Planning guidance for immunization clinics for COVID-19 vaccines: Vaccine product comparison and overview of key features

• September 9, 2022 (primary series for 6 months to 4 years of age).

• November 19, 2021 (primary series for 5 to 11 years of age).
• August 19, 2022 (first booster for 5 to 11 years of age).

• December 9, 2022 (booster dose for 5 to 11 years of age).

• 6 months to 4 years of age for the primary series.

• 5 through 11 years of age for the primary series and for first booster.

• 5 through 11 years of age for the booster dose.

• 0.2 mL (3 mcg of mRNA encoding original strain spike protein)^{Footnote b}.

• 0.2 mL (10 mcg of mRNA encoding original strain spike protein)^{Footnote b}.

• 0.2 mL (10 mcg of mRNA: 5 mcg encoding original strain spike protein and 5 mcg of mRNA encoding Omicron BA.4/BA.5 spike protein)^{Footnote b}.

• Polyethylene glycol (PEG)
• Tromethamine (trometamol or Tris)

• Polyethylene glycol (PEG)
• Tromethamine (trometamol or Tris)

• Polyethylene glycol (PEG)
• Tromethamine (trometamol or Tris)

• Ultra-frozen at -90°C to -60°C until expiry.
• Do not store vials at -25°C to -15°C.
• Refrigerator (2°C to 8°C) for 10 weeks.
• Room temperature: no more than a total of 12 hours before dilution and no more than 12 hours post-dilution^{Footnote b}.
• Once punctured for dilution, use within 12 hours. Punctured vials can be stored at room temperature or refrigerated (between 2°C to 25°C).
• Must not be used beyond 12 hours after first puncture.
• Do not refreeze once thawed.

• Ultra-frozen at -90°C to -60°C until expiry.
• Do not store vials at -25°C to -15°C.
• Refrigerator (2°C to 8°C) for 10 weeks.
• Room temperature: no more than a total of 12 hours before dilution and no more than 12 hours post-dilution^{Footnote b}.
• Once punctured for dilution, use within 12 hours. Punctured vials can be stored at room temperature or refrigerated (between 2°C to 25°C).
• Do not refreeze once thawed.

• Ultra-frozen at -90°C to -60°C until expiry.
• Do not store vials at -25°C to -15°C.
• Refrigerator (2°C to 8°C) for 10 weeks.
• Room temperature: no more than a total of 12 hours before dilution and no more than 12 hours post-dilution^{Footnote b}.
• Once punctured for dilution, use within 12 hours. Punctured vials can be stored at room temperature or refrigerated (between 2°C to 25°C).
• Do not refreeze once thawed.

• If local redistribution is needed, full cartons containing unpunctured vials may be transported at -90°C to -60°C; full cartons or individual unpunctured vials may also be transported at 2°C to 8°C.

• There is not enough data to support transportation of open vials and loaded syringes.

• If local redistribution is needed, full cartons containing unpunctured vials may be transported at -90°C to -60°C; full cartons or individual unpunctured vials may also be transported at 2°C to 8°C.

• There is not enough data to support transportation of open vials and loaded syringes.

• If local redistribution is needed, full cartons containing unpunctured vials may be transported at -90°C to -60°C; full cartons or individual unpunctured vials may also be transported at 2°C to 8°C.

• There is not enough data to support transportation of open vials and loaded syringes.

• Yes – 0.9% sodium chloride diluent provided by the manufacturer^{Footnote b}.
• 2.2 mL of diluent is added to the vial.
• Store diluent at room temperature.

• Yes – 0.9% sodium chloride diluent provided by the manufacturer^{Footnote b}.
• 1.3 mL of diluent is added to the vial.
• Store diluent at room temperature.

• Yes – 0.9% sodium chloride diluent provided by the manufacturer^{Footnote b}.
• 1.3 mL of diluent is added to the vial.
• Store diluent at room temperature.

• Preferentially use a low dead-volume syringe and/or needle.
• 21-gauge or narrower needle for reconstitution.
• 22- to 25-gauge needle for administration^{Footnote f}.

• Preferentially use a low dead-volume syringe and/or needle.
• 21-gauge or narrower needle for reconstitution.
• 22- to 25-gauge needle for administration^{Footnote f}.

