Chemical substances in Batch 4 of the Challenge

Risk management action milestones

The risk management action milestones table outlines the risk management actions that were proposed for each chemical substance in this batch of the Chemical Management Plan's Challenge Initiative that met the criteria of section 64 of the Canadian Environmental Protection Act, 1999 (CEPA 1999). These proposed risk management actions were published in the risk management approaches for these substances. For the complete wording of these proposed actions, please refer to the risk management approaches.

Adding substances to Schedule 1

Three substances in this batch have been included in final orders to add to Schedule 1. One substance, BNST, was subsequently deleted.

Deleting substances from Schedule 1

In October 2020, BNST was deleted from Schedule 1.

BNST was added to Schedule 1 as a result of the 2009 assessment of Batch 4 of the CMP's Challenge Initiative, where it was found to meet the criteria set out in section 64 (a) of CEPA 1999. New information on BNST was obtained following the 2009 assessment; therefore, BNST was re-assessed in the December 2017 Final Screening Assessment for Substituted Diphenylamines (SDPAs), where the Government of Canada concluded that BNST did not meet the criteria under section 64 of CEPA 1999. Based on the results of the final screening assessment, the Government of Canada has deleted BNST from Schedule 1 of CEPA 1999.

Applying Significant New Activity provisions

View the Significant New Activity Publications under the Canadian Environmental Protection Act, 1999. Orders are subject to potential amendments under the Significant New Activity (SNAc) Review.

For additional guidance on submitting information required as part of SNAc notifications, please see the Guidelines for the Notification and Testing of New Substances: Chemicals and Polymers.

Varying the requirements under the Significant New Activity provisions

In July 2019, a notice of intent to amend the DSL to vary the requirements under the SNAc provisions for 4 substances in this batch (CAS RNs 1154-59-2, 1176-74-5, 64325-78-6, 70776-86-2) was published in the Canada Gazette, Part I: Vol. 153, No. 30 - July 27, 2019 for a 60-day public comment period. The proposed amendments are an outcome of the SNAc Review. The DSL amendments do not come into force until the final order is published in the Canada Gazette, Part II. Any current requirements under the SNAc provisions remain in effect until then.

In January 2017, a notice of intent to amend the DSL to vary the requirements under the SNAc provisions for diethyl sulfate (CAS RN 64-67-5) and dimethyl sulfate (CAS RN 77-78-1) was published in the Canada Gazette, Part I: Vol. 151, No. 2 - January 14, 2017 for a 60-day public comment period. The proposed amendments are an outcome of the SNAc Review. The DSL amendments do not come into force until the final order is published in the Canada Gazette, Part II. Any current requirements under the SNAc provisions remain in effect until then.

Rescinding the requirements under the Significant New Activity provisions

In July 2019, the requirements under the SNAc provisions for amines, C18-22-tert-alkyl, ethoxylated (CAS RN 68443-10-7) were proposed to be rescinded. This substance was subject to the SNAc provisions as a result of the 2009 screening assessment of substances in this batch. It was later included in the High Hazard Not in Commerce Substances SNAc Review Group, under the SNAc Review. That review led to the recommendation that the requirements under the SNAc provisions for this substance be rescinded. Furthermore, the substance is not currently in commerce in Canada. Therefore, a notice of intent to amend the DSL to rescind the requirements under the SNAc provisions was published in the Canada Gazette, Part I: Vol. 153, No. 30 - July 27, 2019 for a 60-day public comment period. Current SNAc requirements remain in effect until the final order is published in the Canada Gazette, Part II.

