazeutika Produktionsges.m.b.H | N/A | 2014-10-23 | 2020-10-23 | Yes | 2023-04-23 |
| antihemophilic factor VIII (recombinant), singlechain (also known as lonoctocog alfa) | 190891 | Afstyla | CSL Behring Canada Inc. | N/A | 2016-12-12 | 2022-12-12 | Yes | 2025-06-12 |
| anthrax antigen filtrate | 212387 | Biothrax | Emergent Biodefense Operations Lansing LLC | N/A | 2018-12-13 | 2024-12-13 | N/A | 2026-12-13 |
| antihemophilic factor VIII (recombinant, B-domain truncated), PEGylated (turoctocog alfa pegol) | 218531 | Esperoct | Novo Nordisk Canada Inc. | N/A | 2019-07-04 | 2025-07-04 | Yes | 2028-01-04 |
| apalutamide | 211942 | Erleada | Janssen Inc. | N/A | 2018-07-03 | 2024-07-03 | N/A | 2026-07-03 |
| apremilast | 169862 | Otezla | Amgen Canada Inc. | N/A | 2014-11-12 | 2020-11-12 | N/A | 2022-11-12 |
| asfotase alfa | 179340 | Strensiq | Alexion Pharma International Sàrl | N/A | 2015-08-14 | 2021-08-14 | Yes | 2024-02-14 |
| asunaprevir | 172617 | Sunvepra | Bristol-Myers Squibb Canada | N/A | 2016-03-09 | 2022-03-09 | N/A | 2024-03-09 |
| atezolizumab | 196843 | Tecentriq | Hoffmann-La Roche Limited | N/A | 2017-04-12 | 2023-04-12 | N/A | 2025-04-12 |
| avelumab | 204052 | Bavencio | EMD Serono, a Division of EMD Inc., Canada | N/A | 2017-12-18 | 2023-12-18 | N/A | 2025-12-18 |
| axicabtagene ciloleucel | 218389 | Yescarta | Gilead Sciences Canada Inc | N/A | 2019-02-13 | 2025-02-13 | N/A | 2027-02-13 |
| azelastine hydrochloride | 169604 | Dymista | Meda Pharmaceuticals Ltd. | N/A | 2014-10-23 | 2020-10-23 | Yes | 2023-04-23 |
| baloxavir marboxil | 227361 | Xofluza | Hoffmann-La Roche Limited | N/A | 2020-02-19 | 2026-02-19 | Yes | 2028-08-19 |
| baricitinib | 193687 | Olumiant | Eli Lilly Canada Inc. | N/A | 2018-08-17 | 2024-08-17 | N/A | 2026-08-17 |
| bazedoxifene acetate | 160681 | Duavive | Pfizer Canada Inc. | N/A | 2014-10-23 | 2020-10-23 | N/A | 2022-10-23 |
| benralizumab | 204008 | Fasenra | AstraZeneca Canada Inc. | N/A | 2018-02-22 | 2024-02-22 | Yes | 2026-08-22 |
| bepotastine besilate | 179294 | Bepreve | Bausch and Lomb Incorporated | N/A | 2016-07-27 | 2022-07-27 | Yes | 2025-01-27 |
| bictegravir | 203718 | Biktarvy | Gilead Sciences Canada, Inc. | N/A | 2018-07-10 | 2024-07-10 | Yes | 2027-01-10 |
| bilastine | 184231 | Blexten | Aralez Pharmaceutials Canada Inc. | N/A | 2016-04-21 | 2022-04-21 | Yes | 2024-10-21 |
| binimetinib | 237410 | Mektovi | Pfizer Canada ULC | N/A | 2021-03-02 | 2027-03-02 | N/A | 2029-03-02 |
| blinatumomab | 181723 | Blincyto | Amgen Canada Incorporated | N/A | 2015-12-22 | 2021-12-22 | Yes | 2024-06-22 |
| bosutinib | 152211 | Bosulif | Pfizer Canada Inc. | N/A | 2014-03-07 | 2020-03-07 | N/A | 2022-03-07 |
| botulism antitoxin heptavalen C/ D/ F/ G - (equine) | 190645 | Bat | Emergent BioSolutions Inc. | N/A | 2016-12-08 | 2022-12-08 | Yes | 2025-06-08 |
| brexpiprazole | 192684 | Rexulti | Otsuka Pharmaceutical Co. Ltd. | N/A | 2017-02-16 | 2023-02-16 | Yes | 2025-08-16 |
| brexucabtagene autoleucel | 246355 | Tecartus | Gilead Sciences Canada, Inc. | N/A | 2021-06-08 | 2027-06-08 | N/A | 2029-06-08 |
| brigatinib | 210369 | Alunbrig | Takeda Canada Incorporated | N/A | 2018-07-26 | 2024-07-26 | N/A | 2026-07-26 |
| brivaracetam | 183355 | Brivlera | UCB Canada Incorporated | N/A | 2016-03-09 | 2022-03-09 | Yes | 2024-09-09 |
| brodalumab | 195317 | Siliq | Bausch Health, Canada Inc. | N/A | 2018-03-06 | 2024-03-06 | N/A | 2026-03-06 |
| brolucizumab | 226224 | Beovu | Novartis Pharmaceuticals Canada Inc. | N/A | 2020-03-12 | 2026-03-12 | N/A | 2028-03-12 |
| bromfenac sodium sesquihydrate | 171657 | Prolensa | Bausch & Lomb Incorporated | N/A | 2015-03-26 | 2021-03-26 | N/A | 2023-03-26 |
| burosumab | 216239 | Crysvita | Kyowa Kirin Limited | N/A | 2018-12-05 | 2024-12-05 | Yes | 2027-06-05 |
| cabotegravir sodium | 227315 | Vocabria | ViiV Healthcare ULC | N/A | 2020-03-18 | 2026-03-18 | N/A | 2028-03-18 |
| cabotegravir | 227315 | Cabenuva | ViiV Healthcare ULC | N/A | 2020-03-18 | 2026-03-18 | N/A | 2028-03-18 |
| cabozantinib (supplied as cabozantinib (S)-malate) | 206230 | Cabometyx | Ipsen Biopharmaceuticals Canada Inc. | N/A | 2018-09-14 | 2024-09-14 | N/A | 2026-09-14 |
| calcifediol | 205392 | Rayaldee | Vifor Fresenius Medical Care Renal Pharma Ltd | N/A | 2018-07-10 | 2024-07-10 | N/A | 2026-07-10 |
| canagliflozin | 157505 | Invokana | Janssen Inc. | Invokamet Invokamet XR |
2014-05-23 | 2020-05-23 | N/A | 2022-05-23 |
| caplacizumab | 230001 | Cablivi | Sanofi-Aventis Canada Inc. | N/A | 2020-02-28 | 2026-02-28 | N/A | 2028-02-28 |
| carfilzomib | 184479 | Kyprolis | Amgen Canada Inc. | N/A | 2016-01-15 | 2022-01-15 | N/A | 2024-01-15 |
| carglumic acid | 171358 | Carbaglu | Recordati Rare Diseases | N/A | 2015-04-10 | 2021-04-10 | Yes | 2023-10-10 |
| cedazuridine | 234610 | Inqovi | Otsuka Pharmaceutical Co., Ltd. | N/A | 2020-07-07 | 2026-07-07 | N/A | 2028-07-07 |
| ceftolozane | 178006 | Zerbaxa | Merck Canada Inc. | N/A | 2015-09-30 | 2021-09-30 | N/A | 2023-09-30 |
| cemiplimab | 218718 | Libtayo | Sanofi-Aventis Canada Inc. | N/A | 2019-04-10 | 2025-04-10 | N/A | 2027-04-10 |
| cenegermin | 218145 | Oxervate | Dompé farmaceutici S.p.A. | N/A | 2019-02-08 | 2025-02-08 | N/A | 2027-02-08 |
| ceritinib | 175702 | Zykadia | Novartis Pharmaceuticals Canada Inc. | N/A | 2015-03-27 | 2021-03-27 | N/A | 2023-03-27 |
| cerliponase alfa | 216539 | Brineura | Biomarin International Limited | N/A | 2018-12-19 | 2024-12-19 | Yes | 2027-06-19 |
| coagulation factor IX (recombinant), albumin fusion protein (rIX-FP) | 180793 | Idelvion | CSL Behring Canada Inc. | N/A | 2016-01-26 | 2022-01-26 | Yes | 2024-07-26 |
| coagulation factor IX (recombinant), pegylated (nonacog beta pegol) | 201114 | Rebinyn | Novo Nordisk Canada Inc. | N/A | 2017-11-29 | 2023-11-29 | Yes | 2026-05-29 |
| coagulation factor IX, Fc fusion protein | 163614 | Alprolix | Sanofi-Aventis Canada Inc. | N/A | 2014-03-20 | 2020-03-20 | Yes | 2022-09-20 |
| cobimetinib | 182788 | Cotellic | Hoffmann-La Roche Limited | N/A | 2016-02-22 | 2022-02-22 | N/A | 2024-02-22 |
| crisaborole | 206906 | Eucrisa | Pfizer Canada Inc. | N/A | 2018-06-07 | 2024-06-07 | Yes | 2026-12-07 |
| cysteamine bitartrate | 191347 | Procysbi | Horizon Pharma Ireland Ltd. | N/A | 2017-06-13 | 2023-06-13 | Yes | 2025-12-13 |
| daclatasvir | 172616 | Daklinza | Bristol-Myers Squibb Canada | N/A | 2015-08-13 | 2021-08-13 | N/A | 2023-08-13 |
| daclizumab beta | 190458 | Zinbryta | Biogen Canada Inc. | N/A | 2016-12-08 | 2022-12-08 | N/A | 2024-12-08 |
| dacomitinib | 214572 | Vizimpro | Pfizer Canada Inc. | N/A | 2019-02-26 | 2025-02-26 | N/A | 2027-02-26 |
| dalbavancin (supplied as dalbavancin hydrochloride) | 212390 | Xydalba | Cipher Pharmaceuticals Inc. | N/A | 2018-09-04 | 2024-09-04 | N/A | 2026-09-04 |
| dapagliflozin propanediol | 160877 | Forxiga | AstraZeneca Canada Inc. | Xigduo Qtern |
2014-12-12 | 2020-12-12 | N/A | 2022-12-12 |
| daratumumab | 187648 | Darzalex | Janssen Inc. | Darzalex SC | 2016-06-29 | 2022-06-29 | N/A | 2024-06-29 |
| darolutamide | 226146 | Nubeqa | Bayer Inc. | N/A | 2020-02-20 | 2026-02-20 | N/A | 2028-02-20 |
| deferiprone | 162924 | Ferriprox | Chiesi Canada Corp. | N/A | 2015-02-13 | 2021-02-13 | Yes | 2023-08-13 |
| defibrotide sodium | 200808 | Defitelio | Jazz Pharmaceuticals Ireland Limited | N/A | 2017-07-10 | 2023-07-10 | Yes | 2026-01-10 |
| difluprednate | 154517 | Durezol | Novartis Pharmaceuticals Canada Inc. | N/A | 2013-11-04 | 2019-11-04 | Yes | 2022-05-04 |
| dimethyl fumarate | 154776 | Tecfidera | Biogen Idec Canada Inc. | N/A | 2013-04-03 | 2019-04-03 | Yes | 2021-10-03 |
| dinutuximab | 212066 | Unituxin | United Therapeutics Corporation | N/A | 2018-11-28 | 2024-11-28 | Yes | 2027-05-28 |
| dolutegravir sodium | 161084 | Tivicay | ViiV Healthcare ULC | Triumeq Juluca Dovato |