• Preferentially use a low dead-volume syringe and/or needle.
• 21-gauge or narrower needle for reconstitution.
• 22- to 25-gauge needle for administration^{Footnote f}.

Multi-dose vial.

After dilution with 2.2 mL of diluent, contains 10 doses of 0.2 mL^{Footnote b}.

Preservative-free.

Multi-dose vial.

After dilution with 1.3 mL of diluent, contains 10 doses of 0.2 mL^{Footnote b}.

Preservative-free.

Multi-dose vial.

After dilution with 1.3 mL of diluent, contains 10 doses of 0.2 mL^{Footnote b}.

Preservative-free.

• 12 months after manufacturing date printed on vial label.

• 12 months after manufacturing date printed on vial label.

• 12 months after manufacturing date printed on vial label.

02527863/33881000087102

02531461/37691000087106

mRNA

mRNA

One dose (0.3 mL) contains 30 mcg of mRNA encoding original strain spike protein (embedded in lipid nanoparticles).

One dose (0.3 mL) contains 15 mcg of mRNA encoding original strain spike protein and 15 mcg of mRNA encoding Omicron BA.4/BA.5 spike protein (both embedded in lipid nanoparticles).

• March 15, 2022 (primary series for 12 years and older). This replaces purple capped product that was authorized on December 9, 2020, for the primary series for 16 years and older and extended to 12 to 15 year olds on May 5, 2021. First booster recommendations were made on September 11, 2021 for 18 years of age and over.
• June 1, 2022 (first booster for 16 and 17 year olds).

• October 7, 2022 (booster dose for 12 years and older).

• 12 years and older for the primary series.
• 16 years and older for first booster.

• 12 years and older for booster dose.

• 0.3 mL (30 mcg of mRNA encoding original strain spike protein).

• 0.3 mL (30 mcg of mRNA: 15 mcg encoding original strain spike protein and 15 mcg of mRNA encoding Omicron BA.4/BA.5 spike protein).

2 doses, 3 weeks apart

Not authorized

First booster: at least 6 months after completing the primary series for 16 years and older.

Booster at least 3 to 6 months after completing the primary series for 12 years and older.

Trans-membrane prefusion spike protein of the original strain

Trans-membrane prefusion spike protein of the original and Omicron BA.4/BA.5 strains

• Polyethylene glycol (PEG)
• Tromethamine (trometamol or Tris)

• Polyethylene glycol (PEG)
• Tromethamine (trometamol or Tris)

None

None

• Ultra frozen at -90°C to -60°C until expiry.
• Do not store vials at -25°C to -15°C.
• Refrigerator (2°C to 8°C) for 10 weeks.
• Room temperature: no more than a total of 12 hours before first puncture and no more than 12 hours after first puncture^{Footnote b}.
• Once punctured, use within 12 hours. Punctured vials can be stored at room temperature or refrigerated (between 2°C to 25°C).
• Do not refreeze once thawed.

• Ultra frozen at -90°C to -60°C until expiry.
• Do not store vials at -25°C to -15°C.
• Refrigerator (2°C to 8°C) for 10 weeks.
• Room temperature: no more than a total of 12 hours before first puncture and no more than 12 hours after first puncture^{Footnote b}.
• Once punctured, use within 12 hours. Punctured vials can be stored at room temperature or refrigerated (between 2°C to 25°C).
• Do not refreeze once thawed.

• If local redistribution is needed, full cartons containing unpunctured vials may be transported at -90°C to -60°C; full cartons or individual unpunctured vials may also be transported at 2°C to 8°C.

• There is not enough data to support transportation of open vials and loaded syringes.

• If local redistribution is needed, full cartons containing unpunctured vials may be transported at -90°C to -60°C; full cartons or individual unpunctured vials may also be transported at 2°C to 8°C.

• There is not enough data to support transportation of open vials and loaded syringes.

• No.

• No.

Intramuscular

Intramuscular

• Preferentially use a low dead-volume syringe and/or needle.
• 22- to 25-gauge needle for administration^{Footnote f}.

• Preferentially use a low dead-volume syringe and/or needle.
• 22- to 25-gauge needle for administration^{Footnote f}.

Multi-dose vial.

2.25 mL in a vial; 6 doses of 0.3 mL^{Footnote b}.

