Recommendations for public health programs on the use of pneumococcal vaccines in children, including the use of 15-valent and 20-valent conjugate vaccines

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Organization: Public Health Agency of Canada

Date published: 2024-03-11

Cat.: HP5-239/1-2024E-PDF

ISBN: 978-0-660-70388-6

Pub.: 230765

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Preamble

The National Advisory Committee on Immunization (NACI) is an External Advisory Body that provides the Public Health Agency of Canada (PHAC) with independent, ongoing and timely medical, scientific, and public health advice in response to questions from PHAC relating to immunization.

In addition to burden of disease and vaccine characteristics, PHAC has expanded the mandate of NACI to include the systematic consideration of programmatic factors in developing evidence-based recommendations to facilitate timely decision-making for publicly funded vaccine programs at provincial and territorial levels.

The additional factors to be systematically considered by NACI include economics, ethics, equity, feasibility and acceptability. Not all NACI statements will require in-depth analyses of all programmatic factors. While systematic consideration of programmatic factors will be conducted using evidence-informed tools to identify distinct issues that could impact decision-making for recommendation development, only distinct issues identified as being specific to the vaccine or vaccine-preventable disease will be included.

This statement contains NACI's independent advice and recommendations, which are based upon the best current available scientific knowledge. This document is being disseminated for information purposes. People administering the vaccine should also be aware of the contents of the relevant product monograph. Recommendations for use and other information set out herein may differ from that set out in the product monographs of the Canadian manufacturers of the vaccines. Manufacturer(s) have sought approval of the vaccines and provided evidence as to its safety and efficacy only when it is used in accordance with the product monographs. NACI members and liaison members conduct themselves within the context of PHAC's Policy on Conflict of Interest, including yearly declaration of potential conflict of interest.

Summary of information contained in this NACI statement

The following highlights key information for immunization providers. Please refer to the remainder of the statement for details.

What

The bacterium Streptococcus pneumoniae can lead to invasive pneumococcal disease (IPD), a serious communicable disease, and other infections such as community acquired pneumonia and acute otitis media. There are currently more than 100 known serotypes of S. pneumoniae. The majority of pneumococcal infections are caused by only a portion of these serotypes.

Health Canada has recently authorized two new pneumococcal conjugate (Pneu-C) vaccines for infants, children and adolescents 6 weeks through 17 years of age:

  • Pneu-C-15 (15-valent) is authorized with an indication for prevention of IPD caused by 15 serotypes of S. pneumoniae.
  • Pneu-C-20 (20-valent) is authorized with an indication for prevention of IPD caused by 20 serotypes of S. pneumoniae.

Who

IPD is most common in young children, older adults, and groups at increased risk due to a medical condition and/or environmental/living conditions (see Table 1). NACI continues to recommend that all routine infant immunization programs in Canada include a conjugate pneumococcal vaccine.

For routine immunization programs in children less than 5 years of age who are not at increased risk of IPD:

  • NACI recommends that either Pneu-C-15 or Pneu-C-20 should be the current product of choice for children less than five years of age in routine immunization programs.

For children at increased risk of IPD due to a medical and/or environmental/living conditions (Table 1):

  • NACI recommends that Pneu-C-20 should be used for children 2 months to less than 18 years of age who have conditions that result in increased risk of IPD. Children who have started their pneumococcal vaccine series with Pneu-C-13 or Pneu-C-15 should complete their series with Pneu-C-20.
  • NACI recommends that children under 18 years of age who are at increased risk of IPD due to medical and/or environmental/living conditions and who have completed their recommended immunization schedule with Pneu-C-13 or Pneu-C-15, should receive one catch-up (additional) dose of Pneu-C-20.
  • NACI recommends that Pneu-C-20 should be offered to children less than 18 years of age who received a hematopoietic stem cell transplant (HSCT) after consultation with their transplant specialist.

For additional information, including supporting evidence and rationale for these recommendations, please see Recommendations.

Table 1: Risk conditions resulting in increased risk of IPD

Medical risk conditions

  • Chronic cerebrospinal fluid (CSF) leak
  • Cochlear implants, including those who are to receive implants. The highest risk is in the weeks following implant. It is best to administer prior to implant but surgery should not be delayed to administer vaccine. Vaccine should be given as soon as possible.
  • Chronic kidney disease, particularly those with nephrotic syndrome, on dialysis, or with renal transplant
  • Chronic liver disease, including hepatic cirrhosis and biliary atresia
  • Chronic neurologic condition that may impair clearance of oral secretions
  • Functional or anatomic asplenia (including sickle cell disease and other hemoglobinopathies, congenital or acquired asplenia, or splenic dysfunction)
  • Diabetes mellitus
  • Chronic heart disease (including congenital heart disease and cyanotic heart disease)
  • Chronic lung disease, including asthma requiring acute medical care in the preceding 12 months
  • Congenital immunodeficiencies involving any part of the immune system, including B-lymphocyte (humoral) immunity, T-lymphocyte (cell) mediated immunity, complement system (e.g. properdin, or factor D deficiencies)
  • Immunocompromising therapy, including use of long-term corticosteroids, chemotherapy, radiation therapy, and post-organ transplant therapy
  • HIV infection
  • Hematopoietic stem cell transplant (recipient)* see separate recommendation
  • Malignant neoplasms, including leukemia and lymphoma
  • Solid organ transplant

Environmental or living conditions for individuals

  • Who live in communities or settings experiencing sustained high IPD rates
  • Who are underhoused or experiencing houselessness
  • Who are in residential care for children with complex medical needs

How

Pneu-C-15 and Pneu-C-20 are administered intramuscularly using a single-dose, prefilled syringe. A single dose of Pneu-C-15 and Pneu-C-20 is 0.5ml.

Pneu-C-15 and Pneu-C-20 are provided either using a 3-dose (2+1) schedule at 2 months, 4 months and 12 months of age, or a 4-dose (3+1) schedule at 2 months, 4 months and 6 months followed by a dose at 12 to 15 months of age. For more information on immunization schedules, including for children at increased risk of IPD and by immunization history, refer to the pneumococcal vaccines chapter of the Canadian Immunization Guide and Recommendations (Table 7).

Contraindications for Pneu-C-15 and Pneu-C-20 include hypersensitivity (e.g., anaphylaxis) to the vaccine or any of its components. Pneumococcal vaccines may be administered concurrently with other vaccines, except for a different formulation of pneumococcal vaccine (e.g., do not concurrently administer conjugate and polysaccharide pneumococcal vaccines).

Why

Pneumococcal disease can lead to long-lasting complications and can result in significant morbidity and mortality, especially for young children and other children at increased risk of IPD. The most effective way to prevent these infections is through immunization. Pneu-C-15 and Pneu-C-20 are designed to prevent infection from a larger number of serotypes than previous pneumococcal vaccines.

Introduction

Guidance objective

The need for updated National Advisory Committee on Immunization (NACI) guidance on the pediatric pneumococcal vaccine program arose from the authorization of new pediatric indications for two pneumococcal conjugate (Pneu-C) vaccines. On July 8, 2022, Health Canada authorized the use of a pneumococcal conjugate 15-valent vaccine (Pneu-C-15, Vaxneuvance®), for active immunization of children from 6 weeks through 17 years of age for the prevention of invasive pneumococcal disease (IPD) caused by Streptococcus pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, 22F, 23F and 33F. On July 21, 2023, Health Canada authorized the use of a pneumococcal conjugate 20-valent vaccine (Pneu-C-20, Prevnar 20®) for the prevention of IPD caused by S. pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 8, 9V, 10A, 11A, 12F, 14, 15B, 18C, 19A, 19F, 22F, 23F and 33F in children 6 weeks through 17 years of age.

Note: For purposes of this document, 'children' refers to infants, children and adolescents under 18 years of age.

On October 4th, 2022, NACI provided interim guidance on the use of Pneu-C-15 vaccine, recommending that it may be used interchangeably with Pneu-C-13 in children 6 weeks to 17 years of age. Following the approval of Pneu-C-20 for use in children, additional guidance was requested by Provinces and Territories on the use of these vaccines in routine pediatric immunization programs in Canada.

The primary objectives of this Statement are to:

  • review the evidence on the potential benefits (immunogenicity), risks (safety) and modelled impact and cost-effectiveness of pediatric pneumococcal immunization programs using Pneu-C-15 or Pneu-C-20 on the reduction on the pneumococcal disease burden in Canada.
  • provide recommendations for the use of Pneu-C-15 and Pneu-C-20 vaccines in routine pediatric programs in Canada and for children at increased risk of IPD.

Background on pneumococcal vaccines, immunization programs and recommendations for children in Canada

In Canada, routine immunization programs for IPD for infants include the use of Pneu-C vaccines provided either using a 3-dose (2+1) schedule at 2 months, 4 months and 12 months of age or a 4-dose (3+1) schedule at 2 months, 4 months and 6 months followed by a dose at 12 to 15 months of age. Infants at increased risk of IPD due to an underlying medical condition have previously been recommended to receive the 4-dose schedule of Pneu-C-13 vaccine, as well as one dose of Pneu-P-23 vaccine at 24 months of age, at least 8 weeks after Pneu-C-13 vaccine, to increase protection against additional S. pneumoniae serotypes not contained in Pneu-C-13. Children with certain medical conditions were also recommended an additional booster dose of Pneu-P-23 vaccine at least 5 years after any previous dose of Pneu-P-23 vaccine.

In 2021, it was estimated that 85.1% (95% confidence interval [CI]: 83.1% to 87.0%) of 2-year-old children in Canada had at least 3 doses of the pneumococcal vaccineFootnote 1. The current national vaccination coverage goal by 2025 is to have 95% of 2-year-old children immunized with at least 3 doses of the recommended pneumococcal vaccineFootnote 2.

Methods

In brief, the stages in the preparation of a NACI statement are:

  1. Knowledge synthesis: retrieval and summary of individual studies, and assessment of the risk of bias of included studies.
  2. Summary of vaccine-relevant evidence: benefits (examples would include: immunogenicity, efficacy and effectiveness profiles compared with existing vaccines) and potential harms (safety profile compared with existing vaccines), considering the certainty of the synthesized evidence and, where applicable, the magnitude of effects observed across the studies.
  3. Systematic assessment of program-relevant considerations related to ethics, equity, feasibility, and acceptability (EEFA).
  4. Economic evaluation, including a systematic review of economic evaluations and economic modelling.
  5. Use of all available evidence to inform recommendations.

NACI reviewed the available evidence on Pneu-C-15 and Pneu-C-20 immunogenicity and safety, pneumococcal disease burden, and cost-effectiveness and considerations for ethics, equity, feasibility, and acceptability during meetings held on June 12, July 7 and September 27, 2023. Following NACI discussion, additional evidence on the risk of IPD in children with risk factors was reviewed by the Committee on November 16, 2023. Recommendations on the use of pneumococcal vaccines in pediatric populations were approved on December 5, 2023.

Further information on NACI's process and procedures is available elsewhereFootnote 3. Comprehensive NACI recommendations for the use of pneumococcal vaccines in Canada are provided in the pneumococcal vaccines chapter in the Canadian Immunization Guide (CIG).

Burden of invasive pneumococcal disease

Since 2000, IPD has been nationally notifiable in Canada through the Canadian Notifiable Disease Surveillance System (CNDSS), with all provinces and territories reporting cases that meet the national case definition. For this Statement, the CNDSS line list data used to assess the burden of IPD among different pediatric age groups were available from ten provinces and from the International Circumpolar Surveillance (ICS) program for the three territories. In addition to the three territories, regions of Canada captured in the ICS system also include northern Labrador and northern Quebec. The incidence of IPD in these regions was compared to national IPD incidence using aggregate CNDSS data. All cases were presumed to meet the national case definition of IPD. More information about the CNDSS data is provided at Notifiable Diseases Online, including limitations to the CNDSS data.

The National Microbiology Laboratory (NML) collaborates with public health laboratories to conduct passive, laboratory-based surveillance of IPD in Canada and releases regular reportsFootnote 4. All IPD isolates from public health laboratories are serotyped by the NML, although specimen collection may be limited by variable regional standards, the preliminary nature of some data, and the availability of bacterial isolates for testing. Serotype data may also be biased toward overrepresentation of more virulent serotypes for which medical treatment is sought and clinical specimens are taken. Information on serotype distribution is provided for 80% to 98% of all IPD cases reported to CNDSS.

For the serotype reporting in this Statement, serotype 6C was included with Pneu-C-13 serotypes due to cross protection with 6A. Serotypes 15B and 15C were grouped together as 15B/C because of reported reversible switching between them in vivo during infection, making it difficult to precisely differentiate between the two types.

Additional information on complications of pneumococcal disease were collected through the pediatric hospital-based surveillance network IMPACT (Immunization Monitoring Program, ACTive) which covers 90% of tertiary care pediatric beds in Canada.

There are limited Canadian-specific data on pneumococcal disease in children with medical risk conditions. NACI reviewed information on pneumococcal disease in this population based on data from a recent review conducted to inform the United States (US) Advisory Committee on Immunization PracticesFootnote 5.

Literature review of Pneu-C-15 and Pneu-C-20

The overarching research question to support the evidence review is: What is the efficacy, effectiveness, immunogenicity, and safety of Pneu-C-15 and Pneu-C-20 compared to Pneu-C-13, when used to reduce the risk of IPD in children under 18 years of age?

Population: Children 6 weeks to under 18 years of age with and without additional risk factors for IPD (Table 1) who have never been vaccinated, have an incomplete vaccine series, or have completed their vaccine series (for catch-up/additional doses).

Intervention: Pneu-C-15 or Pneu-C-20 (alone or in a mixed series).

Comparator: Currently recommended age and risk factor-appropriate pneumococcal vaccine schedule.

Outcomes: Death due to S. pneumoniae serotypes included in the vaccine (i.e., vaccine serotype), IPD due to vaccine serotypes, acute otitis media (AOM) or pneumococcal community acquired pneumonia (CAP) due to vaccine serotypes, and serious adverse events following vaccination.

As efficacy/effectiveness and safety data were not published at the time of the initial evidence review, NACI evaluated immunogenicity and safety data accessible in the regulatory submission to Health Canada and/or were presented to NACI by the manufacturer.

Immunogenicity datapoints that were reviewed by NACI included opsonophagocytic (OPA) geometric mean titers (GMT), IgG geometric mean concentrations (GMC), and seroresponse rates (defined according to the World Health Organization standard of either a greater or equal to 4-fold increase in pre-vaccination GMC/GMT ratios or GMC values of greater or equal to 0.35 μg/mL)Footnote 6. The data that were extracted for analysis included information on the study design, population, intervention, comparator, and outcomes of interest. The risk of bias for each study was assessed using the Cochrane Risk of Bias Tool. The Grading of Recommendations, Assessment, Development and Evaluations (GRADE) framework was used to assess the certainty of evidence where possible, based on availability of outcome information. Immunogenicity outcomes (ratios/differences) with Pneu-C-15 or Pneu-C-20 compared to Pneu-C-13 were considered to be numerically lower or higher when all CI values in all studies were less than 1.00 or greater than 1.00, respectively. Serotypes for which these values could not be determined were either those in which CIs were null-inclusive (i.e., included 1.00) or where results were mixed across studies. GRADE data tables for analyzed studies are available in Appendix A.

Literature review of Pneu-C-15 and Pneu-C-20 cost-effectiveness

A systematic review of the cost-effectiveness of Pneu-C-15 and Pneu-C-20 vaccines for preventing pneumococcal disease in infants and children included published studies of economic evaluations conducted in populations aged less than 18 years, comparing currently used vaccines to prevent pneumococcal disease to Pneu-C-15 or Pneu-C-20 and measures of economic outcomes (incremental cost per quality-adjusted life year [QALY], cost per life year, etc.). A systematic literature search for English- and French-language studies was conducted in six electronic databases: Embase, Ovid Medline, International Pharmaceutical Abstracts, EBM Reviews, SCOPUS, and Econlit. The search was limited to records published between January 1, 2018, to March 7, 2023. All costs were adjusted to 2022 Canadian dollars and are reported as such. Additional details of the economic literature review are provided in a supplementary economic evidence summary.

NACI cost-utility analysis

A model-based cost-utility analysis was conducted from health system and societal perspectives. A multi-age static cohort model was used to compare the benefits (in QALYs) and costs (in 2022 Canadian dollars) associated with using Pneu-C-15 or Pneu-C-20 compared to Pneu-C-13 in previously unvaccinated infants that are eligible for routine pneumococcal vaccination. The analysis used a 10-year time horizon, with lifetime costs and consequences of pneumococcal disease discounted at 1.5% and all costs adjusted to 2022 Canadian dollars. Details of the cost-utility analysis are provided in a supplementary economic evidence summary.

Vaccine

There are currently five vaccines in Canada that are authorized for use in children less than 18 years of age:

  • Pneu-P-23 (Pneumovax®23) is a sterile solution of 23 highly purified capsular polysaccharidesFootnote 7.
  • Pneu-C-10 (Synflorix®) is a sterile suspension of saccharides of the capsular antigens of 10 serotypes of S. pneumoniae conjugated to the Non-Typeable Haemophilus influenza protein D, diphtheria or tetanus toxoidFootnote 8.
  • Pneu-C-13 (Prevnar®13) is a sterile solution of polysaccharide capsular antigen of 13 serotypes of S. pneumoniae. The antigens are individually conjugated to a Corynebacterium diphtheriae (CRM197) protein carrierFootnote 9.
  • Pneu-C-15 (Vaxneuvance®) is a sterile suspension of purified capsular polysaccharides from 15 serotypes of S. pneumoniae. The antigens are individually conjugated to diphtheria CRM197 protein carrierFootnote 10.
  • Pneu-C-20 (Prevnar 20TM) is a sterile saccharide suspension of the capsular antigens of 20 serotypes of S. pneumoniae. The antigens are individually conjugated to diphtheria CRM197 proteinFootnote 11.

Additional information about the composition of these vaccines is available in Table 2.

Table 2. Comparison of vaccines authorized for use in children less than 18 years of age in Canada.
Vaccine name PneuMOVAX®23
(Pneu-P-23)
SYNFLORIX®
(Pneu-C-10)
PREVNAR®13
(Pneu-C-13)
VAXNEUVANCE®
(Pneu-C-15)
PREVNAR 20TM
(Pneu-C-20)
Manufacture Merck GSK Pfizer Merck Pfizer
Date of initial authorization in Canada / pediatric age of authorization December 23, 1983 /
2 years old to 17 years old
December 11, 2008/
6 weeks to 5 years old
December 21, 2009/
6 weeks to 17 years old
July 8, 2022 /
6 weeks to 17 years old
May 9, 2022 (adult)
July 21, 2023 (children)/
6 weeks to 17 years old
Type of vaccine Polysaccharide Conjugate Conjugate Conjugate Conjugate
Vaccine composition

25 mcg of capsular polysaccharides from each of S. pneumoniae serotypes 1, 2, 3, 4, 5, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19A, 19F, 20, 22F, 23F and 33F, sodium chloride 0.9 % w/w, phenol 0.25% w/w and water for injection.

