Register of Innovative Drugs
Contact: Office of Patented Medicines and Liaison
- Products for Human Use - Active Data Protection Period
- Products for Human Use - Expired Data Protection Period
- Products for Veterinary Use - Active Data Protection Period
- Products for Veterinary Use - Expired Data Protection Period
| Medicinal Ingredient(s) Footnote 1 |
Submission Number | Innovative Drug | Manufacturer | Drug(s) Containing the Medicinal Ingredient / Variations | Notice of Compliance Date yyyy-mm-dd | 6 Year "No File" Date |
Pediatric Extension Yes/No | Data Protection Ends |
|---|---|---|---|---|---|---|---|---|
| abemaciclib | 215268 | Verzenio | Eli Lilly Canada Inc. | N/A | 2019-04-05 | 2025-04-05 | N/A | 2027-04-05 |
| abrocitinib | 245854 | Cibinqo | Pfizer Canada ULC | N/A | 2022-06-29 | 2028-06-29 | Yes | 2030-12-29 |
| acalabrutinib | 214504 | Calquence | AstraZeneca Canada Inc. | Calquence (acalabrutinib maleate) | 2019-08-23 | 2025-08-23 | N/A | 2027-08-23 |
| ad26.COV2.S (recombinant) | 253702 | Jcovden | Janssen Inc. | N/A | 2021-11-23 | 2027-11-23 | N/A | 2029-11-23 |
| alectinib hydrochloride | 189442 | Alecensaro | Hoffmann-La Roche Limited | N/A | 2016-09-29 | 2022-09-29 | N/A | 2024-09-29 |
| alirocumab | 183116 | Praluent | Sanofi-Aventis Canada Inc. | N/A | 2016-04-11 | 2022-04-11 | Yes | 2024-10-11 |
| alpelisib | 226941 | Piqray | Novartis Pharmaceuticals Canada Inc. | N/A | 2020-03-11 | 2026-03-11 | N/A | 2028-03-11 |
| amifampridine (supplied as amifampridine phosphate) | 232685 | Firdapse | Kye Pharmaceuticals Inc. | N/A | 2020-07-31 | 2026-07-31 | N/A | 2028-07-31 |
| amivantamab | 254440 | Rybrevant | Janssen Inc. | N/A | 2022-03-30 | 2028-03-30 | N/A | 2030-03-30 |
| andexanet alfa | 266464 | Ondexxya | AstraZeneca Canada Inc. | N/A | 2023-06-16 | 2029-06-16 | N/A | 2031-06-16 |
| andusomeran | 275936 | Spikevax XBB.1.5 | Moderna Biopharma Canada Corporation | N/A | 2023-09-12 | 2029-09-12 | Yes | 2032-03-12 |
| anifrolumab | 246187 | Saphnelo | AstraZeneca Canada Inc. | N/A | 2021-11-30 | 2027-11-30 | N/A | 2029-11-30 |
| anthrax antigen filtrate | 212387 | Biothrax | Emergent Biodefense Operations Lansing LLC | N/A | 2018-12-13 | 2024-12-13 | N/A | 2026-12-13 |
| anthrax immune globulin (human) | 200446 | Anthrasil | Emergent BioSolutions Canada Inc. | N/A | 2017-11-06 | 2023-11-06 | Yes | 2026-05-06 |
| antihemophilic factor (recombinant), pegylated | 189709 | Adynovate | Takeda Canada Inc. | N/A | 2016-11-17 | 2022-11-17 | Yes | 2025-05-17 |
| antihemophilic factor (recombinant, B-domain deleted, pegylated) (also known as damoctocog alfa pegol) | 210935 | Jivi | Bayer Inc. | N/A | 2018-10-18 | 2024-10-18 | Yes | 2027-04-18 |
| antihemophilic factor VIII (recombinant), singlechain (also known as lonoctocog alfa) | 190891 | Afstyla | CSL Behring Canada Inc. | N/A | 2016-12-12 | 2022-12-12 | Yes | 2025-06-12 |
| antihemophilic factor VIII (recombinant, B-domain truncated), PEGylated (turoctocog alfa pegol) | 218531 | Esperoct | Novo Nordisk Canada Inc. | N/A | 2019-07-04 | 2025-07-04 | Yes | 2028-01-04 |
| apalutamide | 211942 | Erleada | Janssen Inc. | N/A | 2018-07-03 | 2024-07-03 | N/A | 2026-07-03 |
| asciminib hydrochloride | 255700 | Scemblix | Novartis Pharmaceuticals Canada Inc. | N/A | 2022-06-23 | 2028-06-23 | N/A | 2030-06-23 |
| asfotase alfa | 179340 | Strensiq | Alexion Pharma International Sàrl | N/A | 2015-08-14 | 2021-08-14 | Yes | 2024-02-14 |
| asunaprevir | 172617 | Sunvepra | Bristol-Myers Squibb Canada | N/A | 2016-03-09 | 2022-03-09 | N/A | 2024-03-09 |
| atezolizumab | 196843 | Tecentriq | Hoffmann-La Roche Limited | N/A | 2017-04-12 | 2023-04-12 | Yes | 2025-10-12 |
| atogepant | 253186 | Qulipta | Abbvie Corporation | N/A | 2022-12-22 | 2028-12-22 | N/A | 2030-12-22 |
| avacopan | 248255 | Tavneos | Vifor Fresenius Medical Care Renal Pharma Ltd. | N/A | 2022-04-14 | 2028-04-14 | N/A | 2030-04-14 |
| avalglucosidase alfa | 245680 | Nexviazyme | Sanofi-Aventis Canada Inc. | N/A | 2021-11-12 | 2027-11-12 | Yes | 2030-05-12 |
| avatrombopag maleate | 251688 | Doptelet | Swedish Orphan Biovitrum AB (publ) | N/A | 2023-11-03 | 2029-11-03 | N/A | 2031-11-03 |
| avelumab | 204052 | Bavencio | EMD Serono, a Division of EMD Inc., Canada | N/A | 2017-12-18 | 2023-12-18 | Yes | 2026-06-18 |
| axicabtagene ciloleucel | 218389 | Yescarta | Gilead Sciences Canada Inc | N/A | 2019-02-13 | 2025-02-13 | N/A | 2027-02-13 |
| baloxavir marboxil | 227361 | Xofluza | Hoffmann-La Roche Limited | N/A | 2020-02-19 | 2026-02-19 | Yes | 2028-08-19 |
| baricitinib | 193687 | Olumiant | Eli Lilly Canada Inc. | N/A | 2018-08-17 | 2024-08-17 | N/A | 2026-08-17 |
| belumosudil mesylate | 262997 | Rezurock | Sanofi-Aventis Canada Inc. | N/A | 2022-03-23 | 2028-03-23 | N/A | 2030-03-23 |
| belzutifan | 254495 | Welireg | Merck Canada Inc. | N/A | 2022-07-11 | 2028-07-11 | N/A | 2030-07-11 |
| benralizumab | 204008 | Fasenra | AstraZeneca Canada Inc. | N/A | 2018-02-22 | 2024-02-22 | Yes | 2026-08-22 |
| bepotastine besilate | 179294 | Bepreve | Bausch and Lomb Incorporated | N/A | 2016-07-27 | 2022-07-27 | Yes | 2025-01-27 |
| berotralstat (supplied as berotralstat hydrochloride) | 252301 | Orladeyo | BioCryst Pharmaceuticals, Inc. | N/A | 2022-06-02 | 2028-06-02 | Yes | 2030-12-02 |
| bictegravir | 203718 | Biktarvy | Gilead Sciences Canada, Inc. | N/A | 2018-07-10 | 2024-07-10 | Yes | 2027-01-10 |
| bilastine | 184231 | Blexten | Aralez Pharmaceutials Canada Inc. | N/A | 2016-04-21 | 2022-04-21 | Yes | 2024-10-21 |
| bimekizumab | 238499 | Bimzelx | UCB Canada Inc. | N/A | 2022-02-14 | 2028-02-14 | N/A | 2030-02-14 |
| binimetinib | 237410 | Mektovi | Pfizer Canada ULC | N/A | 2021-03-02 | 2027-03-02 | N/A | 2029-03-02 |
| blinatumomab | 181723 | Blincyto | Amgen Canada Incorporated | N/A | 2015-12-22 | 2021-12-22 | Yes | 2024-06-22 |
| botulism antitoxin heptavalent C/ D/F/ G – (equine) | 190645 | Bat | Emergent BioSolutions Inc. | N/A | 2016-12-08 | 2022-12-08 | Yes | 2025-06-08 |
| brexpiprazole | 192684 | Rexulti | Otsuka Pharmaceutical Co. Ltd. | N/A | 2017-02-16 | 2023-02-16 | Yes | 2025-08-16 |
| brexucabtagene autoleucel | 246355 | Tecartus | Gilead Sciences Canada, Inc. | N/A | 2021-06-08 | 2027-06-08 | N/A | 2029-06-08 |
| brigatinib | 210369 | Alunbrig | Takeda Canada Incorporated | N/A | 2018-07-26 | 2024-07-26 | N/A | 2026-07-26 |
| brivaracetam | 183355 | Brivlera | UCB Canada Incorporated | N/A | 2016-03-09 | 2022-03-09 | Yes | 2024-09-09 |
| brodalumab | 195317 | Siliq | Bausch Health, Canada Inc. | N/A | 2018-03-06 | 2024-03-06 | N/A | 2026-03-06 |
| brolucizumab | 226224 | Beovu | Novartis Pharmaceuticals Canada Inc. | N/A | 2020-03-12 | 2026-03-12 | N/A | 2028-03-12 |
| burosumab | 216239 | Crysvita | Kyowa Kirin Inc. | N/A | 2018-12-05 | 2024-12-05 | Yes | 2027-06-05 |
| cabotegravir | 227315 | Cabenuva | ViiV Healthcare ULC | N/A | 2020-03-18 | 2026-03-18 | Yes | 2028-09-18 |
| cabotegravir sodium | 227315 | Vocabria | ViiV Healthcare ULC | N/A | 2020-03-18 | 2026-03-18 | Yes | 2028-09-18 |
| cabozantinib (supplied as cabozantinib (S)-malate) | 206230 | Cabometyx | Ipsen Biopharmaceuticals Canada Inc. | N/A | 2018-09-14 | 2024-09-14 | N/A | 2026-09-14 |
| calaspargase pegol | 268282 | Asparlas | Servier Canada Inc. | N/A | 2023-11-08 | 2029-11-08 | Yes | 2032-05-08 |
| calcifediol | 205392 | Rayaldee | Eirgen Pharma Ltd. | N/A | 2018-07-10 | 2024-07-10 | N/A | 2026-07-10 |
| cangrelor tetrasodium | 255032 | Kengrexal | Chiesi Farmaceutici S.p.A | N/A | 2023-01-20 | 2029-01-20 | N/A | 2031-01-20 |
| caplacizumab | 230001 | Cablivi | Sanofi-Aventis Canada Inc. | N/A | 2020-02-28 | 2026-02-28 | N/A | 2028-02-28 |
| capmatinib hydrochloride | 255972 | Tabrecta | Novartis Pharmaceuticals Canada Inc. | N/A | 2022-05-26 | 2028-05-26 | N/A | 2030-05-26 |
| carfilzomib | 184479 | Kyprolis | Amgen Canada Inc. | N/A | 2016-01-15 | 2022-01-15 | N/A | 2024-01-15 |
| cariprazine hydrochloride | 249774 | Vraylar | AbbVie Corporation | N/A | 2022-04-22 | 2028-04-22 | N/A | 2030-04-22 |
| cedazuridine | 234610 | Inqovi | Otsuka Pharmaceutical Co., Ltd. | NA | 2020-07-07 | 2026-07-07 | N/A | 2028-07-07 |
| cemiplimab | 218718 | Libtayo | Sanofi-Aventis Canada Inc. | N/A | 2019-04-10 | 2025-04-10 | N/A | 2027-04-10 |
| cenegermin | 218145 | Oxervate | Dompé farmaceutici S.p.A. | N/A | 2019-02-08 | 2025-02-08 | N/A | 2027-02-08 |
| cenobamate | 261689 | Xcopri | Endo Ventures Ltd. | N/A | 2023-06-12 | 2029-06-12 | N/A | 2031-06-12 |
| cerliponase alfa | 216539 | Brineura | Biomarin International Limited | N/A | 2018-12-19 | 2024-12-19 | Yes | 2027-06-19 |
| chAdOx1-S [recombinant] | 253700 | Vaxzevria | AstraZeneca Canada Inc. | N/A | 2021-11-19 | 2027-11-19 | N/A | 2029-11-19 |
| ciltacabtagene autoleucel | 262122 | Carvykti | Janssen Inc. | N/A | 2023-02-09 | 2029-02-09 | N/A | 2031-02-09 |
| clascoterone | 265619 | Winlevi | Sun Pharmaceutical Industries Limited | N/A | 2023-06-15 | 2029-06-15 | Yes | 2031-12-15 |
| coagulation factor IX (recombinant), albumin fusion protein (rIX-FP) | 180793 | Idelvion | CSL Behring Canada Inc. | N/A | 2016-01-26 | 2022-01-26 | Yes | 2024-07-26 |
| coagulation factor IX (recombinant), pegylated (nonacog beta pegol) | 201114 | Rebinyn | Novo Nordisk Canada Inc. | N/A | 2017-11-29 | 2023-11-29 | Yes | 2026-05-29 |
| cobimetinib | 182788 | Cotellic | Hoffmann-La Roche Limited | N/A | 2016-02-22 | 2022-02-22 | N/A | 2024-02-22 |
| concizumab | 267120 | Alhemo | Novo Nordisk Canada Inc. | N/A | 2023-03-10 | 2029-03-10 | Yes | 2031-09-10 |
| crisaborole | 206906 | Eucrisa | Pfizer Canada Inc. | N/A | 2018-06-07 | 2024-06-07 | Yes | 2026-12-07 |
| cysteamine bitartrate | 191347 | Procysbi | Horizon Pharma Ireland Ltd. | N/A | 2017-06-13 | 2023-06-13 | Yes | 2025-12-13 |