Preservative-free.

Multi-dose vial.

2.25 mL in a vial; 6 doses of 0.3 mL^{Footnote b}.

Preservative-free.

• 12 months after manufacturing date printed on vial label.

• 12 months after manufacturing date printed on vial label.

• December 23, 2020 (primary series for 18 years and older).
• August 27, 2021 (primary series for 12 to 17 years of age).
• November 12, 2021 (first booster for 18 years and older).
• March 17, 2022 (primary series for 6 to 11 years of age).

• March 17, 2022 (new concentration and dosage; primary series for 6 to 11 years and booster for 18 years and older).
• July 14, 2022 (primary series for 6 months to 5 years).

• September 1, 2022 (booster dose in individuals aged 18 years and older).

• November 3, 2022 (booster dose in individuals aged 18 years and older).

• 6 years and older for the primary series.
• 18 years and older for first booster.

• 6 months to 11 years for the primary series.
• 18 years and older for first booster.

• 18 years and older for booster dose.

• 18 years and older for booster dose.

• 0.25 mL (50 mcg of mRNA encoding original strain spike protein) for the primary series for ages 6 to 11 years.
• 0.5 mL (100 mcg of mRNA encoding original strain spike protein) for the primary series for ages 12 years and older.
• 0.25 mL (50 mcg of mRNA encoding original strain spike protein) for first booster for ages 18 years and older^{Footnote a}.

• 0.25 mL (25 mcg of mRNA encoding original strain spike protein) for the primary series for ages 6 months to 5 years.
• 0.5 mL (50 mcg of mRNA encoding original strain spike protein) for the primary series for ages 6 to 11 years.
• 0.5 mL (50 mcg of mRNA encoding original strain spike protein) for booster for ages 18 years and older.

• 0.5 mL (50 mcg dose: 25 mcg of mRNA encoding original strain spike protein and 25 mcg of mRNA encoding Omicron BA.1 spike protein) for booster for ages 18 years and older^{Footnote a}.

• 0.5 mL (50 mcg dose of mRNA: 25 mcg of mRNA encoding original strain spike protein and 25 mcg of mRNA encoding Omicron BA.4/BA.5 spike protein) for booster for ages 18 years and older^{Footnote a}.

• Polyethylene glycol (PEG)
• Tromethamine (trometamol or Tris)

• Polyethylene glycol (PEG)
• Tromethamine (trometamol or Tris)

• Polyethylene glycol (PEG)
• Tromethamine (trometamol or Tris)

• Polyethylene glycol (PEG)
• Tromethamine (trometamol or Tris)

• Frozen (-50°C to -15°C) until expiry^{Footnote c}.
• Refrigerated (2°C to 8°C) for up to 30 days prior to first use.
• Room temperature (8°C to 25°C) for a total of up to 24 hours (whether unpunctured or punctured).
• Once punctured, use within 24 hours. Punctured vials can be stored at room temperature or refrigerated (between 2°C to 25°C). Do not puncture the vial more than 20 times.
• Do not refreeze once thawed.

• Frozen (-50°C to -15°C) until expiry^{Footnote c}.
• Refrigerated (2°C to 8°C) for up to 30 days prior to first use.
• Room temperature (8°C to 25°C) for a total of up to 24 hours (whether unpunctured or punctured).
• Once punctured, use within 24 hours. Punctured vials can be stored at room temperature or refrigerated (between 2°C to 25°C). Do not puncture the vial more than 10 times.
• Do not refreeze once thawed.

• Frozen (-50°C to -15°C) until expiry^{Footnote c}.
• Refrigerated (2°C to 8°C) for up to 30 days prior to first use.
• Room temperature (8°C to 25°C) for a total of up to 24 hours (whether unpunctured or punctured).
• Once punctured, use within 24 hours. Punctured vials can be stored at room temperature or refrigerated (between 2°C to 25°C).
• Do not refreeze once thawed.

• Frozen (-50°C to -15°C) until expiry^{Footnote c}.
• Refrigerated (2°C to 8°C) for up to 30 days prior to first use.
• Room temperature (8°C to 25°C) for a total of up to 24 hours (whether unpunctured or punctured).
• Once punctured, use within 24 hours. Punctured vials can be stored at room temperature or refrigerated (between 2°C to 25°C).
• Do not refreeze once thawed.