1 mcg of each saccharide for S. pneumoniae serotypes 1, 5, 6B, 7F, 9V, 14 and 23F, and 3 mcg of saccharide for serotype 4, 18C and 19F,

Non-Typeable Haemophilus influenzae
(NTHi) protein D, diphtheria or tetanus toxoid carrier protein, aluminium (as aluminium
phosphate), sodium chloride and water for injections.

2.2 mcg of each saccharide for S. pneumoniae serotypes 1, 3, 4, 5, 6A, 7F, 9V, 14, 18C, 19A, 19F and 23F, 4.4 mcg of saccharide for serotype 6B,

34 mcg CRM197 carrier protein, 4.25 mg sodium chloride, 100 mcg polysorbate 80, 295 mcg succinic acid and 125 mcg aluminum as aluminum phosphate adjuvant and water for injection

32 mcg of total pneumococcal polysaccharide (2.0 mcg each of polysaccharide serotypes 1, 3, 4, 5, 6A, 7F, 9V, 14, 18C, 19A, 19F, 22F, 23F and 33F and 4.0 mcg of polysaccharide serotype 6B)

conjugated to 30 mcg of CRM197 carrier protein, 125 mcg of
aluminum (as aluminum phosphate adjuvant),
20 mM L-histidine, 1 mg of polysorbate 20,
150 mM sodium chloride and water for
injection.

2.2 mcg of each of S. pneumoniae serotypes 1, 3, 4, 5, 6A, 7F, 8, 9V, 10A, 11A, 12F, 14, 15B, 18C, 19A, 19F, 22F, 23F and 33F saccharides, 4.4 mcg of 6B saccharide,

51 mcg CRM197 carrier protein, 100 mcg polysorbate 80, 295 mcg succinic acid, 4.4 mg sodium chloride, and 125 mcg aluminum as aluminum phosphate adjuvant and water for injection

Route of administration

Intramuscular or subcutaneous injection

Intramuscular injection

Intramuscular injection

Intramuscular injection

Intramuscular injection

Storage Requirements

Multi-dose vial.
Refrigerate at 2°C to 8°C. Discard opened vial after 48 hours.

Single-dose prefilled syringe. Refrigerate at 2°C to 8°C. Do not freeze. Store in original package.

Single-dose prefilled syringe. Refrigerate at 2°C to 8°C. Do not freeze. Store in original package.

Single-dose prefilled syringe. Refrigerate at 2°C to 8°C. Do not freeze. Protect from light. Administer as soon as possible after being removed from the refrigerator.

Single-dose pre-filled syringe. Refrigerate at 2°C to 8°C. Do not freeze. Store horizontally in original package.

A comparison of serotypes included in currently authorized vaccine formulations is provided in Table 3.

Table 3. Serotypes included in current and new pneumococcal vaccine formulations
Serotypes in penumonoccal vaccines
Vaccine 1 4 6B 9V 14 18C 19F 23F 5 7F 3 6A 19A 22F 33F 8 10A 11A 12F 15B 2 9N 17F 20
PNEU-C-10 Y Y Y Y Y Y Y Y Y Y N N N N N N N N N N N N N N
PNEU-C-13 Y Y Y Y Y Y Y Y Y Y Y Y Y N N N N N N N N N N N
PNEU-C-15 Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y N N N N N N N N N
PNEU-C-20 Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y N N N N
PNEU-C-23 Y Y Y Y Y Y Y Y Y Y Y N Y Y Y Y Y Y Y Y Y Y Y Y
Abbreviations: Y: yes; N: no

Evidence summary

Burden of disease

IPD incidence rates by age group

Following the implementation of Pneu-C programs in Canada, between 2001 and 2021, there was an approximately 65% reduction in overall IPD incidence in children under five years of age. Although Pneu-C-7 vaccine had the largest impact on IPD incidence in the under-five age group, further decreases in this age group were observed with the switch to Pneu-C-13 in 2010. Since 2015, when the reported IPD incidence rate in children under five years of age reached 10.7 (95% CI: 9.3-12.2) cases per 100,000 population, the IPD in this age group has remained stable, with the exception being a decrease in the IPD incidence rate in 2020 (IR: 6.1, 95% CI: 5.0-7.3) during the first year of the COVID-19 pandemic. In contrast, since the introduction of Pneu-C programs, the IPD incidence in individuals 5 to 19 has remained low and relatively stable (Figure 1). Between 2014 and 2021, there have been, on average, 214 cases of IPD reported annually for children under five years of age (164 cases per year in the 1-to-4-year age group), and 108 cases per year in the 5- to 19-year-old age group.

Figure 1. IPD incidence rates (per 100,000) by age group following the introduction of Pneu-C programs in Canada, 2001-2021
Figure 1. Text version below.
Figure 1: Text description

A line graph displaying the incidence rate of invasive pneumococcal disease each year from 2001 to 2021, for different age groups including less than 5 years of age, 5 to 19 years of age, 20 to 39 years of age, 40 to 59 years of age, and 60 years of age and older, and highlighting the dates of implementation of Pneu-C-7, Pneu-C-13, and Pneu-P-23 in Canada.

Year Less than 1 1 to 4 5 to 9 10 to 14 15 to 19 20 to 24 25 to 29 30 to 39 40 to 59 60 and over
2001 37.8 25.2 3.6 1.1 1.5 1.6 1.8 2.5 4.1 10.8
2002 50.0 33.5 3.2 1.6 1.2 1.6 2.1 3.5 4.7 15.6
2003 54.5 35.6 4.4 1.2 1.0 1.4 3.0 4.7 6.5 18.3
2004 42.9 31.0 4.3 1.2 1.3 1.6 2.8 4.9 7.6 20.7
2005 25.9 21.4 5.3 1.8 1.3 2.6 3.2 5.0 8.1 20.4
2006 20.3 13.7 4.6 1.8 1.8 2.0 3.8 6.8 9.0 19.1
2007 30.3 15.8 3.4 1.9 2.1 3.4 4.5 7.1 10.2 20.5
2008 29.8 16.7 4.6 1.4 1.4 2.7 3.5 5.2 9.6 21.6
2009 27.8 18.7 5.8 1.6 1.8 2.4 3.5 5.5 8.9 22.3
2010 25.1 16.5 4.8 1.8 1.3 1.9 3.1 5.2 9.0 23.4
2011 20.7 15.5 5.3 2.5 1.7 1.4 3.1 5.4 9.2 21.8
2012 18.3 13.6 4.3 2.5 1.6 2.5 4.0 5.1 9.2 22.9
2013 18.7 11.2 3.8 1.5 1.3 1.5 2.8 4.6 8.4 21.9
2014 17.6 10.9 3.7 1.1 1.0 1.7 2.6 4.4 8.6 21.2
2015 14.4 9.8 3.9 1.2 1.5 1.9 2.8 4.5 8.9 20.6
2016 15.7 12.1 3.6 1.3 1.7 2.3 2.6 4.8 9.0 20.0
2017 15.6 12.3 3.5 1.2 1.4 1.5 2.8 5.3 9.0 21.4
2018 12.0 12.6 3.7 1.2 1.2 1.6 3.6 5.7 11.5 23.4
2019 13.4 11.3 3.8 1.2 1.3 2.1 2.8 6.0 10.3 21.3
2020 6.0 6.1 1.7 0.5 0.8 1.5 2.5 3.9 7.2 11.0
2021 10.3 9.5 1.5 0.4 0.6 2.0 2.5 4.2 6.6 9.3

Data Source: CNDSS

IPD incidence rates by geographic region

Differences in IPD incidence rates are also observed geographically. When compared to those reported for the rest of Canada, the incidence rates of IPD in Northern Canada have been higher across age groups, and particularly in children less than one year of age (incidence rate ratio of 5.9 [95% CI: 4.7-7.5]). Outside of Northern Canada, the incidence rates in 5- to 19-year-old age groups have consistently remained below 5 cases per 100,000 population between 2001 and 2021 (Table 4).

Table 4. Comparison of IPD incidence rate (IR, per 100,000 population) and incidence rate ratios (IRR) between Northern Canada and rest of Canada, by age group, 2002-2021Footnote a
Age group (years) IR Northern Canada IR Rest of Canada IRR (95% CI)
Less than 1 133.0 22.6 5.9 (4.7-7.5)
1-4 36.7 16.0 2.3 (1.8-2.9)
5-9 10.9 3.9 2.8 (1.9-4.0)
10-14 2.8 1.4 1.9 (0.9-4.1)Footnote b
15-19 6.1 1.4 4.4 (2.6-7.3)
Footnote a

Data Source: CNDSS, ICS

Return to footnote a referrer

Footnote b

Not statistically significant

Return to footnote b referrer

IPD reporting according to vaccine serotypes

Excluding a slight increase in 2022, the number of isolates caused by Pneu-C-7 vaccine serotypes has remained relatively stable following the introduction of Pneu-C-13 into routine pediatric programs despite the approximately 25% lower GMC IgG concentrations that were reported in the Pneu-C-7/Pneu-C-13 clinical trials for the shared antigens (although seroresponse rates were similar) [Figure 2]Footnote 9.

Figure 2. Number of IPD isolates by serotype contained in Pneu-C-7 and Pneu-C-13 for pediatric age groups (≤17 years), 2011-2022
Figure 2. Text version below.
Figure 2: Text description

A line graph displaying the number of Streptococcus pneumoniae isolates collected each year from 2011 to 2022, for Pneu-C-7 serotypes and Pneu-C-13/non-Pneu-C-7 serotypes.

Year Number of isolates of:
Pneu-C-7 serotypes Pneu-C-13/non-Pneu-C-7 serotypes
2011 15 281
2012 14 182
2013 14 107
2014 8 75
2015 10 80
2016 18 75
2017 18 68
2018 15 65
2019 27 59
2020 12 38
2021 22 39
2022 48 85

Data Source: National Laboratory Surveillance of IPD in Canada (eSTREP); NML. Preliminary data for 2021 and 2022.

Following the introduction of Pneu-C-13 vaccine into routine pediatric immunization programs, there has been a generally decreasing trend in the proportion of pediatric IPD isolates due to vaccine serotypes, from approximately 58% in 2011 to 31% in 2022. However, the proportion of non-Pneu-C-13 vaccine serotypes has increased from 2011 to 2022. In children less than 18 years of age, the largest increases in vaccine serotypes were observed for Pneu-C-20/non-Pneu-C-15 serotypes (from 15.1% to 22.8%), followed by Pneu-C-15/non-Pneu-C-13 serotypes (from 8.3% to 14.9%) and Pneu-P-23/non-Pneu-C-20 serotypes (from 1.8% to 4.4%); the proportion of IPD isolates caused by non-vaccine type (NVT) serotypes increased from approximately 17% to 28%. Figure 3 provides information by age group.

Figure 3. Proportion of IPD isolates by various vaccine groupings for all pediatric age groups (≤17 years), 2011 and 2022
Figure 3. Text version below.
Figure 3: Text description

A stacked bar graph displaying the percentage of Streptococcus pneumoniae isolates collected from each vaccine category (PNEU-C-13, PNEU-C-15/non-PNEU-C-13, PNEU-C-20/non-PNEU-C-15, PNEU-P-23/non-PNEU-C-20 and other non-vaccine serotypes) in 2011 compared to 2022, for different pediatric age groups: <2 years, 2-4 years and 5-17 years of age.

Age group Year Vaccine (%, N) Total
PNEU-C-13 PNEU-C-15/
non-PNEU-C-13
PNEU-C-20/
non-PNEU-C-15
PNEU-P-23/
non-PNEU-C-20
NVT
Less than 2 years 2011 46.8% (89) 7.9% (15) 17.9% (34) 2.6% (5) 24.7% (47) 190
2022 24.2% (39) 13.0% (21) 24.2% (39) 6.2% (10) 32.3% (52) 161
2 to 4 years 2011 70.6% (108) 11.8% (18) 9.2% (14) 0.7% (1) 7.8% (12) 153
2022 28.2% (33) 16.2% (19) 22.2% (26) 2.6% (3) 30.8% (36) 117
5 to 17 years 2011 59.6% (99) 5.4% (9) 17.5% (29) 1.8% (3) 15.7% (26) 166
2022 40.1% (61) 15.8% (24) 21.7% (33) 2.0% (3) 20.4% (31) 154

Data Source: National Laboratory Surveillance of IPD in Canada (eSTREP); NML. Preliminary data for 2021 and 2022.

In children less than 2 years of age, apart from a slight increase in 19F and 19A serotype isolates, there was an overall decrease in the proportion of isolates caused by Pneu-C-13 serotypes from 2011 to 2014, after which the proportion stabilized (Figure 4).

Figure 4. Proportion of IPD isolates from 2011-2022 by vaccine, for less than 2 years of age
Figure 4. Text version below.
Figure 4: Text description

A stacked bar graph displaying the percentage of Streptococcus pneumoniae isolates collected from each vaccine category (PNEU-C-13, PNEU-C-15/non-PNEU-C-13, PNEU-C-20/non-PNEU-C-15, PNEU-P-23/non-PNEU-C-20 and other non-vaccine serotypes), for children <2 years of age in 2011 to 2022.

Year Vaccine (%, N) Total
PNEU-C-13 PNEU-C-15/
non-PNEU-C-13
PNEU-C-20/
non-PNEU-C-15
PNEU-P-23/
non-PNEU-C-20
NVT
2011 46.8% (89) 7.9% (15) 17.9% (34) 2.6% (5) 24.7% (47) 190
2012 37.5% (60) 13.1% (21) 23.1% (37) 1.9% (3) 24.4% (39) 160
2013 19.8% (34) 24.4% (42) 24.4% (42) 1.7% (3) 29.7% (51) 172
2014 6.8% (10) 21.6% (32) 32.4% (48) 7.4% (11) 31.8% (47) 148
2015 15.4% (22) 25.2% (36) 23.1% (33) 2.8% (4) 33.6% (48) 143
2016 20.7% (34) 18.9% (31) 29.9% (49) 1.8% (3) 28.7% (47) 164
2017 11.9% (18) 22.5% (34) 27.8% (42) 8.6% (13) 29.1% (44) 151
2018 13.2% (15) 16.7% (19) 32.5% (37) 4.4% (5) 33.3% (38) 114
2019 16.8% (23) 20.4% (28) 19.0% (26) 5.8% (8) 38.0% (52) 137
2020 25.9% (22) 16.5% (14) 28.2% (24) 5.9% (5) 23.5% (20) 85
2021 31.1% (37) 15.1% (18) 21.0% (25) 4.2% (5) 28.6% (34) 119
2022 24.2% (39) 13.0% (21) 24.2% (39) 6.2% (10) 32.3% (52) 161

Data Source: National Laboratory Surveillance of IPD in Canada (eSTREP); NML. Preliminary data for 2021 and 2022.

In contrast, the proportion of Pneu-C-20 unique serotypes has increased in children less than 2 years of age, from 25.8% in 2011 to 37.3% in 2022. In 2022, the two additional serotypes contained in Pneu-C-15 would have potentially prevented an additional 13% of IPD cases in children less than 2 years of age, while the 7 additional serotypes contained in Pneu-C-20 would have potentially prevented approximately 37% of additional IPD cases in this age group (Figure 5).

Figure 5. Proportion of IPD isolates with Pneu-C-15 and Pneu-C-20 unique serotypes, among children less than 2 years old
Figure 5. Text version below.
Figure 5: Text description

A stacked bar graph displaying the percentage of Streptococcus pneumoniae isolates collected of each Pneu-C-15/non-Pneu-C-13 (22F and 33F) and Pneu-C-20/non-Pneu-C-15 (8, 10A, 11A, 12F and 15B/C) serotype, including a total combined percentage of all seven serotypes, for children <2 years of age in 2011 to 2022.

Year(n) Serotype(%, n) Combined total (%,n)
PNEU-C-15/non-PNEU-C-13 PNEU-C-20/non-PNEU-C-15
22F 33F 8 10A 11A 12F 15BC
2011 (190) 5.8% (11) 2.1% (4) 2.6% (5) 4.2% (8) 3.2% (6) 2.1% (4) 5.8% (11) 25.8% (49)
2012 (160) 8.8% (14) 4.4% (7) 3.1% (5) 4.4% (7) 4.4% (7) 0.6% (1) 10.6% (17) 36.3% (58)
2013 (172) 14.5% (25) 9.9% (17) 1.7% (3) 7.0% (12) 4.7% (8) 1.2% (2) 9.9% (17) 48.8% (84)
2014 (148) 14.2% (21) 7.4% (11) 1.4% (2) 7.4% (11) 8.8% (13) 2.0% (3) 12.8% (19) 54.1% (80)
2015 (143) 13.3% (19) 11.9% (17) 2.1% (3) 6.3% (9) 1.4% (2) 2.1% (3) 11.2% (16) 48.3% (69)
2016 (164) 11.0% (18) 7.9% (13) 1.2% (2) 9.1% (15) 1.2% (2) 1.2% (2) 17.1% (28) 48.8% (80)
2017 (151) 7.9% (12) 14.6% (22) 1.3% (2) 6.0% (9) 2.0% (3) 2.0% (3) 16.6% (25) 50.3% (76)
2018 (114) 11.4% (13) 5.3% (6) 1.8% (2) 5.3% (6) 4.4% (5) 1.8% (2) 19.3% (22) 49.1% (56)
2019 (137) 11.7% (16) 8.8% (12) 1.5% (2) 4.4% (6) 2.2% (3) 0.0% (0) 10.9% (15) 39.4% (54)
2020 (85) 12.9% (11) 3.5% (3) 1.2% (1) 8.2% (7) 5.9% (5) 1.2% (1) 11.8% (10) 44.7% (38)
2021 (119) 12.6% (15) 2.5% (3) 1.7% (2) 4.2% (5) 0.8% (1) 3.4% (4) 10.9% (13) 36.1% (43)
2022 (161) 11.2% (18) 1.9% (3) 1.2% (2) 5.0% (8) 2.5% (4) 0.6% (1) 14.9% (24) 37.3% (60)

Data Source: National Laboratory Surveillance of IPD in Canada (eSTREP); NML. Preliminary data for 2021 and 2022.

All/Combined total refers to the total combined percentage of all Pneu-C-15/non-Pneu-C-13 (22F and 33F) and Pneu-C-20/non-Pneu-C-15 serotypes (8, 10A, 11A, 12F and 15B/C).