| daclizumab beta | 190458 | Zinbryta | Biogen Canada Inc. | N/A | 2016-12-08 | 2022-12-08 | N/A | 2024-12-08 |
| dacomitinib | 214572 | Vizimpro | Pfizer Canada Inc. | N/A | 2019-02-26 | 2025-02-26 | N/A | 2027-02-26 |
| dalbavancin (supplied as dalbavancin hydrochloride) | 212390 | Xydalba | Endo Ventures Ltd. | N/A | 2018-09-04 | 2024-09-04 | N/A | 2026-09-04 |
| daratumumab | 187648 | Darzalex | Janssen Inc. | Darzalex SC | 2016-06-29 | 2022-06-29 | N/A | 2024-06-29 |
| daridorexant hydrochloride | 255507 | Quviviq | Idorsia Pharmaceuticals Ltd. | N/A | 2023-04-28 | 2029-04-28 | N/A | 2031-04-28 |
| darolutamide | 226146 | Nubeqa | Bayer Inc. | N/A | 2020-02-20 | 2026-02-20 | N/A | 2028-02-20 |
| davesomeran | 267589 | Spikevax Bivalent (Original/Omicron BA.4/5) | Moderna Biopharma Canada Corporation | N/A | 2022-11-03 | 2028-11-03 | Yes | 2031-05-03 |
| defibrotide sodium | 200808 | Defitelio | Jazz Pharmaceuticals Ireland Limited | N/A | 2017-07-10 | 2023-07-10 | Yes | 2026-01-10 |
| deucravacitinib | 259397 | Sotyktu | Bristol-Myers Squibb Canada | N/A | 2022-11-24 | 2028-11-24 | N/A | 2030-11-24 |
| difelikefalin (supplied as difelikefalin acetate) | 254548 | Korsuva | Vifor Fresenius Medical Care Renal Pharma Ltd. | N/A | 2022-08-16 | 2028-08-16 | N/A | 2030-08-16 |
| dinutuximab | 212066 | Unituxin | United Therapeutics Corporation | N/A | 2018-11-28 | 2024-11-28 | Yes | 2027-05-28 |
| doravirine | 211293 | Pifeltro | Merck Canada Inc. | Delstrigo | 2018-10-12 | 2024-10-12 | Yes | 2027-04-12 |
| dostarlimab | 251105 | Jemperli | GlaxoSmithKline Inc. | N/A | 2021-12-23 | 2027-12-23 | N/A | 2029-12-23 |
| dupilumab | 201285 | Dupixent | Sanofi-Aventis Canada Inc. | N/A | 2017-11-30 | 2023-11-30 | Yes | 2026-05-30 |
| durvalumab | 202953 | Imfinzi | AstraZeneca Canada Inc. | N/A | 2017-11-03 | 2023-11-03 | N/A | 2025-11-03 |
| ebola zaire vaccine (rVSVΔG-ZEBOV-GP, live) | 256568 | Ervebo | Merck Canada Inc. | N/A | 2022-11-09 | 2028-11-09 | N/A | 2030-11-09 |
| edaravone | 214391 | Radicava | Mitsubishi Tanabe Pharma Corporation | N/A | 2018-10-03 | 2024-10-03 | N/A | 2026-10-03 |
| edoxaban | 187363 | Lixiana | Servier Canada Inc. | N/A | 2016-11-04 | 2022-11-04 | Yes | 2025-05-04 |
| efgartigimod alfa | 267438 | Vyvgart | Argenx BV | N/A | 2023-09-19 | 2029-09-19 | N/A | 2031-09-19 |
| elagolix | 209513 | Orilissa | AbbVie Corporation | N/A | 2018-10-05 | 2024-10-05 | N/A | 2026-10-05 |
| elasomeran | 252733 | Spikevax | Moderna Biopharma Canada Corporation | Spikevax Bivalent Spikevax Bivalent (Original/Omicron BA.4/5) |
2021-09-16 | 2027-09-16 | Yes | 2030-03-16 |
| elexacaftor | 246955 | Trikafta | Vertex Pharmaceuticals (Canada) Incorporated | N/A | 2021-06-18 | 2027-06-18 | Yes | 2029-12-18 |
| eliglustat tartrate | 183050 | Cerdelga | Genzyme Canada, A division of Sanofi-Aventis Canada Inc. | N/A | 2017-04-21 | 2023-04-21 | N/A | 2025-04-21 |
| elotuzumab | 188144 | Empliciti | Bristol-Myers Squibb Canada | N/A | 2016-06-21 | 2022-06-21 | N/A | 2024-06-21 |
| eluxadoline | 190162 | Viberzi | Allergan Inc. | N/A | 2017-01-26 | 2023-01-26 | N/A | 2025-01-26 |
| emicizumab | 212635 | Hemlibra | Hoffmann-La Roche Limited | N/A | 2018-08-02 | 2024-08-02 | Yes | 2027-02-02 |
| enasidenib mesylate | 217033 | Idhifa | Celgene Inc. | N/A | 2019-02-06 | 2025-02-06 | N/A | 2027-02-06 |
| encorafenib | 237413 | Braftovi | Pfizer Canada ULC | N/A | 2021-03-02 | 2027-03-02 | N/A | 2029-03-02 |
| enfortumab vedotin | 251438 | Padcev | Seagen Inc. | N/A | 2021-10-29 | 2027-10-29 | N/A | 2029-10-29 |
| entrectinib | 227517 | Rozlytrek | Hoffmann-La Roche Limited | N/A | 2020-02-10 | 2026-02-10 | Yes | 2028-08-10 |
| epcoritamab | 271331 | Epkinly | AbbVie Corporation | N/A | 2023-10-13 | 2029-10-13 | N/A | 2031-10-13 |
| eptinezumab | 233288 | Vyepti | Lundbeck Canada Inc. | N/A | 2021-01-11 | 2027-01-11 | N/A | 2029-01-11 |
| erdafitinib | 224529 | Balversa | Janssen Inc. | N/A | 2019-10-25 | 2025-10-25 | N/A | 2027-10-25 |
| erenumab | 208607 | Aimovig | Novartis Pharmaceuticals Canada Inc. | N/A | 2018-08-01 | 2024-08-01 | N/A | 2026-08-01 |
| ertugliflozin | 204724 | Steglatro | Merck Canada Inc. | Steglujan Segluromet |
2018-05-09 | 2024-05-09 | N/A | 2026-05-09 |
| estetrol monohydrate | 236197 | Nextstellis | Searchlight Pharma Inc. | N/A | 2021-03-05 | 2027-03-05 | N/A | 2029-03-05 |
| etranacogene dezaparvovec | 273721 | Hemgenix | CSL Behring Canada Inc. | N/A | 2023-10-23 | 2029-10-23 | N/A | 2031-10-23 |
| evinacumab | 272688 | Evkeeza | Ultragenyx Pharmaceutical Inc. | N/A | 2023-09-22 | 2029-09-22 | Yes | 2032-03-22 |
| evolocumab | 178234 | Repatha | Amgen Canada Inc. | N/A | 2015-09-10 | 2021-09-10 | Yes | 2024-03-10 |
| famtozinameran | 267502 | Comirnaty Original & Omicron BA.4/BA.5 | BioNTech Manufacturing GmbH | N/A | 2022-10-07 | 2028-10-07 | Yes | 2031-04-07 |
| faricimab | 253904 | Vabysmo | Hoffmann-La Roche Limited | N/A | 2022-05-27 | 2028-05-27 | N/A | 2030-05-27 |
| fedratinib (supplied as fedratinib hydrochloride) | 229866 | Inrebic | Bristol-Myers Squibb Canada | N/A | 2020-07-27 | 2026-07-27 | N/A | 2028-07-27 |
| ferric derisomaltose | 193890 | Monoferric | Pharmacosmos A/S | N/A | 2018-06-22 | 2024-06-22 | N/A | 2026-06-22 |
| ferric pyrophosphate citrate | 239850 | Triferic Avnu | Rockwell Medical Inc. | N/A | 2021-04-22 | 2027-04-22 | Yes | 2029-10-22 |
| finafloxacin | 172450 | Xtoro | MerLion Pharmaceuticals GmbH | N/A | 2016-03-11 | 2022-03-11 | Yes | 2024-09-11 |
| finerenone | 258231 | Kerendia | Bayer Inc. | N/A | 2022-10-14 | 2028-10-14 | N/A | 2030-10-14 |
| flibanserin | 189352 | Addyi | Searchlight Pharma Inc. | N/A | 2018-02-27 | 2024-02-27 | N/A | 2026-02-27 |
| florbetaben (18F) | 193105 | Neuraceq | Isologic Innovative Radiopharmaceuticals Ltd. | N/A | 2017-02-22 | 2023-02-22 | N/A | 2025-02-22 |
| follitropin delta | 188743 | Rekovelle | Ferring Inc. | N/A | 2018-03-22 | 2024-03-22 | N/A | 2026-03-22 |
| fostamatinib (supplied as fostamatinib disodium) | 232078 | Tavalisse | Medison Pharma Canada Inc. | N/A | 2020-11-19 | 2026-11-19 | N/A | 2028-11-19 |
| fostemsavir (supplied as fostemsavir tromethamine) | 250213 | Rukobia | ViiV Healthcare ULC | N/A | 2021-10-01 | 2027-10-01 | N/A | 2029-10-01 |
| fremanezumab | 226828 | Ajovy | Teva Canada Limited | N/A | 2020-04-09 | 2026-04-09 | N/A | 2028-04-09 |
| gadoterate meglumine | 186333 | Dotarem | Guerbet | N/A | 2016-11-26 | 2022-11-26 | Yes | 2025-05-26 |
| galcanezumab | 219521 | Emgality | Eli Lilly Canada Inc. | N/A | 2019-07-30 | 2025-07-30 | N/A | 2027-07-30 |
| gemtuzumab ozogamicin | 223091 | Mylotarg | Pfizer Canada ULC | N/A | 2019-11-28 | 2025-11-28 | Yes | 2028-05-28 |
| gilteritinib fumarate | 227918 | Xospata | Astellas Pharma Canada Inc. | N/A | 2019-12-23 | 2025-12-23 | N/A | 2027-12-23 |
| givosiran (supplied as givosiran sodium) | 237194 | Givlaari | Alnylam Netherlands B.V. | N/A | 2020-10-09 | 2026-10-09 | N/A | 2028-10-09 |
| glasdegib | 225793 | Daurismo | Pfizer Canada ULC | N/A | 2020-04-28 | 2026-04-28 | N/A | 2028-04-28 |
| glecaprevir, pibrentasvir | 202233 | Maviret | AbbVie Corporation | N/A | 2017-08-16 | 2023-08-16 | Yes | 2026-02-16 |
| glofitamab | 265517 | Columvi | Hoffmann-La Roche Limited | N/A | 2023-03-24 | 2029-03-24 | N/A | 2031-03-24 |
| glycerol phenylbutyrate | 174219 | Ravicti | Horizon Pharma Ireland Ltd. | N/A | 2016-03-18 | 2022-03-18 | Yes | 2024-09-18 |
| grazoprevir, elbasvir | 185866 | Zepatier | Merck Canada Inc. | N/A | 2016-01-19 | 2022-01-19 | N/A | 2024-01-19 |
| guselkumab | 200590 | Tremfya | Janssen Inc. | N/A | 2017-11-10 | 2023-11-10 | N/A | 2025-11-10 |
| hemin | 212276 | Panhematin | Recordati Rare Diseases Canada Inc. | N/A | 2018-07-13 | 2024-07-13 | N/A | 2026-07-13 |
| hepatitis B surface antigen (recombinant) | 259302 | Prehevbrio | VBI Vaccines Inc. | N/A | 2022-12-06 | 2028-12-06 | N/A | 2030-12-06 |
| icosapent ethyl | 227235 | Vascepa | HLS Therapeutics Inc. | N/A | 2019-12-30 | 2025-12-30 | N/A | 2027-12-30 |
| idarucizumab | 182503 | Praxbind | Boehringer Ingelheim (Canada) Ltd | N/A | 2016-04-29 | 2022-04-29 | N/A | 2024-04-29 |
| idecabtagene vicleucel | 244266 | Abecma | Celgene Inc. | N/A | 2021-05-26 | 2027-05-26 | N/A | 2029-05-26 |
| imelasomeran | 265656 | Spikevax Bivalent | Moderna Biopharma Canada Corporation | N/A | 2022-09-01 | 2028-09-01 | Yes | 2031-03-01 |
| inclisiran sodium | 243470 | Leqvio | Novartis Pharmaceuticals Canada Inc. | N/A | 2021-07-26 | 2027-07-26 | N/A | 2029-07-26 |
| infigratinib (supplied as infigratinib phosphate) | 246904 | Truseltiq | QED Therapeutics, Inc. | N/A | 2021-09-27 | 2027-09-27 | N/A | 2029-09-27 |
| inotersen sodium | 214274 | Tegsedi | Akcea Therapeutics Inc. | N/A | 2018-10-03 | 2024-10-03 | N/A | 2026-10-03 |
| inotuzumab ozogamicin | 204077 | Besponsa | Pfizer Canada Inc. | N/A | 2018-03-15 | 2024-03-15 | N/A | 2026-03-15 |
| insulin degludec | 198124 | Tresiba | Novo Nordisk Canada Inc. | Xultophy | 2017-08-25 | 2023-08-25 | Yes | 2026-02-25 |
| ioflupane (123I) | 201481 | Datscan | GE Healthcare Canada Inc. | N/A | 2017-12-07 | 2023-12-07 | N/A | 2025-12-07 |
| isatuximab | 229245 | Sarclisa | Sanofi-Aventis Canada Inc. | N/A | 2020-04-29 | 2026-04-29 | N/A | 2028-04-29 |
| isavuconazole (supplied as isavuconazonium sulfate) | 208919 | Cresemba | Avir Pharma Inc. | N/A | 2018-12-19 | 2024-12-19 | N/A | 2026-12-19 |
| ivabradine hydrochloride | 166949 | Lancora | Servier Canada Inc. | N/A | 2016-12-23 | 2022-12-23 | Yes | 2025-06-23 |
| ixazomib (supplied as ixazomib citrate) | 190498 | Ninlaro | Takeda Canada Inc. | N/A | 2016-08-04 | 2022-08-04 | N/A | 2024-08-04 |
| ixekizumab | 184993 | Taltz | Eli Lilly Canada Inc. | N/A | 2016-05-25 | 2022-05-25 | Yes | 2024-11-25 |
| lanadelumab | 213920 | Takhzyro | Takeda Canada Inc. | N/A | 2018-09-19 | 2024-09-19 | Yes | 2027-03-19 |