2013-10-31 | 2019-10-31 | Yes | 2022-05-01 |
| doravirine | 211293 | Pifeltro | Merck Canada Inc. | Delstrigo | 2018-10-12 | 2024-10-12 | N/A | 2026-10-12 |
| dulaglutide | 168671 | Trulicity | Eli Lilly Canada Inc. | N/A | 2015-11-10 | 2021-11-10 | N/A | 2023-11-10 |
| dupilumab | 201285 | Dupixent | Sanofi-Aventis Canada Inc. | N/A | 2017-11-30 | 2023-11-30 | Yes | 2026-05-30 |
| durvalumab | 202953 | Imfinzi | AstraZeneca Canada Inc. | N/A | 2017-11-03 | 2023-11-03 | N/A | 2025-11-03 |
| edaravone | 214391 | Radicava | Mitsubishi Tanabe Pharma Corporation | N/A | 2018-10-03 | 2024-10-03 | N/A | 2026-10-03 |
| edoxaban | 187363 | Lixiana | Servier Canada Inc. | N/A | 2016-11-04 | 2022-11-04 | N/A | 2024-11-04 |
| efinaconazole | 159416 | Jublia | Bausch Health, Canada Inc. | N/A | 2013-10-02 | 2019-10-02 | N/A | 2021-10-02 |
| elagolix | 209513 | Orilissa | AbbVie Corporation | N/A | 2018-10-05 | 2024-10-05 | N/A | 2026-10-05 |
| elexacaftor | 246955 | Trikafta | Vertex Pharmaceuticals (Canada) Incorporated | N/A | 2021-06-18 | 2027-06-18 | Yes | 2029-12-18 |
| eliglustat tartrate | 183050 | Cerdelga | Genzyme Canada, A division of Sanofi-aventis Canada Inc. | N/A | 2017-04-21 | 2023-04-21 | N/A | 2025-04-21 |
| elosulfase alfa | 170340 | Vimizim | Biomarin International Limited | N/A | 2014-07-02 | 2020-07-02 | Yes | 2023-01-02 |
| elotuzumab | 188144 | Empliciti | Bristol-Myers Squibb Canada | N/A | 2016-06-21 | 2022-06-21 | N/A | 2024-06-21 |
| eluxadoline | 190162 | Viberzi | Allergan inc. | N/A | 2017-01-26 | 2023-01-26 | N/A | 2025-01-26 |
| emicizumab | 212635 | Hemlibra | Hoffmann-La Roche Limited | N/A | 2018-08-02 | 2024-08-02 | Yes | 2027-02-02 |
| empagliflozin | 162552 | Jardiance | Boehringer Ingelheim (Canada) Ltd. | Synjardy Glyxambi |
2015-07-23 | 2021-07-23 | N/A | 2023-07-23 |
| enasidenib mesylate | 217033 | Idhifa | Celgene Inc. | N/A | 2019-02-06 | 2025-02-06 | N/A | 2027-02-06 |
| encorafenib | 237413 | Braftovi | Pfizer Canada ULC | N/A | 2021-03-02 | 2027-03-02 | N/A | 2029-03-02 |
| entrectinib | 227517 | Rozlytrek | Hoffmann-La Roche Limited | N/A | 2020-02-10 | 2026-02-10 | Yes | 2028-08-10 |
| eptinezumab | 233288 | Vyepti | Lundbeck Canada Inc. | N/A | 2021-01-11 | 2027-01-11 | N/A | 2029-01-11 |
| erdafitinib | 224529 | Balversa | Janssen Inc. | N/A | 2019-10-25 | 2025-10-25 | N/A | 2027-10-25 |
| erenumab | 208607 | Aimovig | Novartis Pharmaceuticals Canada Inc. | N/A | 2018-08-01 | 2024-08-01 | N/A | 2026-08-01 |
| ertugliflozin | 204724 | Steglatro | Merck Canada Inc. | Steglujan Segluromet |
2018-05-09 | 2024-05-09 | N/A | 2026-05-09 |
| eslicarbazepine acetate | 165665 | Aptiom | Sunovion Pharmaceuticals Canada Inc. | N/A | 2014-07-08 | 2020-07-08 | Yes | 2023-01-08 |
| estetrol monohydrate | 236197 | Nextstellis | Searchlight Pharma Inc. | N/A | 2021-03-05 | 2027-03-05 | N/A | 2029-03-05 |
| evolocumab | 178234 | Repatha | Amgen Canada Inc. | N/A | 2015-09-10 | 2021-09-10 | Yes | 2024-03-10 |
| fedratinib (supplied as fedratinib hydrochloride) | 229866 | Inrebic | Celgene Inc. | N/A | 2020-07-27 | 2026-07-27 | N/A | 2028-07-27 |
| ferric pyrophosphate citrate | 239850 | Triferic Avnu | Rockwell Medical Inc. | N/A | 2021-04-22 | 2027-04-22 | Yes | 2029-10-22 |
| finafloxacin | 172450 | Xtoro | MerLion Pharmaceuticals GmbH | N/A | 2016-03-11 | 2022-03-11 | Yes | 2024-09-11 |
| flibanserin | 189352 | Addyi | Searchlight Pharma Inc. | N/A | 2018-02-27 | 2024-02-27 | N/A | 2026-02-27 |
| florbetaben (18F) | 193105 | Neuraceq | Isologic Innovative Radiopharmaceuticals Ltd. | N/A | 2017-02-22 | 2023-02-22 | N/A | 2025-02-22 |
| follitropin delta | 188743 | Rekovelle | Ferring Inc. | N/A | 2018-03-22 | 2024-03-22 | N/A | 2026-03-22 |
| fostamatinib (supplied as fostamatinib disodium) | 232078 | Tavalisse | Medison Pharma Canada Inc. | N/A | 2020-11-19 | 2026-11-19 | N/A | 2028-11-19 |
| fremanezumab | 226828 | Ajovy | Teva Canada Limited | N/A | 2020-04-09 | 2026-04-09 | N/A | 2028-04-09 |
| gadoterate meglumine | 186333 | Dotarem | Guerbet | N/A | 2016-11-26 | 2022-11-26 | Yes | 2025-05-26 |
| galcanezumab | 219521 | Emgality | Eli Lilly Canada Inc. | N/A | 2019-07-30 | 2025-07-30 | N/A | 2027-07-30 |
| galsulfase | 159020 | Naglazyme | BioMarin Pharmaceutical Inc. | N/A | 2013-09-16 | 2019-09-16 | Yes | 2022-03-16 |
| gemtuzumab ozogamicin | 223091 | Mylotarg | Pfizer Canada ULC | N/A | 2019-11-28 | 2025-11-28 | Yes | 2028-05-28 |
| gilteritinib fumarate | 227918 | Xospata | Astellas Pharma Canada Inc. | N/A | 2019-12-23 | 2025-12-23 | N/A | 2027-12-23 |
| givosiran (supplied as givosiran sodium) | 237194 | Givlaari | Alnylam Netherlands B.V.. | N/A | 2020-10-09 | 2026-10-09 | N/A | 2028-10-09 |
| glasdegib | 225793 | Daurismo | Pfizer Canada ULC | N/A | 2020-04-28 | 2026-04-28 | N/A | 2028-04-28 |
| glecaprevir, pibrentasvir | 202233 | Maviret | AbbVie Corporation | N/A | 2017-08-16 | 2023-08-16 | Yes | 2026-02-16 |
| glycerol phenylbutyrate | 174219 | Ravicti | Horizon Pharma Ireland Ltd. | N/A | 2016-03-18 | 2022-03-18 | Yes | 2024-09-18 |
| grazoprevir, elbasvir | 185866 | Zepatier | Merck Canada Inc. | N/A | 2016-01-19 | 2022-01-19 | N/A | 2024-01-19 |
| guanfacine hydrochloride | 150741 | Intuniv XR | Takeda Canada Inc. | N/A | 2013-07-05 | 2019-07-05 | Yes | 2022-01-05 |
| guselkumab | 200590 | Tremfya | Janssen Inc. | N/A | 2017-11-10 | 2023-11-10 | N/A | 2025-11-10 |
| haemagglutinin strain A (H5N1) | 115398 | Arepanrix H5N1 | ID Biomedical Corporation of Quebec | N/A | 2013-02-13 | 2019-02-13 | Yes | 2021-08-13 |
| hemin | 212276 | Panhematin | Recordati Rare Diseases Canada Inc. | N/A | 2018-07-13 | 2024-07-13 | N/A | 2026-07-13 |
| ibrutinib | 174029 | Imbruvica | Janssen Inc. | N/A | 2014-11-17 | 2020-11-17 | Yes | 2023-05-17 |
| icatibant acetate | 162918 | Firazyr | Takeda Canada Inc. | N/A | 2014-06-04 | 2020-06-04 | Yes | 2022-12-04 |
| icosapent ethyl | 227235 | Vascepa | HLS Therapeutics Inc. | N/A | 2019-12-30 | 2025-12-30 | N/A | 2027-12-30 |
| idarucizumab | 182503 | Praxbind | Boehringer Ingelheim (Canada) Ltd | N/A | 2016-04-29 | 2022-04-29 | N/A | 2024-04-29 |
| idecabtagene vicleucel | 244266 | Abecma | Celgene Inc. | N/A | 2021-05-26 | 2027-05-26 | N/A | 2029-05-26 |
| idelalisib | 172652 | Zydelig | Gilead Sciences Canada Inc. | N/A | 2015-03-27 | 2021-03-27 | N/A | 2023-03-27 |
| inotersen sodium | 214274 | Tegsedi | Akcea Therapeutics Inc. | N/A | 2018-10-03 | 2024-10-03 | N/A | 2026-10-03 |
| inotuzumab ozogamicin | 204077 | Besponsa | Pfizer Canada Inc. | N/A | 2018-03-15 | 2024-03-15 | N/A | 2026-03-15 |
| insulin degludec | 198124 | Tresiba | Novo Nordisk Canada Inc. | Xultophy | 2017-08-25 | 2023-08-25 | Yes | 2026-02-25 |
| ioflupane (123I) | 201481 | Datscan | GE Healthcare Canada Inc. | N/A | 2017-12-07 | 2023-12-07 | N/A | 2025-12-07 |
| iron isomaltoside 1000 | 193890 | Monoferric | Pharmacosmos A/S | N/A | 2018-06-22 | 2024-06-22 | N/A | 2026-06-22 |
| isatuximab | 229245 | Sarclisa | Sanofi-Aventis Canada Inc. | N/A | 2020-04-29 | 2026-04-29 | N/A | 2028-04-29 |
| isavuconazole (supplied as isavuconazonium sulfate) | 208919 | Cresemba | Avir Pharma Inc. | N/A | 2018-12-19 | 2024-12-19 | N/A | 2026-12-19 |
| ivabradine hydrochloride | 166949 | Lancora | Servier Canada Inc. | N/A | 2016-12-23 | 2022-12-23 | Yes | 2025-06-23 |
| ivermectin | 172733 | Rosiver | Galderma Canada Inc. | N/A | 2015-04-22 | 2021-04-22 | N/A | 2023-04-22 |
| ixazomib (supplied as ixazomib citrate) | 190498 | Ninlaro | Takeda Canada Inc. | N/A | 2016-08-04 | 2022-08-04 | N/A | 2024-08-04 |
| ixekizumab | 184993 | Taltz | Eli Lilly Canada Inc. | N/A | 2016-05-25 | 2022-05-25 | Yes | 2024-11-25 |
| lanadelumab | 213920 | Takhzyro | Takeda Canada Inc. | N/A | 2018-09-19 | 2024-09-19 | Yes | 2027-03-19 |