In children 2 to 4 years of age, the proportion of isolates due to the Pneu-C-13 vaccine serotypes has decreased since 2011 from 70.6% to 28.2% in 2022. Similarly, to the under 2-year age group, a more rapid decrease was observed between 2011 to 2014/15, after which the proportion change stabilized. During the same period, an increase was observed in Pneu-C-15/non-Pneu-C-13 and Pneu-C-20/non-Pneu-15 serotypes (from 11.8% to 16.2%, and 9.2% to 22.2%, respectively) [Figure 6 ].

Figure 6. Proportion of IPD isolates from 2011-2022 by vaccine, for 2-to-4-year age group
Figure 6. Text version below.
Figure 6: Text description

A stacked bar graph displaying the percentage of Streptococcus pneumoniae isolates collected from each vaccine category (PNEU-C-13, PNEU-C-15/non-PNEU-C-13, PNEU-C-20/non-PNEU-C-15, PNEU-P-23/non-PNEU-C-20 and other non-vaccine serotypes), for children 2 to 4 years of age in 2011 to 2022.

Year Vaccine (%, N) Total
PNEU-C-13 PNEU-C-15/
non-PNEU-C-13
PNEU-C-20/
non-PNEU-C-15
PNEU-P-23/
non-PNEU-C-20
NVT
2011 70.6% (108) 11.8% (18) 9.2% (14) 0.7% (1) 7.8% (12) 153
2012 47.8% (66) 13.8% (19) 13.8% (19) 0.7% (1) 23.9% (33) 138
2013 39.4% (37) 12.8% (12) 25.5% (24) 2.1% (2) 20.2% (19) 94
2014 39.6% (40) 12.9% (13) 15.8% (16) 4.0% (4) 27.7% (28) 101
2015 23.0% (17) 17.6% (13) 27.0% (20) 4.1% (3) 28.4% (21) 74
2016 21.6% (22) 16.7% (17) 21.6% (22) 2.0% (2) 38.2% (39) 102
2017 26.6% (33) 12.1% (15) 18.5% (23) 0.0% (0) 42.7% (53) 124
2018 26.8% (26) 20.6% (20) 24.7% (24) 0.0% (0) 27.8% (27) 97
2019 27.9% (29) 16.3% (17) 24.0% (25) 1.0% (1) 30.8% (32) 104
2020 22.7% (10) 18.2% (8) 18.2% (8) 4.5% (2) 36.4% (16) 44
2021 19.4% (14) 8.3% (6) 36.1% (26) 1.4% (1) 34.7% (25) 72
2022 28.2% (33) 16.2% (19) 22.2% (26) 2.6% (3) 30.8% (36) 117

Data Source: National Laboratory Surveillance of IPD in Canada (eSTREP); NML. Preliminary data for 2021 and 2022.

In 2022, the two additional serotypes contained in Pneu-C-15 would have potentially prevented
approximately 16% of additional IPD cases in children 2 to 4 years of age, while the 7 additional serotypes contained in Pneu-C-20 would have potentially prevented approximately 39% of additional IPD cases in this age group (Figure 7).

Figure 7. Proportion of IPD isolates with Pneu-C-15/20 unique serotypes, among children 2 to 4 years old
Figure 7. Text version below.
Figure 7: Text description

A stacked bar graph displaying the percentage of Streptococcus pneumoniae isolates collected of each Pneu-C-15/non-Pneu-C-13 (22F and 33F) and Pneu-C-20/non-Pneu-C-15 (8, 10A, 11A, 12F and 15B/C) serotype, including a total combined percentage of all seven serotypes, for children 2 to 4 years of age in 2011 to 2022.

Year (n) Serotype (%, N) Combined total (%, N)
PNEU-C-15/non-PNEU-C-13 PNEU-C-20/non-PNEU-C-15
22F 33F 8 10A 11A 12F 15BC
2011 (153) 9.2% (14) 2.6% (4) 0.7% (1) 0.7% (1) 0.7% (1) 1.3% (2) 5.9% (9) 20.9% (32)
2012 (138) 11.6% (16) 2.2% (3) 0.7% (1) 4.3% (6) 3.6% (5) 0.7% (1) 4.3% (6) 27.5% (38)
2013 (94) 9.6% (9) 3.2% (3) 0.0% (0) 6.4% (6) 1.1% (1) 1.1% (1) 17.0% (16) 38.3% (36)
2014 (101) 11.9% (12) 1.0% (1) 0.0% (0) 1.0% (1) 3.0% (3) 0.0% (0) 11.9% (12) 28.7% (29)
2015 (74) 14.9% (11) 2.7% (2) 2.7% (2) 8.1% (6) 0.0% (0) 0.0% (0) 16.2% (12) 44.6% (33)
2016 (102) 12.7% (13) 3.9% (4) 3.9% (4) 1.0% (1) 2.0% (2) 1.0% (1) 13.7% (14) 38.2% (39)
2017 (124) 10.5% (13) 1.6% (2) 1.6% (2) 3.2% (4) 4.0% (5) 0.0% (0) 9.7% (12) 30.6% (38)
2018 (97) 13.4% (13) 7.2% (7) 2.1% (2) 4.1% (4) 2.1% (2) 0.0% (0) 16.5% (16) 45.4% (44)
2019 (104) 10.6% (11) 5.8% (6) 0.0% (0) 0.0% (0) 8.7% (9) 1.0% (1) 14.4% (15) 40.4% (42)
2020 (44) 9.1% (4) 9.1% (4) 2.3% (1) 11.4% (5) 0.0% (0) 0.0% (0) 4.5% (2) 36.4% (16)
2021 (72) 5.6% (4) 2.8% (2) 4.2% (3) 1.4% (1) 4.2% (3) 0.0% (0) 26.4% (19) 44.4% (32)
2022 (117) 14.5% (17) 1.7% (2) 0.9% (1) 2.6% (3) 2.6% (3) 0.0% (0) 16.2% (19) 38.5% (45)

Data Source: National Laboratory Surveillance of IPD in Canada (eSTREP); NML. Preliminary data for 2021 and 2022.

All/Combined total refers to the total combined percentage of all Pneu-C-15/non-Pneu-C-13 (22F and 33F) and Pneu-C-20/non-Pneu-C-15 serotypes (8, 10A, 11A, 12F and 15B/C).

A similar trend has also been observed in the 5- to 17-year-old age group. In 2022, Pneu-C-15/non-Pneu-C-13 and Pneu-C-20/non-Pneu-15 serotypes contributed to approximately 16% and 22% of isolates, respectively (Figure 8).

Figure 8. Proportion of IPD isolates from 2011-2022 by vaccine, for 5-to-17-year age group
Figure 8. Text version below.
Figure 8: Text description

A stacked bar graph displaying the percentage of Streptococcus pneumoniae isolates collected from each vaccine category (PNEU-C-13, PNEU-C-15/non-PNEU-C-13, PNEU-C-20/non-PNEU-C-15, PNEU-P-23/non-PNEU-C-20 and other non-vaccine serotypes), for children 5 to 17 years of age in 2011 to 2022.

Year Vaccine (%, N) Total
PNEU-C-13 PNEU-C-15/
non-PNEU-C-13
PNEU-C-20/
non-PNEU-C-15
PNEU-P-23/
non-PNEU-C-20
NVT
2011 59.6% (99) 5.4% (9) 17.5% (29) 1.8% (3) 15.7% (26) 166
2012 50.7% (70) 9.4% (13) 21.7% (30) 1.4% (2) 16.7% (23) 138
2013 49.5% (50) 13.9% (14) 14.9% (15) 2.0% (2) 19.8% (20) 101
2014 36.7% (33) 13.3% (12) 14.4% (13) 1.1% (1) 34.4% (31) 90
2015 43.6% (51) 10.3% (12) 13.7% (16) 4.3% (5) 28.2% (33) 117
2016 30.6% (37) 14.0% (17) 20.7% (25) 5.0% (6) 29.8% (36) 121
2017 32.7% (35) 12.1% (13) 17.8% (19) 3.7% (4) 33.6% (36) 107
2018 35.8% (39) 12.8% (14) 17.4% (19) 6.4% (7) 27.5% (30) 109
2019 29.1% (34) 20.5% (24) 13.7% (16) 6.0% (7) 30.8% (36) 117
2020 40.9% (18) 4.5% (2) 31.8% (14) 6.8% (3) 15.9% (7) 44
2021 25.0% (10) 17.5% (7) 10.0% (4) 2.5% (1) 45.0% (18) 40
2022 40.1% (61) 15.8% (24) 21.7% (33) 2.0% (3) 20.4% (31) 154

Data Source: National Laboratory Surveillance of IPD in Canada (eSTREP); National Microbiology Laboratory. Preliminary data for 2021 and 2022.

Between 2018 and 2022, the conjugate-vaccine serotypes that were the most common cause of IPD in children were ST22F, ST15B/C, ST19A and 3 which represented, on average, approximately 12%, 12%, 9% and 8% of all isolates collected per year, respectively (National Laboratory Surveillance of IPD in Canada (eSTREP); NML).

IPD incidence in children at increased risk of IPD due to underlying medical conditions

Data on the risk of pneumococcal disease in the pediatric population in the pneumococcal conjugate vaccine era is available from the US. Even with widespread use of pneumococcal conjugate vaccines, from the period 2007 to 2010, children with certain underlying medical conditions continued to demonstrate an increased burden of pneumococcal diseaseFootnote 12, including IPD, pneumococcal pneumonia and all-cause pneumonia. In 2018–2019, approximately 25% of IPD in children 5 to 18 years occurred in children with immunocompromising conditions, cochlear implants, or cerebrospinal fluid leaksFootnote 13.

Non-invasive pneumococcal disease burden

National surveillance data on AOM and CAP are not available in Canada, and disease burden estimates are based on provincial health administrative data from British Columbia (BC) and Ontario (ON). The estimated incidence rates for CAP following Pneu-C-13 vaccine programme implementation among children less than 5 years of age ranged from 2,500 per 100,000 (BC) to 5,000 per 100,000 (ON). Among children 5 to 17 years of age, the incidence of CAP ranged from 950 per 100,000 (BC) to 1,250 per 100,000 (ON)Footnote 14. The estimated incidence rates for AOM following Pneu-C-13 vaccine programme implementation among children less than 5 years of age ranged from 14,000 per 100,000 (BC) to 25,000 per 100,000 (ON). Among children 5 to 17 years of age, the incidence of AOM ranged from 6,200 per 100,000 (BC) to 7,200 per 100,000 (ON)Footnote 14. (Figure 9). Overall, following the implementation of the Pneu-C-13 vaccine program, the available data suggests limited changes to non-IPD burden, with a slight decrease in AOM incidence in younger childrenFootnote 14.

International studies show that the proportion of CAP cases attributable to S. pneumoniae was estimated to be 6% in infants under 1 year of age and 12% in children 1 to 15 years of ageFootnote 15Footnote 16. The proportion of AOM cases attributable to S. pneumoniae was estimated to be 17% in childrenFootnote 15Footnote 17. Given the reliance on administrative data and limited studies assessing the proportion of non-invasive CAP and AOM by etiology, there is considerable uncertainty about the proportion of non-invasive CAP and AOM due to S. pneumoniae as well as the relevant serotype distribution in children with these infections when they are caused by S. pneumoniae.

Figure 9. Age group-specific incidence of CAP (a) and AOM (b) before and after implementation of Pneu-C-13 vaccine programme in Ontario and British Columbia

a. Community-acquired pneumonia

Figure 9a. Text version below.
Figure 9a: Text description

Age group-specific incidence of CAP (a)

A bar graph displaying the incidence rate of Community Acquired Pneumonia (CAP) in British Columbia (on the far left), and in Ontario (on the left), pre-PNEU-C-13 in blue and following the introduction of PNEU-C-13 period in orange children 4 years old and younger and in British Columbia (on right) and in Ontario (on the far right) for pre PNEU-C-13 period in blue and following the introduction of PNEU-C-13 period for children 5 to 17 years old.

Age group Province Period Incidence per 100,000 population
0 to 4 years British Columbia Pre-PNEU-C-13 period 18,639.80
0 to 4 years British Columbia PNEU-C-13 period 13,603.80
0 to 4 years Ontario Pre-PNEU-C-13 period 28,937.90
0 to 4 years Ontario PNEU-C-13 period 25,467.60
5 to 17 years British Columbia Pre-PNEU-C-13 period 7,648.40
5 to 17 years British Columbia PNEU-C-13 period 6,205.70
5 to 17 years Ontario Pre-PNEU-C-13 period 7,998.60
5 to 17 years Ontario PNEU-C-13 period 7,225.90

b. Acute otitis media

Figure 9b. Text version below.
Figure 9b: Text description

Age group-specific incidence of AOM (b)

A bar graph displaying the incidence rate of Acute Otitis Media (AOM) in British Columbia (on the far left), and in Ontario (on the left), pre-PNEU-C-13 in blue and following the introduction of PNEU-C-13 period in orange children 4 years old and younger and in British Columbia (on right) and in Ontario (on the far right) for pre PNEU-C-13 period in blue and following the introduction of PNEU-C-13 period for children 5 to 17 years old.

Age group Province Period Incidence per 100,000 population
0 to 4 years British Columbia Pre-PNEU-C-13 period 2,671.60
0 to 4 years British Columbia PNEU-C-13 period 2,464.10
0 to 4 years Ontario Pre-PNEU-C-13 period 4,854.20
0 to 4 years Ontario PNEU-C-13 period 4,991.10
5 to 17 years British Columbia Pre-PNEU-C-13 period 957.60
5 to 17 years British Columbia PNEU-C-13 period 945.20
5 to 17 years Ontario Pre-PNEU-C-13 period 1,289.80
5 to 17 years Ontario PNEU-C-13 period 1,249.00

Figures adapted from Nasreen S et al., 2022Footnote 14.

Immunogenicity, efficacy and safety of Pneu-C-15 and Pneu-C-20 in pediatric populations

There are currently no efficacy or effectiveness data available for Pneu-C-15 or Pneu-C-20 vaccines for any pediatric indication. NACI reviewed the evidence on safety and immunogenicity of Pneu-C-15 vaccine from eight Phase 2/3 clinical trials which included a range of pediatric populations, and which used different vaccine schedules. An additional trial, V114-022, provided information about immunogenicity and safety following the immunization of 14 hematopoietic stem cell transplant (HSCT) participants 3 to 17 years of age (with 8 receiving Pneu-C-15)Footnote 18. For the Pneu-C-20 vaccine, data on the safety and immunogenicity was available from five Phase 2/3 clinical trials. Summary of key clinical trial information that was reviewed by NACI is provided in Table 8.

Overall, a comparative analysis of data reported in Pneu-C-15 studies V114-008, V114-025, V114-027 and V114-029Footnote 19Footnote 20Footnote 21Footnote 22, and in Pneu-C-20 studies B7471003, B7471011, B747B1012, and B7471013Footnote 23Footnote 24Footnote 25Footnote 26 showed congruent immune response patterns following vaccination with using either a 2+1 or 3+1 immunization schedule in healthy vaccine-naïve infants (Table 9, Table 10, Table 11, Table 12, Table 13). In addition, there were no differences found in reported adverse events and the overall safety profiles of higher-valent vaccines when compared to Pneu-C-13 (Table 13, Table 14, Table 15).

Immunogenicity

NACI reviewed the available evidence on immunogenicity of Pneu-C-15 and Pneu-C-20 vaccines in the context of routine pediatric immunization programs as well as catch-up and re-immunization schedules. The infant schedules used in the studies included a two dose (provided at 2 and 4 months of age) or three dose (provided at 2, 4 and 6 months of age) priming series followed by an additional dose at 11 to 15 months of age. Studies that evaluated Pneu-C-15 immunogenicity in pre-term infants also used an alternative priming schedule in which the vaccine was provided at 2, 3 and 4 months of age as well as 11-15 months. Immunogenicity was measured one month following dose administration and evaluated post dose 2 (PD2), 3 (PD3) and 4 (PD4). In all infant studies, Pneu-C vaccines were provided concomitantly with other recommended pediatric vaccines.

Immunogenicity of Pneu-C-15 in pediatric populations

Immunogenicity following immunization with Pneu-C-15 was reported in seven Phase 2/3 clinical trials that included healthy children (five studies), children with sickle cell disease (one study) and children with HIV infection (one study) (Table 8).

In the pivotal double-blind clinical trial V114-025Footnote 20 that used a 2+1 vaccination schedule, immunogenicity was measured in healthy infants aged 2 to 15 months who were vaccinated with Pneu-C-13 (n=593) or Pneu-C-15 (n=591). When analyzed according to relative differences in antibody concentrations, lower GMC ratios were observed following dose 2 (PD2) and dose 3 (PD3) with Pneu-C-15 vaccination for the majority of serotypes (9/13 and 11/13, respectively). In Pneu-C-15 recipients, the lowest titres were reported for serotypes 1, 5 and 6A, PD3. Similarly, when assessed by OPA GMT, functional antibodies were lower for 11/13 serotypes PD3 in Pneu-C-15 recipients compared to Pneu-C-13 recipients. However, differences between these vaccines were less pronounced when immunogenicity was reported as seroresponse rate differences, with lower values measured for 3/13 and 6/13 shared serotypes PD2 and PD3, respectively. The patterns of IgG immune responses between doses in this study were generally comparable between the intervention groups, demonstrating significant antibody waning prior to the administration of the booster dose, as well as rapid boosting following the receipt of the booster dose, confirming the presence of immune memory. A summary of GRADE evidence is provided in Table 9.

In three clinical trials that used a 3+1 vaccination schedule (V114-008, V114-027, V114-029)Footnote 19Footnote 21Footnote 22, immunogenicity was assessed in close to 1,400 healthy infant Pneu-C-15 recipients. Lower antibody concentrations were consistently reported after Pneu-C-15 administration for 5/13 shared serotypes PD3 (synthesis of 2 trials) and PD4 (synthesis of 3 trials). Compared to Pneu-C-13, OPA GMT ratios were numerically lower for serotypes 4, 6A, 19A and 23F, PD3 as well as serotypes 1, 3, 5, 6B, 7F and 9V PD4 in Pneu-C-15 recipients (synthesis of 2 trials). There were notable uncertainties regarding the differences in seroresponse rates between groups PD3 and PD4. Similar to what was observed following a two-dose primary schedule, the pattern of antibody waning following the receipt of the primary series was comparable and significant PD3, while PD4 administration immune responses demonstrated a pattern that was conclusive with the establishment of immune memory. A summary of immunogenicity data reported in studies V114-008, V114-025, V114-027 and V114-029 and a summary of GRADE evidence is provided in Table 10.

Mixed schedules

The V114-027 trialFootnote 21 was the only trial that evaluated the immunogenicity of mixed schedules. In this study, 900 healthy participants 40 to 90 days of age were randomized to one of five groups (n=180 per group) to receive a complete four dose series with Pneu-C-13 or Pneu-C- 15, or a mixed regimen initiated with one, two or three doses of Pneu-C-13 and continued with Pneu-C-15.