| larotrectinib (supplied as larotrectinib sulfate) | 219998 | Vitrakvi | Bayer Inc. | N/A | 2019-07-10 | 2025-07-10 | Yes | 2028-01-10 |
| latanoprostene bunod | 211732 | Vyzulta | Bausch & Lomb Incorporated | N/A | 2018-12-27 | 2024-12-27 | N/A | 2026-12-27 |
| lefamulin acetate | 233292 | Xenleta | Sunovion Pharmaceuticals Canada Inc. | N/A | 2020-07-10 | 2026-07-10 | N/A | 2028-07-10 |
| lemborexant | 231286 | Dayvigo | Eisai Limited | N/A | 2020-11-04 | 2026-11-04 | N/A | 2028-11-04 |
| lenacapavir (supplied as lenacapavir sodium) | 262999 | Sunlenca | Gilead Sciences Canada, Inc. | N/A | 2022-11-02 | 2028-11-02 | N/A | 2030-11-02 |
| lenvatinib mesylate | 180877 | Lenvima | Eisai Limited | N/A | 2015-12-22 | 2021-12-22 | Yes | 2024-06-22 |
| letermovir | 204165 | Prevymis | Merck Canada Inc. | N/A | 2017-11-01 | 2023-11-01 | N/A | 2025-11-01 |
| lifitegrast | 199810 | Xiidra | Novartis Pharmaceuticals Canada Inc. | N/A | 2017-12-22 | 2023-12-22 | N/A | 2025-12-22 |
| lisocabtagene maraleucel | 247562 | Breyanzi | Celgene Inc. | N/A | 2022-05-06 | 2028-05-06 | N/A | 2030-05-06 |
| lixisenatide | 193862 | Adlyxine | Sanofi-Aventis Canada Inc. | Soliqua | 2017-05-25 | 2023-05-25 | N/A | 2025-05-25 |
| lorlatinib | 215733 | Lorbrena | Pfizer Canada ULC | N/A | 2019-02-22 | 2025-02-22 | N/A | 2027-02-22 |
| lumacaftor | 181715 | Orkambi | Vertex Pharmaceuticals (Canada) Incorporated | N/A | 2016-01-26 | 2022-01-26 | Yes | 2024-07-26 |
| lumasiran (supplied as lumasiran sodium) | 254883 | Oxlumo | Alnylam Netherlands B.V. | N/A | 2022-03-07 | 2028-03-07 | Yes | 2030-09-07 |
| lurbinectedin | 247485 | Zepzelca | Jazz Pharmaceuticals Ireland Limited | N/A | 2021-09-29 | 2027-09-29 | N/A | 2029-09-29 |
| luspatercept | 236441 | Reblozyl | Celgene Inc. | N/A | 2020-09-25 | 2026-09-25 | N/A | 2028-09-25 |
| lutetium (177Lu) oxodotreotide | 217184 | Lutathera | Advanced Accelerator Applications USA, Inc. | N/A | 2019-01-09 | 2025-01-09 | N/A | 2027-01-09 |
| lutetium (177Lu) vipivotide tetraxetan | 260951 | Pluvicto | Advanced Accelerator Applications USA, Inc. | N/A | 2022-08-25 | 2028-08-25 | N/A | 2030-08-25 |
| maralixibat chloride | 271030 | Livmarli | Mirum Pharmaceuticals, Inc. | N/A | 2023-07-21 | 2029-07-21 | Yes | 2032-01-21 |
| maribavir | 259676 | Livtencity | Takeda Canada Inc. | N/A | 2022-09-15 | 2028-09-15 | N/A | 2030-09-15 |
| mavacamten | 258772 | Camzyos | Bristol-Myers Squibb Canada | N/A | 2022-11-08 | 2028-11-08 | N/A | 2030-11-08 |
| mecasermin | 235023 | Increlex | Ipsen Biopharmaceuticals Canada Inc. | N/A | 2020-12-17 | 2026-12-17 | Yes | 2029-06-17 |
| mepolizumab | 179850 | Nucala | GlaxoSmithKline Inc. | N/A | 2015-12-03 | 2021-12-03 | Yes | 2024-06-03 |
| midostaurin | 201101 | Rydapt | Novartis Pharmaceuticals Canada Inc. | N/A | 2017-07-21 | 2023-07-21 | Yes | 2026-01-21 |
| mifepristone | 160063 | Mifegymiso | Linepharma International Limited | N/A | 2015-07-29 | 2021-07-29 | Yes | 2024-01-29 |
| migalastat hydrochloride | 196956 | Galafold | Amicus Therapeutics Canada Inc. | N/A | 2017-09-05 | 2023-09-05 | Yes | 2026-03-05 |
| mirikizumab | 266471 | Omvoh | Eli Lilly Canada Inc. | N/A | 2023-07-20 | 2029-07-20 | N/A | 2031-07-20 |
| mogamulizumab | 251277 | Poteligeo | Kyowa Kirin, Inc. | N/A | 2022-06-02 | 2028-06-02 | N/A | 2030-06-02 |
| necitumumab | 193689 | Portrazza | Eli Lilly Canada Inc. | N/A | 2017-03-16 | 2023-03-16 | N/A | 2025-03-16 |
| neisseria meningitidis serogroup B recombinant lipoprotein 2086 (rLP2086) subfamily A and Neisseria meningitidis serogroup B recombinant lipoprotein 2086 (rLP2086) subfamily B | 195550 | Trumenba | Pfizer Canada Inc. | N/A | 2017-10-05 | 2023-10-05 | Yes | 2026-04-05 |
| neratinib maleate | 218224 | Nerlynx | Knight Therapeutics Inc. | N/A | 2019-07-16 | 2025-07-16 | N/A | 2027-07-16 |
| netupitant | 196495 | Akynzeo | Knight Therapeutics Inc. | N/A | 2017-09-28 | 2023-09-28 | N/A | 2025-09-28 |
| niraparib | 216792 | Zejula | GlaxoSmithKline Inc. | Akeega | 2019-06-27 | 2025-06-27 | N/A | 2027-06-27 |
| nirmatrelvir | 259186 | Paxlovid | Pfizer Canada ULC | N/A | 2022-01-17 | 2028-01-17 | N/A | 2030-01-17 |
| nirsevimab | 269388 | Beyfortus | AstraZeneca Canada Inc. | N/A | 2023-04-19 | 2029-04-19 | Yes | 2031-10-19 |
| nivolumab | 180828 | Opdivo | Bristol-Myers-Squibb Canada | Opdualag | 2015-09-25 | 2021-09-25 | Yes | 2024-03-25 |
| nusinersen | 200070 | Spinraza | Biogen Canada Inc. | N/A | 2017-06-29 | 2023-06-29 | Yes | 2025-12-29 |
| obeticholic acid | 198418 | Ocaliva | Advanz Pharma Canada Inc. | N/A | 2017-05-24 | 2023-05-24 | Yes | 2025-11-24 |
| obiltoxaximab | 230825 | Anthim | Elusys Therapeutics, Inc. | N/A | 2020-07-30 | 2026-07-30 | N/A | 2028-07-30 |
| ocrelizumab | 198094 | Ocrevus | Hoffmann-La Roche Limited | N/A | 2017-08-14 | 2023-08-14 | N/A | 2025-08-14 |
| odevixibat | 273741 | Bylvay | Medison Pharma Canada Inc. | N/A | 2023-10-30 | 2029-10-30 | Yes | 2032-04-30 |
| olaparib | 182823 | Lynparza | AstraZeneca Canada Inc. | N/A | 2016-04-29 | 2022-04-29 | N/A | 2024-04-29 |
| olaratumab | 203478 | Lartruvo | Eli Lilly Canada Inc. | N/A | 2017-11-23 | 2023-11-23 | N/A | 2025-11-23 |
| onasemnogene abeparvovec | 239719 | Zolgensma | Novartis Pharmaceuticals Canada Inc. | N/A | 2020-12-15 | 2026-12-15 | Yes | 2029-06-15 |
| osimertinib mesylate | 188171 | Tagrisso | AstraZeneca Canada Inc. | N/A | 2016-07-05 | 2022-07-05 | N/A | 2024-07-05 |
| ospemifene | 222001 | Osphena | Duchesnay Inc. | N/A | 2021-07-16 | 2027-07-16 | N/A | 2029-07-16 |
| ozanimod (supplied as ozanimod hydrochloride) | 232761 | Zeposia | Celgene Inc. | N/A | 2020-10-02 | 2026-10-02 | N/A | 2028-10-02 |
| ozenoxacin | 192925 | Ozanex | Ferrer Internacional, S.A. | N/A | 2017-05-01 | 2023-05-01 | Yes | 2025-11-01 |
| palbociclib | 182048 | Ibrance | Pfizer Canada Inc. | N/A | 2016-03-16 | 2022-03-16 | Yes | 2024-09-16 |
| palovarotene | 252065 | Sohonos | Ipsen Biopharmaceuticals Canada Inc. | N/A | 2022-01-21 | 2028-01-21 | Yes | 2030-07-21 |
| patiromer sorbitex calcium | 210368 | Veltassa | Vifor Fresenius Medical Care Renal Pharma Ltd. | N/A | 2018-10-03 | 2024-10-03 | N/A | 2026-10-03 |
| patisiran (as patisiran sodium) | 221896 | Onpattro | Alnylam Netherlands B.V. | N/A | 2019-06-07 | 2025-06-07 | N/A | 2027-06-07 |
| pegcetacoplan | 263432 | Empaveli | Swedish Orphan Biovitrium AB (publ) | N/A | 2022-12-08 | 2028-12-08 | N/A | 2030-12-08 |
| pegvaliase | 251687 | Palynziq | BioMarin International Limited | N/A | 2022-03-30 | 2028-03-30 | Yes | 2030-09-30 |
| pemigatinib | 242569 | Pemazyre | Incyte Corporation | N/A | 2021-09-17 | 2027-09-17 | N/A | 2029-09-17 |
| peramivir | 191280 | Rapivab | BioCryst Pharmaceuticals Inc. | N/A | 2017-01-05 | 2023-01-05 | N/A | 2025-01-05 |
| pitolisant hydrochloride | 238175 | Wakix | Endo Ventures Ltd. | N/A | 2021-05-25 | 2027-05-25 | N/A | 2029-05-25 |
| plecanatide | 215288 | Trulance | Bausch Health, Canada Inc. | N/A | 2019-10-10 | 2025-10-10 | N/A | 2027-10-10 |
| pneumococcal polysaccharide serotypes 22F and 33F conjugated to CRM-197. | 247042 | Vaxneuvance | Merk Canada Inc. | N/A | 2021-11-16 | 2027-11-16 | Yes | 2030-05-16 |
| pneumococcal polysaccharide serotypes 8, 10A, 11A, 12F and 15B individually conjugated to CRM197 protein | 253111 | Prevnar 20 | Pfizer Canada ULC | N/A | 2022-05-09 | 2028-05-09 | Yes | 2030-11-09 |
| polatuzumab vedotin | 232303 | Polivy | Hoffmann-La Roche Limited | N/A | 2020-07-09 | 2026-07-09 | N/A | 2028-07-09 |
| ponesimod | 239537 | Ponvory | Janssen Inc. | N/A | 2021-04-28 | 2027-04-28 | N/A | 2029-04-28 |
| pralatrexate | 207545 | Folotyn | Servier Canada Inc. | N/A | 2018-10-26 | 2024-10-26 | N/A | 2026-10-26 |
| pralsetinib | 243731 | Gavreto | Hoffmann-La Roche Limited | N/A | 2021-06-30 | 2027-06-30 | N/A | 2029-06-30 |
| prasterone | 198822 | Intrarosa | Cosette Pharmaceuticals, Inc. | N/A | 2019-11-01 | 2025-11-01 | N/A | 2027-11-01 |
| propiverine hydrochloride | 188323 | Mictoryl / Mictoryl Pediatric | Duchesnay Inc. | N/A | 2017-01-05 | 2023-01-05 | Yes | 2025-07-05 |
| ravulizumab | 217955 | Ultomiris | Alexion Pharma GmbH | N/A | 2019-08-28 | 2025-08-28 | Yes | 2028-02-28 |
| raxtozinameran | 276302 | Comirnaty Omicron XBB.1.5 | BioNTech Manufacturing GmbH | N/A | 2023-09-28 | 2029-09-28 | N/A | 2031-09-28 |
| recombinant haemagglutinin protein-strain A (H1N1) recombinant haemagglutinin protein-strain A (H3N2) recombinant haemagglutinin protein-strain B (Victoria) recombinant haemagglutinin protein-strain B (Yamagata) |
235672 | Supemtek | Sanofi Pasteur Limited | N/A | 2021-01-14 | 2027-01-14 | N/A | 2029-01-14 |
| recombinant human hyaluronidase | 247727 | Hyqvia | Takeda Canada Inc. | N/A | 2022-01-14 | 2028-01-14 | Yes | 2030-07-14 |
| relatlimab | 256629 | Opdualag | Bristol-Myers Squibb Canada | N/A | 2023-09-13 | 2029-09-13 | Yes | 2032-03-13 |
| relugolix | 267148 | Myfembree | Sumitomo Pharma Switzerland GmbH | Orgovyx | 2023-09-22 | 2029-09-22 | N/A | 2031-09-22 |
| remdesivir | 240551 | Veklury | Gilead Sciences Canada, Inc. | N/A | 2020-07-27 | 2026-07-27 | Yes | 2029-01-27 |
| reslizumab | 185873 | Cinqair | Teva Canada Limited | N/A | 2016-07-20 | 2022-07-20 | Yes | 2025-01-20 |
| respiratory syncytial virus prefusion F protein (RSVPreF3) | 269021 | Arexvy | GlaxoSmithKline Inc. | N/A | 2023-08-04 | 2029-08-04 | N/A | 2031-08-04 |
| ribociclib (supplied as ribociclib succinate) | 203884 | Kisqali | Novartis Pharmaceuticals Canada Inc. | N/A | 2018-03-02 | 2024-03-02 | N/A | 2026-03-02 |
| riltozinameran | 266189 | Comirnaty Original / Omicron BA.1 | BioNTech Manufacturing GmbH | N/A | 2022-10-21 | 2028-10-21 | Yes | 2031-04-21 |
| rimegepant | 268384 | Nurtec ODT | Pfizer Canada ULC | N/A | 2023-12-01 | 2029-12-01 | N/A | 2031-12-01 |