| larotrectinib (supplied as larotrectinib sulfate) | 219998 | Vitrakvi | Bayer Inc. | N/A | 2019-07-10 | 2025-07-10 | Yes | 2028-01-10 |
| latanoprostene bunod | 211732 | Vyzulta | Bausch & Lomb Incorporated | N/A | 2018-12-27 | 2024-12-27 | N/A | 2026-12-27 |
| ledipasvir | 173180 | Harvoni | Gilead Sciences Canada Inc. | N/A | 2014-10-15 | 2020-10-15 | Yes | 2023-04-15 |
| lefamulin acetate | 233292 | Xenleta | Sunovion Pharmaceuticals Canada Inc. | N/A | 2020-07-10 | 2026-07-10 | N/A | 2028-07-10 |
| lemborexant | 231286 | Dayvigo | Eisai Limited | N/A | 2020-11-04 | 2026-11-04 | N/A | 2028-11-04 |
| lenvatinib mesylate | 180877 | Lenvima | Eisai Limited | N/A | 2015-12-22 | 2021-12-22 | N/A | 2023-12-22 |
| letermovir | 204165 | Prevymis | Merck Canada Inc. | N/A | 2017-11-01 | 2023-11-01 | N/A | 2025-11-01 |
| levomilnacipran hydrochloride | 167319 | Fetzima | Allergan Inc. | N/A | 2015-05-08 | 2021-05-08 | N/A | 2023-05-08 |
| lifitegrast | 199810 | Xiidra | Novartis Pharmaceuticals Canada Inc. | N/A | 2017-12-22 | 2023-12-22 | N/A | 2025-12-22 |
| linaclotide | 161056 | Constella | Forest Laboratories Canada Inc. | N/A | 2013-12-02 | 2019-12-02 | N/A | 2021-12-02 |
| lixisenatide | 193862 | Adlyxine | Sanofi-aventis Canada Inc. | Soliqua | 2017-05-25 | 2023-05-25 | N/A | 2025-05-25 |
| lomitapide mesylate | 160385 | Juxtapid | Aegerion Pharmaceuticals Canada Ltd. | N/A | 2014-02-04 | 2020-02-04 | N/A | 2022-02-04 |
| lorlatinib | 215733 | Lorbrena | Pfizer Canada ULC | N/A | 2019-02-22 | 2025-02-22 | N/A | 2027-02-22 |
| lubiprostone | 179333 | Amitiza | Sucampo Pharma Americas LLC | N/A | 2015-10-14 | 2021-10-14 | N/A | 2023-10-14 |
| lumacaftor | 181715 | Orkambi | Vertex Pharmaceuticals (Canada) Incorporated | N/A | 2016-01-26 | 2022-01-26 | Yes | 2024-07-26 |
| luspatercept | 236441 | Reblozyl | Celgene Inc. | N/A | 2020-09-25 | 2026-09-25 | N/A | 2028-09-25 |
| lutetium177 Lu oxodotreotide | 217184 | Lutathera | Advanced Accelerator Applications USA, Inc. | N/A | 2019-01-09 | 2025-01-09 | N/A | 2027-01-09 |
| macitentan | 161372 | Opsumit | Janssen Inc. | N/A | 2013-11-06 | 2019-11-06 | Yes | 2022-05-06 |
| mecasermin | 235023 | Increlex | Ipsen Biopharmaceuticals Canada Inc. | N/A | 2020-12-17 | 2026-12-17 | Yes | 2029-06-17 |
| mepolizumab | 179850 | Nucala | GlaxoSmithKline Inc. | N/A | 2015-12-03 | 2021-12-03 | Yes | 2024-06-03 |
| midostaurin | 201101 | Rydapt | Novartis Pharmaceuticals Canada Inc. | N/A | 2017-07-21 | 2023-07-21 | Yes | 2026-01-21 |
| mifepristone | 160063 | Mifegymiso | Linepharma International Limited | N/A | 2015-07-29 | 2021-07-29 | Yes | 2024-01-29 |
| migalastat hydrochloride | 196956 | Galafold | Amicus Therapeutics UK LTD | N/A | 2017-09-05 | 2023-09-05 | N/A | 2025-09-05 |
| modified vaccinia virus (ankara-bavarian nordic) | 144762 | Imvamune | Bavarian Nordic A/S | N/A | 2013-11-21 | 2019-11-21 | N/A | 2021-11-21 |
| naloxegol oxalate | 167790 | Movantik | Knight Therapeutics Inc. | N/A | 2015-06-02 | 2021-06-02 | N/A | 2023-06-02 |
| necitumumab | 193689 | Portrazza | Eli Lilly Canada Inc. | N/A | 2017-03-16 | 2023-03-16 | N/A | 2025-03-16 |
| neisseria meningitidis serogroup A polysaccharide, neisseria meningitidis serogroup C polysaccharide, neisseria meningitidis serogroup W-135 polysaccharide, neisseria meningitidis serogroup Y polysaccharide, conjugated to tetanus toxoid carrier protein | 154290 | Nimenrix | Pfizer Canada Inc. | N/A | 2013-03-05 | 2019-03-05 | Yes | 2021-09-05 |
| neisseria meningitidis serogroup B recombinant lipoprotein 2086 (rLP2086) subfamily A and Neisseria meningitidis serogroup B recombinant lipoprotein 2086 (rLP2086) subfamily B | 195550 | Trumenba | Pfizer Canada Inc. | N/A | 2017-10-05 | 2023-10-05 | Yes | 2026-04-05 |
| neratinib maleate | 218224 | Nerlynx | Knight Therapeutics Inc. | N/A | 2019-07-16 | 2025-07-16 | N/A | 2027-07-16 |
| netupitant | 196495 | Akynzeo | Elvium Life Sciences | N/A | 2017-09-28 | 2023-09-28 | N/A | 2025-09-28 |
| nintedanib (supplied as nintedanib esilate) | 176043 | Ofev | Boehringer Ingelheim (Canada) Ltd | N/A | 2015-06-25 | 2021-06-25 | N/A | 2023-06-25 |
| niraparib | 216792 | Zejula | GlaxoSmithKline Inc. | N/A | 2019-06-27 | 2025-06-27 | N/A | 2027-06-27 |
| nivolumab | 180828 | Opdivo | Bristol-Myers-Squibb Canada | N/A | 2015-09-25 | 2021-09-25 | Yes | 2024-03-25 |
| nusinersen | 200070 | Spinraza | Biogen Canada Inc. | N/A | 2017-06-29 | 2023-06-29 | Yes | 2025-12-29 |
| obeticholic acid | 198418 | Ocaliva | Intercept Pharmaceuticals Inc. | N/A | 2017-05-24 | 2023-05-24 | N/A | 2025-05-24 |
| obiltoxaximab | 230825 | Anthim | Elusys Therapeutics, Inc. | N/A | 2020-07-30 | 2026-07-30 | N/A | 2028-07-30 |
| obinutuzumab | 168227 | Gazyva | Hoffmann-La Roche Limited | N/A | 2014-11-25 | 2020-11-25 | N/A | 2022-11-25 |
| ocrelizumab | 198094 | Ocrevus | Hoffmann-La Roche Limited | N/A | 2017-08-14 | 2023-08-14 | N/A | 2025-08-14 |
| ocriplasmin | 161356 | Jetrea | ThromboGenics N.V. | N/A | 2013-08-13 | 2019-08-13 | N/A | 2021-08-13 |
| olaparib | 182823 | Lynparza | AstraZeneca Canada Inc. | N/A | 2016-04-29 | 2022-04-29 | N/A | 2024-04-29 |
| olaratumab | 203478 | Lartruvo | Eli Lilly Canada Inc. | N/A | 2017-11-23 | 2023-11-23 | N/A | 2025-11-23 |
| ombitasvir, paritaprevir, dasabuvir sodium | 174739 | Holkira Pak | Abbvie Corporation | Technivie | 2014-12-22 | 2020-12-22 | N/A | 2022-12-22 |
| onasemnogene abeparvovec | 239719 | Zolgensma | Novartis Pharmaceuticals Canada Inc. | N/A | 2020-12-15 | 2026-12-15 | Yes | 2029-06-15 |
| osimertinib mesylate | 188171 | Tagrisso | AstraZeneca Canada Inc. | N/A | 2016-07-05 | 2022-07-05 | N/A | 2024-07-05 |
| ospemifene | 222001 | Osphena | Duchesnay Inc. | N/A | 2021-07-16 | 2027-07-16 | N/A | 2029-07-16 |
| ozanimod (supplied as ozanimod hydrochloride) | 232761 | Zeposia | Celgene Inc. | N/A | 2020-10-02 | 2026-10-02 | N/A | 2028-10-02 |
| ozenoxacin | 192925 | Ozanex | Ferrer Internacional, S.A. | N/A | 2017-05-01 | 2023-05-01 | Yes | 2025-11-01 |
| palbociclib | 182048 | Ibrance | Pfizer Canada Inc. | N/A | 2016-03-16 | 2022-03-16 | Yes | 2024-09-16 |
| pasireotide diaspartate | 145005 | Signifor | Novartis Pharmaceuticals Canada Inc. | Signifor Lar | 2013-09-23 | 2019-09-23 | N/A | 2021-09-23 |
| patiromer sorbitex calcium | 210368 | Veltassa | Vifor Fresenius Medical Care Renal Pharma Ltd. | N/A | 2018-10-03 | 2024-10-03 | N/A | 2026-10-03 |
| patisiran (as patisiran sodium) | 221896 | Onpattro | Alnylam Netherlands B.V. | N/A | 2019-06-07 | 2025-06-07 | N/A | 2027-06-07 |
| peginterferon beta-1a | 166974 | Plegridy | Biogen Idec Canada Inc. | N/A | 2015-08-10 | 2021-08-10 | N/A | 2023-08-10 |
| pembrolizumab | 175884 | Keytruda | Merck Canada Inc. | N/A | 2015-05-19 | 2021-05-19 | Yes | 2023-11-19 |
| peramivir | 191280 | Rapivab | BioCryst Pharmaceuticals Inc. | N/A | 2017-01-05 | 2023-01-05 | N/A | 2025-01-05 |
| perampanel | 153747 | Fycompa | Eisai Limited | N/A | 2013-04-04 | 2019-04-04 | Yes | 2021-10-04 |
| pitolisant hydrochloride | 238175 | Wakik | Endo Ventures Ltd. | N/A | 2021-05-25 | 2027-05-25 | N/A | 2029-05-25 |
| plecanatide | 215288 | Trulance | Bausch Health, Canada Inc. | N/A | 2019-10-10 | 2025-10-10 | N/A | 2027-10-10 |
| polatuzumab vedotin | 232303 | Polivy | Hoffmann-La Roche Limited | N/A | 2020-07-09 | 2026-07-09 | N/A | 2028-07-09 |
| polidocanol | 177359 | Varithena | Provensis Ltd. | N/A | 2015-08-04 | 2021-08-04 | N/A | 2023-08-04 |
| pomalidomide | 165891 | Pomalyst | Celgene Inc. | N/A | 2014-01-20 | 2020-01-20 | Yes | 2022-07-20 |
| pralatrexate | 207545 | Folotyn | Servier Canada Inc. | N/A | 2018-10-26 | 2024-10-26 | N/A | 2026-10-26 |
| pralsetinib | 243731 | Gavreto | Hoffmann-La Roche Limited | N/A | 2021-06-30 | 2027-06-30 | N/A | 2029-06-30 |
| prasterone | 198822 | Intrarosa | Endoceutics Inc. | N/A | 2019-11-01 | 2025-11-01 | N/A | 2027-11-01 |