When assessed by serotype-specific seroresponse rates, a mixed regimen consisting of two or three Pneu-C-15 doses elicited generally comparable immune responses PD3 to those observed after Pneu-C-13 only administration. Similar GMC ratios between a Pneu-C-13-only schedule and a mixed schedule using two doses of Pneu-C-15 were also observed PD3 and PD4. In a mixed schedule with three Pneu-C-15 doses, lower GMC ratios were observed for 4/13 shared serotypes both PD3 and PD4.

As seen with schedules that used only Pneu-C-13 or Pneu-C-15 vaccine, significant antibody waning was observed across all mixed intervention groups PD3, while the fourth dose led to a steep increase in antibody concentrations that were comparable or superior to those observed PD3.

Catch-up vaccination: vaccine-naïve and children with an incomplete Pneu-C series

In the double-blind V114-024 clinical trialFootnote 27, 602 healthy pneumococcal vaccine-naïve children or children who previously received a partial series of a licensed pneumococcal conjugate vaccine (Pneu-C-7, Pneu-C-10 or Pneu-C-13) were randomized to receive an age-appropriate schedule using one to three catch-up doses of either Pneu-C-13 or Pneu-C-15 vaccine. The study stratified children in five groups according to age (7 to 11 months, 12 to 23 months, greater or equal to 2 to less than 6 years, and greater or equal to 6 to 17 years), with all participants less than 2 years of age being Pneu-C vaccine-naïve. In all age groups, serotype-specific antibody concentrations and seroresponse rates at 30 days following the last dose were generally comparable between intervention groups for all common vaccine serotypes and significantly higher for the Pneu-C-15 unique serotypes.

Re-vaccination: children at increased risk of IPD with a completed Pneu-C-13 series

In the V114-023 trialFootnote 28, 99 children 5 to 17 years old with sickle cell disease were randomized in a 2:1 ratio to receive a single dose of either Pneu-C-15 or Pneu-C-13. When assessed by serotype-specific IgG GMCs at 30 days post Pneu-C vaccination, immune responses were generally similar between groups for the shared serotypes and higher for the Pneu-C-15 unique serotypes. Over 75% of Pneu-C-15 recipients achieved greater or equal to 4-fold rise in antibody concentrations for the two unique serotypes whereas only 42% and 58% of vaccine recipients achieved greater or equal to 4-fold rise OPA GMTs for the serotype 33F and 22F, respectively.

In the V114-030 studyFootnote 29, 400 children 6 to 17 years old with HIV were randomized in a 1:1 ratio to receive a single dose of either Pneu-C-15 or Pneu-C-13 vaccine followed by Pneu-P-23 at week 8 post immunization. At 30 days following the administration of Pneu-C-15, IgG GMC were numerically similar for all 13 shared and higher for the two unique serotypes. One month following Pneu-P-23 administration, antibody concentrations were generally similar between groups, although numerically lower for all serotypes compared to those observed one month prior, post Pneu-C administration.

Pre-term infants

An integrated analysis of over 350 pre-term infants who were enrolled in studies V114-025, V114-027, V114-029 and V114-031Footnote 20Footnote 21Footnote 22Footnote 30 demonstrated that, overall, immune responses following Pneu-C-15 vaccination were generally comparable to those observed in pre-term infants receiving Pneu-C-13 for the shared serotypes and consistent with those observed in term infants receiving four doses of Pneu-C-15 vaccine (including IgG GMC and OPA GMT). Over 85% and 96% of pre-term infants receiving Pneu-C-15 achieved seroprotective IgG concentrations of greater or equal to 0.35 μg/mL for each of the vaccine serotypes PD3 and PD4, respectively.

Immunogenicity of Pneu-C-20 in pediatric populations

A pivotal clinical study B7471012Footnote 25 measured immune responses in infants following a 2+1 immunization schedule. The observed IgG antibody concentrations PD2 and PD3 were lower for all common serotypes among Pneu-C-20 recipients compared to Pneu-C-13 recipients. While a lower seroresponse was reported for 9/13 shared serotypes PD2, seroresponse PD3 was only lower for ST3 while for the majority of other shared serotypes (12/13) it was uncertain due to the inclusion of null. The OPA GMTs were generally lower at all time points for the shared serotypes except for ST19A, PD3. A summary of the GRADE assessment is provided in Table 11.

Two clinical trials measured immune responses using a 3+1 infant schedule. In the pivotal B7471011 studyFootnote 24, antibody concentrations were lower for all shared serotypes PD3 and for 12/13 serotypes PD4 compared to Pneu-C-13 recipients. While, similarly, lower seroresponse rates were observed for the majority (8/13) of shared serotypes PD3, there were only 2 shared serotypes (ST1 and ST3) for which lower seroresponse rates were reported PD4. The OPA GMTs were also generally lower for the majority of shared serotypes PD3 and PD4. A very similar pattern of IgG GMC, seroresponse rates and OPA GMTs were also reported PD3 and PD4 in the second, smaller, trial titled B7471003Footnote 23. A summary of GRADE assessment is provided in Table 12.

In all infant studies there was an observed congruency in immune response patterns between intervention groups, independent of the schedule used. There was an observed antibody waning (both for total and functional antibodies) following the completion of the primary series and significant antibody boosting following the receipt of the additional dose. In all studies, one month after the additional dose, antibody levels surpassed those observed after the completion of the primary series, demonstrating the establishment of immune memory in all vaccine recipients.

Re-vaccination: children who completed a routine Pneu-C-13 series

In children 5 to 17 years of age, immunization elicited increases in OPA GMTs for all vaccine serotypes, with the pre/post increase in OPA GMTs for the 7 serotypes not contained in Pneu-C-13 ranging from 11.5 to 499-fold. Immunogenicity data from vaccine-experienced individuals was available from only one study (B7471014)Footnote 31. In this study, 425 children less than 5 years of age previously immunized with greater or equal to 3 doses of Pneu-C-13 and 406 children 5 to 17 years of age (regardless of prior pneumococcal vaccination status) were recruited to receive one dose of Pneu-C-20. Among study participants less than 5 years of age, increases in IgG concentrations were observed for all 20 vaccine contained serotypes with at least 83% achieving predefined IgG concentrations of the 7 additional serotypes, except for serotype 12F (40.0%).

Immunogenicity of routinely administered pediatric vaccines when administered concurrently with Pneu-C-15 or Pneu-C-20

Concurrent administration of Pneu-C-15 or Pneu-C-20 with other routinely administered pediatric vaccines was assessed in all infant clinical trials. In addition to pneumococcal vaccines, participants also received diphtheria, tetanus, pertussis, poliomyelitis (serotypes 1, 2 and 3), hepatitis A, hepatitis B, Haemophilus influenzae type b, measles, mumps, rubella, varicella, and rotavirus vaccines, either as monovalent or combination vaccines. Immune responses to all antigens provided concomitantly with Pneu-C-15 or Pneu-C-20 were similar to those observed in Pneu-C-13 recipients as assessed by the individual antigen-specific response rates (for the combination and monovalent vaccines) or GMT (rotavirus vaccine) at 30 days following the completion of the primary series and the receipt of the additional dose, in both the 2+1 and 3+1 immunization schedule.

Evidence on safety

NACI reviewed the available evidence on safety of Pneu-C-15 and Pneu-C-20 vaccines in the context of routine pediatric immunization programs and catch-up and re-immunization schedules. Evidence on safety was available from clinical trials involving children receiving one or more doses of Pneu-C-15 or Pneu-C-20 vaccine and, in most of the trials, one or more doses of Pneu-C-13 vaccine.

Evidence on safety of Pneu-C-15 in pediatric populations

Adverse events (AE) following immunization with Pneu-C-15 vaccine were reported in eight clinical trials. Overall, 5,399 children received one or more doses of Pneu-C-15 and 3,280 children received one or more doses of Pneu-C-13. The measured safety endpoints included the proportion of participants with solicited local and systemic AEs 1 to 14 days post-vaccination, maximum body temperature measurements 1 to 7 days post-vaccination and serious adverse events (SAEs), up to 6 months following vaccination.

A GRADE assessment of studies that reported safety results for three outcomes of interest (total SAEs, vaccine-related SAEs and death) using 2+1 and 3+1 schedules, concluded that in vaccine-naïve infants there was moderate to high certainty evidence of little to no difference between the Pneu-C-13 and Pneu-C-15 groups (and low to moderate certainty evidence of little to no difference for immunocompromised infants due to small sample size) [Table 13].

A GRADE assessment of studies that reported safety results of additional vaccine doses in vaccine-experienced children concluded that there was moderate certainty evidence of little to no difference between vaccines for all measured safety outcomes (Table 14).

A separate integrated analysis of the final safety database (data from studies V114-025, -027, -029 and -031 that had a similar study design and population) included data from 3,589 healthy infants who received at least one dose of Pneu-C-15 and 2,058 who received at least one dose of Pneu-C-13. Solicited AEs accounted for the majority of reported safety events and were mostly of short duration (3 days or less) and of mild to moderate intensity. The proportions of participants with local and systemic AEs (solicited and unsolicited) after each dose in the primary series, after the booster dose, and after any dose were similar in both intervention groups. In infants, the most frequently reported AEs after any dose of Pneu-C-15 were irritability (range: 47% to 55.1%), somnolence (22.8% to 40.7%), injection-site pain (19.1% to 27.1%), and decreased appetite and other injection-site reactions (less than 20%). In children 11 to 15 months of age, the most frequently reported AEs were irritability (45.7%), somnolence (21.8%), injection-site pain (21%), decreased appetite (19.4%) and other injection-site reactions (erythema, swelling, induration; all less than 22%).

For the majority of participants who received Pneu-C-15, study investigators reported maximum body temperature measurements of less than 38.0 °C, with a temperature distribution that was comparable between intervention groups. Of the participants with a maximum body temperature higher than 38.0 °C, no significant differences were observed between Pneu-C-13 and Pneu-C-15 vaccine recipients after any vaccine dose. SAEs were reported for 10% (n=358) of Pneu-C-15 recipients and 10.5% (n=217) of Pneu-C-13 recipients. While the majority of SAEs were deemed to be non-vaccine related, there were three vaccine-related SAEs reported in 2 participants in the Pneu-C-15 group and 1 participant in the Pneu-C-13 group (all were pyrexia requiring hospitalization). There were 4 deaths (2 in Pneu-C-13 and 2 in Pneu-C-15 recipients), of which none were considered to be related to either of the vaccines.

Pre-term infants

The safety of Pneu-C-15 was assessed in over 170 pre-term infants (gestational age less than 37 weeks) who were immunized using a four-dose schedule. The safety profile following vaccination with Pneu-C-15 was similar to that observed in term infants. The frequency of SAEs was similar between groups (14.9% for Pneu-C-15 and 14.4% for Pneu-C-13). There were no vaccine related SAEs or deaths reported among this small group of pre-term infants.

Evidence on safety of Pneu-C-20 in pediatric populations

Safety data following immunization with Pneu-C-20 vaccine was available from five clinical trials (B7471003, B7471011, B7471012, B7471013, and B7471014)Footnote 23Footnote 24Footnote 25Footnote 26Footnote 31. One (B7471014) was a single-arm trial (n=839) with vaccine-experienced children and was evaluated separatelyFootnote 31. Overall, from the four assessed trials (B7471003, B7471011, B7471012, B7471013)Footnote 23Footnote 24Footnote 25Footnote 26, 2,833 infants received one or more doses of Pneu-C-20 and 2,320 infants received one or more doses of Pneu-C-13. In addition, there were 831 children 15 months through 17 years of age who received at least 1 dose of Pneu-C-20 vaccine. The measured safety endpoints included the proportion of participants with solicited local and systemic AEs 1-7 days post-vaccination (including immediate AEs occurring within 30 minutes post-vaccination), AEs one month after each dose and SAEs up to 6 months following vaccination. A GRADE analysis of studies that reported safety results using 2+1 and 3+1 schedules concluded that there was low to moderate certainty evidence of little to no difference between vaccines for all measured safety outcomes (very low to low among the immunocompromised groups, Table 15).

A separate integrated safety analysis (data from studies B7471003, B7471011, B7471012 and B7471013 that had similar study designs and populations) included data from 2,812 healthy infants who received at least one dose of Pneu-C-20 and 2,299 who received at least one dose of Pneu-C-13Footnote 23Footnote 24Footnote 25Footnote 26. The rates of local reactions and systemic events among infants receiving Pneu-C-20 and Pneu-C-13 after any dose were similar, with the most commonly reported AEs in Pneu-C-20 recipients being irritability (range 59.1% to 71.3%), somnolence (37.0% to 66.5%), injection site pain (33.5% to 46.3%), decreased appetite (22.7% to 26.0%), and other injection site reactions (15.1% to 24.7%). In children 11 to 15 months of age, the most frequently reported AEs in the 3-dose study (B7471012)Footnote 25 and 4-dose studies (B7471003, B7471011, B7471013)Footnote 23Footnote 24Footnote 26 were irritability (58.5% in 3-dose study and 71% in 4-dose studies), somnolence (37.7% and 50.9%), injection-site pain (33.4% and 42.4%), decreased appetite (26.4% and 39.3%), and other injection site reactions (redness or swelling) (15.1% and 36.9%).

For the majority of participants who received Pneu-C-20, study investigators reported maximum body temperature measurements of less than 38.0 °C, with a temperature distribution that was comparable between vaccine groups. Of the participants with a maximum body temperature higher than 38.0°C, no significant differences were observed between Pneu-C-13 and Pneu-C-20 vaccine recipients after any vaccine dose. SAEs were reported for 4.8% of Pneu-C-20 recipients and 4.5% of Pneu-C-13 recipients. While the majority of SAEs were assessed as non-vaccine related, one SAE with onset 7 days after the first vaccine dose was assessed as possibly related to either Pneu-C-20 or one of the concomitant vaccines received. The study participant was hospitalized with fever, painful swelling in the right groin and a right inguinal hernia. Laboratory tests revealed elevated inflammatory markers (C-reactive protein and procalcitonin) and a negative blood culture. The study participant was treated with antibiotics in hospital and the event resolved. There were no deaths reported in any of the Pneu-C-20 pediatric trials.

Pre-term infants

The safety of Pneu-C-20 was assessed in 110 pre-term infants (gestational age greater or equal to 34 to less than 37 weeks) who were immunized with a four-dose schedule (at 2, 4, 6, and 12 to 15 months of age). The safety profile of Pneu-C-20 and Pneu-C-13 was similar to that observed in term infants, including both local reactions and systemic events after each dose. The frequency of AEs reported up to one month post dose 3 was 31.2% for Pneu-C-20 and 23.5% for Pneu-C-13. The frequency of AEs reported up to one month post dose 4 was similar between groups (14.3% for Pneu-C-20 and 17.2% for Pneu-C-13). The percentages of participants with SAEs from Dose 1 to 6 months after Dose 4 were also similar between the two groups (4.4% and 5.6% for Pneu-C-20 and Pneu-C-13 groups, respectively).

Ethics, equity, feasibility and acceptability considerations

NACI uses a published, peer-reviewed framework and evidence-informed tools to ensure that issues related to ethics, equity, feasibility, and acceptability (EEFA) are systematically assessed and integrated into its guidanceFootnote 32.

Infants and children under 5 years of age are at higher risk of IPD compared to children 5 years and age and older and benefit from a routine pneumococcal immunization program. Vaccination of the young pediatric population provides both direct protection and indirect protection to other vulnerable populations (e.g. older adults). Previous recommendations on the use of pneumococcal vaccines in children have also recognized that some groups require additional vaccine doses to provide optimal protection (i.e., the 3+1 vaccine schedule, additional dose with Pneu-P-23), particularly for individuals who may experience decreased immune response due to underlying medical conditions. The continued use of both age- and risk-based vaccine recommendations promotes equitable access to pneumococcal vaccination for those who are most in need of protection.

Children with medical risk factors have been identified as being at increased risk of IPD. Social, environmental, or living conditions can also increase the risk of severe illness and should be considered. The higher disease burden of IPD observed in Northern Canada can be attributed to a variety of intersecting factors, including environmental/living factors (e.g. crowding), the younger age distribution compared to the general Canadian population, and decreased access to health care. Therefore, living in communities or settings experiencing sustained high levels of IPD, or being subject to ongoing risk of IPD due to other environmental or living conditions (i.e., houselessness or residential care) should be identified as risk factors that result in increased risk of IPD. In the case of Indigenous communities, autonomous decisions should be made by Indigenous Peoples with the support of healthcare and public health partners in accordance with the United Nations Declaration on the Rights of Indigenous PeoplesFootnote 33.

The new higher-valent pneumococcal conjugate vaccines offer an opportunity to protect children against additional serotypes compared to Pneu-C-13, and further reduce the burden of IPD. Vaccine coverage of the pediatric pneumococcal vaccines is high in the Canadian population (with an estimated coverage of 85.1% in 2021), and with a routine vaccination program already in place, no change in vaccine uptake is anticipated as a result of the adoption of the higher-valent pneumococcal conjugate vaccines.

Conjugate vaccines induce formation of long-term memory cells, provide longer duration of protection, reduce mucosal carriage of bacteria, and have an anamnestic response, in a way that polysaccharide vaccines do not. Therefore, while Pneu-C-20 may not contain as many serotypes as Pneu-P-23, the advantages of a conjugate vaccine outweigh the slightly reduced breadth in serotype coverage. This was considered sufficient to eliminate the need for Pneu-P-23 and would contribute to simplifying the pediatric vaccine schedule, improving program feasibility.

Provinces and territories have previously transitioned from the use of Pneu-C-7 to Pneu-C-13 in pediatric pneumococcal vaccination programs and demonstrated the feasibility of adopting new vaccine products. There will be similar challenges including needing to update communications (e.g. protocols and training, public messaging), minimizing vaccine wastage, and implementing catch-up guidance for specific cohorts. A notable barrier expected in the transition to the use of higher-valent pneumococcal vaccines is the cost of the new vaccines, and there may be variability in how or when each jurisdiction is able to adopt any new recommendations on the use of the higher-valent vaccines. Some jurisdictions may opt to focus on offering the new products initially to certain populations at increased risk of IPD, while others may also factor in local serotype epidemiology in their choice of product. The use of a single product in both routine and high-risk programs for children and adults would reduce program complexity and reduce the chance for administering a different vaccine than intended.

Economics

A systematic review and de novo model-based economic evaluation were used as economic evidence to inform decision-making for the use of Pneu-C-15 and Pneu-C-20 in the pediatric population. Full details, including assumptions and limitations, are provided in a supplementary economic evidence summary.