Summary of Batch 4 substances and publications

Substances that meet one or more criteria in section 64 of CEPA 1999
CAS RN Chemical substance Final order and RIAS Public comments on the proposed risk management approach Final screening assessment Proposed risk management approach Public comments on the draft screening assessment and risk management scope
64-67-5 Diethyl sulfate HTML HTML HTML HTML HTML
77-78-1 Dimethyl sulfate HTML HTML HTML HTML HTML
Substances that do not meet any of the criteria in section 64 of CEPA 1999
CAS RN Chemical substance Public comments Final screening assessment
110-54-3 Hexane HTML HTML
115-39-9 Bromophenol Blue HTML HTML
115-40-2 Bromcresol Purple HTML HTML
125-31-5 Xylenol Blue HTML HTML
1154-59-2 Benzamide, 3,5-dichloro-N-(3,4-dichlorophenyl)-2-hydroxy-(3,3',4',5-tetrachlorosalicylanilide) None HTML
1176-74-5 Benzoic acid, 2-[(3,5-dibromo-4-hydroxyphenyl)(3,5-dibromo-4-oxo-2,5-cyclohexadien-1-ylidene)methyl]-, ethyl ester None HTML
17321-77-6 Clomipramine Hydrochloride HTML HTML
62625-32-5 PBTBO HTML HTML
64325-78-6 Adenosine, N-benzoyl-5 -O-[bis(4-methoxyphenyl)phenylmethyl]-2 -deoxy- None HTML
68308-48-5 ATAEP HTML HTML
68443-10-7 Amines, C18-22-tert-alkyl, ethoxylated None HTML
68921-45-9Table 1 footnote 1 BNST HTML HTML
70776-86-2 2-Butanone, 4-[[[1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenyl]methyl](3-oxo-3-phenylpropyl)amino]-, [1R-(1α,4aβ,10aα)]- None HTML
79357-73-6 ATACP HTML HTML
Substances for which the Government of Canada concluded that the exposures to 1,3-butadiene (a substance on Schedule 1 to the Act) identified in the assessment should be considered in relation to ongoing risk management activities undertaken for 1,3-butadiene under CEPA 1999
CAS RN Chemical substance Public comments Final screening assessment
75-28-5 Isobutane containing 1,3-butadiene HTML HTML
106-97-8 Butane containing 1,3-butadiene HTML HTML
Timelines
Date Substances affected Activity
October 28, 2020 CAS RN 68921-45-9 Publication in Canada Gazette, Part II, of a final order deleting BNST from Schedule 1 of CEPA 1999.
July 27, 2019 CAS RNs 68443-10-7, 1154-59-2, 1176-74-5, 64325-78-6, and 70776-86-2 Publication in Canada Gazette, Part I, of a notice of intent to amend the DSL to vary the requirements under the SNAc provisions for CAS RNs 1154-59-2, 1176-74-5, 64325-78-6, and 70776-86-2 and to rescind the SNAc requirements for CAS RN 68443-10-7, and start of 60-day public comment period.
December 13, 2017 CAS RN 68921-45-9 Publication in Canada Gazette, Part II of Regulations amending the Prohibition of Certain Toxic Substances Regulations, 2012 to remove restrictions on BNST.
December 9, 2017 CAS RN 68921-45-9 Publication in Canada Gazette, Part I, of a proposed order deleting BNST from Schedule 1 of CEPA 1999, and start of 60-day public comment period.
December 9, 2017 CAS RN 68921-45-9 Publication in Canada Gazette, Part I, of final assessment decisions under section 68 and subsection 77(6) of CEPA 1999 on 14 SDPAs.
January 14, 2017 CAS RNs 64-67-5 and 77-78-1 Publication in the Canada Gazette, Part I, of a notice of intent to amend the DSL to vary the SNAc requirements, and start of 60-day public comment period.
February 8, 2017 CAS RN 68921-45-9 Deadline for submission of public comments on the draft screening assessment for the 14 SDPAs and consultation document on BNST.
December 10, 2016 CAS RN 68921-45-9 Publication in Canada Gazette, Part I, and start of 60-day public comment period on the draft screening assessment of 14 SDPAs and a consultation document on BNST.
January 30, 2013 CAS RNs 64-67-5 and 77-78-1 Publication in Canada Gazette, Part II, of an order amending the DSL to apply the SNAc provisions of CEPA 1999.
January 2, 2013 CAS RN 68921-45-9 Publication in Canada Gazette, Part II, of Regulations amending the Prohibition of Certain Toxic Substances Regulations, 2012 to add BNST.
July 30, 2011 CAS RNs 64-67-5 and 77-78-1 Publication in Canada Gazette, Part I, of notice of intent to amend the DSL to apply the SNAc provisions of CEPA 1999, and start of 60-day public comment period.
March 2, 2011 CAS RNs 64-67-5, 77-78-1 and 68921-45-9 Publication in Canada Gazette, Part II, of a final order adding 3 substances to Schedule 1.
October 3, 2009 CAS RNs 64-67-5, 77-78-1 and 68921-45-9 Publication in Canada Gazette, Part I of proposed order adding substances to Schedule 1, and start of 60-day public comment period.
August 19, 2009 CAS RNs 1154-59-2, 1176-74-5, 64325-78-6, 68443-10-7 and 70776-86-2 Publication in Canada Gazette, Part II, of an order amending the DSL to apply the SNAc provisions of CEPA 1999.
August 1, 2009 All Batch 4 substances Publication in Canada Gazette, Part I, of final assessment decision under subsection 77(6), release of proposed risk management approaches, and start of 60-day public comment period on the proposed risk management approaches.
January 24, 2009 All Batch 4 substances Publication in Canada Gazette, Part I, and start of 60-day public comment period on (a) the draft screening assessment, (b) the proposal to pursue one of the measures as specified under subsection 77(2) and (c) the risk management scopes.
January 24, 2009 CAS RNs 1154-59-2, 1176-74-5, 64325-78-6, 68443-10-7 and 70776-86-2 Publication in Canada Gazette, Part I, of notice of intent to amend the DSL to apply the SNAc provisions of CEPA 1999, and start of 60-day public comment period.
May 16, 2008 All Batch 4 substances Deadline for submission of additional information by interested stakeholders, including on the extent and nature of the management/stewardship of Batch 4 substances.
March 18, 2008 All Batch 4 substances Deadline for submission of information under the section 71 notice on Batch 4 substances (if no extension granted).
November 17, 2007 All Batch 4 substances Release of Batch 4 of the Challenge and the accompanying technical documents.