| ripretinib | 234688 | Qinlock | Deciphera Pharmaceuticals, LLC | N/A | 2020-06-19 | 2026-06-19 | N/A | 2028-06-19 |
| risankizumab | 215753 | Skyrizi | AbbVie Corporation | N/A | 2019-04-17 | 2025-04-17 | Yes | 2027-10-17 |
| risdiplam | 242373 | Evrysdi | Hoffman-La Roche Limited | N/A | 2021-04-14 | 2027-04-14 | Yes | 2029-10-14 |
| ritlecitinib tosylate | 268723 | Litfulo | Pfizer Canada ULC | N/A | 2023-11-29 | 2029-11-29 | Yes | 2032-05-29 |
| romosozumab | 197713 | Evenity | Amgen Canada Inc. | N/A | 2019-06-17 | 2025-06-17 | N/A | 2027-06-17 |
| rupatadine (supplied as rupatadine fumarate) | 186488 | Rupall | Medexus Inc. | N/A | 2016-07-20 | 2022-07-20 | Yes | 2025-01-20 |
| sacituzumab govitecan | 248753 | Trodelvy | Gilead Sciences Canada, Inc. | N/A | 2021-09-24 | 2027-09-24 | N/A | 2029-09-24 |
| sacubitril | 182734 | Entresto | Novartis Pharmaceuticals Canada Inc. | N/A | 2015-10-02 | 2021-10-02 | Yes | 2024-04-02 |
| safinamide (as safinamide mesylate) | 207115 | Onstryv | Valeo Pharma Inc. | N/A | 2019-01-10 | 2025-01-10 | N/A | 2027-01-10 |
| sarilumab | 191745 | Kevzara | Sanofi-Aventis Canada Inc. | N/A | 2017-01-12 | 2023-01-12 | N/A | 2025-01-12 |
| SARS-CoV-2 recombinant spike protein | 255370 | Nuvaxovid | Novavax Inc. | N/A | 2022-02-17 | 2028-02-17 | Yes | 2030-08-17 |
| satralizumab | 233642 | Enspryng | Hoffmann-La Roche Limited | N/A | 2020-06-01 | 2026-06-01 | Yes | 2028-12-01 |
| sebelipase alfa | 204085 | Kanuma | Alexion Pharma GmbH | N/A | 2017-12-15 | 2023-12-15 | Yes | 2026-06-15 |
| selexipag | 182114 | Uptravi | Janssen Inc. | N/A | 2016-01-20 | 2022-01-20 | Yes | 2024-07-20 |
| selinexor | 253182 | Xpovio | FORUS Therapeutics Inc. | N/A | 2022-05-31 | 2028-05-31 | N/A | 2030-05-31 |
| selpercatinib | 243748 | Retevmo | Loxo Oncology Inc. | N/A | 2021-06-15 | 2027-06-15 | Yes | 2029-12-15 |
| selumetinib sulfate | 243733 | Koselugo | Alexion Pharma GmbH | N/A | 2022-08-31 | 2028-08-31 | Yes | 2031-03-03 |
| semaglutide | 202059 | Ozempic | Novo Nordisk Canada Inc. | Rybelsus Wegovy |
2018-01-04 | 2024-01-04 | N/A | 2026-01-04 |
| setmelanotide acetate | 268412 | Imcivree | Rhythm Pharmaceuticals, Inc. | N/A | 2023-05-05 | 2029-05-05 | Yes | 2031-11-05 |
| siponimod | 223225 | Mayzent | Novartis Pharmaceuticals Canada Inc. | N/A | 2020-02-20 | 2026-02-20 | N/A | 2028-02-20 |
| sodium zirconium cyclosilicate | 218799 | Lokelma | AstraZeneca Canada Inc. | N/A | 2019-07-25 | 2025-07-25 | N/A | 2027-07-25 |
| solriamfetol hydrochloride | 237511 | Sunosi | Axsome Malta Ltd. | N/A | 2021-05-13 | 2027-05-13 | N/A | 2029-11-13 |
| somapacitan | 267443 | Sogroya | Novo Nordisk Canada Inc. | N/A | 2023-07-26 | 2029-07-26 | Yes | 2032-01-26 |
| somatrogon | 246729 | Ngenla | Pfizer Canada ULC | N/A | 2021-10-26 | 2027-10-26 | Yes | 2030-04-26 |
| sonidegib phosphate | 229407 | Odomzo | Sun Pharmaceutical Industries Ltd. | N/A | 2020-06-12 | 2026-06-12 | N/A | 2028-06-12 |
| sotorasib | 248435 | Lumakras | Amgen Canada Inc. | N/A | 2021-09-10 | 2027-09-10 | N/A | 2029-09-10 |
| spesolimab | 267362 | Spevigo | Boehringer Ingelheim (Canada) Ltd. | N/A | 2023-03-22 | 2029-03-22 | N/A | 2031-03-22 |
| sucroferric oxyhydroxide | 201492 | Velphoro | Vifor Fresenius Medical Care Renal Pharma Ltd. | N/A | 2018-01-05 | 2024-01-05 | N/A | 2026-01-05 |
| sugammadex sodium | 180385 | Bridion | Merck Canada Inc. | N/A | 2016-02-05 | 2022-02-05 | Yes | 2024-08-05 |
| suvorexant | 196367 | Belsomra | Merck Canada Inc. | N/A | 2018-11-29 | 2024-11-29 | N/A | 2026-11-29 |
| tafamidis meglumine | 228368 | Vyndaqel | Pfizer Canada ULC | Vyndamax | 2020-01-20 | 2026-01-20 | N/A | 2028-01-20 |
| tafasitamab | 247025 | Minjuvi | Incyte Corporation | N/A | 2021-08-19 | 2027-08-19 | N/A | 2029-08-19 |
| talazoparib (supplied as talazoparib tosylate) | 220584 | Talzenna | Pfizer Canada ULC | N/A | 2019-09-06 | 2025-09-06 | N/A | 2027-09-06 |
| tebentafusp | 258717 | Kimmtrak | Immunocore Ireland Limited | N/A | 2022-06-07 | 2028-06-07 | N/A | 2030-06-07 |
| teclistamab | 269369 | Tecvayli | Janssen Inc. | N/A | 2023-07-26 | 2029-07-26 | N/A | 2031-07-26 |
| tecovirimat monohydrate | 247561 | Tpoxx | Siga Technologies, Inc. | N/A | 2021-11-29 | 2027-11-29 | Yes | 2030-05-29 |
| teduglutide | 180223 | Revestive | Takeda Canada Inc. | N/A | 2015-09-04 | 2021-09-04 | Yes | 2024-03-04 |
| telotristat ethyl (as telotristat etiprate) | 208730 | Xermelo | SERB SAS | N/A | 2018-10-10 | 2024-10-10 | N/A | 2026-10-10 |
| tenapanor hydrochloride | 224850 | Ibsrela | Knight Therapeutics Inc. | N/A | 2020-04-15 | 2026-04-15 | N/A | 2028-04-15 |
| tenofovir alafenamide hemifumarate | 181399 | Genvoya | Gilead Sciences Canada Inc. | Descovy Odefsey Vemlidy Symtuza Biktarvy |
2015-11-27 | 2021-11-27 | Yes | 2024-05-27 |
| tepotinib (supplied as tepotinib hydrochloride) | 242300 | Tepmetko | EMD Serono, a Division of EMD Inc., Canada | N/A | 2021-05-27 | 2027-05-27 | N/A | 2029-05-27 |
| tezacaftor | 211292 | Symdeko | Vertex Pharmaceuticals (Canada) Incorporated | Trikafta | 2018-06-27 | 2024-06-27 | Yes | 2026-12-27 |
| tezepelumab | 256188 | Tezspire | AstraZeneca Canada Inc. | N/A | 2022-07-28 | 2028-07-28 | Yes | 2031-01-28 |
| tildrakizumab | 224036 | Ilumya | Sun Pharmaceutical Industries Ltd. | N/A | 2021-05-19 | 2027-05-19 | N/A | 2029-05-19 |
| tipiracil hydrochloride | 205852 | Lonsurf | Taiho Pharma Canada Inc. | N/A | 2018-01-25 | 2024-01-25 | N/A | 2026-01-25 |
| tirbanibulin | 262080 | Onakta | AVIR Pharma Inc. | N/A | 2023-05-12 | 2029-05-12 | N/A | 2031-05-12 |
| tirzepatide | 259103 | Mounjaro | Eli Lilly Canada Inc. | N/A | 2022-11-24 | 2028-11-24 | N/A | 2030-11-24 |
| tisagenlecleucel | 213547 / 213698 |
Kymriah | Novartis Pharmaceuticals Canada Inc. | N/A | 2018-09-05 | 2024-09-05 | Yes | 2027-03-05 |
| tixagevimab / cilgavimab | 258295 | Evusheld | AstraZeneca Canada Inc. | N/A | 2022-04-14 | 2028-04-14 | N/A | 2030-04-14 |
| tozinameran | 252736 | Comirnaty | BioNTech Manufacturing GmbH | Comirnaty Original & Omicron BA.4/BA.5 Comirnaty Original/Omicron BA.1 |
2021-09-16 | 2027-09-16 | Yes | 2030-03-16 |
| tralokinumab | 245877 | Adtralza | LEO Pharma Inc. | N/A | 2021-10-13 | 2027-10-13 | Yes | 2030-04-13 |
| trastuzumab deruxtecan | 242104 | Enhertu | AstraZeneca Canada Inc. | N/A | 2021-04-15 | 2027-04-15 | N/A | 2029-04-15 |
| tremelimumab | 262740 | Imjudo | AstraZeneca Canada Inc. | N/A | 2023-08-31 | 2029-08-31 | N/A | 2031-08-31 |
| trifarotene | 221945 | Aklief | Galderma Canada Inc. | N/A | 2019-11-25 | 2025-11-25 | Yes | 2028-05-25 |
| triheptanoin | 242196 | Dojolvi | Ultragenyx Pharmaceutical Inc. | N/A | 2021-02-15 | 2027-02-15 | Yes | 2029-08-15 |
| tucatinib | 235295 | Tukysa | Seagen Inc. | N/A | 2020-06-05 | 2026-06-05 | N/A | 2028-06-05 |
| ubrogepant | 256191 | Ubrelvy | AbbVie Corporation | N/A | 2022-11-10 | 2028-11-10 | N/A | 2030-11-10 |
| upadacitinib | 223734 | Rinvoq | AbbVie Corporation | N/A | 2019-12-23 | 2025-12-23 | Yes | 2028-06-23 |
| ursodoxicoltaurine | 253502 | Albrioza | Amylyx Pharmaceuticals Inc. | N/A | 2022-06-10 | 2028-06-10 | N/A | 2030-06-10 |
| varicella-zoster virus glycoprotein E (gE) | 200244 | Shingrix | GlaxoSmithKline Inc. | N/A | 2017-10-13 | 2023-10-13 | N/A | 2025-10-13 |
| velpatasvir | 190521 | Epclusa | Gilead Sciences Canada Inc. | Vosevi | 2016-07-11 | 2022-07-11 | Yes | 2025-01-11 |
| venetoclax | 190761 | Venclexta | AbbVie Corporation | N/A | 2016-09-30 | 2022-09-30 | N/A | 2024-09-30 |
| vericiguat | 240862 | Verquvo | Bayer Inc. | N/A | 2023-04-28 | 2029-04-28 | N/A | 2031-04-28 |
| vernakalant hydrochloride | 190817 | Brinavess | Cipher Pharmaceuticals Inc. | N/A | 2017-03-13 | 2023-03-13 | N/A | 2025-03-13 |
| vilazodone hydrochloride | 176820 | Viibryd | AbbVie Corporation | N/A | 2015-07-16 | 2021-07-16 | Yes | 2024-01-16 |
| virus-like particles (VLP) of sars-cov-2 spike protein | 254598 | Covifenz | Medicago Inc. | N/A | 2022-02-24 | 2028-02-24 | N/A | 2030-02-24 |
| von willebrand factor (recombinant) (vonicog alfa) | 213188 | Vonvendi | Takeda Canada Inc. | N/A | 2019-01-10 | 2025-01-10 | N/A | 2027-01-10 |
| vorapaxar sulfate | 179320 | Zontivity | Xspire Pharma, LLC | N/A | 2016-05-13 | 2022-05-13 | N/A | 2024-05-13 |
| voretigene neparvovec | 233097 | Luxturna | Novartis Pharmaceuticals Canada Inc. | N/A | 2020-10-13 | 2026-10-13 | Yes | 2029-04-13 |
| voxilaprevir | 202324 | Vosevi | Gilead Sciences Canada Inc. | N/A | 2017-08-16 | 2023-08-16 | N/A | 2025-08-16 |
| vutrisiran sodium | 267923 | Amvuttra | Alnylam Netherlands B.V. | N/A | 2023-10-18 | 2029-10-18 | N/A | 2031-10-18 |
| zanubrutinib | 242748 | Brukinsa | BeiGene Switzerland GmbH | N/A | 2021-03-01 | 2027-03-01 | N/A | 2029-03-01 |
| Medicinal Ingredient(s) Footnote 1 |
Submission Number | Innovative Drug | Manufacturer | Drug(s) Containing the Medicinal Ingredient / Variations |
Notice of Compliance Date yyyy-mm-dd | 6 Year "No File" Date |
Pediatric Extension Yes/No | Data Protection Ends |
|---|---|---|---|---|---|---|---|---|
| empagliflozin | 162552 | Jardiance | Boehringer Ingelheim (Canada) Ltd. | Synjardy Glyxambi |
2015-07-23 | 2021-07-23 | N/A | 2023-07-23 |
| abatacept | 098531 | Orencia | Bristol-Myers Squibb Canada | N/A | 2006-06-29 | 2012-06-29 | Yes | 2014-12-29 |
| abiraterone acetate | 138343 | Zytiga | Janssen Inc. | N/A | 2011-07-27 | 2017-07-27 | N/A | 2019-07-27 |
| acamprosate calcium | 103287 | Campral | Mylan Pharmaceuticals ULC | N/A | 2007-03-16 | 2013-03-16 | N/A | 2015-03-16 |
| aclidinium bromide | 157598 | Tudorza Genuair | AstraZeneca Canada Inc. | Duaklir Genuair | 2013-07-29 | 2019-07-29 | N/A | 2021-07-29 |
| afatinib dimaleate | 158730 | Giotrif | Boehringer Ingelheim (Canada) Ltd. | N/A | 2013-11-01 | 2019-11-01 | N/A | 2021-11-01 |