Systematic review

A systematic search of the peer-reviewed and grey literature identified two model-based economic evaluations comparing Pneu-C-15 to Pneu-C-13 in pediatric populations. Both studies evaluated routine infant programs and did not evaluate vaccination strategies for groups at increased risk for IPD. No studies were identified that included Pneu-C-20 as of March 7, 2023. The studies were conducted in the United States and were cost-utility analyses that used a societal perspectiveFootnote 34Footnote 35. One of the studies was industry sponsoredFootnote 35. Both models were static and did not include transmission dynamics. Indirect protection effects were included as a percent reduction in IPD or all pneumococcal disease in individuals not receiving Pneu-C-15 vaccineFootnote 34Footnote 35. Both models employed a similar approach to model the risk of pneumococcal disease, including IPD, non-bacteremic pneumococcal pneumonia, pneumococcal AOM and long-term post-meningitis sequelae as health outcomes.

Despite differences in perspective used, model type, and time horizon, both studies concluded that Pneu-C-15 use was associated with lower costs and improved health outcomes, dominating Pneu-C-13; however, these analyses assumed that Pneu-C-15 and Pneu-C-13 were priced equivalently in the base caseFootnote 34Footnote 35. In sensitivity analyses, results were robust to alternate assumptions about vaccine effectiveness, coverage, and indirect effects, with Pneu-C-15 remaining the dominant strategy when Pneu-C-15 and Pneu-C-13 were priced equivalentlyFootnote 34Footnote 35. In a threshold analysis, Pneu-C-15 was shown to remain the dominant strategy up to a maximum price per dose that is 18% higher than Pneu-C-13Footnote 35. A catch-up campaign using Pneu-C-15 for all children aged 2 to 5 years who were previously fully vaccinated with Pneu-C-13 was unlikely to be cost-effective, with ICERs exceeding $3.5 million per QALY gainedFootnote 34.

Cost-utility analysis

A static cost-utility model developed by NACI evaluated the cost-effectiveness of the use of Pneu-C-15 and Pneu-C-20 compared to Pneu-C-13 in previously unvaccinated Canadian infants eligible for routine pneumococcal vaccination. The analysis did not include an evaluation of vaccination strategies for individuals at increased risk for IPD. Both Pneu-C-15 and Pneu-C-20 were projected to improve health outcomes compared to Pneu-C-13, with Pneu-C-20 averting twice as many IPD cases as Pneu-C-15 over the 10-year model time period (median estimate of 468 vs. 221 cases averted). In the base-case sequential analysis that compared all possible vaccination strategies, the ICERs for Pneu-C-15 and Pneu-C-20 were $58,800 (vs. Pneu-C-13) and $135,200 (vs. Pneu-C-15) per QALY gained, respectively, for the health system perspective.

For the societal perspective, sequential ICERs were $18,300 (vs. Pneu-C-13) and $93,400 (vs. Pneu-C-15) per QALY gained for Pneu-C-15 and Pneu-C-20, respectively. Results were highly sensitive to assumed vaccine price. Base case values were $71, $78, and $90 per dose of Pneu-C-13, Pneu-C-15, and Pneu-C-20, respectively; lower assumed vaccine prices for Pneu-C-15 and Pneu-C-20 increased their cost-effectiveness. The base-case analysis excluded indirect protection effects; if use of Pneu-C-15 or Pneu-C-20 in the pediatric population results in lower pneumococcal disease incidence in the rest of the population due to indirect protection effects, ICERs would be substantially reduced. Serotype replacement was not evaluated in the analysis. In a setting with higher pneumococcal disease burden and higher medical costs, use of Pneu-C-20 was a dominant strategy (less costly and more effective) compared to Pneu-C-13 and Pneu-C-15 for both the health system and societal perspectives. The results of the health economic modelling are subject to limitations associated with simplifying assumptions and data uncertainty, which are discussed in greater detail in a supplementary economic evidence summary.

Additional economic evidence

Two additional economic evaluations that included both Pneu-C-15 and Pneu-C-20 became available after completion of the systematic review and were also reviewed. One evaluation was a comparison of three cost-utility analyses (two industry funded) that was conducted in the United States (US)Footnote 36 and the second evaluation was a cost-utility analysis conducted in QuebecFootnote 37. The US analysis compared the use of Pneu-C-20 to Pneu-C-13 or Pneu-C-15, using a 3+1 schedule in children less than 2 years of age. The Quebec analysis compared the use of a 2+1 schedule of Pneu-C-15 or Pneu-C-20 to a schedule of 2 doses of Pneu-C-10 plus 1 dose of Pneu-C-13 (the current pneumococcal vaccine schedule used in Quebec). All models were static but differed in structure, analytic time frame, assumptions about indirect protection effects, vaccine price, and other parameters. Neither evaluation conducted a sequential analysis comparing all three vaccination schedules. A formal comparison across the models was not conducted.

Both evaluations showed that Pneu-C-20 was expected to improve health outcomes compared to other vaccination options. For the US analysis, which used a societal perspective, results varied across models, with ICERs for Pneu-C-20 ranging from dominant to $74,200 per QALY compared to Pneu-C-13, and dominant to $162,700 per QALY compared to Pneu-C-15. The largest ICERs were seen with the non-industry funded model. For the Quebec analysis, when compared to current standard of care, both Pneu-C-15 and Pneu-C-20 had ICERs above commonly used cost-effectiveness thresholds, using the health system perspective. When Pneu-C-20 was compared to Pneu-C-15, the ICER was below commonly used thresholds for the health system perspective, and Pneu-C-20 dominated Pneu-C-15 for the societal perspective. These additional economic evaluations demonstrate that the estimated cost-effectiveness of Pneu-C-15 and Pneu-C-20 are sensitive to model assumptions and input parameters.

Recommendations

Following the review of available evidence summarized above, NACI continues to recommend that all routine infant immunization programs in Canada include a conjugate pneumococcal vaccine. NACI further makes the following recommendations for public health program decision-making (see Table 6 for a more detailed explanation of strength of NACI recommendations and grade of the body of evidence). As previously indicated in this Statement, the reference to "children" includes infants, children, and adolescents.

Recommendations for routine immunization programs in children less than 5 years of age who are not at increased risk of IPD

  1. NACI recommends that either Pneu-C-15 or Pneu-C-20 should be the current product of choice for children less than five years of age for routine immunization programs. (Strong NACI recommendation)

See the Management Options Table (Table 5) for a summary of the relative merits of each pneumococcal conjugate vaccine for use in routine programs, including EEFA considerations.

Summary of evidence, rationale, and additional considerations

  • The vaccine effectiveness and duration of protection of Pneu-C-15 and Pneu-C-20 are currently unknown. Both Pneu-C-15 and Pneu-C-20 are immunogenic in pediatric populations and offer additional serotype coverage compared to Pneu-C-13. Immune responses are lower after Pneu-C-15 and Pneu-C-20 than Pneu-C-13 for several shared serotypes. It is unknown how this may impact vaccine effectiveness, duration of protection, carriage, and herd immunity. Ongoing and enhanced surveillance of pneumococcal disease in Canada is recommended.
  • No safety signals following any of the Pneu-C vaccines have been identified to date (Table 13).
  • The new higher-valent pneumococcal conjugate vaccines can protect children against additional serotypes compared to Pneu-C-13 and are expected to further reduce the burden of IPD. With five additional serotypes compared to Pneu-C-15, Pneu-C-20 is expected to have a larger impact on IPD. Inclusion of Pneu-C-20 in routine programs for all children may simplify immunization programs and provide the most indirect benefits to other populations.
  • In the base case cost-effectiveness analysis performed by NACI, Pneu-C-15 is more likely to be a cost-effective option than Pneu-C-20. However, Pneu-C-15 or Pneu-C-20 may be cost-effective depending on the price per dose of each vaccine or whether the broader impacts of vaccination are considered with a societal perspective and/or inclusion of potential indirect effects.
  • Pneu-C-13 only or a mixed Pneu-C-10/Pneu-C-13 schedule can be used if Pneu-C-15 or Pneu-C-20 are unavailable or inaccessible.
  • Consistent with previous guidance, NACI recommends that all pneumococcal vaccines may be administered concomitantly with other vaccines, except for Pneu-P-23. No conjugate pneumococcal vaccine should be given concomitantly with Pneu-P-23.

Recommendations on the use of pneumococcal vaccines for children with medical conditions or environmental or living conditions that place them at increased risk of IPD

See Table 1 for medical risk factors and environmental or living conditions that result in increased risk of IPD in children.

  1. NACI recommends that Pneu-C-20 should be used for infants and children at increased risk of IPD who are initiating their pneumococcal vaccine series, and for series completion for those who have started their vaccine series with Pneu-C-13 or Pneu-C-15. (Strong NACI Recommendation)
    • Infants at increased risk of IPD should be immunized with Pneu-C-20 vaccine using a 4-dose (3+1) schedule at 2 months, 4 months, 6 months and a dose at 12 to 15 months of age.
    • Infants and children who have not initiated their immunization schedule by 7 months of age should be immunized according to the schedule provided in Table 7.
    • Children two years of age and older who are at increased risk of IPD and have never received any pneumococcal vaccination, should receive one dose of Pneu-C-20.
    • A vaccine series started with Pneu-C-13 or Pneu-C-15 should be completed with Pneu-C-20 according to the recommended schedule shown in Table 7.
    • Children at increased risk of IPD who have completed a vaccine series appropriate for age that includes at least one dose of Pneu-C-20 do not require further doses at this time.

Summary of evidence, rationale, and additional considerations

  • Pneu-C-20 was safe and immunogenic in studies with pediatric populations at high risk of IPD.
  • The use of Pneu-C-20 in children at increased risk of IPD provides protection for a larger number of serotypes compared to other conjugate vaccines.
  • Children at increased risk of IPD who have received at least one dose of Pneu-C-20, do not require Pneu-P-23.
  • It is not known whether additional doses of Pneu-C-20 would confer added benefit, therefore additional doses are not required at this time. NACI will assess the evidence as it becomes available.
  • A cost-effectiveness analysis for populations at increased risk of IPD was not conducted due to limited data for these populations.

Recommendations on catch-up doses for children with medical conditions or environmental or living conditions that place them at increased risk of IPD

  1. a) NACI recommends that children under 18 years of age who have medical risk factors and who have completed their recommended immunization schedule with Pneu-C-13 or Pneu-C-15, should receive one catch-up (additional) dose of Pneu-C-20. (Strong NACI recommendation)
    • Those with medical risk factors who have previously received Pneu-P-23 should be given one dose of Pneu-C-20 at a one-year interval from the last dose of Pneu-P-23.
  2. b) NACI recommends that children under 18 years of age who have environmental or living conditions that result in increased risk for IPD, and who have completed their recommended immunization schedule with Pneu-C-13 or Pneu-C-15, should receive one catch-up (additional) dose of Pneu-C-20. (Strong NACI recommendation)
    • In communities and settings experiencing sustained high IPD rates, an assessment of local epidemiologic trends should be used to inform groups for vaccination programs.
    • In First Nations, Metis, or Inuit communities, autonomous decisions should be made by Indigenous Peoples with the support of healthcare and public health partners in accordance with the United Nations Declaration on the Rights of Indigenous Peoples.

Summary of evidence, rationale, and additional considerations

  • A catch-up dose with Pneu-C-20 for children at increased risk of IPD (medical and/or environmental/ living conditions) who have completed their recommended immunization schedule will provide broader serotype protection, along with the immune advantages of conjugate vaccines.
  • For children who are not at increased risk of IPD due to medical and/or environmental or living conditions and have completed a recommended immunization series with Pneu-C-13, a catch-up (additional) dose of Pneu-C-15 or Pneu-C-20 is not recommended.
  • A cost-effectiveness analysis for catch-up programs was not conducted due to limited data for these populations.

Recommendations for recipients of hematopoietic stem cell transplant

  1. NACI recommends that pneumococcal conjugate vaccine Pneu-C-20 should be offered to children less than 18 years of age who received a hematopoietic stem cell transplant (HSCT) after consultation with their transplant specialist. (Strong NACI recommendation)
    • A primary series of 3 doses of Pneu-C-20 starting 3 to 9 months after transplant should be administered at least 4 weeks apart, followed by an additional dose of Pneu-C-20 12 to 18 months post-transplant (6 to 12 months after the last dose of Pneu-C-20).
    • The recommended timing of Pneu-C-20 for HSCT recipients should be determined in consultation with the recipient's transplant specialist.

Summary of evidence, rationale, and additional considerations

  • Pneu-C-20 offers protection against additional serotypes for these individuals, along with the immune advantages of conjugate vaccines. Pneu-P-23 is no longer recommended in the vaccine series for this population.
Table 5. Management options table for the routine immunization of children
Vaccine Factors for consideration Decision points
Pneu-C-15

Epidemiology
The percentage of IPD isolates attributed to Pneu-C-15 unique serotypes (22F and 33F) increased from 8% to 15% among all children between 2011 and 2022.

In 2022, 13% (less than 2 years old) and 16% (2 to 4 and 5 to 17 years old) of isolates from IPD cases were due to the two unique serotypes (22F and 33F) contained in Pneu-C-15.

Immunogenicity
Immune responses after 2 or 3 infant priming doses and 1 additional dose (2+1 or 3+1 schedules) were lower or had overlapping confidence intervals for most shared serotypes with Pneu-C-13 but higher for shared serotype 3.

Safety
Similar safety profile between Pneu-C-15 and Pneu-C-13

Economic analysis
Compared to Pneu-C-13, cost-utility analysis of Pneu-C-15 from a health system perspective in routine healthy infant program showed an incremental cost-effectiveness ratio (ICER) of $60,000. The ICER is highly sensitive to cost of Pneu-C-15 and the magnitude of indirect effects, which were not considered in the base model.

Epidemiology

  • Children under 2 years of age have the highest burden of IPD compared to other age groups. Some children also have medical or environmental or living conditions that increase their risk of IPD.
  • Pneu-C-15 and Pneu-C-20 contain different serotypes, which can have different impacts on IPD rates based on local serotype epidemiology.

Immunogenicity

  • Immune responses for shared serotypes are lower compared to Pneu-C-13 for both Pneu-C-15 and Pneu-C-20 vaccines. Pneu-C-15 may induce higher immune responses to serotype 3 compared to Pneu-C-13 and Pneu-C-20. The clinical significance of the differences in immune responses between Pneu-C-15 and Pneu-C-20 compared to Pneu-C-13 is currently unknown.
  • The impact on direct and indirect protection of lower total and functional antibody levels are not known for IPD, AOM and CAP.
  • Immunogenicity data for immunocompromised individuals is limited for Pneu-C-15 and is not available for Pneu-C-20.

Effectiveness

  • No efficacy or effectiveness data are available for Pneu-C-15 and Pneu-C-20. The vaccines were approved based on immunogenicity.
  • The duration of protection against pneumococcal disease and rate of waning following Pneu-C-15 and Pneu-C-20 compared to Pneu-C-13 is currently unknown.

Safety

  • All pneumococcal conjugate vaccines have similar safety profiles.

Economics

  • The cost-effectiveness of Pneu-C-15 and Pneu-C-20 is primarily dependent on vaccine price. At the assumed base case vaccine prices, Pneu-C-15 may be cost-effective using commonly used cost-effectiveness thresholds. Pneu-C-20 may be cost-effective at a lower vaccine price.
  • If use of Pneu-C-15 and Pneu-C-20 in the pediatric population reduces pneumococcal disease in the broader population due to indirect effects, particularly in adults, the vaccines are more likely to be cost-effective.
  • The cost-effectiveness of Pneu-C-15 and Pneu-C-20 when used for populations at increased risk of IPD is not known.

Feasibility/Acceptability/Equity

  • The introduction of either of the higher-valent vaccines into routine programs is likely to be feasible and is unlikely to affect uptake of pneumococcal vaccines.
  • There is high coverage with the existing routine program, and no changes in vaccine uptake are expected as a result of adopting the new conjugate vaccines.
  • Populations at increased risk of IPD would most benefit from receiving the pneumococcal vaccine offering the broadest serotype coverage.
  • The use of Pneu-C-20 for all children would provide broader indirect protection compared to Pneu-C-13 and Pneu-C-15.
  • The use of a single product in both routine and high-risk programs for children and adults would reduce program complexity and decrease the risk of program error. However, vaccine cost may be a limitation, resulting in the use of multiple vaccine products.
  • The choice of vaccine in a jurisdiction may change over time, depending on factors including the local serotype and age-specific epidemiology of IPD.
Pneu-C-20

Epidemiology
Between 2011 and 2022, IPD among all children caused by Pneu-C-20/non-Pneu-C-15 unique serotypes increased from15% to 23%.

In 2022, 37% (less than 2 years old) and 38% (2 to 4 and 5 to 17 years old) of IPD cases were caused by the seven serotypes (8, 10A, 11A, 12F, 15B/C, 22F and 33F) contained in Pneu-C-20 and not in Pneu-C-13.

Immunogenicity
Immune responses after 2 or 3 infant doses and 1 booster dose (2+1 or 3+1 schedule) for Pneu-C-20 were lower for most shared serotypes with Pneu-C-13, including shared serotype 3.

Safety
Similar safety profiles between Pneu-C-20 and Pneu-C-13

Economic analysis
Compared to Pneu-C-15, cost-utility analysis of Pneu-C-20 from a health system perspective in routine healthy infant programs showed an incremental cost-effectiveness ratio (ICER) of $135,000. The ICER is highly sensitive to cost of Pneu-C-20 and the magnitude of indirect effects.

Pneu-C-13

Epidemiology
Following the introduction of Pneu-C-13, there has been a generally decreasing trend in the proportion of pediatric IPD isolates received by the NML due to vaccine serotypes. However, the proportion of non-Pneu-C-13 vaccine serotypes have increased from 2011 to 2022.

Feasibility
Pneu-C-13 is currently being used in pediatric vaccination programs; however supply may change as new pneumococcal vaccines become available.