| ponatinib hydrochloride | 165121 | Iclusig | Ariad Pharmaceuticals Inc. | N/A | 2015-04-02 | 2021-04-02 | N/A | 2023-04-02 |
| ponesimod | 239537 | Ponvory | Janssen Inc. | N/A | 2021-04-28 | 2027-04-28 | N/A | 2029-04-28 |
| propiverine hydrochloride | 188323 | Mictoryl / Mictoryl Pediatric | Duchesnay Inc. | N/A | 2017-01-05 | 2023-01-05 | Yes | 2025-07-05 |
| radium - 223 dichloride | 161312 | Xofigo | Bayer Inc. | N/A | 2013-12-12 | 2019-12-12 | N/A | 2021-12-12 |
| ramucirumab | 176810 | Cyramza | Eli Lilly Canada Inc. | N/A | 2015-07-16 | 2021-07-16 | N/A | 2023-07-16 |
| ravulizumab | 217955 | Ultomiris | Alexion Pharma GmbH | N/A | 2019-08-28 | 2025-08-28 | N/A | 2027-08-28 |
| recombinant haemagglutinin protein-strain A (H1N1) recombinant haemagglutinin protein-strain A (H3N2) recombinant haemagglutinin protein-strain B (Victoria) recombinant haemagglutinin protein-strain B (Yamagata) |
235672 | Supemtek | Sanofi Pasteur Limited | N/A | 2021-01-14 | 2027-01-14 | N/A | 2029-01-14 |
| recombinant human papillomavirus types 31, 33, 45, 52 and 58 | 170006 | Gardasil 9 | Merck Canada Inc. | N/A | 2015-02-05 | 2021-02-05 | Yes | 2023-08-05 |
| recombinant neisseria meningitidis group B NHBA fusion protein, recombinant neisseria meningitidis group B NadA protein, recombinant neisseria meningitidis group B FHBP fusion protein, outer membrane vesicle (neisseria meningitidis group B NZ98/254 strain) | 147275 | Bexsero | GlaxoSmithKline Inc. | N/A | 2013-12-06 | 2019-12-06 | Yes | 2022-06-06 |
| recombinant porcine factor VIII (antihemophilic factor (recombinant), porcine sequence) | 177290 | Obizur | Takeda Canada Inc. | N/A | 2015-10-14 | 2021-10-14 | N/A | 2023-10-14 |
| regorafenib monohydrate | 157970 | Stivarga | Bayer Inc. | N/A | 2013-03-11 | 2019-03-11 | Yes | 2021-09-11 |
| remdesivir | 240551 | Veklury | Gilead Sciences Canada, Inc. | N/A | 2020-07-27 | 2026-07-27 | N/A | 2028-07-27 |
| reslizumab | 185873 | Cinqair | Teva Canada Limited | N/A | 2016-07-20 | 2022-07-20 | Yes | 2025-01-20 |
| ribociclib (supplied as ribociclib succinate) | 203884 | Kisqali | Novartis Pharmaceuticals Canada Inc. | N/A | 2018-03-02 | 2024-03-02 | N/A | 2026-03-02 |
| rifaximin | 161256 | Zaxine | Salix Pharmaceuticals Inc. | N/A | 2013-08-13 | 2019-08-13 | N/A | 2021-08-13 |
| riociguat | 162761 | Adempas | Bayer Inc. | N/A | 2013-09-19 | 2019-09-19 | N/A | 2021-09-19 |
| ripretinib | 234688 | Qinlock | Deciphera Pharmaceuticals, LLC | N/A | 2020-06-19 | 2026-06-19 | N/A | 2028-06-19 |
| risankizumab | 215753 | Skyrizi | AbbVie Corporation | N/A | 2019-04-17 | 2025-04-17 | N/A | 2027-04-17 |
| risdiplam | 242373 | Evrysdi | Hoffman-La Roche Limited | N/A | 2021-04-14 | 2027-04-14 | Yes | 2029-10-14 |
| romidepsin | 152293 | Istodax | Celgene Inc. | N/A | 2013-10-16 | 2019-10-16 | N/A | 2021-10-16 |
| romosozumab | 197713 | Evenity | Amgen Canada Inc. | N/A | 2019-06-17 | 2025-06-17 | N/A | 2027-06-17 |
| rupatadine (supplied as rupatadine fumarate) | 186488 | Rupall | Medexus Pharmaceuticals Inc. | N/A | 2016-07-20 | 2022-07-20 | Yes | 2025-01-20 |
| sacubitril | 182734 | Entresto | Novartis Pharmaceuticals Canada Inc. | N/A | 2015-10-02 | 2021-10-02 | Yes | 2024-04-02 |
| safinamide (as safinamide mesylate) | 207115 | Onstryv | Valeo Pharma Inc. | N/A | 2019-01-10 | 2025-01-10 | N/A | 2027-01-10 |
| sarilumab | 191745 | Kevzara | Sanofi-aventis Canada Inc. | N/A | 2017-01-12 | 2023-01-12 | N/A | 2025-01-12 |
| satralizumab | 233642 | Enspryng | Hoffmann-La Roche Limited | N/A | 2020-06-01 | 2026-06-01 | Yes | 2028-12-01 |
| sebelipase alfa | 204085 | Kanuma | Alexion Pharma GmbH | N/A | 2017-12-15 | 2023-12-15 | Yes | 2026-06-15 |
| secukinumab | 170732 | Cosentyx | Novartis Pharmaceuticals Canada Inc. | N/A | 2015-02-27 | 2021-02-27 | Yes | 2023-08-27 |
| selexipag | 182114 | Uptravi | Janssen Inc. | N/A | 2016-01-20 | 2022-01-20 | N/A | 2024-01-20 |
| selpercatinib | 243748 | Retevmo | Loxo Oncology Inc. | N/A | 2021-06-15 | 2027-06-15 | Yes | 2029-12-15 |
| semaglutide | 202059 | Ozempic | Novo Nordisk Canada Inc. | Rybelsus | 2018-01-04 | 2024-01-04 | N/A | 2026-01-04 |
| siltuximab | 174291 | Sylvant | EUSA Pharma (UK) Limited | N/A | 2014-12-03 | 2020-12-03 | N/A | 2022-12-03 |
| simeprevir | 164021 | Galexos | Janssen Inc. | N/A | 2013-11-18 | 2019-11-18 | N/A | 2021-11-18 |
| siponimod | 223225 | Mayzent | Novartis Pharmaceuticals Canada Inc. | N/A | 2020-02-20 | 2026-02-20 | N/A | 2028-02-20 |
| sodium zirconium cyclosilicate | 218799 | Lokelma | AstraZeneca Canada Inc. | N/A | 2019-07-25 | 2025-07-25 | N/A | 2027-07-25 |
| sofosbuvir | 165043 | Sovaldi | Gilead Sciences Canada Inc. | Harvoni Epclusa Vosevi |
2013-12-13 | 2019-12-13 | N/A | 2021-12-13 |
| solriamfetol hydrochloride | 237511 | Sunosi | Jazz Pharmaceuticals Ireland Ltd. | N/A | 2021-05-13 | 2027-05-13 | N/A | 2029-11-13 |
| sonidegib phosphate | 229407 | Odomzo | Sun Pharma Global FZE | N/A | 2020-06-12 | 2026-06-12 | N/A | 2028-06-12 |
| sucroferric oxyhydroxide | 201492 | Velphoro | Vifor Fresenius Medical Care Renal Pharma Ltd. | N/A | 2018-01-05 | 2024-01-05 | N/A | 2026-01-05 |
| sugammadex sodium | 180385 | Bridion | Merck Canada Inc. | N/A | 2016-02-05 | 2022-02-05 | N/A | 2024-02-05 |
| suvorexant | 196367 | Belsomra | Merck Canada Inc. | N/A | 2018-11-29 | 2024-11-29 | N/A | 2026-11-29 |
| tafamidis meglumine | 228368 | Vyndaqel | Pfizer Canada ULC | Vyndamax | 2020-01-20 | 2026-01-20 | N/A | 2028-01-20 |
| tafluprost | 165596 | Saflutan | Purdue Pharma | N/A | 2014-05-26 | 2020-05-26 | N/A | 2022-05-26 |
| talazoparib (supplied as talazoparib tosylate) | 220584 | Talzenna | Pfizer Canada ULC | N/A | 2019-09-06 | 2025-09-06 | N/A | 2027-09-06 |
| taliglucerase alfa | 140854 | Elelyso | Pfizer Canada Inc. | N/A | 2014-05-29 | 2020-05-29 | Yes | 2022-11-29 |
| tedizolid phosphate | 173603 | Sivextro | Merck Canada Inc. | N/A | 2015-03-17 | 2021-03-17 | N/A | 2023-03-17 |
| teduglutide | 180223 | Revestive | Takeda Canada Inc. | N/A | 2015-09-04 | 2021-09-04 | Yes | 2024-03-04 |
| telotristat ethyl (as telotristat etiprate) | 208730 | Xermelo | Ipsen Biopharmaceuticals Canada Inc. | N/A | 2018-10-10 | 2024-10-10 | N/A | 2026-10-10 |
| tenapanor hydrochloride | 224850 | Ibsrela | Knight Therapeutics Inc. | N/A | 2020-04-15 | 2026-04-15 | N/A | 2028-04-15 |
| tenofovir alafenamide hemifumarate | 181399 | Genvoya | Gilead Sciences Canada Inc. | Descovy Odefsey Vemlidy Symtuza Biktarvy |
2015-11-27 | 2021-11-27 | Yes | 2024-05-27 |
| tepotinib (supplied as tepotinib hydrochloride) | 242300 | Tepmetko | EMD Serono, a Division of EMD Inc., Canada | N/A | 2021-05-27 | 2027-05-27 | N/A | 2029-05-27 |
| teriflunomide | 160646 | Aubagio | Genzyme Canada a division of Sanofi-aventis Canada Inc. | N/A | 2013-11-14 | 2019-11-14 | Yes | 2022-05-14 |
| tesamorelin | 131836 | Egrifta | Theratechnologies Inc. | N/A | 2014-04-29 | 2020-04-29 | N/A | 2022-04-29 |
| tezacaftor | 211292 | Symdeko | Vertex Pharmaceuticals (Canada) Incorporated | N/A | 2018-06-27 | 2024-06-27 | Yes | 2026-12-27 |
| tildrakizumab | 224036 | Ilumya | Sun Pharma Global FZE | N/A | 2021-05-19 | 2027-05-19 | N/A | 2029-05-19 |
| tisagenlecleucel | 213547 / 213698 | Kymriah | Novartis Pharmaceuticals Canada Inc. | N/A | 2018-09-05 | 2024-09-05 | Yes | 2027-03-05 |
| tofacitinib | 154642 | Xeljanz | Pfizer Canada Inc. | N/A | 2014-04-17 | 2020-04-17 | Yes | 2022-10-17 |
| trastuzumab deruxtecan | 242104 | Enhertu | AstraZeneca Canada Inc. | N/A | 2021-04-15 | 2027-04-15 | N/A | 2029-04-15 |
| trastuzumab emtansine | 162414 | Kadcyla | Hoffmann-La Roche Limited | N/A | 2013-09-11 | 2019-09-11 | N/A | 2021-09-11 |
| trifarotene | 221945 | Aklief | Galderma Canada Inc. | N/A | 2019-11-25 | 2025-11-25 | Yes | 2028-05-25 |
| tipiracil hydrochloride | 205852 | Lonsurf | Taiho Pharma Canada Inc. | N/A | 2018-01-25 | 2024-01-25 | N/A | 2026-01-25 |
