Calcium 2-ethylhexanoate and 2-ethylhexyl-2-ethylhexanoate
hexanoic acid, 2-ethyl-, calcium salt
CAS Registry Number 136-51-6
hexanoic acid, 2-ethyl-, 2-ethylhexyl ester
CAS Registry Number 7425-14-1
On this page
- About these substances
- Exposure of Canadians and the environment
- Key health and ecological effects (hazard)
- Risk assessment outcomes
- Preventive actions and reducing risk
- Important to know
- The Government of Canada conducted a science-based evaluation, called a screening assessment to address the potential for harm to Canadians and to the environment from calcium 2-ethylhexanoate and 2-ethylhexyl 2-ethylhexanoate.
- Under the Canadian Environmental Protection Act, 1999 (CEPA 1999), the risk posed by a substance is determined by considering both its hazardous properties (its potential to cause adverse human health or ecological effects) and the amount of exposure there is to people and the environment. A substance may have hazardous properties; however, the risk to human health or to the environment may be low depending upon the level of exposure.
- The ecological hazard and exposure potentials of these substances were classified using the Ecological Risk Classification of Organic Substances Approach.
- As a result of this screening assessment, 2-ethylhexyl 2-ethylhexanoate is concluded to be harmful to human health, but not to the environment at current levels of exposure.
- Calcium 2-ethylhexanoate may be associated with effects of concern for human health; however, the risk to Canadians is low at current levels of exposure. Therefore, it is concluded that calcium 2-ethylhexanoate is not harmful to human health or to the environment at current levels of exposure.
About these substances
- This screening assessment focuses on the substances, calcium 2-ethylhexanoate and 2-ethylhexyl 2-ethylhexanoate.
- These substances were assessed as part of the third phase of the Chemicals Management Plan (CMP).
- The Government gathers information on substances, including details on their commercial status in Canada, to support risk assessment and risk management of substances under the CMP.
- In Canada, calcium 2-ethylhexanoate is used in interior and exterior household paints and 2-ethylhexyl 2-ethylhexanoate is an ingredient in certain cosmetic products.
- Calcium 2-ethylhexanoate may be used in the manufacture of some food packaging materials and 2-ethylhexyl 2-ethylhexanoate may occur naturally in very low concentrations in a limited number of foods; however, this exposure is considered to be negligible.
Exposure of Canadians and the environment
- Canadians may be exposed to calcium 2-ethylhexanoate through the use of indoor and outdoor household paints, and to 2-ethylhexyl 2-ethylhexanoate through the use of certain cosmetics, including foot lotion and face make-up.
- These substances were identified as having a low ecological exposure potential.
Key health and ecological effects (hazard)
- There were limited health effects (hazard) data for calcium 2-ethylhexanoate and 2-ethylhexyl 2-ethylhexanoate, therefore, a comparative approach using similar chemicals, called read-across, was used for assessing potential health effects.
- Using data available for a related substance (2-ethylhexanoic acid; a breakdown product), developmental effects, as well as adverse effects on organs (namely the liver), were identified as the important or "critical" effects for characterizing the risk to human health from exposure to calcium 2-ethylhexanoate and 2-ethylhexyl 2-ethylhexanoate.
- Both substances were identified as having a low ecological hazard potential.
Risk assessment outcomes
- Based upon the information presented in this screening assessment, the risk to human health from calcium 2-ethylhexanoate is considered to be low at current levels of exposure; however it was determined that 2-ethylhexyl-2-ethylhexanoate may pose a risk to human health.
- The Ecological Risk Classification of Organic Substances Approach characterized calcium 2-ethylhexanoate and 2-ethylhexyl-2-ethylhexanoate as posing a low risk to the environment.
- The Government of Canada published the Final Screening Assessment for Calcium 2-Ethylhexanoate and 2-Ethylhexyl 2-ethylhexanoate on December 15, 2018.
Screening assessment conclusions
- As a result of this assessment, the Government concluded that calcium 2-ethylhexanoate is not harmful to human health at current levels of exposure, whereas 2-ethylhexyl 2-ethylhexanoate is harmful to human health at current levels of exposure.
- The Government also concluded that calcium 2-ethylhexanoate and 2-ethylhexyl 2-ethylhexanoate are not entering the environment at levels that are harmful to the environment.
Preventive actions and reducing risk
- The Government of Canada published the Risk Management Approach for 2-Ethylhexyl 2-ethylhexanoate on December 15, 2018.
- This publication has a 60-day public comment period ending on February 13, 2019.
- The proposed order adding 2-ethylhexyl-2-ethylhexanoate to Schedule 1 of CEPA 1999, also called the List of Toxic Substances, was published for a 60-day public comment period ending on May 1, 2019.
- The application of the Significant New Activity (SNAc) provisions under CEPA, 1999 to 2-ethylhexyl 2-ethylhexanoate is being considered. This would require that the Government be notified of any proposed new activities related to this substance (for example, manufacture or use of the substance in a different quantity). The substance would be subject to further assessment to determine if the new activity requires further risk management consideration.
- Although calcium 2-ethylhexanoate is not considered to be harmful to human health at current levels of exposure, this substance is considered to have a health effect of concern based on its potential developmental effects. Therefore, there may be a potential risk for human health if exposure levels were to increase.
- For this reason, follow-up activities to track changes in exposure and/or commercial use patterns for calcium 2-ethylhexanoate have been considered and application of the SNAc provisions to this substance have been proposed.
- Stakeholders will have the opportunity to provide feedback on the notice of intent to amend the Domestic Substances List to apply the SNAc provisions to calcium 2-ethylhexanoate during a 60-day public comment period, ending on February 13, 2019.
- Further information and updates on risk management actions can be found in the CMP risk management actions table and the two year rolling risk management activities and consultations schedule.
Important to know
- Cosmetic products must include a list of all ingredients on the product label using the International Nomenclature of Cosmetic Ingredients (INCI). 2-Ethylhexyl 2-ethylhexanoate would be identified under the INCI name: Ethylhexyl Ethylhexanoate.
- Calcium 2-ethylhexanoate and 2-ethylhexyl-2-ethylhexanoate may be found in certain products available to consumers. Canadians should follow any safety warnings and directions on product labels and dispose of products responsibly.
- Canadians who may be exposed to calcium 2-ethylhexanoate and 2-ethylhexyl-2-ethylhexanoate in the workplace should consult with their employer and an occupational health and safety (OHS) representative about safe handling practices, applicable laws, and requirements under OHS legislation and the Workplace Hazardous Materials Information System (WHMIS).
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