Benzenamine, N-phenyl-, reaction products with styrene and 2,4,4-trimethylpentene (BNST): CAS RN 68921-45-9

BNST is an SDPA that was assessed in 2009. Subsequent to the publication of that assessment, other SDPAs were identified for assessment based on their potential risks to the environment and their similarity with BNST. Significant new information also became available regarding the inherent toxicity and bioaccumulation potential of these substances, which brought into question the validity of the previous assessment conclusion for BNST. As a result, BNST has been re-assessed with these other SDPAs as part of the Substance Groupings Initiative of the Chemicals Management Plan.

In December 2017, the Final Screening Assessment for Substituted Diphenylamines was released and the related notice was published in the Canada Gazette, Part I: Vol. 151, No. 49 - December 9, 2017. The final screening assessment concluded that none of the 14 SDPAs assessed pose a risk to the environment or to human health and, therefore, do not meet any of the criteria under section 64 of CEPA 1999. This conclusion applies to BNST, which was considered among the 14 SDPAs, and which had previously been found to meet the criteria set out in section 64 (a) of CEPA 1999 in its 2009 screening assessment. Based on results of the final screening assessment, the Government of Canada has deleted BNST from Schedule 1 of CEPA 1999. The Prohibition of Certain Toxic Substances Regulations, 2012, were also amended to remove the restrictions on BNST.

In December 2016, the Draft Screening Assessment for Substituted Diphenylamines was published for a 60-day public comment period. Given the proposed change in conclusion for BNST and potential implications to the regulatory requirements for this substance, the Government of Canada also published a Consultation Document on the Proposed Approach Regarding Future Regulatory Amendments for BNST for a 60-day public comment period.

Final screening assessments and risk management approaches

In August 2009, the final screening assessments for this batch were released and the related notices were published in the Canada Gazette, Part I: Vol. 143, No. 31 - August 1, 2009.

The final screening assessments concluded that 3 substances in this batch (CAS RNS 64-67-5, 77-78-1, and 68921-45-9) meet one or more criteria in section 64 of CEPA 1999. The Government proposed to add these substances to Schedule 1 of the Act. Proposed risk management approaches were also released on this date for the substances in this batch which met the criteria in section 64 of CEPA 1999.

For the remaining 2 substances in this batch (CAS RNs 75-28-5 and 106-97-8), the assessment that was conducted evaluated the exposure to, and potential risk from, 1,3-butadiene in isobutane containing 1,3-butadiene and in butane containing 1,3-butadiene. It was concluded that exposure to 1,3-butadiene from the uses of butane containing 1,3-butadiene and isobutane containing 1,3-butadiene should be considered in relation to the ongoing risk management of 1,3-butadiene conducted under CEPA 1999.

A screening assessment of the substances isobutane and butane, in the absence of 1,3-butadiene, was later undertaken in January 2017 as part of a group of substances known as short-chain alkanes.

Draft screening assessments and risk management scopes

New information was received from industry or interested stakeholders for each of the 18 substances in this batch. In January 2009, the draft screening assessments were released and the related notices were published in the Canada Gazette, Part I: Vol. 143, No. 4 - January 24, 2009. Risk management scopes were also released in conjunction with these publications.

Information gathering

2007 Mandatory survey – section 71 notice

In November 2007, a notice was published in Canada Gazette, Part I: Vol. 141, No. 46 - November 17, 2007 under section 71 of CEPA 1999.  This section 71 notice applied to all 18 substances in this batch.

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