| triheptanoin | 242196 | Dojolvi | Ultragenyx Pharmaceutical Inc. | N/A | 2021-02-15 | 2027-02-15 | Yes | 2029-08-15 |
| tucatinib | 235295 | Tukysa | Seagen Inc. | N/A | 2020-06-05 | 2026-06-05 | N/A | 2028-06-05 |
| turoctocog alfa | 170796 | Zonovate | Novo Nordisk Canada Inc. | N/A | 2014-12-08 | 2020-12-08 | Yes | 2023-06-08 |
| umeclidinium bromide | 161585 | Anoro Ellipta | GlaxoSmithKline Inc. | Incruse Ellipta | 2013-12-23 | 2019-12-23 | N/A | 2021-12-23 |
| upadacitinib | 223734 | Rinvoq | AbbVie Corporation | N/A | 2019-12-23 | 2025-12-23 | N/A | 2027-12-23 |
| varicella-zoster virus glycoprotein E (gE) | 200244 | Shingrix | GlaxoSmithKline Inc. | N/A | 2017-10-13 | 2023-10-13 | N/A | 2025-10-13 |
| vedolizumab | 169414 | Entyvio | Takeda Canada Inc. | N/A | 2015-01-29 | 2021-01-29 | Yes | 2023-07-29 |
| velpatasvir | 190521 | Epclusa | Gilead Sciences Canada Inc. | Vosevi | 2016-07-11 | 2022-07-11 | Yes | 2025-01-11 |
| venetoclax | 190761 | Venclexta | AbbVie Corporation | N/A | 2016-09-30 | 2022-09-30 | N/A | 2024-09-30 |
| vernakalant hydrochloride | 190817 | Brinavess | Cipher Pharmaceuticals Inc. | N/A | 2017-03-13 | 2023-03-13 | N/A | 2025-03-13 |
| vilanterol trifenatate | 157301 | Breo Ellipta | GlaxoSmithKline Inc. | Anoro Ellipta Trelegy Ellipta |
2013-07-03 | 2019-07-03 | Yes | 2022-01-03 |
| vilazodone hydrochloride | 176820 | Viibryd | Allergan Inc. | N/A | 2015-07-16 | 2021-07-16 | Yes | 2024-01-16 |
| von willebrand factor (recombinant) (vonicog alfa) | 213188 | Vonvendi | Takeda Canada Inc. | N/A | 2019-01-10 | 2025-01-10 | N/A | 2027-01-10 |
| vorapaxar sulfate | 179320 | Zontivity | Toprol Acquisition LLC | N/A | 2016-05-13 | 2022-05-13 | N/A | 2024-05-13 |
| voretigene neparvovec | 233097 | Luxturna | Novartis Pharmaceuticals Canada Inc. | N/A | 2020-10-13 | 2026-10-13 | Yes | 2029-04-13 |
| vortioxetine hydrobromide | 159019 | Trintellix | Lundbeck Canada Inc. | N/A | 2014-10-22 | 2020-10-22 | Yes | 2023-04-22 |
| voxilaprevir | 202324 | Vosevi | Gilead Sciences Canada Inc. | N/A | 2017-08-16 | 2023-08-16 | N/A | 2025-08-16 |
| zanubrutinib | 242748 | Brukinsa | BeiGene Switzerland GmbH | N/A | 2021-03-01 | 2027-03-01 | N/A | 2029-03-01 |
| Medicinal Ingredient(s) Footnote 1 |
Submission Number | Innovative Drug | Manufacturer | Drug(s) Containing the Medicinal Ingredient / Variations |
Notice of Compliance Date yyyy-mm-dd | 6 Year "No File" Date |
Pediatric Extension Yes/No | Data Protection Ends |
|---|---|---|---|---|---|---|---|---|
| pertuzumab | 158419 | Perjeta | Hoffmann-La Roche Limited | Perjeta-Herceptin Combo Pack Phesgo | 2013-04-12 | 2019-04-12 | N/A | 2021-04-12 |
| rotigotine | 145523 | Neupro | UCB Canada Inc. | N/A | 2013-03-21 | 2019-03-21 | N/A | 2021-03-21 |
| abatacept | 098531 | Orencia | Bristol-Myers Squibb Canada | N/A | 2006-06-29 | 2012-06-29 | Yes | 2014-12-29 |
| abiraterone acetate | 138343 | Zytiga | Janssen Inc. | N/A | 2011-07-27 | 2017-07-27 | N/A | 2019-07-27 |
| acamprosate calcium | 103287 | Campral | Mylan Pharmaceuticals ULC | N/A | 2007-03-16 | 2013-03-16 | N/A | 2015-03-16 |
| aclidinium bromide | 157598 | Tudorza Genuair | AstraZeneca Canada Inc. | Duaklir Genuair | 2013-07-29 | 2019-07-29 | N/A | 2021-07-29 |
| alglucosidase alfa | 103381 | Myozyme | Genzyme Canada Inc. | N/A | 2006-08-14 | 2012-08-14 | Yes | 2015-02-14 |
| aliskiren hemifumarate | 105388 | Rasilez | Novartis Pharmaceuticals Canada Inc. |
|
2007-11-14 | 2013-11-14 | N/A | 2015-11-14 |
| ambrisentan | 113287 | Volibris | GlaxoSmithKline Inc. | N/A | 2008-03-20 | 2014-03-20 | N/A | 2016-03-20 |
| anidulafungin | 110202 | Eraxis | Pfizer Canada Inc. | N/A | 2007-11-14 | 2013-11-14 | Yes | 2016-05-14 |
| apixaban | 141873 | Eliquis | Bristol-Myers Squibb Canada | N/A | 2011-12-16 | 2017-12-16 | Yes | 2020-06-16 |
| aprepitant | 108483 | Emend | Merck Frosst Canada Ltd. |
|
2007-08-24 | 2013-08-24 | N/A | 2015-08-24 |
| aripiprazole | 120192 | Abilify | Bristol-Myers Squibb Canada | Abilify Maintena | 2009-07-09 | 2015-07-09 | Yes | 2018-01-09 |
| asenapine maleate | 127427 | Saphris | Merck Canada Inc. | N/A | 2011-10-07 | 2017-10-07 | Yes | 2020-04-07 |
| axitinib | 144404 | Inlyta | Pfizer Canada Inc. | N/A | 2012-07-12 | 2018-07-12 | Yes | 2021-01-12 |
| azacitidine | 127108 | Vidaza | Celgene | N/A | 2009-10-23 | 2015-10-23 | N/A | 2017-10-23 |
| azilsartan medoxomil potassium | 145305 | Edarbi | Valeant Canada LP | Edarbyclor | 2012-03-08 | 2018-03-08 | N/A | 2020-03-08 |
| belimumab | 137699 | Benlysta | GlaxoSmithKline Inc. | N/A | 2011-07-06 | 2011-07-06 | N/A | 2019-07-06 |
| bendamustine hydrochloride | 149814 | Treanda | Teva Canada Limited | N/A | 2012-08-24 | 2018-08-24 | Yes | 2021-02-24 |
| besifloxacin | 123400 | Besivance | Bausch & Lomb Inc. | N/A | 2009-10-23 | 2015-10-23 | Yes | 2018-04-23 |
| boceprevir | 141556 | Victrelis | Merck Canada Inc. | Victrelis Triple | 2011-07-29 | 2017-07-29 | N/A | 2019-07-29 |
| brentuximab vedotin | 154851 | Adcetris | Seattle Genetics Inc. | N/A | 2013-02-01 | 2019-02-01 | N/A | 2021-02-01 |
| cabazitaxel | 137421 | Jevtana | Sanofi-aventis Canada Inc. | N/A | 2011-06-16 | 2017-06-16 | Yes | 2019-12-16 |
| canakinumab | 131009 | Ilaris | Novartis Pharmaceuticals Canada Inc. | N/A | 2010-02-26 | 2016-02-26 | Yes | 2018-08-26 |
| catridecacog | 152228 | Tretten | Novo Nordisk Canada Inc. | N/A | 2012-07-19 | 2018-07-19 | Yes | 2021-01-19 |
| catumaxomab | 142629 | Removab | Fresenius Biotech GmbH | N/A | 2012-05-11 | 2018-05-11 | N/A | 2020-05-11 |
| ceftobiprole medocaril | 112752 | Zeftera | Janssen Inc. | N/A | 2008-06-26 | 2014-06-26 | N/A | 2016-06-26 |
| certolizumab pegol | 120296 | Cimzia | UCB Canada Inc. | N/A | 2009-08-12 | 2015-08-12 | N/A | 2017-08-12 |
| ciclesonide | 101419 | Alvesco | Takeda Canada Inc. |
|
2006-09-11 | 2012-09-11 | Yes | 2015-03-11 |
| clevidipine | 125287 | Cleviprex | Chiesi Farmaceutici S.p.A. | N/A | 2011-04-15 | 2017-04-15 | N/A | 2019-04-15 |
| clofarabine | 121874 | Clolar | Sanofi-aventis Canada Inc. | N/A | 2009-07-16 | 2015-07-16 | Yes | 2018-01-16 |
| colesevelam hydrochloride | 133463 | Lodalis | Valeant Canada LP / Valeant Canada S.E.C. | N/A | 2011-09-22 | 2017-09-22 | N/A | 2019-09-22 |
| collagenase clostridium histolyticum | 147788 | Xiaflex | Endo Ventures Ltd. | N/A | 2012-07-05 | 2018-07-05 | N/A | 2020-07-05 |
| crizotinib | 145155 | Xalkori | Pfizer Canada Inc. | N/A | 2012-04-25 | 2018-04-25 | Yes | 2020-10-25 |
| dabigatran etexilate mesilate | 114887 | Pradaxa | Boehringer Ingelheim (Canada) Ltd. | N/A | 2008-06-10 | 2014-06-10 | N/A | 2016-06-10 |
| dabrafenib mesylate | 157590 | Tafinlar | Novartis Pharmaceuticals Canada Inc. | N/A | 2013-07-16 | 2019-07-16 | N/A | 2021-07-16 |
| daptomycin | 102320 | Cubicin | Cubist Pharmaceuticals, Incorporated | N/A | 2007-09-24 | 2013-09-24 | Yes | 2016-03-24 |
| darunavir ethanolate | 103324 | Prezista | Janssen Inc. | N/A | 2006-07-28 | 2012-07-28 | Yes | 2015-01-28 |
| dasatinib monohydrate | 104993 | Sprycel | Bristol-Myers Squibb Canada | N/A | 2007-03-26 | 2013-03-26 | N/A | 2015-03-26 |
| deferasirox | 099621 | Exjade | Novartis Pharmaceuticals Canada Inc. | N/A | 2006-10-18 | 2012-10-18 | Yes | 2015-04-18 |
| degarelix acetate | 120421 | Firmagon | Ferring Inc. | N/A | 2009-11-16 | 2015-11-16 | N/A | 2017-11-16 |
| denosumab | 121139 | Prolia | Amgen Canada Inc. | Xgeva | 2010-08-06 | 2016-08-06 | N/A | 2018-08-06 |
| desvenlafaxine succinate | 115439 | Pristiq | Pfizer Canada Inc. | N/A | 2009-02-04 | 2015-02-04 | Yes | 2017-08-04 |
| dexmedetomidine hydrochloride | 126931 | Precedex | Pfizer Canada Inc. | N/A | 2009-12-09 | 2015-12-09 | Yes | 2018-06-09 |
| dienogest | 132174 | Visanne | Bayer Inc. | Natazia | 2011-10-12 | 2017-10-12 | Yes | 2020-04-12 |