Table 6. Strength of NACI recommendations based on factors not isolated to strength of evidence (e.g., public health need)
Strength of recommendation Strong Discretionary
Wording "should/should not be offered" "may/may not be offered"
Rationale

Known/anticipated advantages outweigh known/anticipated disadvantages ("should"),
OR Known/Anticipated disadvantages outweigh known/anticipated advantages ("should not")

Known/anticipated advantages are closely balanced with known/anticipated disadvantages, OR uncertainty in the evidence of advantages and disadvantages exists
Implication A strong recommendation applies to most populations/individuals and should be followed unless a clear and compelling rationale for an alternative approach is present. A discretionary recommendation may be considered for some populations/individuals in some circumstances. Alternative approaches may be reasonable.
Table 7. Recommended schedules for Pneu-C-20 vaccine for children 2 months to less than 18 years of age at increased risk of IPD, by Pneu-C vaccination historyFootnote a
Age at presentation for immunization Number of previously received Pneu-C doses Recommended schedule for Pneu-C-20Footnote b
2 months to less than 7 months 0 dose 3 doses + 1 dose at 12 to 15 months of age
1 dose 2 doses + 1 dose at 12 to 15 months of age
2 doses 1 dose + 1 dose at 12 to 15 months of age
7 months to less than 12 months 0 doses 2 doses + 1 dose at 12-15 months of age
1 dose 1 dose at 7 to less than 12 months of age + 1 dose at 12 to 15 months of age
2 doses 1 dose at 12 to 15 months of age
12 months to less than 24 months 0 dose 2 doses
1 dose at less than 12 months of age
2 or more doses at less than 12 months of age 1 dose
0 or 1 dose at less than 12 months of age AND 1 dose at 12 months of age or older
24 months to less than 60 months
(5 years)
0 doses of Pneu-C-20 1 dose
5 years to less than 18 years 0 doses of Pneu-C-20 1 dose only for children at high risk
Footnote 1

Refer to immunocompromised persons for information about immunization of HSCT recipients.

Return to footnote a referrer

Footnote 2

The minimum interval between doses of pneumococcal conjugate vaccine is 8 weeks.

Return to footnote b referrer

Research and surveillance priorities

  • Determining the direct (vaccinated children) and indirect (unvaccinated children and adults) impact of Pneu-C-15 and Pneu-C-20 programs on the burden of disease (AOM, CAP, IPD) in individuals with and without risk factors for invasive disease.
  • Determining the immunological correlates of protection against various disease outcomes (severity and disease manifestations).
  • Determining the duration of immunity and need for additional doses for different Pneu-C-15 and Pneu-C-20 schedules including mixed schedule programs.
  • Determining the impact of vaccination with Pneu-C-15 and Pneu-C-20 on carriage and serotype switching.
  • Determining any rare and very rare adverse events that may not have been reported due to limited sample size in clinical trials.
  • Enhancing ongoing pneumococcal disease surveillance including non-IPD pneumococcal diseases and S. pneumoniae carriage.

List of abbreviations

AE
Adverse event
AEFI
Adverse event following immunization
AOM
Acute otitis media
CAP
Community acquired pneumonia
CI
Confidence interval
CIC
Canadian Immunization Committee
CIG
Canadian Immunization Guide
CIQ
Quebec Immunization committee
CNDSS
Canadian Notifiable Disease Surveillance System
CRM197
Corynebacterium diphtheriae
DALY
Disability adjusted life years
EEFA
Ethics, equity, feasibility, acceptability
eSTREP
Enhanced Streptococcus Surveillance System
EtD
Evidence to Decision
GMC
Geometric mean concentration
GMT
Geometric mean titre
GRADE
Grading of Recommendations, Assessment, Development and Evaluation
HIV
Human Immunodeficiency Virus
HSCT
Hematopoietic Stem Cell Transplant
IC
Immunocompromising conditions
ICER
Incremental cost-effective ratio
ICS
International Circumpolar Surveillance
IgG
Immunoglobulin G
IMPACT
Immunization Monitoring Program, ACTive
IPD
Invasive pneumococcal disease
NACI
National Advisory Committee on Immunization
NML
National Microbiology Laboratory
NVT
Non-vaccine type
NWT
Northwest Territories
OPA
Opsonophagocytic Activity
OR
Odds ratio
pCAP
Pneumococcal community-acquired pneumonia
PD2
Following dose 2
PD3
Following dose 3
PD4
Following dose 4
PHAC
Public Health Agency of Canada
Pneu-C
Pneumococcal conjugate vaccine
Pneu-C-10
10-valent pneumococcal conjugate vaccine
Pneu-C-13
13-valent pneumococcal conjugate vaccine
Pneu-C-15
15-valent pneumococcal conjugate vaccine
Pneu-C-20
20-valent pneumococcal conjugate vaccine
Pneu-P
Pneumococcal polysaccharide vaccine
Pneu-P-23
23-valent pneumococcal polysaccharide vaccine
PP
Pneumococcal pneumonia
QALY
Quality adjusted life-years
RD
Risk Difference
RoB
Risk of bias
RR
Relative Risk
SAE
Serious adverse events
SES
Socioeconomic Status
ST
Serotype
ST3
Serotype 3
US
United States
VE
Vaccine Efficacy

Acknowledgements

This statement was prepared by: A Wierzbowski, M Salvadori, O Baclic, E Wong, A Tuite, N Islam, G Gebretekle, R Pless, A Howarth, M Hersi, A Stevens, K Young, and K Hildebrand on behalf of NACI.

NACI gratefully acknowledges the contribution of: C Tremblay, M Tunis, F Khan, R Yorke, J Montroy, A Haynes as well as A Golden, I Martin, K Franklin, C Primeau, M Laverty, G Metz and other members of the PHAC NML and VPD Surveillance Teams.

NACI Pneumococcal Working Group

NACI Pneumococcal Working Group Members: K Hildebrand (Chair), J Papenburg, P De Wals, N Brousseau, J Bettinger, D Fisman, J Kellner, S Rechner, G Tyrrell, A McGeer, S Nasreen, and M Kobayashi (Centers for Disease Control and Prevention, US).

Ex-officio representatives: M Knight (First Nations and Inuit Health Branch, ISC), G Coleman (Biologic and Radiopharmaceutical Drugs Directorate, HC), K Franklin (VPD Surveillance), C Primeau (VPD Surveillance), I Martin (National Microbiology Laboratory), A Golden (National Microbiology Laboratory) and G Metz (Vaccine Safety).

PHAC participants: E Wong, A Wierzbowski, R Pless, O Baclic, M Tunis, A Stevens, G Gebretekle, N Islam, J Montroy, A Tuite, F Crane, F Khan, M Hersi, A Simmons, and C Tremblay.

NACI

NACI members: S Deeks (Chair) R Harrison (Vice-Chair), M Andrew, J Bettinger, N Brousseau, H Decaluwe, P De Wals, E Dubé, V Dubey, K Hildebrand, K Klein, M O'Driscoll, J Papenburg, A Pham-Huy, B Sander, and S Wilson.

Liaison representatives: L Bill/ M Nowgesic (Canadian Indigenous Nurses Association), LM Bucci (Canadian Public Health Association), S Buchan (Canadian Association for Immunization Research, Evaluation and Education) E Castillo (Society of Obstetricians and Gynaecologists of Canada), J Comeau (Association of Medical Microbiology and Infectious Disease Control), J MacNeil (Center for Disease control and Prevention) M Osmack (Indigenous Physicians Association of Canada), J Potter (College of Family Physicians of Canada), M Lavoie (Council of Chief Medical Officers of Health), D Moore (Canadian Paediatric Society), M Naus (Canadian Immunization Committee), and A Ung (Canadian Pharmacists Association).

Ex-officio representatives: V Beswick-Escanlar (National Defence and the Canadian Armed Forces), E Henry (Centre for Immunization Programs (CIP), PHAC), M Lacroix (Public Health Ethics Consultative Group, PHAC), C Pham (Biologic and Radiopharmaceutical Drugs Directorate, Health Canada), S Ogunnaike-Cooke (CIRID, PHAC), P Fandja (Marketed Health Products Directorate, HC), M Routledge (National Microbiology Laboratory, PHAC), and T Wong (First Nations and Inuit Health Branch, Indigenous Services Canada).

Appendix A: Tables

Table 8. Summary of Pneu-C-15 and Pneu-C-20 clinical trials
Study Comparisons Study design Participants

V114-008: A Study to Evaluate the Safety, Tolerability, and Immunogenicity of Two Lots of V114 in Healthy InfantsFootnote 19

Pneu-C-15 Lot 1
vs
Pneu-C-15 Lot 2
vs
Pneu-C-13

4-dose series per group

Phase 2, randomized to Pneu-C-15 Lot 1 (N=351), Pneu-C-15 Lot 2 (N=350), or Pneu-C-13 (N=350)
Total randomized = 1051

Children aged 42 to 90 days, inclusively, in good health who are pneumococcal vaccine-naïve.

Gender (total study): 49.8% female
Ethnicity (total study): 86.3% non-Hispanic or non-Latino; 13.1% Hispanic or Latino
Race (total study): 83.3% White; 8.7% Black or African American; 6.2% Multiple; 0.7% Asian; 0.6% American Indian or Alaska Native
Age (total study):
Range=42-90 days
Mean=8.7 weeks

Authors state participant demographics were similar between groups.

V114-023: A Study to Evaluate the Safety, Tolerability, and Immunogenicity of V114 in Children with Sickle Cell DiseaseFootnote 28

Pneu-C-15 vs
Pneu-C-13
1-dose per group

Phase 3, randomized to single dose of Pneu-C-15 (N=70) or Pneu-C-13 (N=34)
Total randomized = 104

Children aged 5 to 17 years, who have sickle-cell disease and are pneumococcal vaccine-naïve (as defined in trial: did not receive vaccine within 3 years of study entry).

Gender (total study): 45.6% female
Ethnicity (total study): 66.0% Hispanic or Latino; 34% non-Hispanic or non-Latino
Race (total study): 60.2% Black or African American; 16.5% Multiple; 11.7% American Indian or Alaska Native; 11.7% White
Age (total study):
Range=5 to 17 years
Median=11 years
Mean=10.8 years

Clinical study report states participant demographics were similar between groups.

V114-024: Safety and Immunogenicity of Catch-up Vaccination Regimens of V114Footnote 27

Pneu-C-15 vs Pneu-C-13

7 to 11 months of age: 3-dose series per group
12 to 23 months of age: 2-dose series per group
2 to 17 years of age: 1-dose per group

Phase 3,
7 to 11 months of age: randomized to Pneu-C-15 (N=64) or Pneu-C-13 (N=64)
12 to 23 months of age: randomized to Pneu-C-15 (N=62) or Pneu-C-13 (N=64)
2 to 17 years of age: randomized to Pneu-C-15 (N=177) or Pneu-C-13 (N=175)
Total randomized = 606

Children aged 7 to 11 months of age, or 12 to 23 months of age in good health who are pneumococcal vaccine-naïve. Children aged 2 to 17 years of age in good health who are either pneumococcal vaccine-naïve or vaccine-experienced.
Gender (total study):
7 to 11 months of age: 48.4% female
12 to 23 months of age: 54.0% female
2 to 17 years of age: 47.7% female
Ethnicity (total study):
7 to 11 months of age: 100.0% non-Hispanic or non-Latino
12 to 23 months of age: 99.2% non-Hispanic or non-Latino; 0.8% Hispanic or Latino
2 to 17 years of age: 99.4% non-Hispanic or non-Latino
Race (total study):
7 to 11 months of age: 82.8% Asian; 22 (17.2%) White
12 to 23 months of age: 83.3% Asian; 16.7% White
2 to 17 years of age: 66.8% White; 33.0% Asian; 0.3% Multiple
Age (total study):
7 to 11 months of age: 21.1%
12 to 23 months of age: 20.8%
2 to 17 years of age: 37.3%
Median age:
7 to 11 months of age: 8.0 months
12 to 23 months of age: 18.0 months
2 to 17 years of age: 4.0 years
Authors state participant demographics were similar between groups.

V114-025: Safety, Tolerability, and Immunogenicity of V114 in Healthy InfantsFootnote 20

Pneu-C-15 vs Pneu-C-13

Full-term infants (greater or equal to 37 weeks gestational age at birth): 3-dose series per group

Pre-term infants (less than 37 weeks gestation age): 4-dose series per group

Phase 3, randomized to Pneu-C-15 (N=591) or Pneu-C-13 (N=593)
Total randomized = 1184

Children aged 42 to 90 days, inclusively, in good health who are pneumococcal vaccine-naïve.

Gender (total study): 48.2% female
Ethnicity (total study): 88.7% non-Hispanic or non-Latino; 11.1% Hispanic or Latino
Race (total study): 96.9% White; 1.0% Multiple 0.8% American Indian or Alaska Native, 0.8% Asian, 0.6% Black or African American
Age (total study):
Range=6-12 weeks
Median=8 weeks

Clinical study report states participant demographics were similar between groups.

V114-027: A Study to Evaluate the Interchangeability of V114 and Prevnar 13™ in Healthy InfantsFootnote 21

Pneu-C-15 (4 doses)
vs
Pneu-C-15 (3 doses) + Pneu-C-13 (1 dose)
vs
Pneu-C-15 (2 doses) + Pneu-C-13 (2 doses)
vs
Pneu-C-15 (1 dose) + Pneu-C-13 (3 dose)
vs
Pneu-C-13 (4 doses)

Phase 3, randomized to Pneu-C-15 (4 doses; N=180), or
Pneu-C-15 + Pneu-P-23 (3+1 doses; N=180), Pneu-C-15 + Pneu-P-23 (2+2 doses; N=180), Pneu-C-15 + Pneu-P-23 (1+3 doses; N=181), or Pneu-P-23 (4 doses; N=179)

Total randomized: 900

Children aged 42 to 90 days, inclusively, in good health who are pneumococcal vaccine-naïve.
Gender (total study): 47.3% female
Ethnicity (total study): 76.2% non-Hispanic or non-Latino; 23.7% Hispanic or Latino
Race (total study): 61.4% White; 19.7% Asian; 14.8% Multiple; 3.8% Black or African American; 0.2% Native Hawaiian or Other Pacific Islander; 0.1% American Indian or Alaska Native
Age (total study):
Range=42-90 days
Median=9.0
Mean=8.6 weeks
Clinical study report states participant demographics were similar between groups.

V114-029: Safety, Tolerability, and Immunogenicity of V114 in Healthy InfantsFootnote 22

Pneu-C-15 vs Pneu-C-13

4-dose series per group

Phase 3, randomized to Pneu-C-15 (n=860) or Pneu-C-13 (n=860)
Total randomized: 1720

Children aged 42 to 90 days, inclusively, in good health who are pneumococcal vaccine-naïve.
Gender (total study): 48.1% female
Ethnicity (total study): 75% non-Hispanic or non-Latino; 24% Hispanic or Latino
Race (total study): 55.6% White; 26.2% Asian; 10.3% Multiple; 6.1% Black or African American; 1.1% American Indian or Alaska Native; 0.6% Native Hawaiian or Other Pacific Islander
Age (total study):
Range=42-90 days
Median=8.0
Mean=8.4 weeks

Clinical study report states participant demographics were similar between groups.

V114-030: Safety and Immunogenicity of V114 in Children Infected with Human Immunodeficiency VirusFootnote 29

Pneu-C-15+ Pneu-P-23 vs Pneu-C-13 + Pneu-P-23

2-dose series per group (first dose=Pneu-C vaccine; second dose=Pneu-P-23 vaccine)

Phase 3, randomized to Pneu-C-15+Pneu-P-23 (N=203) or Pneu-C-13+Pneu-P-23 (N=204)

Total randomized = 407

Children aged 6 to 17 years, who have Human Immunodeficiency Virus and are vaccine-naïve, previously vaccinated with a less than 13-valent Pneu-C, partially vaccinated with Pneu-C-13, or has a history of previous Pneu-C-13 vaccination greater or equal to 3 years before Visit 2 (Day 1).

Gender (total study): 47.9% female
Ethnicity (total study): 99.3% non-Hispanic or non-Latino; 0.2% Hispanic or Latino
Race (total study): 40.8% Black or African American; 31.4% Asian; 21.9% White; 5.2% Multiple
Age (total study):
Range=6-17 years
Median=13 years
Mean=12.7 years
History of pneumococcal vaccination (total study): History of Pneu-C vaccination: 7.4%
History of Pneu-P-23 vaccination: 0.2%

Clinical study report states participant demographics were similar between groups.

V114-031: A Study to Evaluate the Safety and Tolerability of V114 and Prevnar 13™ in Healthy InfantsFootnote 30

Pneu-C-15 vs Pneu-C-13
4-dose series per group

Phase 3, randomized to Pneu-C-15 (n=1972) or Pneu-C-13 (n=437)
Total randomized = 2409

Children aged 42 to 90 days, inclusively, in good health who are pneumococcal vaccine-naïve.
Gender (total study): 48.8% female
Ethnicity (total study): 84.7% non-Hispanic or non-Latino; 15.2% Hispanic or Latino
Race (total study): 49.9% White; 36.6% Asian; 7.7% Multiple; 3.5% American Indian or Alaska Native; 3.0% Black or African American; 0.1% Native Hawaiian or Other Pacific Islander
Age (total study):
Range=6-17 years
Mean=8.7 years

Clinical study report states participant demographics were similar between groups.

B7471003: Trial to Evaluate the Safety and Immunogenicity of a Multivalent Pneumococcal Vaccine in Healthy InfantsFootnote 23

Pneu-C-20 vs Pneu-C-13

4-dose series per group

Phase 2, randomized to Pneu-C-20 (n=232) or Pneu-C-13 (n=228)

Total randomized = 460

Children aged 42 to 98 days, inclusively, in good health who are pneumococcal vaccine-naïve.

Gender (total study): 49.3% female
Ethnicity (total study): 82.4% non-Hispanic or non-Latino; 17.6% Hispanic or Latino
Race (total study): 72.2% White; 13.9% Black or African American; 8.0% Multiple; 3.0% Asian; 1.5% American Indian or Alaska Native; 0.9% Native Hawaiian or Other Pacific Islander
Age (total study):
Range=44-95 days
Median=64 days
Mean=64.5 days

Clinical study report states participant demographics were similar between groups.

B7471011: 20-valent Pneumococcal Conjugate Vaccine Safety and Immunogenicity Study of a 4-Dose Series in Healthy InfantsFootnote 24

Pneu-C-20 vs Pneu-C-13

4-dose series per group

Phase 3, randomized to Pneu-C-20 (n=1004) or Pneu-C-13 (n=993)

Total randomized = 1997

Children aged 42 to 98 days, inclusively, in good health who are pneumococcal vaccine-naïve.

Gender (total study): 48.5% female
Ethnicity (total study): 66.4% non-Hispanic or non-Latino; 30.4% Hispanic or Latino
Race (total study): 75.3% White; 11.0% Black or African American; 7.1% Multiple; 1.6% Asian; 0.4% American Indian or Alaska Native; 0.2% Native Hawaiian or Other Pacific Islander
Age (total study):
Range=42-97 days
Median=64 days
Mean=65.8 days

Clinical study report states participant demographics were similar between groups.

B7471012: 20-valent Pneumococcal Conjugate Vaccine Safety and Immunogenicity Study of a 3-Dose Series in Healthy InfantsFootnote 25

Pneu-C-20 vs Pneu-C-13

3-dose series per group

Phase 3, randomized to Pneu-C-20 (n=603) or Pneu-C-13 (n=604)

Total randomized = 1207

Children aged 42 to 112 days, inclusively, in good health who are pneumococcal vaccine-naïve.