• Frozen transport preferred at -50°C to -15°C.
• Refrigerated at 2°C to 8°C for up to 12 cumulative hours in qualified containers permitted.

• Open vials and syringes may be transported at 2°C to 25°C for up to 24 hours as long as total time at room temperature does not exceed 24 hours and total time post-puncture does not exceed 24 hours.

• Frozen transport preferred at -50°C to -15°C.
• Refrigerated at 2°C to 8°C for up to 12 cumulative hours in qualified containers permitted.

• Open vials and syringes may be transported at 2°C to 25°C for up to 24 hours as long as total time at room temperature does not exceed 24 hours and total time post-puncture does not exceed 24 hours.

• Frozen transport preferred at -50°C to -15°C.
• Refrigerated at 2°C to 8°C for up to 12 cumulative hours in qualified containers permitted.

• Open vials and syringes may be transported at 2°C to 25°C for up to 24 hours as long as total time at room temperature does not exceed 24 hours and total time post-puncture does not exceed 24 hours.

• Frozen transport preferred at -50°C to -15°C.
• Refrigerated at 2°C to 8°C for up to 12 cumulative hours in qualified containers permitted.

• Open vials and syringes may be transported at 2°C to 25°C for up to 24 hours as long as total time at room temperature does not exceed 24 hours and total time post-puncture does not exceed 24 hours.

• No.

• No.

• No.

• No.

• Preferentially use a low dead-volume syringe and/or needle.
• 22- to 25-gauge needle for administration^{Footnote e}.

• Preferentially use a low dead-volume syringe and/or needle.
• 22- to 25-gauge needle for administration^{Footnote e}.

• Preferentially use a low dead-volume syringe and/or needle.
• 22- to 25-gauge needle for administration^{Footnote e}.

• Preferentially use a low dead-volume syringe and/or needle.
• 22- to 25-gauge needle for administratione^{Footnote e}.

Multi-dose vial.

0.20 mg/mL; 5 mL in a vial; 10 doses of 0.5 mL; 20 doses of 0.25 mL.

Stopper should not be punctured more than 20 times.

Preservative-free.

Multi-dose vial.

0.10 mg/mL; 2.5 mL in a vial; 5 doses of 0.5 mL; 10 doses of 0.25 mL.

Stopper should not be punctured more than 10 times.

Preservative-free.

Multi-dose vial.

0.10 mg/mL; 2.5 mL in a vial; 5 doses of 0.5 mL.

Preservative-free.

Multi-dose vial.

0.10 mg/mL; 2.5 mL in a vial; 5 doses of 0.5 mL.

Preservative-free.

• Expiry date printed on vial and carton labels but it may be extended. For further information on shelf life extensions, see this website: shelf life extension for the Spikevax (elasomeran) COVID-19 vaccine with printed expiry dates on vial and carton labels.

• Expiry date printed on vial and carton labels but it may be extended. For further information on shelf life extensions, see this website: shelf life extension for the Spikevax (elasomeran) COVID-19 vaccine with printed expiry dates on vial and carton labels.

• Expiry date printed on vial and carton labels but it may be extended. For further information on shelf life extensions, see this website: shelf life extension for the Spikevax (elasomeran) COVID-19 vaccine with printed expiry dates on vial and carton labels.

• Expiry date printed on vial and carton labels but it may be extended. For further information on shelf life extensions, see this website: shelf life extension for the Spikevax (elasomeran) COVID-19 vaccine with printed expiry dates on vial and carton labels.

• March 5, 2021 (primary series for 18 years and over).
• May 11, 2022 (first booster for 18 years and older).

• February 17, 2022 (primary series for 18 years and older).
• November 17, 2022 (first booster for 18 years and older).

• February 24, 2022 (the primary series for 18 to 64 years of age).

• 18 years and older for the primary series and first booster.

• 18 years and older for the primary series and first booster.

• 18 to 64 years of age for the primary series.

• 0.5 mL (5 x 10¹⁰ viral particles per dose encoding original strain spike protein).

• 0.5 mL (5 mcg of original strain spike protein).

• 0.5 mL (3.75 mcg of original strain spike protein).