| doripenem monohydrate | 113640 | Doribax | Janssen Inc. | N/A | 2009-09-02 | 2015-09-02 | N/A | 2017-09-02 |
| dronedarone hydrochloride | 121065 | Multaq | Sanofi-aventis Canada Inc. | N/A | 2009-08-11 | 2015-08-11 | N/A | 2017-08-11 |
| duloxetine hydrochloride | 110028 | Cymbalta | Eli Lilly Canada Inc. | N/A | 2007-11-01 | 2013-11-01 | Yes | 2016-05-01 |
| eculizumab | 122467 | Soliris | Alexion Pharma International Sàrl | N/A | 2009-01-28 | 2015-01-28 | Yes | 2017-07-28 |
| eltrombopag olamine | 123984 | Revolade | Novartis Pharmaceuticals Canada Inc. | N/A | 2011-01-12 | 2011-01-12 | Yes | 2019-07-12 |
| elvitegravir, cobicistat | 152198 | Stribild | Gilead Sciences Canada Inc. | Tybost Vitekta Prezcobix Evotaz Genvoya Symtuza |
2012-11-26 | 2018-11-26 | N/A | 2020-11-26 |
| enzalutamide | 159678 | Xtandi | Astellas Pharma Canada Inc. | N/A | 2013-05-29 | 2019-05-29 | N/A | 2021-05-29 |
| eplerenone | 120440 | Inspra | Pfizer Canada Inc. | N/A | 2009-02-26 | 2015-02-26 | Yes | 2017-08-26 |
| eribulin mesylate | 141946 | Halaven | Eisai Limited | N/A | 2011-12-14 | 2017-12-14 | N/A | 2019-12-14 |
| etravirine | 113100 | Intelence | Janssen Inc. | N/A | 2008-03-27 | 2014-03-27 | Yes | 2016-09-27 |
| everolimus | 125809 | Afinitor | Novartis Pharmaceuticals Canada Inc. | Certican | 2009-12-14 | 2015-12-14 | Yes | 2018-06-14 |
| exenatide | 128932 | Byetta | AstraZeneca Canada Inc. | Bydureon | 2011-01-13 | 2017-01-13 | N/A | 2019-01-13 |
| ezogabine | 134659 | Potiga | GlaxoSmithKline Inc. | N/A | 2012-10-18 | 2018-10-18 | N/A | 2020-10-18 |
| fampridine | 132859 | Fampyra | Biogen Idec Canada Inc. | N/A | 2012-02-10 | 2018-02-10 | N/A | 2020-02-10 |
| febuxostat | 129969 | Uloric | Takeda Canada Inc. | N/A | 2010-09-22 | 2016-09-22 | N/A | 2018-09-22 |
| ferumoxytol | 133250 | Feraheme | AMAG Pharmaceuticals Inc. | N/A | 2011-12-08 | 2017-12-08 | N/A | 2019-12-08 |
| fesoterodine fumarate | 142326 | Toviaz | Pfizer Canada Inc. | N/A | 2012-02-09 | 2018-02-09 | Yes | 2020-08-09 |
| fidaxomicin | 151086 | Dificid | Merck Canada Inc. | N/A | 2012-06-07 | 2018-06-07 | N/A | 2020-06-07 |
| fingolimod hydrochloride | 137516 | Gilenya | Novartis Pharmaceuticals Canada Inc. | N/A | 2011-03-09 | 2017-03-09 | N/A | 2019-03-09 |
| fludeoxyglucose 18F | 091404 | Cantrace | Ipet Pharmaceuticals Inc. | N/A | 2006-07-27 | 2012-07-27 | N/A | 2014-07-27 |
| fluticasone furoate | 107372 | Avamys | GlaxoSmithKline Inc. | N/A | 2007-08-14 | 2013-08-14 | Yes | 2016-02-14 |
| gadofosveset trisodium | 096420 | Vasovist | Berlex Canada Inc. | N/A | 2006-10-31 | 2012-10-31 | N/A | 2014-10-31 |
| gadoxetate disodium | 127609 | Primovist | Bayer Inc. | N/A | 2010-01-14 | 2016-01-14 | N/A | 2018-01-14 |
| golimumab | 120525 | Simponi | Janssen Inc. | N/A | 2009-04-07 | 2015-04-07 | N/A | 2017-04-07 |
| idebenone | 117672 | Catena | Santhera Pharmaceuticals Ltd. | N/A | 2008-07-23 | 2014-07-23 | Yes | 2017-01-23 |
| idursulfase | 109857 | Elaprase | Shire Human Genetic Therapies, Inc. | N/A | 2007-06-13 | 2013-06-13 | Yes | 2015-12-13 |
| indacaterol maleate | 143984 | Onbrez Breezhaler | Novartis Pharmaceuticals Canada Inc. | Ultibro Breezhaler | 2011-12-06 | 2017-12-06 | N/A | 2019-12-06 |
| influenza virus type A (H1N1), influenza virus type A (H3N2), influenza virus type B | 129379 | FluMist | AstraZeneca Canada Incorporated | FluMist Quadrivalent | 2010-06-22 | 2016-06-22 | Yes | 2018-12-22 |
| ingenol mebutate | 153285 | Picato | Leo Pharma Inc. | N/A | 2013-01-30 | 2019-01-30 | N/A | 2021-01-30 |
| ipilimumab | 138178 | Yervoy | Bristol-Myers Squibb Canada | N/A | 2012-02-01 | 2018-02-01 | Yes | 2020-08-01 |
| ivacaftor | 155318 | Kalydeco | Vertex Pharmaceuticals (Canada) Inc. | OrkambiSymdeko | 2012-11-26 | 2018-11-26 | Yes | 2021-05-26 |
| lacosamide | 116632 | Vimpat | UCB Canada Inc. | N/A | 2010-09-30 | 2016-09-30 | N/A | 2018-09-30 |
| lanreotide | 098949 | Somatuline Autogel | Ipsen Biopharm Limited | N/A | 2006-07-17 | 2012-07-17 | N/A | 2014-07-17 |
| human C1 esterase inhibitor | 121221 | Berinert | CSL Behring Canada Inc. | Haegarda | 2010-05-31 | 2016-05-31 | N/A | 2018-05-31 |
| lanthanum carbonate | 102240 | Fosrenol | Shire BioChem Inc. | N/A | 2006-10-17 | 2012-10-17 | N/A | 2014-10-17 |
| lapatinib ditosylate | 110294 | Tykerb | Novartis Pharmaceuticals Canada Inc. | N/A | 2009-05-15 | 2015-05-15 | N/A | 2017-05-15 |
| lenalidomide | 111952 | Revlimid | Celgene | N/A | 2008-01-17 | 2014-01-17 | N/A | 2016-01-17 |
| linagliptin | 140881 | Trajenta | Boehringer Ingelheim (Canada) Ltd. | Jentadueto Glyxambi | 2011-07-28 | 2017-07-28 | N/A | 2019-07-28 |
| liraglutide | 119928 | Victoza | Novo Nordisk Canada Inc. |
|
2010-05-21 | 2016-05-21 | N/A | 2018-05-21 |
| lisdexamfetamine dimesylate | 120534 | Vyvanse | Shire Pharma Canada ULC. | N/A | 2009-02-19 | 2015-02-19 | Yes | 2017-08-19 |
| loteprednol etabonate | 117199 | Alrex | Bausch & Lomb Inc. |
|
2008-12-23 | 2014-12-23 | N/A | 2016-12-23 |
| lumiracoxib | 102465 | Prexige | Novartis Pharmaceuticals Canada Inc. | N/A | 2006-11-02 | 2012-11-02 | N/A | 2014-11-02 |
| lurasidone hydrochloride | 145406 | Latuda | Sunovion Pharmaceuticals Canada Inc. | N/A | 2012-06-13 | 2018-06-13 | Yes | 2020-12-13 |
| maraviroc | 112435 | Celsentri | ViiV Healthcare ULC | N/A | 2007-09-21 | 2013-09-21 | N/A | 2015-09-21 |
| methoxy polyethylene gycol epoetin beta | 106461 | Mircera | Hoffmann-La Roche Ltd. | N/A | 2008-03-31 | 2014-03-31 | N/A | 2016-03-31 |
| methylnaltrexone bromide | 114266 | Relistor | Salix Pharmaceuticals, Inc. | N/A | 2008-03-28 | 2014-03-28 | N/A | 2016-03-28 |
| micafungin sodium | 078577 | Mycamine | Astellas Pharma Canada, Inc. | N/A | 2007-05-22 | 2013-05-22 | N/A | 2015-05-22 |
| mirabegron | 153806 | Myrbetriq | Astellas Pharma Canada Inc. | N/A | 2013-03-06 | 2019-03-06 | N/A | 2021-03-06 |
| natalizumab | 093001 | Tysabri | Biogen Idec Canada Inc. | N/A | 2006-09-28 | 2012-09-28 | N/A | 2014-09-28 |
| nebivolol hydrochloride | 152353 | Bystolic | Allergan Inc. | N/A | 2012-12-21 | 2018-12-21 | 2020-12-21 | |
| nelarabine | 099994 | Atriance | Novartis Pharmaceuticals Canada Inc. | N/A | 2007-09-22 | 2013-09-22 | Yes | 2016-03-22 |
| nepafenac | 114004 | Nevanac | Alcon Canada Inc. | Ilevro | 2008-04-17 | 2014-04-17 | N/A | 2016-04-17 |
| nesiritide | 111760 | Natrecor | Janssen Inc. | N/A | 2007-11-08 | 2013-11-08 | N/A | 2015-11-08 |
| nilotinib hydrochloride monohydrate | 110305 | Tasigna | Novartis Pharmaceuticals Canada Inc. | N/A | 2008-09-09 | 2014-09-09 | N/A | 2016-09-09 |
| ofatumumab | 128188 | Arzerra | Novartis Pharmaceuticals Canada Inc. | N/A | 2012-03-09 | 2018-03-09 | N/A | 2020-03-09 |
| olmesartan medoxomil | 115991 | Olmetec | Merck Canada Inc. | Olmetec Plus | 2008-10-28 | 2014-10-28 | yes | 2017-04-28 |
| olodaterol hydrochloride | 155649 | Striverdi Respimat | Boehringer Ingelheim (Canada) Ltd. | Inspiolto Respimat | 2013-06-11 | 2019-06-11 | N/A | 2021-06-11 |
| oxaliplatin | 109965 | Eloxatin | Sanofi-aventis Canada Inc. | N/A | 2007-06-15 | 2013-06-15 | Yes | 2015-12-15 |
| paliperidone | 108748 | Invega | Janssen Inc. | Invega Sustenna | 2007-09-26 | 2013-09-26 | Yes | 2016-03-26 |
| palonosetron hydrochloride | 145491 | Aloxi | Purdue Pharma | Akynzeo | 2012-03-14 | 2018-03-14 | N/A | 2020-03-14 |
| panitumumab | 105601 | Vectibix | Amgen Canada Inc. | N/A | 2008-04-03 | 2014-04-03 | N/A | 2016-04-03 |
| pazopanib hydrochloride | 128332 | Votrient | Novartis Pharmaceuticals Canada Inc. | N/A | 2010-05-27 | 2016-05-27 | N/A | 2018-05-27 |
| pirfenidone | 153849 | Esbriet | Hoffmann-La Roche Limited | N/A | 2012-10-01 | 2018-10-01 | N/A | 2020-10-01 |
| plerixafor | 142638 | Mozobil | Sanofi-aventis Canada Inc. | N/A | 2011-12-08 | 2017-12-08 | N/A | 2019-12-08 |