Gender (total study): 49.3% female
Ethnicity (total study): 96.6% non-Hispanic or non-Latino; 0.4% Hispanic or Latino
Race (total study): 97.8% White; 1.1% Asian; 0.2% Multiple
Age (total study):
Range=43-112 days
Median=68 days
Mean=69.4 days

Clinical study report states participant demographics were similar between groups.

B7471013: 20-valent Pneumococcal Conjugate Vaccine Safety Study in Healthy InfantsFootnote 26

Pneu-C-20 vs Pneu-C-13

4-dose series per group

Phase 3, randomized to Pneu-C-20 (n=1006) or Pneu-C-13 (n=505)

Total randomized = 1511

Children aged 42 to 98 days, inclusively, in good health who are pneumococcal vaccine-naïve.

Gender (total study): 49.4% female
Ethnicity (total study): 61.5% non-Hispanic or non-Latino; 37.3% Hispanic or Latino
Race (total study): 87.4% White; 4.7% Black or African American; 3.7% Multiple; 2.1% Asian; 0.3% American Indian or Alaska Native; 0.3% Native Hawaiian or Other Pacific Islander
Age (total study):
Range=43-98 days
Median=64 days
Mean=64.8 days

Clinical study report states participant demographics were similar between groups.

B7471014: Safety and Immunogenicity Study of 20vPnC in Healthy Children 15 Months Through 17 Years of AgeFootnote 31

Pneu-C-20 (before vs after vaccination)

1 dose per group

Phase 3,

greater or equal to 15 to less than 24 months of age: Pneu-C-20 (N=210)
greater or equal to 2 to less than 5 years of age: Pneu-C-20 (N=219)
greater or equal to 5 to less than 10 years of age: Pneu-C-20 (N=203)
greater or equal to 10 to less than 18 years of age: Pneu-C-20 (N=207)

Total randomized = 839

Cohort 1 and 2: children aged greater or equal to 15 months to less than 5 years, in good health who previously received at least 3 doses of Pneu-C-13 with the last dose administered greater than 2 months before study enrollment. Excluded if previously received any investigational pneumococcal vaccine or with Pneu-P-23.

Cohort 3 and 4: children aged greater or equal to 5 years to less than 18 years, in good health. Excluded if previously received any investigational pneumococcal vaccine or with Pneu-P-23.

Gender (total study):
greater or equal to 15 to less than 24 months of age: 44.0% female
greater or equal to 2 to less than 5 years of age: 50.9% female
greater or equal to 5 to less than 10 years of age: 46.3% female
greater or equal to 10 to less than 18 years of age: 43.9% female
Ethnicity (total study):
greater or equal to 15 to less than 24 months of age: 82.3% non-Hispanic or non-Latino; 16.7% Hispanic or Latino
greater or equal to 2 to less than 5 years of age: 79.2% non-Hispanic or non-Latino; 20.8% Hispanic or Latino
greater or equal to 5 to less than 10 years of age: 83.6% non-Hispanic or non-Latino; 15.4% Hispanic or Latino
greater or equal to 10 to less than 18 years of age: 78.5% non-Hispanic or non-Latino; 21.0% Hispanic or Latino
Race (total study):
greater or equal to 15 to less than 24 months of age: 80.4% White; 12.4% Black or African American; 4.8% Multiple; 1.4% Asian
greater or equal to 2 to less than 5 years of age: 80.1% White; 12.0% Black or African American; 6.0% Multiple; 0.5% American Indian or Alaska Native
greater or equal to 5 to less than 10 years of age: 86.6% White; 10.9% Black or African American; 2.5% Multiple
greater or equal to 10 to less than 18 years of age: 86.8% White; 8.3% Black or African American; 4.4% Multiple; 0.5% Native Hawaiian or Other Pacific Islander
Age (total study):
greater or equal to 15 to less than 24 months of age: 25.0%
greater or equal to 2 to less than 5 years of age: 26.1%
greater or equal to 5 to less than 10 years of age: 24.2%
greater or equal to 10 to less than 18 years of age: 24.7%
Median age (total study):
greater or equal to 15 to less than 24 months of age: 18.1 months
greater or equal to 2 to less than 5 years of age: 3.0 years
greater or equal to 5 to less than 10 years of age: 7.0 years
greater or equal to 10 to less than 18 years of age: 14.0 years

Clinical study report states participant demographics were similar between groups. There were slightly more male participants in each age cohort, except in participants greater or equal to 2 to less than 5 years of age (Cohort 2, which had an approximately equal distribution).

Table 9. Summary of evidence from 2+1 Pneu-C-15 studies
Measured outcome

Healthy children

GMT OPA ratios
No GRADE assessment

No data reported after dose 2. Lower for 11/13 shared serotypes following dose 3; higher for ST3 and ST14 following dose 3. Higher for both unique serotypes.

GMC IgG ratios
Moderate certainty of evidence (both doses)

Lower for 9/13 shared serotypes 11/13 following dose 2 and dose 3, respectively higher for ST23F following dose 2, and for ST3 following dose 2 and dose 3; mixed or null-inclusive results for remaining serotypes. Higher for both unique serotypes following dose 2 and 3.

% seroresponders: shared serotypes
Low certainty of evidence (dose 2), moderate certainty of evidence (dose 3)

Lower for 3/13 shared serotypes 6/13 following dose 2 and dose 3, respectively; higher for ST23F following dose 2, and for ST3 following dose 2 and dose 3; null-inclusive results for remaining serotypes.

% seroresponders: unique serotypes
Moderate certainty of evidence (both doses)

Higher for unique serotypes following dose 2 and dose 3.

Vaccine-related serious adverse events
High certainty of evidence

Pneu-C-15, N= 0/587
Pneu-C-13, N= 1/591
Relative: Peto OR: 0.14 (0.00 to 6.87)
Absolute: 1 fewer per 1,000 (2 fewer to 10 more)

Total serious adverse events
Moderate certainty of evidence

Pneu-C-15, N= 57/587
Pneu-C-13, N= 70/591
Relative: RR 0.82 (0.59 to 1.14)
Absolute: 21 fewer per 1,000 (49 fewer to 17 more)

Deaths
High certainty of evidence

No deaths were observed.

Table 10. Summary of evidence from 3+1 Pneu-C-15 studies
Measured outcome Healthy children and immunocompetent, high-risk children Immunocompromised children

GMT OPA ratios

Lower for 4/13 and 10/13 shared serotypes following dose 3 and 4, respectively; higher for ST3 following dose 3 but lower following dose 4; mixed results for remaining serotypes. Higher for both unique serotypes following dose 3 and 4.

No GRADE assessment

GMC IgG ratios

Lower for 5/13 shared serotypes following dose 3 and dose 4; higher for ST3 following dose 3 and dose 4; mixed or null-inclusive results for remaining serotypes. Higher for both unique serotypes following dose 3 and 4.

Moderate certainty of evidence (both doses)

Low certainty of evidence (both doses)

% seroresponders: shared serotypes

Mixed or null-inclusive results for 12/13 shared serotypes following dose 3 and dose 4; higher for ST3 following dose 3 and dose 4.

Moderate certainty of evidence (3rd dose), low certainty of evidence (4th dose)

Low certainty of evidence (3rd dose), very low certainty of evidence (4th dose)

% seroresponders: unique serotypes

Higher for unique serotypes following dose 3 and dose 4.

Moderate certainty of evidence (both doses)

Low certainty of evidence (both doses)

Vaccine-related serious adverse events at 6 months

Pneu-C-15, N= 4/3699
Pneu-C-13, N= 0/1814
Relative: Peto OR 4.01 (0.41 to 39.22)
Absolute: 0 per 1,000 (0 - 0)

High certainty of evidence

Moderate certainty of evidence

Total serious adverse events at 6 months

Pneu-C-15, N= 338/3699
Pneu-C-13, N= 162/1814
Relative: RR 1.03 (0.86 to 1.24)
Absolute: 3 more per 1,000 (13 fewer to 21 more)

Moderate certainty of evidence

Low certainty of evidence

Deaths at 6 months

Pneu-C-15, N= 3/3699
Pneu-C-13, N= 2/1814
Relative: Peto OR 0.74 (0.11 to 5.15)
Absolute: 0 per 1,000 (1 fewer to 5 more)

High certainty of evidence

Moderate certainty of evidence

Table 11. Summary of evidence from 2+1 Pneu-C-20 studies
Measured outcome

Healthy children

GMT OPA ratios
No GRADE assessment

Lower for 13/13 and 12/13 shared serotypes following dose 2 and dose 3, respectively; higher for ST19A following dose 3. Higher for all unique serotypes following dose 2 and dose 3.

GMC IgG ratios
Moderate certainty of evidence (both doses)

Lower for 13/13 shared serotypes following both dose 2 and dose 3; higher for all unique serotypes following dose 2 and dose 3.

% seroresponders: shared serotypes
Moderate certainty of evidence (dose 2), low certainty of evidence (dose 3)

Lower for 9/13 and 1/13 (ST3) shared serotypes following dose 2 and dose 3, respectively; null-inclusive results for remaining serotypes.

% seroresponders: unique serotypes
Moderate certainty of evidence (both doses)

Higher for all unique serotypes following dose 2 and dose 3.

Vaccine-related adverse events
Moderate certainty of evidence

Pneu-C-20, N= 1/601
Pneu-C-13, N= 0/603
Relative: Peto OR 7.41 (0.15 to 373.63)
Absolute: RD 0 per 1,000 (0 to 10 more)

Total serious adverse events
Low certainty of evidence

Pneu-C-20, N= 34/601
Pneu-C-13, N= 40/603
Relative: RR 0.85 (0.55 to 1.33)
Absolute: 10 fewer per 1,000 (30 fewer to 22 more)

Deaths
Moderate certainty of evidence

No deaths were observed.

Table 12. Summary of evidence from 3+1 Pneu-C-20 studies
Measured outcome

Healthy children and immunocompetent, high-risk children

Immunocompromised children

GMT OPA ratios Lower for 8/13 and 12/13 shared serotypes following dose 3 and 4, respectively. Higher for both unique serotypes following dose 3 and 4.
No GRADE assessment
GMC IgG ratios Lower for 13/13 and 12/13 shared serotypes following dose 3 and dose 4, respectively; null-inclusive for ST14 following dose 4. Higher for both unique serotypes following dose 3 and 4.
Moderate certainty of evidence (both doses) Low certainty of evidence (both doses)
% seroresponders: shared serotypes Mixed or null-inclusive results for 8/13 and 2/13 shared serotypes following dose 3 and dose 4, respectively; null-inclusive results for remaining serotypes.
Moderate certainty of evidence (dose 3), low certainty of evidence (dose 4) Low certainty of evidence (dose 3), very low certainty of evidence (dose 4)
% seroresponders: unique serotypes Higher for unique serotypes following dose 3 and dose 4.
Moderate certainty of evidence (both doses) Low certainty of evidence (both doses)
Vaccine-related serious adverse events at 6 months No vaccine-related events observed.
Moderate certainty of evidence Low certainty of evidence
Total serious adverse events at 6 months

Pneu-C-20, N= 101/2232
Pneu-C-13, N= 64/1717
Relative: RR 1.24 (0.71 to 2.15) 
Absolute: 9 more per 1,000 (11 fewer to 43 more)

Low certainty of evidence Very low certainty of evidence
Deaths at 6 months No deaths were observed.
Moderate certainty of evidence Low certainty of evidence
Table 13. GRADE evidence summary of safety of Pneu-C-15 compared with Pneu-C-13 in vaccine-naïve children (routine schedules)
Outcome Summary of findings Comments/summary
Number of studies,
study design
Pneu-C-15 Pneu-C-13 Impact – quantitative or narrative Certainty of evidence
Up to 6 months after vaccine, per protocol analysis: 2+1 schedule
Vaccine-related SAE

Assessed with GRADE
1 RCT (V114-025)Footnote 20

N=0/587 N=1/591

Relative effects: Peto OR: 0.14 (0.00 to 6.87)
Absolute effects: 1 fewer per 1,000 (2 fewer to 10 more)

ModerateFootnote a There is probably little to no difference between vaccines in the occurrence of vaccine-related SAEs
Total SAE

Assessed with GRADE:
1 RCT
(V114-025)Footnote 20

N=57/587 N=70/591

Relative effects: RR 0.82 (0.59 to 1.14)
Absolute effects: 21 fewer per 1,000 (49 fewer to 17 more)

ModerateFootnote b There is probably little to no difference between vaccines in the occurrence of SAEs
Death

Assessed with GRADE:
1 RCT
(V114-025)Footnote 20

N=0/587 N=0/591 No deaths were observed ModerateFootnote a There is probably little to no difference between vaccines in the occurrence of deaths
Up to 6 months after vaccine, per protocol analysis: 3+1 schedule
Vaccine-related SAE

Assessed with GRADE:
4 RCTs
(V114-008, V114-027, V114-029, V114-031)Footnote 19Footnote 21Footnote 22Footnote 30

N=4/3,699 N=0/1,814

Relative effects: Peto OR: 4.01 (0.41 to 39.22)
Absolute effects: 0 per 1,000 (0 to 0)

High There is little to no difference between vaccines in the occurrence of vaccine-related SAEs
ModerateFootnote d for immunocompromised persons (IC) There is probably little to no difference between vaccines in the occurrence of vaccine-related SAEs
Total SAE

Assessed with GRADE:
4 RCTs
(V114-008, V114-027, V114-029, V114-031)Footnote 19Footnote 21Footnote 22Footnote 30

N= 338/3,699 N=162/1,814

Relative effects: RR 1.03 (0.86 to 1.24)
Absolute effects: 3 fewer per 1,000 (13 fewer to 21 more)

ModerateFootnote c There is probably little to no difference between vaccines in the occurrence of SAEs
LowFootnote cFootnote d for IC There may be little to no difference between vaccines in the occurrence of SAEs
Death

Assessed with GRADE:
4 RCTs
(V114-008, V114-027, V114-029, V114-031)Footnote 19Footnote 21Footnote 22Footnote 30

N=3/3,699 N=2/1,814

Relative effects: Peto OR: 0.74 (0.11 to 5.15)
Absolute effects:0 per 1,000 (1 fewer to 5 more)

High There is little to no difference between vaccines in the occurrence of deaths
ModerateFootnote d for IC There is probably little to no difference between vaccines in the occurrence of deaths
Footnote 1

Downrating for imprecision as the optimal information size was not met.

Return to footnote a referrer

Footnote 2

Downrating for imprecision as the CI of the absolute effect includes the possibility of an important decrease in SAEs with Pneu-C-15.

Return to footnote b referrer

Footnote 3

Downrating for imprecision as the CI of the absolute effect includes the possibility of an important increase in SAEs with Pneu-C-15.

Return to footnote c referrer

Footnote 4

Downrating for indirectness as none of the trials included children with immunocompromising conditions.

Return to footnote d referrer

Table 14. Safety of Pneu-C-15 compared with Pneu-C-13 in vaccine-experienced children
Outcome Summary of findings Comments/summary
Number of studies, study design Pneu-C-15 Pneu-C-13 Impact – quantitative or narrative Certainty of evidence
Up to 6 months after vaccine, per protocol analysis
Vaccine-related SAE

Assessed with GRADE:
2 RCTs
(V114-023,
V114-030)Footnote 28Footnote 29

N=0/272 N=0/238 No vaccine-related events observed ModerateFootnote a There is probably little to no difference between vaccines in the occurrence of vaccine-related SAEs
Total SAE

Assessed with GRADE:
2 RCTs
(V114-023,
V114-030)Footnote 28Footnote 29

N=14/272 N=9/238

Relative effects: RR 0.81 (0.38 to 1.72)
Absolute effects: 7 fewer per 1,000 (23 fewer to 27 more)

ModerateFootnote a There is probably little to no difference between vaccines in the occurrence of SAEs
Death

Assessed with GRADE:
2 RCTs
(V114-023,
V114-030)Footnote 28Footnote 29

N=0/272

N=0/238

No deaths were observed

ModerateFootnote a

There is probably little to no difference between vaccines in the occurrence of deaths

Footnote 1

Downrating by -1.00 for imprecision as did not meet review information size (400 people with events, or for very few to no events, greater or equal to 4,000 sample size).

Return to footnote a referrer

Table 15. Safety of Pneu-C-20 compared with Pneu-C-13 in vaccine-naïve children (routine)
Outcome Summary of findings Comments/summary
Number of studies, study design Pneu-C-20 Pneu-C-13 Impact – quantitative or narrative Certainty of evidence
Up to 6 months after vaccine, per protocol analysis: 2+1 schedule
Vaccine-related SAE

Assessed with GRADE:
1 RCT
(B7471012)Footnote 25

N=1/601 N=0/603

Relative effects: Peto OR 7.41 (0.15 to 373.63)
Absolute effects: 0 per 1,000 (0 to 10 more)

ModerateFootnote a There is probably little to no difference between vaccines in the occurrence of vaccine-related SAEs
Total SAE

Assessed with GRADE:
1 RCT
(B7471012)Footnote 25

N=34/601 N=40/603

Relative effects: RR 0.85 (0.55 to 1.33)
Absolute effects: 10 fewer per 1,000 (30 fewer to 22 more)

LowFootnote b There may be little to no difference between vaccines in the occurrence of SAEs
Death

Assessed with GRADE:
1 RCT
(B7471012)Footnote 25

N=0/601 N=0/603 No deaths were observed ModerateFootnote a There is probably little to no difference between vaccines in the occurrence of deaths
Up to 6 months after vaccine, per protocol analysis: 3+1 schedule
Vaccine-related SAE

Assessed with GRADE:
3 RCT
(B474-1003, B7471011,
B7471013)Footnote 23Footnote 24Footnote 26

N=0/2,232 N=0/1,717 No vaccine-related events observed ModerateFootnote a There is probably little to no difference between vaccines in the occurrence of vaccine-related SAEs
Low for ICFootnote aFootnote c There may be little to no difference between vaccines in the occurrence of vaccine-related SAEs
Total SAE

Assessed with GRADE:
3 RCT
(B474-1003, B7471011,
B7471013)Footnote 23Footnote 24Footnote 26

N=101/2,232 N=64/1,717

Relative effects: RR 1.24 (0.71 to 2.15)
Absolute effects: 9 more per 1,000 (11 fewer to 43 more)

LowFootnote dFootnote e There may be little to no difference between vaccines in the occurrence of SAEs
Very low for ICFootnote cFootnote dFootnote e There may be little to no difference between vaccines in the occurrence of SAEs, but the evidence is very uncertain
Death

Assessed with GRADE:
3 RCT
(B474-1003, B7471011,
B7471013)Footnote 23Footnote 24Footnote 26

N=0/2,232 N=0/1,717 No deaths were observed ModerateFootnote a There is probably little to no difference between vaccines in the occurrence of deaths
Low for ICFootnote aFootnote c There may be little to no difference between vaccines in the occurrence of deaths
Footnote 1

Downrating by -1.00 for imprecision as did not meet review information size (400 people with events, or for very few to no events, greater or equal to 4,000 sample size).