| aflibercept | 149321 | Eylea | Bayer Inc. | N/A | 2013-11-08 | 2019-11-08 | N/A | 2021-11-08 |
| albiglutide | 165145 | Eperzan | GlaxoSmithKline Inc. | N/A | 2015-07-15 | 2021-07-15 | N/A | 2023-07-15 |
| alglucosidase alfa | 103381 | Myozyme | Genzyme Canada Inc. | N/A | 2006-08-14 | 2012-08-14 | Yes | 2015-02-14 |
| aliskiren hemifumarate | 105388 | Rasilez | Novartis Pharmaceuticals Canada Inc. | Rasilez HCT Rasilamlo |
2007-11-14 | 2013-11-14 | N/A | 2015-11-14 |
| alogliptin benzoate | 158335 | Nesina | Takeda Canada Inc. | Kazano Oseni |
2013-11-27 | 2019-11-27 | N/A | 2021-11-27 |
| ambrisentan | 113287 | Volibris | GlaxoSmithKline Inc. | N/A | 2008-03-20 | 2014-03-20 | N/A | 2016-03-20 |
| anidulafungin | 110202 | Eraxis | Pfizer Canada Inc. | N/A | 2007-11-14 | 2013-11-14 | Yes | 2016-05-14 |
| antihemophilic factor (recombinant BDD), Fc fusion protein | 163447 | Eloctate | Sanofi-Aventis Canada Inc. | N/A | 2014-08-22 | 2020-08-22 | Yes | 2023-02-22 |
| antihemophilic factor (recombinant, B-domain deleted) (also known as simoctocog alfa) | 169551 | Nuwiq | Octapharma Pharmazeutika Produktionsges.m.b.H | N/A | 2014-10-23 | 2020-10-23 | Yes | 2023-04-23 |
| apixaban | 141873 | Eliquis | Bristol-Myers Squibb Canada | N/A | 2011-12-16 | 2017-12-16 | Yes | 2020-06-16 |
| apremilast | 169862 | Otezla | Amgen Canada Inc. | N/A | 2014-11-12 | 2020-11-12 | N/A | 2022-11-12 |
| aprepitant | 108483 | Emend | Merck Frosst Canada Ltd. | Emend Tri-Pack Emend IV |
2007-08-24 | 2013-08-24 | N/A | 2015-08-24 |
| aripiprazole | 120192 | Abilify | Bristol-Myers Squibb Canada | Abilify Maintena | 2009-07-09 | 2015-07-09 | Yes | 2018-01-09 |
| asenapine maleate | 127427 | Saphris | Merck Canada Inc. | N/A | 2011-10-07 | 2017-10-07 | Yes | 2020-04-07 |
| axitinib | 144404 | Inlyta | Pfizer Canada Inc. | N/A | 2012-07-12 | 2018-07-12 | Yes | 2021-01-12 |
| azacitidine | 127108 | Vidaza | Celgene | N/A | 2009-10-23 | 2015-10-23 | N/A | 2017-10-23 |
| azelastine hydrochloride | 169604 | Dymista | BGP Pharma ULC | N/A | 2014-10-23 | 2020-10-23 | Yes | 2023-04-23 |
| azilsartan medoxomil potassium | 145305 | Edarbi | Valeant Canada LP | Edarbyclor | 2012-03-08 | 2018-03-08 | N/A | 2020-03-08 |
| bazedoxifene acetate | 160681 | Duavive | Pfizer Canada Inc. | N/A | 2014-10-23 | 2020-10-23 | N/A | 2022-10-23 |
| belimumab | 137699 | Benlysta | GlaxoSmithKline Inc. | N/A | 2011-07-06 | 2017-07-06 | N/A | 2019-07-06 |
| bendamustine hydrochloride | 149814 | Treanda | Teva Canada Limited | N/A | 2012-08-24 | 2018-08-24 | Yes | 2021-02-24 |
| besifloxacin | 123400 | Besivance | Bausch & Lomb Inc. | N/A | 2009-10-23 | 2015-10-23 | Yes | 2018-04-23 |
| boceprevir | 141556 | Victrelis | Merck Canada Inc. | Victrelis Triple | 2011-07-29 | 2017-07-29 | N/A | 2019-07-29 |
| bosutinib | 152211 | Bosulif | Pfizer Canada Inc. | N/A | 2014-03-07 | 2020-03-07 | N/A | 2022-03-07 |
| brentuximab vedotin | 154851 | Adcetris | Seattle Genetics Inc. | N/A | 2013-02-01 | 2019-02-01 | N/A | 2021-02-01 |
| bromfenac sodium sesquihydrate | 171657 | Prolensa | Bausch & Lomb Incorporated | N/A | 2015-03-26 | 2021-03-26 | N/A | 2023-03-26 |
| cabazitaxel | 137421 | Jevtana | Sanofi-aventis Canada Inc. | N/A | 2011-06-16 | 2017-06-16 | Yes | 2019-12-16 |
| canagliflozin | 157505 | Invokana | Janssen Inc. | Invokamet Invokamet XR |
2014-05-23 | 2020-05-23 | N/A | 2022-05-23 |
| canakinumab | 131009 | Ilaris | Novartis Pharmaceuticals Canada Inc. | N/A | 2010-02-26 | 2016-02-26 | Yes | 2018-08-26 |
| carglumic acid | 171358 | Carbaglu | Recordati Rare Diseases | N/A | 2015-04-10 | 2021-04-10 | Yes | 2023-10-10 |
| catridecacog | 152228 | Tretten | Novo Nordisk Canada Inc. | N/A | 2012-07-19 | 2018-07-19 | Yes | 2021-01-19 |
| catumaxomab | 142629 | Removab | Fresenius Biotech GmbH | N/A | 2012-05-11 | 2018-05-11 | N/A | 2020-05-11 |
| ceftobiprole medocaril | 112752 | Zeftera | Janssen Inc. | N/A | 2008-06-26 | 2014-06-26 | N/A | 2016-06-26 |
| ceftolozane | 178006 | Zerbaxa | Merck Canada Inc. | N/A | 2015-09-30 | 2021-09-30 | N/A | 2023-09-30 |
| ceritinib | 175702 | Zykadia | Novartis Pharmaceuticals Canada Inc. | N/A | 2015-03-27 | 2021-03-27 | N/A | 2023-03-27 |
| certolizumab pegol | 120296 | Cimzia | UCB Canada Inc. | N/A | 2009-08-12 | 2015-08-12 | N/A | 2017-08-12 |
| ciclesonide | 101419 | Alvesco | Takeda Canada Inc. | Omnaris Omnaris HFA |
2006-09-11 | 2012-09-11 | Yes | 2015-03-11 |
| clevidipine | 125287 | Cleviprex | Chiesi Farmaceutici S.p.A. | N/A | 2011-04-15 | 2017-04-15 | N/A | 2019-04-15 |
| clofarabine | 121874 | Clolar | Sanofi-aventis Canada Inc. | N/A | 2009-07-16 | 2015-07-16 | Yes | 2018-01-16 |
| coagulation factor IX, Fc fusion protein | 163614 | Alprolix | Sanofi-Aventis Canada Inc. | N/A | 2014-03-20 | 2020-03-20 | Yes | 2022-09-20 |
| colesevelam hydrochloride | 133463 | Lodalis | Valeant Canada LP / Valeant Canada S.E.C. | N/A | 2011-09-22 | 2017-09-22 | N/A | 2019-09-22 |
| collagenase clostridium histolyticum | 147788 | Xiaflex | Endo Ventures Ltd. | N/A | 2012-07-05 | 2018-07-05 | N/A | 2020-07-05 |
| crizotinib | 145155 | Xalkori | Pfizer Canada Inc. | N/A | 2012-04-25 | 2018-04-25 | Yes | 2020-10-25 |
| dabigatran etexilate mesilate | 114887 | Pradaxa | Boehringer Ingelheim (Canada) Ltd. | N/A | 2008-06-10 | 2014-06-10 | N/A | 2016-06-10 |
| dabrafenib mesylate | 157590 | Tafinlar | Novartis Pharmaceuticals Canada Inc. | N/A | 2013-07-16 | 2019-07-16 | N/A | 2021-07-16 |
| daclatasvir | 172616 | Daklinza | Bristol-Myers Squibb Canada | N/A | 2015-08-13 | 2021-08-13 | N/A | 2023-08-13 |
| dapagliflozin propanediol | 160877 | Forxiga | AstraZeneca Canada Inc. | Xigduo Qtern |
2014-12-12 | 2020-12-12 | N/A | 2022-12-12 |
| daptomycin | 102320 | Cubicin | Cubist Pharmaceuticals, Incorporated | N/A | 2007-09-24 | 2013-09-24 | Yes | 2016-03-24 |
| darunavir ethanolate | 103324 | Prezista | Janssen Inc. | N/A | 2006-07-28 | 2012-07-28 | Yes | 2015-01-28 |
| dasatinib monohydrate | 104993 | Sprycel | Bristol-Myers Squibb Canada | N/A | 2007-03-26 | 2013-03-26 | N/A | 2015-03-26 |
| deferasirox | 099621 | Exjade | Novartis Pharmaceuticals Canada Inc. | N/A | 2006-10-18 | 2012-10-18 | Yes | 2015-04-18 |
| deferiprone | 162924 | Ferriprox | Chiesi Canada Corp. | N/A | 2015-02-13 | 2021-02-13 | Yes | 2023-08-13 |
| degarelix acetate | 120421 | Firmagon | Ferring Inc. | N/A | 2009-11-16 | 2015-11-16 | N/A | 2017-11-16 |
| denosumab | 121139 | Prolia | Amgen Canada Inc. | Xgeva | 2010-08-06 | 2016-08-06 | N/A | 2018-08-06 |
| desvenlafaxine succinate | 115439 | Pristiq | Pfizer Canada Inc. | N/A | 2009-02-04 | 2015-02-04 | Yes | 2017-08-04 |
| dexmedetomidine hydrochloride | 126931 | Precedex | Pfizer Canada Inc. | N/A | 2009-12-09 | 2015-12-09 | Yes | 2018-06-09 |
| dienogest | 132174 | Visanne | Bayer Inc. | Natazia | 2011-10-12 | 2017-10-12 | Yes | 2020-04-12 |
| difluprednate | 154517 | Durezol | Novartis Pharmaceuticals Canada Inc. | N/A | 2013-11-04 | 2019-11-04 | Yes | 2022-05-04 |
| dimethyl fumarate | 154776 | Tecfidera | Biogen Idec Canada Inc. | N/A | 2013-04-03 | 2019-04-03 | Yes | 2021-10-03 |
| dolutegravir sodium | 161084 | Tivicay | ViiV Healthcare ULC | Triumeq Juluca Dovato |
2013-10-31 | 2019-10-31 | Yes | 2022-05-01 |
| doripenem monohydrate | 113640 | Doribax | Janssen Inc. | N/A | 2009-09-02 | 2015-09-02 | N/A | 2017-09-02 |
| dronedarone hydrochloride | 121065 | Multaq | Sanofi-aventis Canada Inc. | N/A | 2009-08-11 | 2015-08-11 | N/A | 2017-08-11 |
| dulaglutide | 168671 | Trulicity | Eli Lilly Canada Inc. | N/A | 2015-11-10 | 2021-11-10 | N/A | 2023-11-10 |
| duloxetine hydrochloride | 110028 | Cymbalta | Eli Lilly Canada Inc. | N/A | 2007-11-01 | 2013-11-01 | Yes | 2016-05-01 |
| eculizumab | 122467 | Soliris | Alexion Pharma International Sàrl | N/A | 2009-01-28 | 2015-01-28 | Yes | 2017-07-28 |
| efinaconazole | 159416 | Jublia | Bausch Health, Canada Inc. | N/A | 2013-10-02 | 2019-10-02 | N/A | 2021-10-02 |
| elosulfase alfa | 170340 | Vimizim | Biomarin International Limited | N/A | 2014-07-02 | 2020-07-02 | Yes | 2023-01-02 |
| eltrombopag olamine | 123984 | Revolade | Novartis Pharmaceuticals Canada Inc. | N/A | 2011-01-12 | 2017-01-12 | Yes | 2019-07-12 |
| elvitegravir, cobicistat | 152198 | Stribild | Gilead Sciences Canada Inc. | Tybost Vitekta Prezcobix Evotaz Genvoya Symtuza |
2012-11-26 | 2018-11-26 | N/A | 2020-11-26 |
| enzalutamide | 159678 | Xtandi | Astellas Pharma Canada Inc. | N/A | 2013-05-29 | 2019-05-29 | N/A | 2021-05-29 |
| eplerenone | 120440 | Inspra | Pfizer Canada Inc. | N/A | 2009-02-26 | 2015-02-26 | Yes | 2017-08-26 |
| eribulin mesylate | 141946 | Halaven | Eisai Limited | N/A | 2011-12-14 | 2017-12-14 | N/A | 2019-12-14 |
| eslicarbazepine acetate | 165665 | Aptiom | Sunovion Pharmaceuticals Canada Inc. | N/A | 2014-07-08 | 2020-07-08 | Yes | 2023-01-08 |
| etravirine | 113100 | Intelence | Janssen Inc. | N/A | 2008-03-27 | 2014-03-27 | Yes | 2016-09-27 |
| everolimus | 125809 | Afinitor | Novartis Pharmaceuticals Canada Inc. | Certican | 2009-12-14 | 2015-12-14 | Yes | 2018-06-14 |
| exenatide | 128932 | Byetta | AstraZeneca Canada Inc. | Bydureon | 2011-01-13 | 2017-01-13 | N/A | 2019-01-13 |
| ezogabine | 134659 | Potiga | GlaxoSmithKline Inc. | N/A | 2012-10-18 | 2018-10-18 | N/A | 2020-10-18 |
| fampridine | 132859 | Fampyra | Biogen Idec Canada Inc. | N/A | 2012-02-10 | 2018-02-10 | N/A | 2020-02-10 |
| febuxostat | 129969 | Uloric | Takeda Canada Inc. | N/A | 2010-09-22 | 2016-09-22 | N/A | 2018-09-22 |
| ferumoxytol | 133250 | Feraheme | AMAG Pharmaceuticals Inc. | N/A | 2011-12-08 | 2017-12-08 | N/A | 2019-12-08 |
| fesoterodine fumarate | 142326 | Toviaz | Pfizer Canada Inc. | N/A | 2012-02-09 | 2018-02-09 | Yes | 2020-08-09 |
| fidaxomicin | 151086 | Dificid | Merck Canada Inc. | N/A | 2012-06-07 | 2018-06-07 | N/A | 2020-06-07 |