| pneumococcal polysaccharide serotype 1, 4, 5, 6B, 7F, 9V, 14, 23F conjugated to protein D carrier protein; serotype 18C conjugated to tetanus toxoid carrier protein; serotype 19F conjugated to diphtheria toxoid carrier protein | 119056 | Synflorix | GlaxoSmithKline Inc. | N/A | 2008-12-11 | 2014-12-11 | Yes | 2017-06-11 |
| pneumococcal polysaccharide serotype 1, 3, 5, 6A, 7F, 19A conjugated to diphtheria CRM197 protein | 122881 | Prevnar 13 | Pfizer Canada Inc. | N/A | 2009-12-21 | 2015-12-21 | Yes | 2018-06-21 |
| posaconazole | 108193 | Posanol | Merck Canada Inc. | N/A | 2007-03-26 | 2013-03-26 | Yes | 2015-09-26 |
| prasugrel hydrochloride | 121143 | Effient | Eli Lilly Canada Inc. | N/A | 2010-04-16 | 2016-04-16 | Yes | 2018-10-16 |
| prucalopride succinate | 141157 | Resotran | Janssen Inc. | N/A | 2011-12-07 | 2017-12-07 | N/A | 2019-12-07 |
| raltegravir potassium | 113408 | Isentress | Merck Frosst Canada Inc. | N/A | 2007-11-27 | 2013-11-27 | Yes | 2016-05-27 |
| ranibizumab | 110233 | Lucentis | Novartis Opthalmics, Novartis Pharmaceuticals | N/A | 2007-06-26 | 2013-06-26 | N/A | 2015-06-26 |
| rasagiline mesylate | 101846 | Azilect | Teva Pharmaceuticals Industries Ltd. | N/A | 2006-08-17 | 2012-08-17 | N/A | 2014-08-17 |
| recombinant human papillomavirus type 11 L1, type 16 L1, type 18 L1, type 6 L1 protein | 102682 | Gardasil | Merck Frosst Canada Ltd., | N/A | 2006-07-10 | 2012-07-10 | Yes | 2015-01-10 |
| remestemcel-L | 150026 | Prochymal | Osiris Therapeutics Inc. | N/A | 2012-05-17 | 2018-05-17 | Yes | 2020-11-17 |
| retapamulin | 109037 | Altargo | GlaxoSmithKline Inc. | N/A | 2008-03-19 | 2014-03-19 | Yes | 2016-09-19 |
| rilpivirine hydrochloride | 137484 | Edurant | Janssen Inc. | Complera Odefsey Juluca |
2011-07-21 | 2017-07-21 | Yes | 2020-01-21 |
| rivaroxaban | 119111 | Xarelto | Bayer Healthcare | N/A | 2008-09-15 | 2014-09-15 | N/A | 2016-09-15 |
| roflumilast | 127683 | Daxas | Takeda Canada Inc. | N/A | 2010-11-23 | 2016-11-23 | N/A | 2018-11-23 |
| romiplostim | 117327 | Nplate | Amgen Canada Inc. | N/A | 2009-02-19 | 2015-02-19 | Yes | 2017-08-19 |
| rotavirus RIX4414 strain, live, attenuated (human) | 109624 | Rotarix | GlaxoSmithKline Inc. | N/A | 2007-10-09 | 2013-10-09 | Yes | 2016-04-09 |
| rotavirus vaccine, live, oral type G1, type G2, type G3, type G4, type P1(8) (human) | 100399 | Rotateq | Merck Frosst Canada Ltd. | N/A | 2006-08-01 | 2012-08-01 | Yes | 2015-02-01 |
| rubidium 82 chloride | 138823 | Ruby-Fill | Jubilant Draximage Inc. | N/A | 2011-09-20 | 2017-09-20 | N/A | 2019-09-20 |
| rufinamide | 139913 | Banzel | Eisai Limited | N/A | 2011-06-22 | 2017-06-22 | Yes | 2019-12-22 |
| ruxolitinib phosphate | 151723 | Jakavi | Novartis Pharmaceuticals Canada Inc. | N/A | 2012-06-19 | 2018-06-19 | N/A | 2020-06-19 |
| sapropterin dihydrochloride | 128151 | Kuvan | BioMarin Pharmaceutical Inc. | N/A | 2010-04-30 | 2016-04-30 | Yes | 2018-10-30 |
| saxagliptin hydrochloride | 123854 | Onglyza | AstraZeneca Canada Inc. |
|
2009-09-14 | 2015-09-14 | N/A | 2017-09-14 |
| silodosin | 121740 | Rapaflo | Purdue Pharma | N/A | 2011-01-11 | 2017-01-11 | N/A | 2019-01-11 |
| sitagliptin phosphate | 103039 | Januvia | Merck Frosst Canada Ltd. |
|
2007-12-14 | 2013-12-14 | N/A | 2015-12-14 |
| sitaxsentan sodium | 101934 | Thelin | Pfizer Canada Inc. | N/A | 2007-05-30 | 2013-05-30 | N/A | 2015-05-30 |
| sodium fluoride 18F | 145561 | NaF Plus | Isologic Innovative Radiopharmaceuticals Ltd. | N/A | 2013-02-11 | 2019-02-11 | N/A | 2021-02-11 |
| sorafenib | 102070 | Nexavar | Bayer Inc. | N/A | 2006-07-28 | 2012-07-28 | N/A | 2014-07-28 |
| stiripentol | 142417 | Diacomit | Biocodex SA | N/A | 2012-12-21 | 2018-12-21 | Yes | 2021-06-21 |
| tapentadol hydrochloride | 133167 | Nucynta CR | Janssen Inc. | Nucynta IR Nucynta Extended Release |
2010-12-02 | 2016-12-02 | N/A | 2018-12-02 |
| telaprevir | 142482 | Incivek | Vertex Pharmaceuticals (Canada) Inc. | N/A | 2011-08-16 | 2017-08-162 | N/A | 2019-08-10 |
| telavancin hydrochloride | 107792 | Vibativ | Pendopharm Division of de Pharmascience Inc. | N/A | 2009-09-29 | 2015-09-29 | N/A | 2017-09-29 |
| telbivudine | 104469 | Sebivo | Novartis Pharmaceuticals Canada Inc. | N/A | 2006-11-28 | 2012-11-28 | N/A | 2014-11-28 |
| temsirolimus | 109201 | Torisel | Pfizer Canada Inc. | N/A | 2007-12-21 | 2013-12-21 | Yes | 2016-06-21 |
| ticagrelor | 132218 | Brilinta | AstraZeneca Canada Incorporated | N/A | 2011-05-30 | 2017-05-30 | N/A | 2019-05-30 |
| tigecycline | 094870 | Tygacil | Pfizer Canada Inc. | N/A | 2006-09-14 | 2012-09-14 | N/A | 2014-09-14 |
| tocilizumab | 121089 | Actemra | Hoffmann-La Roche Ltd. | N/A | 2010-04-30 | 2016-04-30 | Yes | 2018-10-30 |
| tolvaptan | 139413 | Samsca | Otsuka Pharmaceutical Co. Ltd. | Jinarc | 2011-07-25 | 2017-07-25 | N/A | 2019-07-25 |
| trabectedin | 124729 | Yondelis | Janssen Inc. | N/A | 2010-05-13 | 2016-05-13 | N/A | 2018-05-13 |
| trametinib | 157665 | Mekinist | Novartis Pharmaceuticals Canada Inc. | N/A | 2013-07-18 | 2019-07-18 | N/A | 2021-07-18 |
| ulipristal acetate | 156861 | Fibristal | Allergan Inc. | N/A | 2013-06-24 | 2019-06-24 | N/A | 2021-06-24 |
| ustekinumab | 114272 | Stelara | Janssen Inc. | N/A | 2008-12-12 | 2014-12-12 | N/A | 2016-12-12 |
| vandetanib | 126822 | Caprelsa | Genzyme Canada, a division of Sanofi-aventis Canada Inc. | N/A | 2012-01-12 | 2018-01-12 | N/A | 2020-01-12 |
| varenicline tartrate | 104007 | Champix | Pfizer Canada Inc. | N/A | 2007-01-24 | 2013-01-24 | Yes | 2015-07-24 |
| velaglucerase alfa | 132604 | Vpriv | Shire Human Genetic Therapies, Inc. | N/A | 2010-10-01 | 2016-10-01 | Yes | 2019-04-01 |
| vemurafenib | 148693 | Zelboraf | Hoffmann-La Roche Ltd. | N/A | 2012-02-15 | 2018-02-15 | N/A | 2020-02-15 |
| vismodegib | 154608 | Erivedge | Hoffmann-La Roche Ltd. | N/A | 2013-07-12 | 2019-07-12 | N/A | 2021-07-12 |
| vorinostat | 104562 | Zolinza | Merck Frosst Canada Ltd. | N/A | 2009-06-11 | 2015-06-11 | N/A | 2017-06-11 |
| ziprasidone hydrochloride monohydrate | 078188 | Zeldox | Pfizer Canada Inc. | N/A | 2007-08-27 | 2013-08-27 | Yes | 2016-02-27 |
| zucapsaicin | 121952 | Zuacta | Sanofi aventis Canada Inc. | N/A | 2010-07-15 | 2016-07-15 | N/A | 2018-07-15 |
| Medicinal Ingredient(s) Footnote 1 |
Submission Number |
Innovative Drug | Manufacturer | Drug(s) Containing the Medicinal Ingredient / Variations | Notice of Compliance Date yyyy-mm-dd | 6 Year "No File" Date |
Data Protection Ends |
|---|---|---|---|---|---|---|---|
| afoxolaner | 163768 | Nexgard | Boehringer Ingelheim Animal Health Canada Inc. | Nexgard Spectra Nexgard Combo |
2014-07-08 | 2020-07-08 | 2022-07-08 |
| amlodipine besilate | 218786 | Amodip Flavoured Tablets | Ceva Animal Health Inc. | N/A | 2020-03-25 | 2026-03-25 | 2028-03-25 |
| avilamycin | 156949 | Surmax 100 Premix | Elanco Canada Limited | Surmax 200 Premix | 2014-02-18 | 2020-02-18 | 2022-02-18 |
| bedinvetmab | 237723 | Librela | Zoetis Canada Inc. | N/A | 2021-02-01 | 2027-02-01 | 2029-02-01 |
| ciclesonide | 200882 | Aservo Equihaler | Boehringer Ingelheim Animal Health Canada Inc. | N/A | 2020-04-30 | 2026-04-30 | 2028-04-30 |
| clodronate disodium tetrahydrate | 172789 | Osphos Injection | Dechra Ltd. | N/A | 2015-05-06 | 2021-05-06 | 2023-05-06 |
| closantel sodium | 180678 | Flukiver | Elanco Division Eli Lilly Canada Inc | N/A | 2015-11-24 | 2021-11-24 | 2023-11-24 |
| derquantel | 184844 | Startect | Zoetis Canada Inc. | N/A | 2016-04-27 | 2022-04-27 | 2024-04-27 |
| fluralaner | 166320 | Bravecto | Intervet Canada Corp. | Vitrecto Bravecto One |
2014-05-23 | 2020-05-23 | 2022-05-23 |
| grapiprant | 211760 | Galliprant | Elanco Canada Limited | N/A | 2019-01-08 | 2025-01-08 | 2027-01-08 |
| lotilaner | 193712 | Credelio | Elanco Canada Limited | N/A | 2017-12-29 | 2023-12-29 | 2025-12-29 |
| lubabegron | 166199 | Experior 10 | Elanco Canada Limited | Experior 50 | 2018-11-07 | 2024-11-07 | 2026-11-07 |