• Polysorbate 80

• Polysorbate 80

• Polysorbate 80
• Polyethylene glycol (PEG)
• Kanamycin
• Carbenicillin

• Frozen (-25°C to -15°C). The expiry date for frozen storage is printed on the vial and carton after "EXP".
• Refrigerated (2°C to 8°C) for a single period of up to 11 months, not exceeding the original expiry date. Upon moving the product to a refrigerator, the updated expiry date must be written on the carton.
• Once punctured, use within 6 hours. After the first puncture: store refrigerated (2°C to 8°C) for up to 6 hours or store at room temperature (25°C max) for up to 3 hours.

• Unopened vials can be stored refrigerated (2°C to 8°C) for a maximum of 9 months.
• After first puncture: use within 6 hours. Punctured vials can be stored between 2°C to 25°C.
• Do not freeze.

• Store unopened vials and adjuvant in a refrigerator (2°C to 8°C) until expiry (check expiry of antigen and adjuvant).
• Once the antigen and adjuvant are mixed, the vaccine must be used within 6 hours, and handled and stored at room temperature (20°C to 30°C). Do not refrigerate a vial mixed with the adjuvant; if the mixed vaccine is refrigerated, it must be discarded^{Footnote c}.
• Do not freeze.

• Frozen -25°C to -15°C.
• 2°C to 8°C as long as the appropriate storage conditions (temperature, time) are applied.

• Open vials and syringes may be transported at 2°C to 8°C for up to 6 hours as long as they are used within 6 hours of first puncture.

• 2°C to 8°C and the temperature monitored during transport.

• Open vials may be transported at 2°C to 25°C for up to 6 hours as long as total time post puncture does not exceed 6 hours. A loaded syringe should not be transported aside from routine foot traffic in a clinical or medical setting.

• Unpunctured vials may be transported at 2°C to 8°C.

• Once the antigen and adjuvant components are mixed, the vaccine must be used within 6 hours, and handled and stored at room temperature (20°C to 30°C). Do not refrigerate mixed vials.

• No.

• No.

• Yes – AS03 adjuvant provided by the manufacturer^{Footnote c}.
• 2.5 mL of adjuvant added to the antigen vial.
• Before mixing with antigen, refrigerate adjuvant at 2°C to 8°C with the COVIFENZ antigen vial in the packaging until expiry.
• After mixing with the antigen, store at room temperature (20°C to 30°C) and use within 6 hours. Do not refrigerate mixed vials.

• 22- to 25-gauge needle for administration^{Footnote e}.

• 22- to 25-gauge needle for administration^{Footnote e}.

• 21-gauge or wider needle for reconstitution is recommended (23-gauge may be used). See product monograph for technique to withdraw the adjuvant^{Footnote c}.
• 23-gauge needle for administration is recommended. (25-gauge may be used. Note: ensure that the needle is securely attached to the syringe and administer slowly).

Multi-dose vial.

5 x 10¹⁰ virus particles per 0.5 mL dose; 3.1 mL in a vial; 5 doses of 0.5 mL.

Multi-dose vial.

5 mcg/0.5 ml; 5 mL in a vial; 10 doses of 0.5 mL.

Multi-dose vial.

Comes as 2.5 mL of antigen in a vial (larger vial) and 2.5 mL of AS03 adjuvant in another vial (smaller vial). After mixing adjuvant with the antigen, contains 3.75 mcg of original strain per 0.5 mL dose; 10 doses of 0.5 mL in reconstituted vial^{Footnote c}.

Preservative-free.

• The expiry date for storage at -25°C to -15°C is printed on the vial and carton after "EXP".
• The expiry date at 2°C to 8°C after thaw is for a single period of up to 11 months, not exceeding the original expiry date (EXP) on the labels.
• Upon moving the product to a refrigerator at 2°C to 8°C, the updated expiry date must be written on the carton and the vaccine should be used or discarded by the updated expiry date. The original expiry date should be made unreadable.

• Do not use this vaccine after the expiry date, which is stated on the label after EXP. The expiry date refers to the last day of that month.

• Check the expiry date on the antigen and adjuvant vials. The shelf-life on outer cartons, containing the antigen and the adjuvant, is based on the component with the shorter expiry date.