| fingolimod hydrochloride | 137516 | Gilenya | Novartis Pharmaceuticals Canada Inc. | N/A | 2011-03-09 | 2017-03-09 | N/A | 2019-03-09 |
| fludeoxyglucose 18F | 091404 | Cantrace | Ipet Pharmaceuticals Inc. | N/A | 2006-07-27 | 2012-07-27 | N/A | 2014-07-27 |
| fluticasone furoate | 107372 | Avamys | GlaxoSmithKline Inc. | N/A | 2007-08-14 | 2013-08-14 | Yes | 2016-02-14 |
| gadofosveset trisodium | 096420 | Vasovist | Berlex Canada Inc. | N/A | 2006-10-31 | 2012-10-31 | N/A | 2014-10-31 |
| gadoxetate disodium | 127609 | Primovist | Bayer Inc. | N/A | 2010-01-14 | 2016-01-14 | N/A | 2018-01-14 |
| galsulfase | 159020 | Naglazyme | BioMarin Pharmaceutical Inc. | N/A | 2013-09-16 | 2019-09-16 | Yes | 2022-03-16 |
| golimumab | 120525 | Simponi | Janssen Inc. | N/A | 2009-04-07 | 2015-04-07 | N/A | 2017-04-07 |
| guanfacine hydrochloride | 150741 | Intuniv XR | Takeda Canada Inc. | N/A | 2013-07-05 | 2019-07-05 | Yes | 2022-01-05 |
| haemagglutinin strain A (H5N1) | 115398 | Arepanrix H5N1 | ID Biomedical Corporation of Quebec | N/A | 2013-02-13 | 2019-02-13 | Yes | 2021-08-13 |
| human C1 esterase inhibitor | 121221 | Berinert | CSL Behring Canada Inc. | Haegarda | 2010-05-31 | 2016-05-31 | N/A | 2018-05-31 |
| ibrutinib | 174029 | Imbruvica | Janssen Inc. | N/A | 2014-11-17 | 2020-11-17 | Yes | 2023-05-17 |
| icatibant acetate | 162918 | Firazyr | Takeda Canada Inc. | N/A | 2014-06-04 | 2020-06-04 | Yes | 2022-12-04 |
| idebenone | 117672 | Catena | Santhera Pharmaceuticals Ltd. | N/A | 2008-07-23 | 2014-07-23 | Yes | 2017-01-23 |
| idelalisib | 172652 | Zydelig | Gilead Sciences Canada Inc. | N/A | 2015-03-27 | 2021-03-27 | N/A | 2023-03-27 |
| idursulfase | 109857 | Elaprase | Shire Human Genetic Therapies, Inc. | N/A | 2007-06-13 | 2013-06-13 | Yes | 2015-12-13 |
| indacaterol maleate | 143984 | Onbrez Breezhaler | Novartis Pharmaceuticals Canada Inc. | Ultibro Breezhaler | 2011-12-06 | 2017-12-06 | N/A | 2019-12-06 |
| influenza virus type A (H1N1), influenza virus type A (H3N2), influenza virus type B | 129379 | FluMist | AstraZeneca Canada Incorporated | FluMist Quadrivalent | 2010-06-22 | 2016-06-22 | Yes | 2018-12-22 |
| ingenol mebutate | 153285 | Picato | Leo Pharma Inc. | N/A | 2013-01-30 | 2019-01-30 | N/A | 2021-01-30 |
| ipilimumab | 138178 | Yervoy | Bristol-Myers Squibb Canada | N/A | 2012-02-01 | 2018-02-01 | Yes | 2020-08-01 |
| ivacaftor | 155318 | Kalydeco | Vertex Pharmaceuticals (Canada) Inc. | Orkambi Symdeko |
2012-11-26 | 2018-11-26 | Yes | 2021-05-26 |
| ivermectin | 172733 | Rosiver | Galderma Canada Inc. | N/A | 2015-04-22 | 2021-04-22 | N/A | 2023-04-22 |
| lacosamide | 116632 | Vimpat | UCB Canada Inc. | N/A | 2010-09-30 | 2016-09-30 | N/A | 2018-09-30 |
| lanreotide | 098949 | Somatuline Autogel | Ipsen Biopharm Limited | N/A | 2006-07-17 | 2012-07-17 | N/A | 2014-07-17 |
| lanthanum carbonate | 102240 | Fosrenol | Shire BioChem Inc. | N/A | 2006-10-17 | 2012-10-17 | N/A | 2014-10-17 |
| lapatinib ditosylate | 110294 | Tykerb | Novartis Pharmaceuticals Canada Inc. | N/A | 2009-05-15 | 2015-05-15 | N/A | 2017-05-15 |
| ledipasvir | 173180 | Harvoni | Gilead Sciences Canada Inc. | N/A | 2014-10-15 | 2020-10-15 | Yes | 2023-04-15 |
| lenalidomide | 111952 | Revlimid | Celgene | N/A | 2008-01-17 | 2014-01-17 | N/A | 2016-01-17 |
| levomilnacipran hydrochloride | 167319 | Fetzima | Abbvie Corporation | N/A | 2015-05-08 | 2021-05-08 | N/A | 2023-05-08 |
| linaclotide | 161056 | Constella | Forest Laboratories Canada Inc. | N/A | 2013-12-02 | 2019-12-02 | N/A | 2021-12-02 |
| linagliptin | 140881 | Trajenta | Boehringer Ingelheim (Canada) Ltd. | Jentadueto Glyxambi |
2011-07-28 | 2017-07-28 | N/A | 2019-07-28 |
| liraglutide | 119928 | Victoza | Novo Nordisk Canada Inc. | Saxenda Xultophy |
2010-05-21 | 2016-05-21 | N/A | 2018-05-21 |
| lisdexamfetamine dimesylate | 120534 | Vyvanse | Shire Pharma Canada ULC. | N/A | 2009-02-19 | 2015-02-19 | Yes | 2017-08-19 |
| lomitapide mesylate | 160385 | Juxtapid | Aegerion Pharmaceuticals Canada Ltd. | N/A | 2014-02-04 | 2020-02-04 | N/A | 2022-02-04 |
| loteprednol etabonate | 117199 | Alrex | Bausch & Lomb Inc. | Lotemax Lotemax Ointment Lotemax Gel |
2008-12-23 | 2014-12-23 | N/A | 2016-12-23 |
| lubiprostone | 179333 | Amitiza | Sucampo Pharma Americas LLC | N/A | 2015-10-14 | 2021-10-14 | N/A | 2023-10-14 |
| lumiracoxib | 102465 | Prexige | Novartis Pharmaceuticals Canada Inc. | N/A | 2006-11-02 | 2012-11-02 | N/A | 2014-11-02 |
| lurasidone hydrochloride | 145406 | Latuda | Sunovion Pharmaceuticals Canada Inc. | N/A | 2012-06-13 | 2018-06-13 | Yes | 2020-12-13 |
| macitentan | 161372 | Opsumit | Janssen Inc. | Opsynvi | 2013-11-06 | 2019-11-06 | Yes | 2022-05-06 |
| maraviroc | 112435 | Celsentri | ViiV Healthcare ULC | N/A | 2007-09-21 | 2013-09-21 | N/A | 2015-09-21 |
| methoxy polyethylene gycol epoetin beta | 106461 | Mircera | Hoffmann-La Roche Ltd. | N/A | 2008-03-31 | 2014-03-31 | N/A | 2016-03-31 |
| methylnaltrexone bromide | 114266 | Relistor | Salix Pharmaceuticals, Inc. | N/A | 2008-03-28 | 2014-03-28 | N/A | 2016-03-28 |
| micafungin sodium | 078577 | Mycamine | Astellas Pharma Canada, Inc. | N/A | 2007-05-22 | 2013-05-22 | N/A | 2015-05-22 |
| mirabegron | 153806 | Myrbetriq | Astellas Pharma Canada Inc. | N/A | 2013-03-06 | 2019-03-06 | N/A | 2021-03-06 |
| modified vaccinia virus (ankara-bavarian nordic) | 144762 | Imvamune | Bavarian Nordic A/S | N/A | 2013-11-21 | 2019-11-21 | N/A | 2021-11-21 |
| naloxegol oxalate | 167790 | Movantik | Knight Therapeutics Inc. | N/A | 2015-06-02 | 2021-06-02 | N/A | 2023-06-02 |
| natalizumab | 093001 | Tysabri | Biogen Idec Canada Inc. | N/A | 2006-09-28 | 2012-09-28 | N/A | 2014-09-28 |
| nebivolol hydrochloride | 152353 | Bystolic | Allergan Inc. | N/A | 2012-12-21 | 2018-12-21 | N/A | 2020-12-21 |
| neisseria meningitidis serogroup A polysaccharide, neisseria meningitidis serogroup C polysaccharide, neisseria meningitidis serogroup W-135 polysaccharide, neisseria meningitidis serogroup Y polysaccharide, conjugated to tetanus toxoid carrier protein | 154290 | Nimenrix | Pfizer Canada Inc. | N/A | 2013-03-05 | 2019-03-05 | Yes | 2021-09-05 |
| nelarabine | 099994 | Atriance | Novartis Pharmaceuticals Canada Inc. | N/A | 2007-09-22 | 2013-09-22 | Yes | 2016-03-22 |
| nepafenac | 114004 | Nevanac | Alcon Canada Inc. | Ilevro | 2008-04-17 | 2014-04-17 | N/A | 2016-04-17 |
| nesiritide | 111760 | Natrecor | Janssen Inc. | N/A | 2007-11-08 | 2013-11-08 | N/A | 2015-11-08 |
| nilotinib hydrochloride monohydrate | 110305 | Tasigna | Novartis Pharmaceuticals Canada Inc. | N/A | 2008-09-09 | 2014-09-09 | N/A | 2016-09-09 |
| nintedanib (supplied as nintedanib esilate) | 176043 | Ofev | Boehringer Ingelheim (Canada) Ltd | N/A | 2015-06-25 | 2021-06-25 | N/A | 2023-06-25 |
| obinutuzumab | 168227 | Gazyva | Hoffmann-La Roche Limited | N/A | 2014-11-25 | 2020-11-25 | N/A | 2022-11-25 |
| ocriplasmin | 161356 | Jetrea | ThromboGenics N.V. | N/A | 2013-08-13 | 2019-08-13 | N/A | 2021-08-13 |
| ofatumumab | 128188 | Arzerra | Novartis Pharmaceuticals Canada Inc. | N/A | 2012-03-09 | 2018-03-09 | N/A | 2020-03-09 |
| olmesartan medoxomil | 115991 | Olmetec | Merck Canada Inc. | Olmetec Plus | 2008-10-28 | 2014-10-28 | Yes | 2017-04-28 |
| olodaterol hydrochloride | 155649 | Striverdi Respimat | Boehringer Ingelheim (Canada) Ltd. | Inspiolto Respimat | 2013-06-11 | 2019-06-11 | N/A | 2021-06-11 |
| ombitasvir, paritaprevir, dasabuvir sodium | 174739 | Holkira Pak | Abbvie Corporation | Technivie | 2014-12-22 | 2020-12-22 | N/A | 2022-12-22 |
| oxaliplatin | 109965 | Eloxatin | Sanofi-aventis Canada Inc. | N/A | 2007-06-15 | 2013-06-15 | Yes | 2015-12-15 |
| paliperidone | 108748 | Invega | Janssen Inc. | Invega Sustenna | 2007-09-26 | 2013-09-26 | Yes | 2016-03-26 |
| palonosetron hydrochloride | 145491 | Aloxi | Purdue Pharma | Akynzeo | 2012-03-14 | 2018-03-14 | N/A | 2020-03-14 |
| panitumumab | 105601 | Vectibix | Amgen Canada Inc. | N/A | 2008-04-03 | 2014-04-03 | N/A | 2016-04-03 |
| pasireotide diaspartate | 145005 | Signifor | Novartis Pharmaceuticals Canada Inc. | Signifor Lar | 2013-09-23 | 2019-09-23 | N/A | 2021-09-23 |
| pazopanib hydrochloride | 128332 | Votrient | Novartis Pharmaceuticals Canada Inc. | N/A | 2010-05-27 | 2016-05-27 | N/A | 2018-05-27 |
| peginterferon beta-1a | 166974 | Plegridy | Biogen Idec Canada Inc. | N/A | 2015-08-10 | 2021-08-10 | N/A | 2023-08-10 |
| pembrolizumab | 175884 | Keytruda | Merck Canada Inc. | N/A | 2015-05-19 | 2021-05-19 | Yes | 2023-11-19 |
| perampanel | 153747 | Fycompa | Eisai Limited | N/A | 2013-04-04 | 2019-04-04 | Yes | 2021-10-04 |
| pertuzumab | 158419 | Perjeta | Hoffmann-La Roche Limited | Perjeta-Herceptin Combo Pack Phesgo |
2013-04-12 | 2019-04-12 | N/A | 2021-04-12 |
| pirfenidone | 153849 | Esbriet | Hoffmann-La Roche Limited | N/A | 2012-10-01 | 2018-10-01 | N/A | 2020-10-01 |
| plerixafor | 142638 | Mozobil | Sanofi-aventis Canada Inc. | N/A | 2011-12-08 | 2017-12-08 | N/A | 2019-12-08 |
| pneumococcal polysaccharide serotype 1, 3, 5, 6A, 7F, 19A conjugated to diphtheria CRM197 protein | 122881 | Prevnar 13 | Pfizer Canada Inc. | N/A | 2009-12-21 | 2015-12-21 | Yes | 2018-06-21 |
| pneumococcal polysaccharide serotype 1, 4, 5, 6B, 7F, 9V, 14, 23F conjugated to protein D carrier protein; serotype 18C conjugated to tetanus toxoid carrier protein; serotype 19F conjugated to diphtheria toxoid carrier protein |
119056 | Synflorix | GlaxoSmithKline Inc. | N/A | 2008-12-11 | 2014-12-11 | Yes | 2017-06-11 |
| polidocanol | 177359 | Varithena | Provensis Ltd. | N/A | 2015-08-04 | 2021-08-04 | N/A | 2023-08-04 |
| pomalidomide | 165891 | Pomalyst | Celgene Inc. | N/A | 2014-01-20 | 2020-01-20 | Yes | 2022-07-20 |