| methadone hydrochloride | 226217 | Comfortan | Eurovet Animal Health B.V. | N/A | 2020-02-25 | 2026-02-25 | 2028-02-25 |
| midazolam | 230770 | Dormazolam | Dechra Regulatory BV | N/A | 2021-06-29 | 2027-06-29 | 2029-06-29 |
| mirtazapine | 232197 | Mirataz | Dechra Ltd. | N/A | 2020-09-08 | 2026-09-08 | 2028-09-08 |
| oclacitinib maleate | 159090 | Apoquel | Zoetis Canada Inc. | N/A | 2014-07-15 | 2020-07-15 | 2022-07-15 |
| peforelin | 190986 | Maprelin XP-10 | Modern Veterinary Therapeutics LLC | N/A | 2017-06-19 | 2023-06-19 | 2025-06-19 |
| pegbovigrastim | 148171 | Imrestor | Elanco Division Eli Lilly Canada Inc. | N/A | 2016-03-09 | 2022-03-09 | 2024-03-09 |
| pergolide mesylate | 158770 | Prascend | Boehringer Ingelheim Animal Health Canada Inc. | N/A | 2013-09-05 | 2019-09-05 | 2021-09-05 |
| pradofloxacin | 161227 | Veraflox | Elanco Canada Limited | N/A | 2015-01-29 | 2021-01-29 | 2023-01-29 |
| sarolaner | 177679 | Simparica | Zoetis Canada Inc. | Revolution Plus Simparica Trio | 2016-02-11 | 2022-02-11 | 2024-02-11 |
| telmisartan | 158760 | Semintra | Boehringer Ingelheim Animal Health Canada Inc. | N/A | 2013-12-12 | 2019-12-12 | 2021-12-12 |
| terbinafine | 170344 | Osurnia | Dechra Ltd. | N/A | 2015-03-26 | 2021-03-26 | 2023-03-26 |
| tetracosactide | 228462 | Cosacthen | Dechra Ltd. | N/A | 2020-04-27 | 2026-04-27 | 2028-04-27 |
| tiludronic acid (as tiludronate disodium) | 171467 | Tildren | CEVA Animal Health | N/A | 2014-12-22 | 2020-12-22 | 2022-12-22 |
| triptorelin (as triptorelin acetate) | 161303 | Ovugel | United-AH II, LLC | N/A | 2014-04-25 | 2020-04-25 | 2022-04-25 |
| Medicinal Ingredient(s) Footnote 1 | Submission Number |
Innovative Drug | Manufacturer | Drug(s) Containing the Medicinal Ingredient / Variations | Notice of Compliance Date yyyy-mm-dd | 6 Year "No File" Date |
Data Protection Ends |
|---|---|---|---|---|---|---|---|
| acetaminophen | 110139 | Pracetam 20% O.S. | Ceva Animal Health Inc. | N/A | 2009-03-05 | 2015-03-05 | 2017-03-05 |
| buprenorphine hydrochloride | 126077 | Vetergesic Multidose | Sogeval UK Limited | N/A | 2010-02-03 | 2016-02-03 | 2018-02-03 |
| cefovecin sodium | 110061 | Convenia | Zoetis Canada Inc. | N/A | 2007-05-30 | 2013-05-30 | 2015-05-30 |
| cefpodoxime proxetil | 149164 | Simplicef | Zoetis Canada Inc. | N/A | 2012-12-06 | 2018-12-06 | 2020-12-06 |
| cephalexin monohydrate | 126970 | Vetolexin | Vétoquinol N.-A Inc. | Cefaseptin | 2010-06-24 | 2016-06-24 | 2018-06-24 |
| dibotermin alfa (rhBMP-2) | 148153 | Truscient | Zoetis Canada Inc. | N/A | 2012-11-20 | 2018-11-20 | 2020-11-20 |
| dirlotapide | 110110 | Slentrol | Zoetis Canada Inc. | N/A | 2008-08-14 | 2014-08-14 | 2016-08-14 |
| emamectin benzoate | 109976 | Slice | Intervet Canada Ltd. | N/A | 2009-06-29 | 2015-06-29 | 2017-06-29 |
| emodepside | 112103 / 112106 / 112107 | Profender | Bayer Healthcare, Animal Health Division | N/A | 2008-08-28 | 2014-08-28 | 2016-08-28 |
| firocoxib | 110661 / 110379 | Previcox | Merial Canada Inc. | N/A | 2007-09-28 | 2013-09-28 | 2015-09-28 |
| fluoxetine hydrochloride | 109825 / 109826 / 110429 | Reconcile | Elanco, Division Eli Lilly Canada Inc. | N/A | 2008-03-28 | 2014-03-28 | 2016-03-28 |
| gamithromycin | 125823 | Zactran | Merial Canada Inc. | N/A | 2010-03-29 | 2016-03-29 | 2018-03-29 |
| gonadotropin releasing factor analogue - protein conjugate | 140525 | Improvest | Zoetis Canada Inc. | N/A | 2011-06-22 | 2017-06-22 | 2019-06-22 |
| ibafloxacin | 110655 / 110657 | Ibaflin gel | Intervet Canada Ltd. | N/A | 2008-01-15 | 2014-01-15 | 2016-01-15 |
| insulin human (recombinant) | 150211 | Prozinc | Boehringer Ingelheim Animal Health Canada | N/A | 2013-04-24 | 2019-04-24 | 2021-04-24 |
| imidapril hydrochloride | 110445 / 110450 / 110476 | Prilium | Vetoquinol N A Inc. | N/A | 2007-07-12 | 2013-07-12 | 2015-07-12 |
| itraconazole | 109769 | Itrafungol | Elanco, Division Eli Lilly Canada Inc. | N/A | 2008-09-23 | 2014-09-23 | 2016-09-23 |
| maropitant | 110342 / 110344 / 110347 / 110348 | Cerenia | Zoetis Canada Inc. | N/A | 2007-09-20 | 2013-09-20 | 2015-09-20 |
| mitratapide | 111600 | Yarvitan | Janssen Pharmaceutica N.V. | N/A | 2009-02-20 | 2015-02-20 | 2017-02-20 |
| mometasone furoate monohydrate | 110289 | Mometamax | Intervet Canada Corp. | N/A | 2010-02-22 | 2016-02-22 | 2018-02-22 |
| permethrin | 133818 | Oridermyl | Vétoquinol N.- A Inc. | N/A | 2011-02-18 | 2017-02-18 | 2019-02-18 |
| phenobarbital | 142445 | Epiphen | Vétoquinol N.-A Inc. | N/A | 2012-04-04 | 2018-04-04 | 2020-04-04 |
| ramipril | 110296 / 110297 / 110298 | Vasotop | Intervet Canada Ltd. | N/A | 2008-09-05 | 2014-09-05 | 2016-09-05 |
| robenacoxib | 128703 | Onsior | Elanco Canada Limited | N/A | 2011-10-03 | 2017-10-03 | 2019-10-03 |
| sevoflurane | 110109 | Sevoflo | Zoetis Canada Inc. | N/A | 2008-03-28 | 2014-03-28 | 2016-03-28 |
| spinosad | 112198 / 112199 / 112202 / 112203 / 112204 | Comfortis | Elanco, Division Eli Lilly Canada Inc. | Trifexis | 2009-08-24 | 2015-08-24 | 2017-08-24 |
| tepoxalin | 109950 / 109956 / 109963 | Zubrin | Schering Plough Canada Inc. | N/A | 2007-10-01 | 2013-10-01 | 2015-10-01 |
| thiamazole | 125706 | Felimazole | Dechra Ltd. | N/A | 2009-08-25 | 2015-08-25 | 2017-08-25 |
| tildipirosin | 148052 | Zuprevo | Intervet Canada Corp. | N/A | 2012-06-13 | 2018-06-13 | 2020-06-13 |
| toceranib phosphate | 123643 | Palladia | Zoetis Canada Inc. | N/A | 2009-12-01 | 2015-12-01 | 2017-12-01 |
| toltrazuril | 122525 | Baycox | Bayer Inc., Bayer Healthcare Animal Health Division | N/A | 2010-08-20 | 2016-08-20 | 2018-08-20 |
| trilostane | 110023 / 110025 / 110221 / 113566 | Vetoryl | Dechra Ltd. | N/A | 2009-01-30 | 2015-01-30 | 2017-01-30 |
| tulathromycin | 112161 | Draxxin | Pfizer Canada Inc., Animal Health Group | N/A | 2006-08-31 | 2012-08-31 | 2014-08-31 |
| zilpaterol hydrochloride | 110019 | Zilmax | Intervet Canada Ltd. | N/A | 2009-03-18 | 2015-03-18 | 2017-03-18 |
Background
The Register of Innovative Drugs is maintained pursuant to subsection C.08.004.1(9) of the Food and Drug Regulations. The register indicates the drugs that are eligible for data protection. Under subsection C.08.004.1(3) a subsequent manufacturer that seeks a notice of compliance on the basis of a direct or indirect comparison between the new drug and an innovative drug may not file a submission before the end of a period of six years after the day on which the first notice of compliance was issued for the innovative new drug. In addition, the notice of compliance cannot be issued before the end of a period of eight years after the day on which the first notice of compliance was issued to the innovator.
The format of the Register of Innovative Drugs is an electronic table, which is updated weekly. The register lists, in alphabetical order, the medicinal ingredients in the innovative drugs which were not previously approved in a drug by the Minister and that are not variations of a previously approved medicinal ingredient. Please note that there may be other medicinal ingredients included in the drugs. The register was re-formatted in summer 2016 to increase the clarity of the information provided regarding the medicinal ingredient, brand name and manufacturer of each innovative drug.
For more information
For information related to treatment options, choices of medications and their uses, illnesses, side effects or drug interactions, please contact your health care professional (for example, doctor, pharmacist, etc.). We do not provide medical advice regarding the use of the products identified in this database.
For other comments or questions, please contact the:
Office of Patented Medicines and Liaison
Email: hc.opml-bmbl.sc@canada.ca
Telephone: 613-941-7281
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