Return to footnote a referrer

Footnote 2

Downrating by -2.00 for imprecision as the CI of the absolute effect includes the possibility of both an important decease and increase in SAEs with Pneu-C-20. The point estimate is reflective of a trivial difference between groups while the lower and upper bound CI values are reflective of a small decrease and small increase in events, respectively.

Return to footnote b referrer

Footnote 3

Downrating by–1.00 for indirectness as none of the trials included children with immunocompromising conditions.

Return to footnote c referrer

Footnote 4

Downrating by –1.00 for inconsistency (I2=63%, p=0.07, some lack of overlap among study results): the outlier study (B7471003) showed appreciably greater absolute effects (29 more per 1,000, 95% CI: 4 fewer to 123 more)Footnote 23.

Return to footnote d referrer

Footnote 5

Downrating by –1.00 for imprecision as the Cis of the absolute effect includes the possibility of an important increase in SAEs with Pneu-C-20. The point estimate and lower CI bound are reflective of a trivial difference between groups, while the upper CI bound is reflective of a small increase in events.

Return to footnote e referrer

Table 16. Comparative summary of evidence from Pneu-C-15 and Pneu-C-20 immunogenicity studies
Immunogenicity measure Findings Pneu-C-15 Findings Pneu-C-20
GMC IgG Ratios
  • In 2+1 schedule, lower for most shared serotypes following dose 2 and dose 3; higher for ST3; higher for all unique serotypes
  • In 3+1 schedule, null-inclusive or mixed for most shared serotypes following dose 3 and dose 4; higher for ST3; higher for all unique serotypes
  • In 2+1 schedule, lower for all shared serotypes following dose 2 and dose 3; higher for all unique serotypes
  • In 3+1 schedule, lower for most shared serotypes (including ST3) following dose 3 and dose 4; higher for all unique serotypes
% Seroresponders
Shared serotypes
  • In 2+1 schedule, lower or null-inclusive for most shared serotypes following dose 2 and dose 3; higher for ST3
  • In 3+1 schedule, null-inclusive or mixed for most shared serotypes following dose 3 and dose 4; higher for ST3
  • In 2+1 schedule, lower for most shared serotypes (including ST3) following dose 2; null-inclusive for most serotypes following dose 3
  • In 3+1 schedule, lower for most shared serotypes (including ST3) following dose 3; null-inclusive for most serotypes (lower for ST3) following dose 4
% Seroresponders
Unique serotypes
  • In 2+1 schedule, higher for unique serotypes following dose 2 and dose 3
  • In 3+1 schedule, higher for unique serotypes following dose 3 and dose 4
  • In 2+1 schedule, higher for unique serotypes following dose 2 and dose 3
  • In 3+1 schedule, higher for unique serotypes following dose 3 and dose 4
GMT OPA RatiosFootnote a
  • In 2+1 schedule, lower for most shared serotypes following dose 3; higher for ST3
  • In 3+1 schedule, null-inclusive or mixed for most shared serotypes (higher for ST3) following dose 3; lower for most shared serotypes (including ST3) following dose 4
  • In 2+1 schedule, lower for all shared serotypes following dose 2 and lower for most shared serotypes (including ST3) following dose 3
  • In 3+1 schedule, lower for most shared serotypes (including ST3) following dose 3 and dose 4
Footnote 1

Was not assessed with GRADE – no CI reported around point estimates.

Return to footnote a referrer

References

Footnote 1

Statistic Canada. Childhood National Immunization Coverage Survey, 2021 [Internet]. Ottawa (ON): Government of Canada; 2023 Jun 12 [cited 2023 Jul 19]. Available from: https://www150.statcan.gc.ca/n1/daily-quotidien/230612/dq230612b-eng.htm.

Return to footnote 1 referrer

Footnote 2

Public Health Agency of Canada (PHAC). Vaccination Coverage Goals and Vaccine Preventable Disease Reduction Targets by 2025 [Internet]. Ottawa (ON): Government of Canada; 2022 Aug 16 [cited 2023 Jun 26]. Available from: https://www.canada.ca/en/public-health/services/immunization-vaccine-priorities/national-immunization-strategy/vaccination-coverage-goals-vaccine-preventable-diseases-reduction-targets-2025.html.

Return to footnote 2 referrer

Footnote 3

National Advisory Committee on Immunization (NACI). National Advisory Committee on Immunization (NACI): Methods and process [Internet]. Ottawa (ON): Government of Canada; 2023 Apr 12 [cited 2023 Jun 26]. Available from: https://www.canada.ca/en/public-health/services/immunization/national-advisory-committee-on-immunization-naci/methods-process.html.

Return to footnote 3 referrer

Footnote 4

Golden A, Griffith A, Demczuk W, Lefebvre B, McGeer A, Tyrrell G, et al. Invasive pneumococcal disease surveillance in Canada, 2020. Canada Communicable Disease Report. 2022 Sep;48(9):396-406. https://doi.org/10.14745/ccdr.v48i09a04.

Return to footnote 4 referrer

Footnote 5

ACIP Updates: Recommendations for Use of 20-Valent Pneumococcal Conjugate Vaccine in Children - United States, 2023. MMWR Morb Mortal Wkly Rep. 2023 Sep 29;72(39):1072. https://doi.org/10.15585/mmwr.mm7239a5.

Return to footnote 5 referrer

Footnote 6

Expert Committee on Biological Standardization. Recommendations for the production and control of pneumococcal conjugate vaccines [Internet]. Geneva (CH): World Health Organization; 2009 [cited 2023 Jun 23]. Available from: https://www.who.int/docs/default-source/biologicals/vaccine-quality/48-pneumo-final-23april-2010.pdf?sfvrsn=6f700ed5_1.

Return to footnote 6 referrer

Footnote 7

Merck Canada Inc. Product Monograph: Pneumovax23 (pneumococcal vaccine, polyvalent, MSD Std.) [Internet]. Kirkland (QC): Merck Canada Inc.; 2016 Apr 15 [cited 2023 Jun 26]. Available from: https://pdf.hres.ca/dpd_pm/00035855.PDF.

Return to footnote 7 referrer

Footnote 8

GlaxoSmithKline Inc. Product Monograph: Synflorix Pneumococcal conjugate vaccine (Non-Typeable Haemophilus influenzae (NTHi) protein D, diphtheria or tetanus toxoid conjugates) adsorbed [Internet]. Mississauga (ON): GlaxoSmithKline Inc.; 2019 Nov 13 [cited 2023 Jun 26]. Available from: https://pdf.hres.ca/dpd_pm/00053908.PDF.

Return to footnote 8 referrer

Footnote 9

Pfizer Canada ULC. Product Monograph: Prevnar13 Pneumococcal 13-valent Conjugate Vaccine (Diphtheria CRM197 Protein) [Internet]. Kirkland (QC): Pfizer Canada ULC; 2019 Aug 08 [cited 2023 Jun 26]. Available from: https://pdf.hres.ca/dpd_pm/00052583.PDF.

Return to footnote 9 referrer

Footnote 10

Merck Canada Inc. Product Monograph: Vaxneuvance (Pneumococcal 15-valent Conjugate Vaccine [CRM197 Protein], adsorbed) [Internet]. Kirkland (QC): Merck Canada Inc.; 2022 Jul 08 [cited 2023 Jun 26]. Available from: https://pdf.hres.ca/dpd_pm/00066824.PDF.

Return to footnote 10 referrer

Footnote 11

Pfizer Canada ULC. Product Monograph: Prevnar20 Pneumococcal 20-valent Conjugate Vaccine (Diphtheria CRM197 Protein) [Internet]. Kirkland (QC): Pfizer Canada ULC; 2022 May 09 [cited 2023 Jun 26]. Available from: https://pdf.hres.ca/dpd_pm/00065729.PDF.

Return to footnote 11 referrer

Footnote 12

Pelton SI, Weycker D, Farkouh RA, Strutton DR, Shea KM, Edelsberg J. Risk of pneumococcal disease in children with chronic medical conditions in the era of pneumococcal conjugate vaccine. Clin Infect Dis. 2014 Sep 01;59(5):615-23. https://doi.org/10.1093/cid/ciu348.

Return to footnote 12 referrer

Footnote 13

National Center for Immunization and Respiratory Diseases. EtR framework for PCV20 use in children aged 2–18 years with certain underlying conditions that increase the risk of pneumococcal disease [Internet]. Atlanta (GA): Centers for Disease Control and Prevention; 2023 Sep 12 [cited 2023 Nov 23]. Available from: https://www.cdc.gov/vaccines/acip/recs/grade/PCV20-child-risk-based-etr.html.

Return to footnote 13 referrer

Footnote 14

Nasreen S, Wang J, Sadarangani M, Kwong JC, Quach C, Crowcroft NS, et al. Estimating population-based incidence of community-acquired pneumonia and acute otitis media in children and adults in Ontario and British Columbia using health administrative data, 2005-2018: a Canadian Immunisation Research Network (CIRN) study. BMJ Open Respir Res. 2022 Jun;9(1):e001218. https://doi.org/10.1136/bmjresp-2022-001218.

Return to footnote 14 referrer

Footnote 15

King L. Pediatric outpatient ARI visits and antibiotic use attributable to serotypes in higher valency PCVs [slides presented at Advisory Committee on Immunization Practices (ACIP) meeting February 22, 2023] [Internet]. Atlanta (GA): Centers for Disease Control and Prevention (CDC); 2023 Feb 22 [cited 2023 Sep 12]. Available from: https://www.cdc.gov/vaccines/acip/meetings/downloads/slides-2023-02/slides-02-22/Pneumococcal-03-King-508.pdf.

Return to footnote 15 referrer

Footnote 16

LeBlanc JJ, ElSherif M, Ye L, MacKinnon-Cameron D, Ambrose A, Hatchette TF, et al. Recalibrated estimates of non-bacteremic and bacteremic pneumococcal community acquired pneumonia in hospitalized Canadian adults from 2010 to 2017 with addition of an extended spectrum serotype-specific urine antigen detection assay. Vaccine. 2022 Apr 20;40(18):2635-46. https://doi.org/10.1016/j.vaccine.2022.02.081.

Return to footnote 16 referrer

Footnote 17

Kim SH, Jeon EJ, Hong SM, Bae CH, Lee HY, Park MK, et al. Bacterial Species and Antibiotic Sensitivity in Korean Patients Diagnosed with Acute Otitis Media and Otitis Media with Effusion. J Korean Med Sci. 2017 Apr;32(4):672-8. https://doi.org/10.3346/jkms.2017.32.4.672.

Return to footnote 17 referrer

Footnote 18

Merck Sharp & Dohme LLC. A Study to Evaluate the Safety, Tolerability, and Immunogenicity of V114 in Allogeneic Hematopoietic Stem Cell Transplant Recipients (V114-022/Pneu-STEM) [Internet]. Bethesda (MD): ClinicalTrials.gov; 2022 [cited 2023 Jun 26]. Available from: https://clinicaltrials.gov/ct2/show/study/NCT03565900.

Return to footnote 18 referrer

Footnote 19

Platt HL, Greenberg D, Tapiero B, Clifford RA, Klein NP, Hurley DC, et al. A Phase II Trial of Safety, Tolerability and Immunogenicity of V114, a 15-Valent Pneumococcal Conjugate Vaccine, Compared With 13-Valent Pneumococcal Conjugate Vaccine in Healthy Infants. Pediatr Infect Dis J. 2020 Aug;39(8):763-70. https://doi.org/10.1097/INF.0000000000002765.

Return to footnote 19 referrer

Footnote 20

Martinon-Torres F, Wysocki J, Szenborn L, Carmona-Martinez A, Poder A, Dagan R, et al. A Phase III, multicenter, randomized, double-blind, active comparator-controlled study to evaluate the safety, tolerability, and immunogenicity of V114 compared with PCV13 in healthy infants (Pneu-PED-EU-1). Vaccine. 2023 May 16;41(21):3387-98. https://doi.org/10.1016/j.vaccine.2023.04.036.

Return to footnote 20 referrer

Footnote 21

Bili A, Dobson S, Quinones J, Phongsamart W, Oberdorfer P, Kosalaraksa P, et al. A phase 3, multicenter, randomized, double-blind study to evaluate the interchangeability of V114, a 15-valent pneumococcal conjugate vaccine, and PCV13 with respect to safety, tolerability, and immunogenicity in healthy infants (Pneu-DIRECTION). Vaccine. 2023 Jan 16;41(3):657-65. https://doi.org/10.1016/j.vaccine.2022.10.072.

Return to footnote 21 referrer

Footnote 22

Lupinacci R, Rupp R, Wittawatmongkol O, Jones J, Quinones J, Ulukol B, et al. A phase 3, multicenter, randomized, double-blind, active-comparator-controlled study to evaluate the safety, tolerability, and immunogenicity of a 4-dose regimen of V114, a 15-valent pneumococcal conjugate vaccine, in healthy infants (Pneu-PED). Vaccine. 2023 Jan 27;41(5):1142-52. https://doi.org/10.1016/j.vaccine.2022.12.054.

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Footnote 23

Senders S, Klein NP, Lamberth E, Thompson A, Drozd J, Trammel J, et al. Safety and Immunogenicity of a 20-valent Pneumococcal Conjugate Vaccine in Healthy Infants in the United States. Pediatr Infect Dis J. 2021 Oct 01;40(10):944-51. https://doi.org/10.1097/INF.0000000000003277.

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Footnote 24

Pfizer. 20-valent Pneumococcal Conjugate Vaccine Safety and Immunogenicity Study of a 4-Dose Series in Healthy Infants [Internet]. Bethesda (MD): ClinicalTrials.gov; 2022 Nov 03 [cited 2023 Jun 26]. Available from: https://clinicaltrials.gov/study/NCT04382326.

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Footnote 25

Pfizer. 20-valent Pneumococcal Conjugate Vaccine Safety and Immunogenicity Study of a 3-Dose Series in Healthy Infants [Internet]. Bethesda (MD): ClinicalTrials.gov; 2023 Jun 05 [cited 2023 Jun 26]. Available from: https://clinicaltrials.gov/ct2/show/study/NCT04546425.

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Footnote 26

Pfizer. 20-valent Pneumococcal Conjugate Vaccine Safety Study in Healthy Infants [Internet]. Bethesda (MD): ClinicalTrials.gov; 2023 Jun 13 [cited 2023 Jun 26]. Available from: https://clinicaltrials.gov/study/NCT04379713.

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Footnote 27

Banniettis N, Wysocki J, Szenborn L, Phongsamart W, Pitisuttithum P, Rämet M, et al. A phase III, multicenter, randomized, double-blind, active comparator-controlled study to evaluate the safety, tolerability, and immunogenicity of catch-up vaccination regimens of V114, a 15-valent pneumococcal conjugate vaccine, in healthy infants, children, and adolescents (Pneu-PLAN). Vaccine. 2022 Oct 19;40(44):6315-25. https://doi.org/10.1016/j.vaccine.2022.09.003.

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Footnote 28

Quinn CT, Wiedmann RT, Jarovsky D, Lopez-Medina E, Rodriguez HM, Papa M, et al. Safety and immunogenicity of V114, a 15-valent pneumococcal conjugate vaccine, in children with SCD: a V114-023 (Pneu-SICKLE) study. Blood Adv. 2023 Feb 14;7(3):414-21. https://doi.org/10.1182/bloodadvances.2022008037.

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Footnote 29

Wilck M, Barnabas S, Chokephaibulkit K, Violari A, Kosalaraksa P, Yesypenko S, et al. A phase 3 study of safety and immunogenicity of V114, a 15-valent PCV, followed by PPSV23, in children living with HIV. AIDS. 2023 Mar 20;37(8):1227-37. https://doi.org/10.1097/QAD.0000000000003551.

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Footnote 30

Merck Sharp & Dohme LLC. A Study to Evaluate the Safety and Tolerability of V114 and Prevnar 13™ in Healthy Infants (V114-031/​Pneu-LINK) [Internet]. Bethesda (MD): ClinicalTrials.gov; 2022 [cited 2023 Jun 26]. Available from: https://clinicaltrials.gov/ct2/show/study/NCT03692871.

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Footnote 31

Pfizer. Safety and Immunogenicity Study of 20vPnC in Healthy Children 15 Months Through 17 Years of Age [Internet]. Bethesda (MD): ClinicalTrials.gov; 2023 Apr 26 [cited 2023 Jun 26]. Available from: https://clinicaltrials.gov/study/NCT04642079.

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Footnote 32

Ismail SJ, Hardy K, Tunis MC, Young K, Sicard N, Quach C. A framework for the systematic consideration of ethics, equity, feasibility, and acceptability in vaccine program recommendations. Vaccine. 2020 Aug 10;38(36):5861,5876. https://doi.org/10.1016/j.vaccine.2020.05.051.

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Footnote 33

Office of the High Commissioner for Human Rights. UN Declaration on the Rights of Indigenous Peoples [Internet]. Geneva (CH): United Nations; 2007 Sep 13 [cited 2023 Jun 23]. Available from: https://www.ohchr.org/en/indigenous-peoples/un-declaration-rights-indigenous-peoples.

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Footnote 34

Prasad N, Stoecker C, Xing W, Cho B, Leidner AJ, Kobayashi M. Public health impact and cost-effectiveness of 15-valent pneumococcal conjugate vaccine use among the pediatric population of the United States. Vaccine. 2023 May 02;41(18):2914-21. https://doi.org/10.1016/j.vaccine.2023.03.045.

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Footnote 35

Huang M, Hu T, Weaver J, Owusu-Edusei K, Elbasha E. Cost-Effectiveness Analysis of Routine Use of 15-Valent Pneumococcal Conjugate Vaccine in the US Pediatric Population. Vaccines (Basel). 2023 Jan 06;11(1):135. https://doi.org/10.3390/vaccines11010135.

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Footnote 36

Ayabina D. Y. Summary of three economic analyses of the use of 20-valent pneumococcal conjugate vaccine (PCV20) in children in the United States [slides presented at Advisory Committee on Immunization Practices (ACIP) meeting June 22, 2023] [Internet]. Atlanta (GA): Centers for Disease Control and Prevention (CDC); 2023 Jun 22 [cited 2023 Nov 24]. Available from: https://www.cdc.gov/vaccines/acip/meetings/downloads/slides-2023-06-21-23/03-Pneumococcal-Ayabina-508.pdf.

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Footnote 37

De Wals P. Personal Communication. 2023.

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