| ponatinib hydrochloride | 165121 | Iclusig | Ariad Pharmaceuticals Inc. | N/A | 2015-04-02 | 2021-04-02 | N/A | 2023-04-02 |
| posaconazole | 108193 | Posanol | Merck Canada Inc. | N/A | 2007-03-26 | 2013-03-26 | Yes | 2015-09-26 |
| prasugrel hydrochloride | 121143 | Effient | Eli Lilly Canada Inc. | N/A | 2010-04-16 | 2016-04-16 | Yes | 2018-10-16 |
| prucalopride succinate | 141157 | Resotran | Janssen Inc. | N/A | 2011-12-07 | 2017-12-07 | N/A | 2019-12-07 |
| radium - 223 dichloride | 161312 | Xofigo | Bayer Inc. | N/A | 2013-12-12 | 2019-12-12 | N/A | 2021-12-12 |
| raltegravir potassium | 113408 | Isentress | Merck Frosst Canada Inc. | N/A | 2007-11-27 | 2013-11-27 | Yes | 2016-05-27 |
| ramucirumab | 176810 | Cyramza | Eli Lilly Canada Inc. | N/A | 2015-07-16 | 2021-07-16 | N/A | 2023-07-16 |
| ranibizumab | 110233 | Lucentis | Novartis Opthalmics, Novartis Pharmaceuticals | N/A | 2007-06-26 | 2013-06-26 | N/A | 2015-06-26 |
| rasagiline mesylate | 101846 | Azilect | Teva Pharmaceuticals Industries Ltd. | N/A | 2006-08-17 | 2012-08-17 | N/A | 2014-08-17 |
| recombinant human papillomavirus type 11 L1, type 16 L1, type 18 L1, type 6 L1 protein | 102682 | Gardasil | Merck Frosst Canada Ltd. | N/A | 2006-07-10 | 2012-07-10 | Yes | 2015-01-10 |
| recombinant human papillomavirus types 31, 33, 45, 52 and 58 | 170006 | Gardasil 9 | Merck Canada Inc. | N/A | 2015-02-05 | 2021-02-05 | Yes | 2023-08-05 |
| recombinant neisseria meningitidis group B NHBA fusion protein, recombinant neisseria meningitidis group B NadA protein, recombinant neisseria meningitidis group B FHBP fusion protein, outer membrane vesicle (neisseria meningitidis group B NZ98/254 strain) | 147275 | Bexsero | GlaxoSmithKline Inc. | N/A | 2013-12-06 | 2019-12-06 | Yes | 2022-06-06 |
| recombinant porcine factor VIII (antihemophilic factor (recombinant), porcine sequence) | 177290 | Obizur | Takeda Canada Inc. | N/A | 2015-10-14 | 2021-10-14 | N/A | 2023-10-14 |
| regorafenib monohydrate | 157970 | Stivarga | Bayer Inc. | N/A | 2013-03-11 | 2019-03-11 | Yes | 2021-09-11 |
| remestemcel-L | 150026 | Prochymal | Osiris Therapeutics Inc. | N/A | 2012-05-17 | 2018-05-17 | Yes | 2020-11-17 |
| retapamulin | 109037 | Altargo | GlaxoSmithKline Inc. | N/A | 2008-03-19 | 2014-03-19 | Yes | 2016-09-19 |
| rifaximin | 161256 | Zaxine | Salix Pharmaceuticals Inc. | N/A | 2013-08-13 | 2019-08-13 | N/A | 2021-08-13 |
| rilpivirine hydrochloride | 137484 | Edurant | Janssen Inc. | Complera Odefsey Juluca |
2011-07-21 | 2017-07-21 | Yes | 2020-01-21 |
| riociguat | 162761 | Adempas | Bayer Inc. | N/A | 2013-09-19 | 2019-09-19 | N/A | 2021-09-19 |
| rivaroxaban | 119111 | Xarelto | Bayer Healthcare | N/A | 2008-09-15 | 2014-09-15 | N/A | 2016-09-15 |
| roflumilast | 127683 | Daxas | Takeda Canada Inc. | N/A | 2010-11-23 | 2016-11-23 | N/A | 2018-11-23 |
| romidepsin | 152293 | Istodax | Celgene Inc. | N/A | 2013-10-16 | 2019-10-16 | N/A | 2021-10-16 |
| romiplostim | 117327 | Nplate | Amgen Canada Inc. | N/A | 2009-02-19 | 2015-02-19 | Yes | 2017-08-19 |
| rotavirus RIX4414 strain, live, attenuated (human) | 109624 | Rotarix | GlaxoSmithKline Inc. | N/A | 2007-10-09 | 2013-10-09 | Yes | 2016-04-09 |
| rotavirus vaccine, live, oral type G1, type G2, type G3, type G4, type P1(8) (human) | 100399 | Rotateq | Merck Frosst Canada Ltd. | N/A | 2006-08-01 | 2012-08-01 | Yes | 2015-02-01 |
| rotigotine | 145523 | Neupro | UCB Canada Inc. | N/A | 2013-03-21 | 2019-03-21 | N/A | 2021-03-21 |
| rubidium 82 chloride | 138823 | Ruby-Fill | Jubilant Draximage Inc. | N/A | 2011-09-20 | 2017-09-20 | N/A | 2019-09-20 |
| rufinamide | 139913 | Banzel | Eisai Limited | N/A | 2011-06-22 | 2017-06-22 | Yes | 2019-12-22 |
| ruxolitinib phosphate | 151723 | Jakavi | Novartis Pharmaceuticals Canada Inc. | N/A | 2012-06-19 | 2018-06-19 | N/A | 2020-06-19 |
| sapropterin dihydrochloride | 128151 | Kuvan | BioMarin Pharmaceutical Inc. | N/A | 2010-04-30 | 2016-04-30 | Yes | 2018-10-30 |
| saxagliptin hydrochloride | 123854 | Onglyza | AstraZeneca Canada Inc. | Komboglyze Qtern |
2009-09-14 | 2015-09-14 | N/A | 2017-09-14 |
| secukinumab | 170732 | Cosentyx | Novartis Pharmaceuticals Canada Inc. | N/A | 2015-02-27 | 2021-02-27 | Yes | 2023-08-27 |
| silodosin | 121740 | Rapaflo | Purdue Pharma | N/A | 2011-01-11 | 2017-01-11 | N/A | 2019-01-11 |
| siltuximab | 174291 | Sylvant | EUSA Pharma (UK) Limited | N/A | 2014-12-03 | 2020-12-03 | N/A | 2022-12-03 |
| simeprevir | 164021 | Galexos | Janssen Inc. | N/A | 2013-11-18 | 2019-11-18 | N/A | 2021-11-18 |
| sitagliptin phosphate | 103039 | Januvia | Merck Frosst Canada Ltd. | Janumet Janumet XR |
2007-12-14 | 2013-12-14 | N/A | 2015-12-14 |
| sitaxsentan sodium | 101934 | Thelin | Pfizer Canada Inc. | N/A | 2007-05-30 | 2013-05-30 | N/A | 2015-05-30 |
| sodium fluoride 18F | 145561 | NaF Plus | Isologic Innovative Radiopharmaceuticals Ltd. | N/A | 2013-02-11 | 2019-02-11 | N/A | 2021-02-11 |
| sofosbuvir | 165043 | Sovaldi | Gilead Sciences Canada Inc. | Harvoni Epclusa Vosevi |
2013-12-13 | 2019-12-13 | N/A | 2021-12-13 |
| sorafenib | 102070 | Nexavar | Bayer Inc. | N/A | 2006-07-28 | 2012-07-28 | N/A | 2014-07-28 |
| stiripentol | 142417 | Diacomit | Biocodex SA | N/A | 2012-12-21 | 2018-12-21 | Yes | 2021-06-21 |
| tafluprost | 165596 | Saflutan | Purdue Pharma | N/A | 2014-05-26 | 2020-05-26 | N/A | 2022-05-26 |
| taliglucerase alfa | 140854 | Elelyso | Pfizer Canada Inc. | N/A | 2014-05-29 | 2020-05-29 | Yes | 2022-11-29 |
| tapentadol hydrochloride | 133167 | Nucynta CR | Janssen Inc. | Nucynta IR Nucynta Extended Release |
2010-12-02 | 2016-12-02 | N/A | 2018-12-02 |
| tedizolid phosphate | 173603 | Sivextro | Merck Canada Inc. | N/A | 2015-03-17 | 2021-03-17 | N/A | 2023-03-17 |
| telaprevir | 142482 | Incivek | Vertex Pharmaceuticals (Canada) Inc. | N/A | 2011-08-16 | 2017-08-16 | N/A | 2019-08-10 |
| telavancin hydrochloride | 107792 | Vibativ | Pendopharm Division of de Pharmascience Inc. | N/A | 2009-09-29 | 2015-09-29 | N/A | 2017-09-29 |
| telbivudine | 104469 | Sebivo | Novartis Pharmaceuticals Canada Inc. | N/A | 2006-11-28 | 2012-11-28 | N/A | 2014-11-28 |
| temsirolimus | 109201 | Torisel | Pfizer Canada Inc. | N/A | 2007-12-21 | 2013-12-21 | Yes | 2016-06-21 |
| teriflunomide | 160646 | Aubagio | Genzyme Canada a division of Sanofi-aventis Canada Inc. | N/A | 2013-11-14 | 2019-11-14 | Yes | 2022-05-14 |
| tesamorelin | 131836 | Egrifta | Theratechnologies Inc. | N/A | 2014-04-29 | 2020-04-29 | N/A | 2022-04-29 |
| ticagrelor | 132218 | Brilinta | AstraZeneca Canada Incorporated | N/A | 2011-05-30 | 2017-05-30 | N/A | 2019-05-30 |
| tigecycline | 094870 | Tygacil | Pfizer Canada Inc. | N/A | 2006-09-14 | 2012-09-14 | N/A | 2014-09-14 |
| tocilizumab | 121089 | Actemra | Hoffmann-La Roche Ltd. | N/A | 2010-04-30 | 2016-04-30 | Yes | 2018-10-30 |
| tofacitinib | 154642 | Xeljanz | Pfizer Canada Inc. | N/A | 2014-04-17 | 2020-04-17 | Yes | 2022-10-17 |
| tolvaptan | 139413 | Samsca | Otsuka Pharmaceutical Co. Ltd. | Jinarc | 2011-07-25 | 2017-07-25 | N/A | 2019-07-25 |
| trabectedin | 124729 | Yondelis | Janssen Inc. | N/A | 2010-05-13 | 2016-05-13 | N/A | 2018-05-13 |
| trametinib | 157665 | Mekinist | Novartis Pharmaceuticals Canada Inc. | N/A | 2013-07-18 | 2019-07-18 | N/A | 2021-07-18 |
| trastuzumab emtansine | 162414 | Kadcyla | Hoffmann-La Roche Limited | N/A | 2013-09-11 | 2019-09-11 | N/A | 2021-09-11 |
| turoctocog alfa | 170796 | Zonovate | Novo Nordisk Canada Inc. | N/A | 2014-12-08 | 2020-12-08 | Yes | 2023-06-08 |
| ulipristal acetate | 156861 | Fibristal | Allergan Inc. | N/A | 2013-06-24 | 2019-06-24 | N/A | 2021-06-24 |
| umeclidinium bromide | 161585 | Anoro Ellipta | GlaxoSmithKline Inc. | Incruse Ellipta | 2013-12-23 | 2019-12-23 | N/A | 2021-12-23 |
| ustekinumab | 114272 | Stelara | Janssen Inc. | N/A | 2008-12-12 | 2014-12-12 | N/A | 2016-12-12 |
| vandetanib | 126822 | Caprelsa | Genzyme Canada, a division of Sanofi-aventis Canada Inc. | N/A | 2012-01-12 | 2018-01-12 | N/A | 2020-01-12 |
| varenicline tartrate | 104007 | Champix | Pfizer Canada Inc. | N/A | 2007-01-24 | 2013-01-24 | Yes | 2015-07-24 |
| vedolizumab | 169414 | Entyvio | Takeda Canada Inc. | N/A | 2015-01-29 | 2021-01-29 | Yes | 2023-07-29 |
| velaglucerase alfa | 132604 | Vpriv | Shire Human Genetic Therapies, Inc. | N/A | 2010-10-01 | 2016-10-01 | Yes | 2019-04-01 |
| vemurafenib | 148693 | Zelboraf | Hoffmann-La Roche Ltd. | N/A | 2012-02-15 | 2018-02-15 | N/A | 2020-02-15 |
| vilanterol trifenatate | 157301 | Breo Ellipta | GlaxoSmithKline Inc. | Anoro Ellipta Trelegy Ellipta |
2013-07-03 | 2019-07-03 | Yes | 2022-01-03 |
| vismodegib | 154608 | Erivedge | Hoffmann-La Roche Ltd. | N/A | 2013-07-12 | 2019-07-12 | N/A | 2021-07-12 |
| vorinostat | 104562 | Zolinza | Merck Frosst Canada Ltd. | N/A | 2009-06-11 | 2015-06-11 | N/A | 2017-06-11 |
| vortioxetine hydrobromide | 159019 | Trintellix | Lundbeck Canada Inc. | N/A | 2014-10-22 | 2020-10-22 | Yes | 2023-04-22 |
| ziprasidone hydrochloride monohydrate | 078188 | Zeldox | Pfizer Canada Inc. | N/A | 2007-08-27 | 2013-08-27 | Yes | 2016-02-27 |
| zucapsaicin | 121952 | Zuacta | Sanofi-aventis Canada Inc. | N/A | 2010-07-15 | 2016-07-15 | N/A | 2018-07-15 |
| Medicinal Ingredient(s) Footnote 1 |
Submission Number |
Innovative Drug | Manufacturer | Drug(s) Containing the Medicinal Ingredient / Variations | Notice of Compliance Date yyyy-mm-dd | 6 Year "No File" Date |
Data Protection Ends |
|---|---|---|---|---|---|---|---|
| amlodipine besilate | 218786 | Amodip Flavoured Tablets | Ceva Animal Health Inc. | N/A | 2020-03-25 | 2026-03-25 | 2028-03-25 |
| bupivacaine hydrochloride | 254222 | Tri-Solfen | Dechra Ltd. | N/A | 2022-06-21 | 2028-06-21 | 2030-06-21 |
| bedinvetmab | 237723 | Librela | Zoetis Canada Inc. | N/A | 2021-02-01 | 2027-02-01 | 2029-02-01 |
| ciclesonide | 200882 | Aservo Equihaler | Boehringer Ingelheim Animal Health Canada Inc. | N/A | 2020-04-30 | 2026-04-30 | 2028-04-30 |
| derquantel | 184844 | Startect | Zoetis Canada Inc. | N/A | 2016-04-27 | 2022-04-27 | 2024-04-27 |
| frunevetmab | 242879 | Solensia | Zoetis Canada Inc. | N/A | 2021-07-27 | 2027-07-27 | 2029-07-27 |
| gonadorelin[6-D-Phe] acetate | 256977 | Gonavet | Modern Veterinary Therapeutics LLC | N/A | 2022-10-20 | 2028-10-20 | 2030-10-20 |
| grapiprant | 211760 | Galliprant | Elanco Canada Limited | N/A | 2019-01-08 | 2025-01-08 | 2027-01-08 |
| isoeugenol | 252779 | Aqui-S | AQUI-S New Zealand Ltd. | N/A | 2023-07-31 | 2029-07-31 | 2031-07-31 |
| lotilaner | 193712 | Credelio | Elanco Canada Limited | Credelio Plus Credelio Cat |
2017-12-29 | 2023-12-29 | 2025-12-29 |
| lubabegron | 166199 | Experior 10 | Elanco Canada Limited | Experior 50 | 2018-11-07 | 2024-11-07 | 2026-11-07 |
| methadone hydrochloride | 226217 | Comfortan | Eurovet Animal Health B.V. | N/A | 2020-02-25 | 2026-02-25 | 2028-02-25 |
| midazolam | 230770 | Dormazolam | Dechra Regulatory BV | N/A | 2021-06-29 | 2027-06-29 | 2029-06-29 |
| mirtazapine | 232197 | Mirataz | Dechra Ltd. | N/A | 2020-09-08 | 2026-09-08 | 2028-09-08 |
| peforelin | 190986 | Maprelin XP-10 | Modern Veterinary Therapeutics LLC | N/A | 2017-06-19 | 2023-06-19 | 2025-06-19 |
| pegbovigrastim | 148171 | Imrestor | Elanco Division Eli Lilly Canada Inc. | N/A | 2016-03-09 | 2022-03-09 | 2024-03-09 |
| sarolaner | 177679 | Simparica | Zoetis Canada Inc. | Revolution Plus Simparica Trio | 2016-02-11 | 2022-02-11 | 2024-02-11 |
| spironolactone | 263787 | Cardalis | Ceva Animal Health Inc. | N/A | 2023-10-11 | 2029-10-11 | 2031-10-11 |
| tetracosactide | 228462 | Cosacthen | Dechra Ltd. | N/A | 2020-04-27 | 2026-04-27 | 2028-04-27 |
| vatinoxan hydrochloride | 256567 | Zenalpha | Dechra Veterinary Products Inc. | N/A | 2023-05-01 | 2029-05-01 | 2031-05-01 |
| velagliflozin L-proline monohydrate | 265785 | Senvelgo | Boehringer Ingelheim Animal Health Canada Inc. | N/A | 2023-11-28 | 2029-11-28 | 2031-11-28 |
| Medicinal Ingredient(s) Footnote 1 | Submission Number |
Innovative Drug | Manufacturer | Drug(s) Containing the Medicinal Ingredient / Variations | Notice of Compliance Date yyyy-mm-dd | 6 Year "No File" Date |
Data Protection Ends |
|---|---|---|---|---|---|---|---|
| acetaminophen | 110139 | Pracetam 20% O.S. | Ceva Animal Health Inc. | N/A | 2009-03-05 | 2015-03-05 | 2017-03-05 |
| afoxolaner | 163768 | Nexgard | Boehringer Ingelheim Animal Health Canada Inc. | Nexgard Spectra Nexgard Combo |
2014-07-08 | 2020-07-08 | 2022-07-08 |
| avilamycin | 156949 | Surmax 100 Premix | Elanco Canada Limited | Surmax 200 Premix | 2014-02-18 | 2020-02-18 | 2022-02-18 |
| buprenorphine hydrochloride | 126077 | Vetergesic Multidose | Sogeval UK Limited | N/A | 2010-02-03 | 2016-02-03 | 2018-02-03 |
| cefovecin sodium | 110061 | Convenia | Zoetis Canada Inc. | N/A | 2007-05-30 | 2013-05-30 | 2015-05-30 |
| cefpodoxime proxetil | 149164 | Simplicef | Zoetis Canada Inc. | N/A | 2012-12-06 | 2018-12-06 | 2020-12-06 |
| cephalexin monohydrate | 126970 | Vetolexin | Vétoquinol N.-A Inc. | Cefaseptin | 2010-06-24 | 2016-06-24 | 2018-06-24 |
| clodronate disodium tetrahydrate | 172789 | Osphos Injection | Dechra Ltd. | N/A | 2015-05-06 | 2021-05-06 | 2023-05-06 |
| closantel sodium | 180678 | Flukiver | Elanco Division Eli Lilly Canada Inc. | N/A | 2015-11-24 | 2021-11-24 | 2023-11-24 |
| dibotermin alfa (rhBMP-2) | 148153 | Truscient | Zoetis Canada Inc. | N/A | 2012-11-20 | 2018-11-20 | 2020-11-20 |
| dirlotapide | 110110 | Slentrol | Zoetis Canada Inc. | N/A | 2008-08-14 | 2014-08-14 | 2016-08-14 |
| emamectin benzoate | 109976 | Slice | Intervet Canada Ltd. | N/A | 2009-06-29 | 2015-06-29 | 2017-06-29 |
| emodepside | 112103 / 112106 / 112107 | Profender | Bayer Healthcare, Animal Health Division | N/A | 2008-08-28 | 2014-08-28 | 2016-08-28 |
| firocoxib | 110661 / 110379 | Previcox | Merial Canada Inc. | N/A | 2007-09-28 | 2013-09-28 | 2015-09-28 |
| fluoxetine hydrochloride | 109825 / 109826 / 110429 | Reconcile | Elanco, Division Eli Lilly Canada Inc. | N/A | 2008-03-28 | 2014-03-28 | 2016-03-28 |
| fluralaner | 166320 | Bravecto | Intervet Canada Corp. | Vitrecto Bravecto One |
2014-05-23 | 2020-05-23 | 2022-05-23 |
| gamithromycin | 125823 | Zactran | Merial Canada Inc. | N/A | 2010-03-29 | 2016-03-29 | 2018-03-29 |
| gonadotropin releasing factor analogue - protein conjugate | 140525 | Improvest | Zoetis Canada Inc. | N/A | 2011-06-22 | 2017-06-22 | 2019-06-22 |
| ibafloxacin | 110655 / 110657 | Ibaflin gel | Intervet Canada Ltd. | N/A | 2008-01-15 | 2014-01-15 | 2016-01-15 |
| insulin human (recombinant) | 150211 | Prozinc | Boehringer Ingelheim Animal Health Canada | N/A | 2013-04-24 | 2019-04-24 | 2021-04-24 |
| imidapril hydrochloride | 110445 / 110450 / 110476 | Prilium | Vetoquinol N A Inc. | N/A | 2007-07-12 | 2013-07-12 | 2015-07-12 |
| itraconazole | 109769 | Itrafungol | Elanco, Division Eli Lilly Canada Inc. | N/A | 2008-09-23 | 2014-09-23 | 2016-09-23 |
| maropitant | 110342 / 110344 / 110347 / 110348 | Cerenia | Zoetis Canada Inc. | N/A | 2007-09-20 | 2013-09-20 | 2015-09-20 |
| mitratapide | 111600 | Yarvitan | Janssen Pharmaceutica N.V. | N/A | 2009-02-20 | 2015-02-20 | 2017-02-20 |
| mometasone furoate monohydrate | 110289 | Mometamax | Intervet Canada Corp. | N/A | 2010-02-22 | 2016-02-22 | 2018-02-22 |
| oclacitinib maleate | 159090 | Apoquel | Zoetis Canada Inc. | N/A | 2014-07-15 | 2020-07-15 | 2022-07-15 |
| pergolide mesylate | 158770 | Prascend | Boehringer Ingelheim Animal Health Canada Inc. | N/A | 2013-09-05 | 2019-09-05 | 2021-09-05 |
| permethrin | 133818 | Oridermyl | Vétoquinol N.- A Inc. | N/A | 2011-02-18 | 2017-02-18 | 2019-02-18 |
| phenobarbital | 142445 | Epiphen | Vétoquinol N.-A Inc. | N/A | 2012-04-04 | 2018-04-04 | 2020-04-04 |
| pradofloxacin | 161227 | Veraflox | Elanco Canada Limited | N/A | 2015-01-29 | 2021-01-29 | 2023-01-29 |
| ramipril | 110296 / 110297 / 110298 | Vasotop | Intervet Canada Ltd. | N/A | 2008-09-05 | 2014-09-05 | 2016-09-05 |
| robenacoxib | 128703 | Onsior | Elanco Canada Limited | N/A | 2011-10-03 | 2017-10-03 | 2019-10-03 |
| sevoflurane | 110109 | Sevoflo | Zoetis Canada Inc. | N/A | 2008-03-28 | 2014-03-28 | 2016-03-28 |
| telmisartan | 158760 | Semintra | Boehringer Ingelheim Animal Health Canada Inc. | N/A | 2013-12-12 | 2019-12-12 | 2021-12-12 |
| spinosad | 112198 / 112199 / 112202 / 112203 / 112204 | Comfortis | Elanco, Division Eli Lilly Canada Inc. | Trifexis | 2009-08-24 | 2015-08-24 | 2017-08-24 |
| tepoxalin | 109950 / 109956 / 109963 | Zubrin | Schering Plough Canada Inc. | N/A | 2007-10-01 | 2013-10-01 | 2015-10-01 |
| terbinafine | 170344 | Osurnia | Dechra Ltd. | N/A | 2015-03-26 | 2021-03-26 | 2023-03-26 |
| thiamazole | 125706 | Felimazole | Dechra Ltd. | N/A | 2009-08-25 | 2015-08-25 | 2017-08-25 |
| tildipirosin | 148052 | Zuprevo | Intervet Canada Corp. | N/A | 2012-06-13 | 2018-06-13 | 2020-06-13 |
| tiludronic acid (as tiludronate disodium) | 171467 | Tildren | CEVA Animal Health | N/A | 2014-12-22 | 2020-12-22 | 2022-12-22 |
| toceranib phosphate | 123643 | Palladia | Zoetis Canada Inc. | N/A | 2009-12-01 | 2015-12-01 | 2017-12-01 |
| toltrazuril | 122525 | Baycox | Bayer Inc., Bayer Healthcare Animal Health Division | N/A | 2010-08-20 | 2016-08-20 | 2018-08-20 |
| trilostane | 110023 / 110025 / 110221 / 113566 | Vetoryl | Dechra Ltd. | N/A | 2009-01-30 | 2015-01-30 | 2017-01-30 |
| triptorelin (as triptorelin acetate) | 161303 | Ovugel | United-AH II, LLC | N/A | 2014-04-25 | 2020-04-25 | 2022-04-25 |
| tulathromycin | 112161 | Draxxin | Pfizer Canada Inc., Animal Health Group | N/A | 2006-08-31 | 2012-08-31 | 2014-08-31 |
| zilpaterol hydrochloride | 110019 | Zilmax | Intervet Canada Ltd. | N/A | 2009-03-18 | 2015-03-18 | 2017-03-18 |
Background
The Register of Innovative Drugs is maintained pursuant to subsection C.08.004.1(9) of the Food and Drug Regulations. The register indicates the drugs that are eligible for data protection. Under subsection C.08.004.1(3) a subsequent manufacturer that seeks a notice of compliance on the basis of a direct or indirect comparison between the new drug and an innovative drug may not file a submission before the end of a period of six years after the day on which the first notice of compliance was issued for the innovative new drug. In addition, the notice of compliance cannot be issued before the end of a period of eight years after the day on which the first notice of compliance was issued to the innovator.
The format of the Register of Innovative Drugs is an electronic table, which is updated weekly. The register lists, in alphabetical order, the medicinal ingredients in the innovative drugs which were not previously approved in a drug by the Minister and that are not variations of a previously approved medicinal ingredient. Please note that there may be other medicinal ingredients included in the drugs. The register was re-formatted in summer 2016 to increase the clarity of the information provided regarding the medicinal ingredient, brand name and manufacturer of each innovative drug.
For more information
For information related to treatment options, choices of medications and their uses, illnesses, side effects or drug interactions, please contact your health care professional (for example, doctor, pharmacist, etc.). We do not provide medical advice regarding the use of the products identified in this database.
For other comments or questions, please contact the:
Office of Patented Medicines and Liaison
Email: opml-bmbl@hc-sc.gc.ca
Telephone: 613-941-7281
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